Switch ID Status Interaction ID Intramolecular ID A Bindingsite A ID Bindingsite A Start Bindingsite A End ID B Bindingsite B ID Bindingsite B Start Bindingsite B End Affected interactor Switch type Switch subtype Switch mechanism Switch direction Switch outcome direction Switch outcome Modification Modification sites Modifying enzymes Effector Cell cycle phase Localisation Pathway PMID SWTI000001 Active INTI000001 UNIPROT:O43561 ELM:LIG_SH2_STAT5 161 164 UNIPROT:P19174 PFAM:PF00017 550 639 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y161 GO:0009898 KEGG:hsa04660;KEGG:hsa04064;KEGG:hsa04650;REACTOME:202403;REACTOME:2172127 PMID: 20610546;PMID: 15065860 SWTI000002 Active INTI000002 TRUE UNIPROT:P31749 ELM:LIG_AGCK_PIF_1 469 474 UNIPROT:P31749 PFAM:PF00069 150 408 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S473 UNIPROT:P42345 PMID: 19324870 SWTI000003 Active INTI000003 TRUE UNIPROT:P05771-2 ELM:LIG_AGCK_PIF_1 656 661 UNIPROT:P05771-2 PFAM:PF00069 342 600 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S660 UNIPROT:P05771-2 PMID: 19324870 SWTI000004 Active INTI000004 UNIPROT:Q12800 ELM:LIG_WW_Pin1_4 326 331 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T329 PMID: 20682773 SWTI000005 Active INTI000005 UNIPROT:P30307 ELM:LIG_PLK 129 131 UNIPROT:P53350 PFAM:PF00659 417 584 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T130 UNIPROT:P06493 GO:0000086 GO:0005634 KEGG:hsa04110 PMID: 12595692 SWTI000006 Active INTI000006 UNIPROT:P30305 ELM:LIG_PLK 49 51 UNIPROT:P53350 PFAM:PF00659 417 584 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S50 UNIPROT:P06493 KEGG:hsa04110 PMID: 21640712 SWTI000007 Active INTI000007 TRUE UNIPROT:P64897 ELM:LIG_FHA_1 19 25 UNIPROT:P64897 PFAM:PF00498 77 140 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T21 UNIPROT:P65728 PMID: 19318624 SWTI000008 Active INTI000008 UNIPROT:P30307 ELM:LIG_14-3-3_3 213 218 UNIPROT:P31946 PFAM:PF00244 5 238 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S216 UNIPROT:O14757 GO:0031576 GO:0005829 KEGG:hsa04110 PMID: 9278512 SWTI000009 Active INTI000009 UNIPROT:P11117 ELM:TRG_ENDOCYTIC_2 413 416 UNIPROT:Q96CW1 PFAM:PF00928 159 435 ID B Uncategorised Uncategorised PTM-dependent Reversible Positive Induction MOD:00696 T156 UNIPROT:Q2M2I8 PMID: 11877457 SWTI000010 Active INTI000010 TRUE UNIPROT:P12931 ELM:LIG_SH2_SRC 530 533 UNIPROT:P12931 PFAM:PF00017 151 233 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y530 PMID: 19299117 SWTI000011 Active INTI000011 UNIPROT:O95644 ELM:MOD_GSK3_1 287 294 UNIPROT:P49841 PFAM:PF00069 56 340 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S294 UNIPROTFAM:cAMP subfamily PMID: 12351631 SWTI000012 Active INTI000012 UNIPROT:O95644 ELM:MOD_GSK3_1 238 245 UNIPROT:P49841 PFAM:PF00069 56 340 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S245 UNIPROTFAM:cAMP subfamily PMID: 12351631 SWTI000013 Active INTI000013 UNIPROT:P00533 ELM:LIG_TKB 1069 1074 UNIPROT:P22681 IPR:IPR024159 47 351 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1069 PMID: 20877636 SWTI000014 Active INTI000014 UNIPROT:O43597 ELM:LIG_TKB 55 60 UNIPROT:P22681 IPR:IPR024159 47 351 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y55 PMID: 20877636 SWTI000015 Active INTI000015 UNIPROT:P01106 ELM:MOD_GSK3_1 55 62 UNIPROT:P49841 PFAM:PF00069 56 340 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S62 UNIPROT:P28482 KEGG:hsa04151 PMID: 14563837 SWTI000016 Active INTI000016 UNIPROT:P04637 ELM:MOD_GSK3_1 30 37 UNIPROT:P49841 PFAM:PF00069 56 340 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S37 UNIPROT:P78527 PMID: 11483158 SWTI000017 Active INTI000017 UNIPROT:P05412 ELM:MOD_GSK3_1 236 243 UNIPROT:P49841 PFAM:PF00069 56 340 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S243 PMID: 1846781 SWTI000018 Active INTI000018 UNIPROT:P24864 ELM:MOD_GSK3_1 392 399 UNIPROT:P49841 PFAM:PF00069 56 340 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S399 UNIPROT:P24941 PMID: 14536078 SWTI000019 Active INTI000019 UNIPROT:P54252 ELM:MOD_GSK3_1 253 260 UNIPROT:P49841 PFAM:PF00069 56 340 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S260 PMID: 17434145 SWTI000020 Active INTI000020 UNIPROT:P03070 ELM:LIG_SCF_FBW7_2 699 705 UNIPROT:Q969H0 PFAM:PF00400 371;411;451;491;531;571;611 407;447;487;527;567;607;650 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T701 PMID: 15611062 SWTI000021 Active INTI000021 UNIPROT:P46531 ELM:LIG_SCF_FBW7_2 2508 2515 UNIPROT:Q969H0 PFAM:PF00400 371;411;451;491;531;571;611 407;447;487;527;567;607;650 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T2511 PMID: 11461910;PMID:11585921 SWTI000022 Active INTI000022 UNIPROT:Q16665 ELM:LIG_ODPH_VHL_1 400 413 UNIPROT:P40337 PFAM:PF01847 58 213 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00678 P402 UNIPROT:Q9GZT9 GO:0005829 KEGG:hsa04066;REACTOME:1234174 PMID: 12050673;PMID: 12788921 SWTI000023 Active INTI000023 UNIPROT:Q16665 ELM:LIG_ODPH_VHL_1 562 574 UNIPROT:P40337 PFAM:PF01847 58 213 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00678 P564 UNIPROT:Q9GZT9 GO:0005829 KEGG:hsa04066;REACTOME:1234174 PMID: 12050673;PMID: 12788921 SWTI000024 Active INTI000024 UNIPROT:Q99814 ELM:LIG_ODPH_VHL_1 403 416 UNIPROT:P40337 PFAM:PF01847 58 213 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00678 P405 UNIPROT:Q9GZT9 GO:0005829 REACTOME:1234174 PMID: 14691554;PMID: 12788921 SWTI000025 Active INTI000025 UNIPROT:Q99814 ELM:LIG_ODPH_VHL_1 529 542 UNIPROT:P40337 PFAM:PF01847 58 213 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00678 P531 UNIPROT:Q9GZT9 GO:0005829 REACTOME:1234174 PMID: 14691554;PMID: 12788921 SWTI000026 Active INTI000026 UNIPROT:Q9Y2N7 ELM:LIG_ODPH_VHL_1 490 502 UNIPROT:P40337 PFAM:PF01847 58 213 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00678 P492 UNIPROT:Q9GZT9 GO:0005829 REACTOME:1234174 PMID: 12538644;PMID: 12788921 SWTI000027 Active INTI000027 UNIPROT:O15350 ELM:LIG_WW_Pin1_4 409 414 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S412 PMID: 15175157 SWTI000028 Active INTI000028 UNIPROT:O15350 ELM:LIG_WW_Pin1_4 439 444 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T442 PMID: 15175157 SWTI000029 Active INTI000029 UNIPROT:O15350 ELM:LIG_WW_Pin1_4 479 484 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T482 PMID: 15175157 SWTI000030 Active INTI000030 UNIPROT:O54918 ELM:LIG_WW_Pin1_4 62 67 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S65 PMID: 1650491 SWTI000031 Active INTI000031 UNIPROT:P01101 ELM:LIG_WW_Pin1_4 229 234 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T232 PMID: 16123044 SWTI000032 Active INTI000032 UNIPROT:P01101 ELM:LIG_WW_Pin1_4 322 327 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T325 PMID: 16123044 SWTI000033 Active INTI000033 UNIPROT:P01101 ELM:LIG_WW_Pin1_4 328 333 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T331 PMID: 16123044 SWTI000034 Active INTI000034 UNIPROT:P01101 ELM:LIG_WW_Pin1_4 371 376 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S374 PMID: 16123044 SWTI000035 Active INTI000035 UNIPROT:P01106 ELM:LIG_WW_Pin1_4 55 60 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T58 PMID: 15048125 SWTI000036 Active INTI000036 UNIPROT:P03409 ELM:LIG_WW_Pin1_4 157 162 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S160 PMID: 19338781 SWTI000037 Active INTI000037 UNIPROT:P04637 ELM:LIG_WW_Pin1_4 30 35 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S33 PMID: 12388558 SWTI000038 Active INTI000038 UNIPROT:P04637 ELM:LIG_WW_Pin1_4 312 317 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S315 PMID: 12397362 SWTI000039 Active INTI000039 UNIPROT:P04637 ELM:LIG_WW_Pin1_4 78 83 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T81 PMID: 12397362 SWTI000040 Active INTI000040 UNIPROT:P05412 ELM:LIG_WW_Pin1_4 60 65 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S63 PMID: 11432833 SWTI000041 Active INTI000041 UNIPROT:P05412 ELM:LIG_WW_Pin1_4 70 75 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S73 PMID: 11432833 SWTI000042 Active INTI000042 UNIPROT:P06876 ELM:LIG_WW_Pin1_4 525 530 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S528 PMID: 18359295 SWTI000043 Active INTI000043 UNIPROT:P10276 ELM:LIG_WW_Pin1_4 74 79 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S77 PMID: 15670742 SWTI000044 Active INTI000044 UNIPROT:P14598 ELM:LIG_WW_Pin1_4 342 347 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S345 PMID: 20956805 SWTI000045 Active INTI000045 UNIPROT:P22736 ELM:LIG_WW_Pin1_4 137 142 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S140 PMID: 22002310 SWTI000046 Active INTI000046 UNIPROT:P22736 ELM:LIG_WW_Pin1_4 428 433 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S431 PMID: 22002310 SWTI000047 Active INTI000047 UNIPROT:P22736 ELM:LIG_WW_Pin1_4 92 97 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S95 PMID: 22002310 SWTI000048 Active INTI000048 UNIPROT:P25322 ELM:LIG_WW_Pin1_4 283 288 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T286 PMID: 11805292 SWTI000049 Active INTI000049 UNIPROT:P29590 ELM:LIG_WW_Pin1_4 400 405 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S403 PMID: 18039859 SWTI000050 Active INTI000050 UNIPROT:P29590 ELM:LIG_WW_Pin1_4 502 507 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S505 PMID: 18039859 SWTI000051 Active INTI000051 UNIPROT:P29590 ELM:LIG_WW_Pin1_4 515 520 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S518 PMID: 18039859 SWTI000052 Active INTI000052 UNIPROT:P29590 ELM:LIG_WW_Pin1_4 524 529 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S527 PMID: 18039859 SWTI000053 Active INTI000053 UNIPROT:P31749 ELM:LIG_WW_Pin1_4 447 452 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T450 PMID: 19448664 SWTI000054 Active INTI000054 UNIPROT:P31749 ELM:LIG_WW_Pin1_4 89 94 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T92 PMID: 19448664 SWTI000055 Active INTI000055 UNIPROT:P33242 ELM:LIG_WW_Pin1_4 200 205 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S203 PMID: 19995909 SWTI000056 Active INTI000056 UNIPROT:P35222 ELM:LIG_WW_Pin1_4 243 248 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S246 PMID: 11533658 SWTI000057 Active INTI000057 UNIPROT:P35568 ELM:LIG_WW_Pin1_4 431 436 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S434 PMID: 21454638 SWTI000058 Active INTI000058 UNIPROT:P35991 ELM:LIG_WW_Pin1_4 112 117 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S115 PMID: 16644721 SWTI000059 Active INTI000059 UNIPROT:P35991 ELM:LIG_WW_Pin1_4 18 23 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S21 PMID: 16644721 SWTI000060 Active INTI000060 UNIPROT:P40763 ELM:LIG_WW_Pin1_4 724 729 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S727 PMID: 17563747 SWTI000061 Active INTI000061 UNIPROT:P46527 ELM:LIG_WW_Pin1_4 184 189 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T187 PMID: 19584057 SWTI000062 Active INTI000062 UNIPROT:P46531 ELM:LIG_WW_Pin1_4 2118 2123 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S2121 PMID: 191517083 SWTI000063 Active INTI000063 UNIPROT:P46531 ELM:LIG_WW_Pin1_4 2129 2134 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T2132 PMID: 191517084 SWTI000064 Active INTI000064 UNIPROT:P46531 ELM:LIG_WW_Pin1_4 2133 2138 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S2136 PMID: 191517088 SWTI000065 Active INTI000065 UNIPROT:P54274 ELM:LIG_WW_Pin1_4 146 151 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T149 PMID: 19060891 SWTI000066 Active INTI000066 UNIPROT:P69713 ELM:LIG_WW_Pin1_4 38 43 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S41 PMID: 17383430 SWTI000067 Active INTI000067 UNIPROT:P78543 ELM:LIG_WW_Pin1_4 144 149 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S147 PMID: 15788397 SWTI000068 Active INTI000068 UNIPROT:P84022 ELM:LIG_WW_Pin1_4 176 181 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T179 PMID: 19122240 SWTI000069 Active INTI000069 UNIPROT:P84022 ELM:LIG_WW_Pin1_4 201 206 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S204 PMID: 19122240 SWTI000070 Active INTI000070 UNIPROT:P84022 ELM:LIG_WW_Pin1_4 205 210 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S208 PMID: 19122240 SWTI000071 Active INTI000071 UNIPROT:P84022 ELM:LIG_WW_Pin1_4 210 215 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S213 PMID: 19122240 SWTI000072 Active INTI000072 UNIPROT:Q01860 ELM:LIG_WW_Pin1_4 9 14 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S12 PMID: 21296877 SWTI000073 Active INTI000073 UNIPROT:Q04206 ELM:LIG_WW_Pin1_4 251 256 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T254 PMID: 14690596 SWTI000074 Active INTI000074 UNIPROT:Q05397 ELM:LIG_WW_Pin1_4 907 912 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S910 PMID: 19595712 SWTI000075 Active INTI000075 UNIPROT:Q14653 ELM:LIG_WW_Pin1_4 336 341 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S339 PMID: 16699525 SWTI000076 Active INTI000076 UNIPROT:Q3U182 ELM:LIG_WW_Pin1_4 133 138 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S136 PMID: 20675384 SWTI000077 Active INTI000077 UNIPROT:Q61457 ELM:LIG_WW_Pin1_4 382 387 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S385 PMID: 16223725 SWTI000078 Active INTI000078 UNIPROT:Q80Z64 ELM:LIG_WW_Pin1_4 49 54 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S52 PMID: 20622153 SWTI000079 Active INTI000079 UNIPROT:Q80Z64 ELM:LIG_WW_Pin1_4 62 67 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S65 PMID: 20622153 SWTI000080 Active INTI000080 UNIPROT:Q8BT07 ELM:LIG_WW_Pin1_4 420 425 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S423 PMID: 19638580 SWTI000081 Active INTI000081 UNIPROT:Q8BT07 ELM:LIG_WW_Pin1_4 423 428 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S426 PMID: 19638580 SWTI000082 Active INTI000082 UNIPROT:Q8BUV3 ELM:LIG_WW_Pin1_4 185 190 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S188 PMID: 17347650 SWTI000083 Active INTI000083 UNIPROT:Q8BUV3 ELM:LIG_WW_Pin1_4 191 196 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S194 PMID: 17347650 SWTI000084 Active INTI000084 UNIPROT:Q8BUV3 ELM:LIG_WW_Pin1_4 197 202 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S200 PMID: 17347650 SWTI000085 Active INTI000085 UNIPROT:Q8CFN5 ELM:LIG_WW_Pin1_4 107 112 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S110 PMID: 20801874 SWTI000086 Active INTI000086 UNIPROT:Q8CFN5 ELM:LIG_WW_Pin1_4 95 100 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S98 PMID: 20801874 SWTI000087 Active INTI000087 UNIPROT:Q92945 ELM:LIG_WW_Pin1_4 178 183 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S181 PMID: 19770516 SWTI000088 Active INTI000088 UNIPROT:Q99K48 ELM:LIG_WW_Pin1_4 409 414 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T412 PMID: 15701524 SWTI000089 Active INTI000089 UNIPROT:Q99K48 ELM:LIG_WW_Pin1_4 427 432 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T430 PMID: 15701524 SWTI000090 Active INTI000090 UNIPROT:Q99K48 ELM:LIG_WW_Pin1_4 449 454 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T452 PMID: 15701524 SWTI000091 Active INTI000091 UNIPROT:Q99MK8 ELM:LIG_WW_Pin1_4 667 672 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S670 PMID: 20080565 SWTI000092 Active INTI000092 UNIPROT:Q9BR01 ELM:LIG_WW_Pin1_4 5 10 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T8 PMID: 19439498;20920535 SWTI000093 Active INTI000093 UNIPROT:Q9BR01 ELM:LIG_WW_Pin1_4 8 13 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T11 PMID: 19439498;20920535 SWTI000094 Active INTI000094 UNIPROT:Q9ERA0 ELM:LIG_WW_Pin1_4 288 293 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S291 PMID: 20682773 SWTI000095 Active INTI000095 UNIPROT:Q9ERA0 ELM:LIG_WW_Pin1_4 306 311 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S309 PMID: 20682773 SWTI000096 Active INTI000096 UNIPROT:Q9ERA0 ELM:LIG_WW_Pin1_4 326 331 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T329 PMID: 20682773 SWTI000097 Active INTI000097 UNIPROT:Q9HC98 ELM:LIG_WW_Pin1_4 212 217 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S215 PMID: 16476580 SWTI000098 Active INTI000098 UNIPROT:Q9HC98 ELM:LIG_WW_Pin1_4 242 247 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S245 PMID: 16476580 SWTI000099 Active INTI000099 UNIPROT:Q9NY61 ELM:LIG_WW_Pin1_4 143 148 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T146 PMID: 17468107 SWTI000100 Active INTI000100 UNIPROT:Q9UER7 ELM:LIG_WW_Pin1_4 175 180 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S178 PMID: 17938171 SWTI000101 Active INTI000101 UNIPROT:Q9Y618 ELM:LIG_WW_Pin1_4 1238 1243 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T1241 PMID: 188385533 SWTI000102 Active INTI000102 UNIPROT:Q9Y618 ELM:LIG_WW_Pin1_4 1441 1446 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T1444 PMID: 188385536 SWTI000103 Active INTI000103 UNIPROT:Q9Y6H5 ELM:LIG_WW_Pin1_4 208 213 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S211 PMID: 16365047 SWTI000104 Active INTI000104 UNIPROT:Q9Y6H5 ELM:LIG_WW_Pin1_4 212 217 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S215 PMID: 16365047 SWTI000105 Active INTI000105 UNIPROT:O35147 ELM:LIG_14-3-3_1 134 139 UNIPROT:P31946 PFAM:PF00244 5 238 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S137 UNIPROT:P47196 GO:0005829 KEGG:rno04151;REACTOME:2721265 PMID: 9369453;PMID: 12049737 SWTI000106 Active INTI000106 UNIPROT:P03076 ELM:LIG_14-3-3_1 254 259 UNIPROT:P63104 PFAM:PF00244 3 236 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S257 PMID: 9428519 SWTI000107 Active INTI000107 UNIPROT:P54253 ELM:LIG_14-3-3_1 772 777 UNIPROT:P63104 PFAM:PF00244 3 236 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S775 UNIPROT:P31749 PMID: 12757707 SWTI000108 Active INTI000108 UNIPROT:Q99683 ELM:LIG_14-3-3_1 963 968 UNIPROT:P63104 PFAM:PF00244 3 236 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S966 PMID: 10411906 SWTI000109 Active INTI000109 UNIPROT:A2ALK8 ELM:LIG_14-3-3_2 355 361 UNIPROT:Q9CQV8 PFAM:PF00244 5 238 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S359 PMID: 9341175 SWTI000110 Active INTI000110 UNIPROT:P32418 ELM:LIG_14-3-3_2 388 394 UNIPROT:P62258 PFAM:PF00244 4 239 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S392 GO:0009898 PMID: 16679322 SWTI000111 Active INTI000111 UNIPROT:P98177 ELM:LIG_14-3-3_2 193 199 UNIPROT:P63104 PFAM:PF00244 3 236 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S197 UNIPROT:P31749 PMID: 16114898 SWTI000112 Active INTI000112 UNIPROT:Q04206 ELM:LIG_14-3-3_2 41 47 UNIPROT:Q04917 PFAM:PF00244 4 241 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S45 UNIPROTFAM:I-kappa-B kinase subfamily PMID: 16931600 SWTI000113 Active INTI000113 UNIPROT:Q14432 ELM:LIG_14-3-3_2 424 430 UNIPROT:P63104 PFAM:PF00244 3 236 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S428 UNIPROTFAM:PKC subfamily PMID: 16153182 SWTI000114 Active INTI000114 UNIPROT:Q63572 ELM:LIG_14-3-3_2 435 441 UNIPROT:P35213 PFAM:PF00244 5 238 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S439 PMID: 11555644 SWTI000115 Active INTI000115 UNIPROT:P43565 ELM:LIG_14-3-3_3 1072 1077 UNIPROT:P34730 PFAM:PF00244 5 241 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T1075 UNIPROT:P17157 PMID: 16308562 SWTI000116 Active INTI000116 UNIPROT:P56524 ELM:LIG_14-3-3_3 629 634 UNIPROT:P31946 PFAM:PF00244 5 238 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S632 PMID: 10869435 SWTI000117 Active INTI000117 UNIPROT:Q13085 ELM:LIG_BRCT_BRCA1_1 1262 1266 UNIPROT:P38398 PFAM:PF00533 1648;1756 1723;1842 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S1263 PMID: 16698035 SWTI000118 Active INTI000118 UNIPROT:Q6UWZ7 ELM:LIG_BRCT_BRCA1_1 405 409 UNIPROT:P38398 PFAM:PF00533 1648;1756 1723;1842 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S406 PMID: 17525340 SWTI000119 Active INTI000119 UNIPROT:Q8WXE1 ELM:LIG_BRCT_BRCA1_1 238 242 UNIPROT:P38398 PFAM:PF00533 1648;1756 1723;1842 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S239 PMID: 17616665 SWTI000120 Active INTI000120 UNIPROT:Q99708 ELM:LIG_BRCT_BRCA1_1 326 330 UNIPROT:P38398 PFAM:PF00533 1648;1756 1723;1842 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S327 PMID: 16101277 SWTI000121 Active INTI000121 UNIPROT:Q9BX63 ELM:LIG_BRCT_BRCA1_1 989 993 UNIPROT:P38398 PFAM:PF00533 1648;1756 1723;1842 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S990 PMID: 14576433;PMID: 15133502 SWTI000122 Active INTI000122 UNIPROT:Q9BX63 ELM:LIG_BRCT_BRCA1_2 989 995 UNIPROT:P38398 PFAM:PF00533 1648;1756 1723;1842 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S990 PMID: 14576433 SWTI000123 Active INTI000123 UNIPROT:P16104 ELM:LIG_BRCT_MDC1_1 139 143 UNIPROT:Q14676 PFAM:PF00533 1883;1993 1960;2072 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S140 UNIPROT:Q13315,UNIPROT:P78527 PMID: 16377563;PMID: 15059890 SWTI000124 Active INTI000124 TRUE UNIPROT:O96017 ELM:LIG_FHA_1 66 72 UNIPROT:O96017 PFAM:PF00498 113 192 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T68 PMID: 12049740 SWTI000125 Active INTI000125 UNIPROT:P14737 ELM:LIG_FHA_1 601 607 UNIPROT:P22216 PFAM:PF00498 601 681 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T603 GO:0005634 KEGG:sce04111;KEGG:sce04113 PMID: 11846568 SWTI000126 Active INTI000126 UNIPROT:P34217 ELM:LIG_FHA_1 303 309 UNIPROT:P22216 PFAM:PF00498 66 133 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T305 PMID: 15024067 SWTI000127 Active INTI000127 UNIPROT:Q9SYQ8 ELM:LIG_FHA_1 866 872 UNIPROT:P46014 PFAM:PF00498 208 284 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T868 PMID: 16042389 SWTI000128 Active INTI000128 UNIPROT:P14737 ELM:LIG_FHA_2 153 159 UNIPROT:P22216 PFAM:PF00498 66 133 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T155 GO:0005634 KEGG:sce04111;KEGG:sce04113 PMID: 11846567 SWTI000129 Active INTI000129 UNIPROT:P14737 ELM:LIG_FHA_2 190 196 UNIPROT:P22216 PFAM:PF00498 66 133 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T192 GO:0005634 KEGG:sce04111;KEGG:sce04113 PMID: 11846567 SWTI000130 Active INTI000130 UNIPROT:P18887 ELM:LIG_FHA_2 521 527 UNIPROT:Q7Z2E3 PFAM:PF00498 25 116 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T523 UNIPROT:P68400 PMID: 15367657 SWTI000131 Active INTI000131 UNIPROT:Q13426 ELM:LIG_FHA_2 231 237 UNIPROT:Q96T60 IPR:IPR008984 7 112 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T233 UNIPROT:P68400 PMID: 15385968 SWTI000132 Active INTI000132 UNIPROT:Q924T3 ELM:LIG_FHA_2 229 235 UNIPROT:Q9JLV6 IPR:IPR008984 7 112 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T231 PMID: 15749016 SWTI000133 Active INTI000133 UNIPROT:Q9P7T4 ELM:LIG_FHA_2 643 649 UNIPROT:Q09170 PFAM:PF00498 60 133 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T645 PMID: 14585996 SWTI000134 Active INTI000134 UNIPROT:P00533 ELM:LIG_PTB_Phospho_1 1104 1110 UNIPROT:Q99704 PFAM:PF02174 151 254 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1110 PMID: 15476828 SWTI000135 Active INTI000135 UNIPROT:P21860 ELM:LIG_PTB_Phospho_1 1322 1328 UNIPROT:P29353 PFAM:PF00640 162 318 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1328 PMID: 8026468 SWTI000136 Active INTI000136 UNIPROT:P14784 ELM:LIG_PTB_Phospho_1 358 364 UNIPROT:P29353 PFAM:PF00640 162 318 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y364 PMID: 8643566 SWTI000137 Active INTI000137 UNIPROT:P24394 ELM:LIG_PTB_Phospho_1 491 497 UNIPROT:P35568 PFAM:PF02174 160 262 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y497 PMID: 9697832;PMID: 8599766 SWTI000138 Active INTI000138 UNIPROT:P06213 ELM:LIG_PTB_Phospho_1 993 999 UNIPROT:P29353 PFAM:PF00640 162 318 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y999 PMID: 8626723 SWTI000139 Active INTI000139 UNIPROT:P05106 ELM:LIG_PTB_Phospho_1 767 773 UNIPROT:Q99704 PFAM:PF02174 151 254 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y773 PMID: 12606711;PMID: 20739287;PMID: 18156175 SWTI000140 Active INTI000140 UNIPROT:P05106 ELM:LIG_PTB_Phospho_1 779 785 UNIPROT:P29353 PFAM:PF00640 162 318 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y785 PMID: 20739287 SWTI000141 Active INTI000141 UNIPROT:P16144 ELM:LIG_PTB_Phospho_1 1590 1596 UNIPROT:P29353 PFAM:PF00640 162 318 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1596 PMID: 11044453 SWTI000142 Active INTI000142 UNIPROT:Q07954 ELM:LIG_PTB_Phospho_1 4501 4507 UNIPROT:P29353 PFAM:PF00640 162 318 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y4507 PMID: 12789267 SWTI000143 Active INTI000143 UNIPROT:P03077 ELM:LIG_PTB_Phospho_1 244 250 UNIPROT:P98083 PFAM:PF00640 162 318 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y250 PMID: 7543098 SWTI000144 Active INTI000144 UNIPROT:Q61006 ELM:LIG_PTB_Phospho_1 547 553 UNIPROT:Q18PE0 PFAM:PF02174 110 204 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y553 PMID: 20603078 SWTI000145 Active INTI000145 UNIPROT:P04629 ELM:LIG_PTB_Phospho_1 490 496 UNIPROT:P29353 PFAM:PF00640 162 318 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y496 PMID: 8524391 SWTI000146 Active INTI000146 UNIPROT:P35546 ELM:LIG_PTB_Phospho_1 1057 1063 UNIPROT:P97465 PFAM:PF02174 151 254 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1063 PMID: 14607833 SWTI000147 Active INTI000147 UNIPROT:Q92835 ELM:LIG_PTB_Phospho_1 1016 1022 UNIPROT:P29353 PFAM:PF00640 162 318 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1022 PMID: 9083021;PMID: 9099679 SWTI000148 Active INTI000148 UNIPROT:Q92835 ELM:LIG_PTB_Phospho_1 909 915 UNIPROT:P29353 PFAM:PF00640 162 318 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y915 PMID: 9083021;PMID: 9099679 SWTI000149 Active INTI000149 TRUE UNIPROT:O00141 ELM:LIG_AGCK_PIF_1 418 423 UNIPROT:O00141 PFAM:PF00069 98 355 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S422 UNIPROT:P42345 PMID: 11500365;PMID: 18925875 SWTI000150 Active INTI000150 TRUE UNIPROT:P11792 ELM:LIG_AGCK_PIF_1 733 738 UNIPROT:P11792 PFAM:PF00069 412 671 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T737 UNIPROT:P35169 PMID: 21531713;PMID: 17560372 SWTI000151 Active INTI000151 TRUE UNIPROT:P18654 ELM:LIG_AGCK_PIF_1 382 387 UNIPROT:P18654 PFAM:PF00069 68;422 327;679 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S386 UNIPROT:P18654 PMID: 10856237 SWTI000152 Active INTI000152 TRUE UNIPROT:P31751 ELM:LIG_AGCK_PIF_1 470 475 UNIPROT:P31751 PFAM:PF00069 152 409 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S474 PMID: 12434148 SWTI000153 Active INTI000153 TRUE UNIPROT:P67999 ELM:LIG_AGCK_PIF_1 408 413 UNIPROT:P67999 PFAM:PF00069 91 352 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T412 PMID: 11500365 SWTI000154 Active INTI000154 TRUE UNIPROT:Q13464 ELM:LIG_AGCK_PIF_1 394 399 UNIPROT:Q13464 PFAM:PF00069 76 338 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T398 PMID: 18204440 SWTI000155 Active INTI000155 TRUE UNIPROT:Q96BR1 ELM:LIG_AGCK_PIF_1 482 487 UNIPROT:Q96BR1 PFAM:PF00069 162 419 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S486 PMID: 16790420 SWTI000156 Active INTI000156 TRUE UNIPROT:Q9ERE3 ELM:LIG_AGCK_PIF_1 482 487 UNIPROT:Q9ERE3 PFAM:PF00069 162 419 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S486 PMID: 14604990 SWTI000157 Active INTI000157 UNIPROT:O00221 ELM:LIG_SCF-TrCP1_1 156 161 UNIPROT:Q9Y297 PFAM:PF00400 297;333;373;416;456;496;545 329;369;409;452;492;532;581 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S157;S161 PMID: 10497169;PMID: 9135156 SWTI000158 Active INTI000158 UNIPROT:P03230 ELM:LIG_SCF-TrCP1_1 210 215 UNIPROT:Q9UKB1 PFAM:PF00400 232;270;310;353;393;433;482 266;306;346;389;429;469;518 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S211;S215 PMID: 14523018 SWTI000159 Active INTI000159 UNIPROT:P05923 ELM:LIG_SCF-TrCP1_1 51 56 UNIPROT:Q9Y297 PFAM:PF00400 297;333;373;416;456;496;545 329;369;409;452;492;532;581 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S52;S56 PMID: 14561767 SWTI000160 Active INTI000160 UNIPROT:P16471 ELM:LIG_SCF-TrCP1_1 348 353 UNIPROT:Q9UKB1 PFAM:PF00400 232;270;310;353;393;433;482 266;306;346;389;429;469;518 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S349;S353 PMID: 15082796 SWTI000161 Active INTI000161 UNIPROT:P18848 ELM:LIG_SCF-TrCP1_1 218 224 UNIPROT:Q9Y297 PFAM:PF00400 297;333;373;416;456;496;545 329;369;409;452;492;532;581 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S219;S224 PMID: 11238952 SWTI000162 Active INTI000162 UNIPROT:P19838 ELM:LIG_SCF-TrCP1_1 926 932 UNIPROT:Q9Y297 PFAM:PF00400 297;333;373;416;456;496;545 329;369;409;452;492;532;581 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S927;S932 PMID: 12482991 SWTI000163 Active INTI000163 UNIPROT:P25963 ELM:LIG_SCF-TrCP1_1 31 36 UNIPROT:Q9Y297 PFAM:PF00400 297;333;373;416;456;496;545 329;369;409;452;492;532;581 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S32;S36 PMID: 9990852;PMID: 10230406;PMID: 10497169 SWTI000164 Active INTI000164 UNIPROT:Q12959 ELM:LIG_SCF-TrCP1_1 597 602 UNIPROT:Q9Y297 PFAM:PF00400 297;333;373;416;456;496;545 329;369;409;452;492;532;581 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S598;S602 PMID: 12902344 SWTI000165 Active INTI000165 UNIPROT:Q15653 ELM:LIG_SCF-TrCP1_1 18 23 UNIPROT:Q9Y297 PFAM:PF00400 297;333;373;416;456;496;545 329;369;409;452;492;532;581 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S19;S23 PMID: 10497169 SWTI000166 Active INTI000166 UNIPROT:Q53EL6 ELM:LIG_SCF-TrCP1_1 70 76 UNIPROT:Q9Y297 PFAM:PF00400 297;333;373;416;456;496;545 329;369;409;452;492;532;581 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S71;S76 PMID: 17053147 SWTI000167 Active INTI000167 UNIPROT:Q6PGQ7 ELM:LIG_SCF-TrCP1_1 496 501 UNIPROT:Q9Y297 PFAM:PF00400 297;333;373;416;456;496;545 329;369;409;452;492;532;581 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S497;T501 PMID: 18378770 SWTI000168 Active INTI000168 UNIPROT:Q9HAW4 ELM:LIG_SCF-TrCP1_1 29 34 UNIPROT:Q9Y297 PFAM:PF00400 297;333;373;416;456;496;545 329;369;409;452;492;532;581 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S30;S34 PMID: 16885022 SWTI000169 Active INTI000169 UNIPROT:Q9UKT4 ELM:LIG_SCF-TrCP1_1 144 149 UNIPROT:Q9Y297 PFAM:PF00400 297;333;373;416;456;496;545 329;369;409;452;492;532;581 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S145;S149 GO:0051324 GO:0005829 KEGG:hsa04114;REACTOME:174113 PMID: 12791266 SWTI000170 Active INTI000170 UNIPROT:Q8QGV2 ELM:LIG_WW_Pin1_4 183 188 UNIPROT:Q9I9K6 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T186 PMID: 17360425 SWTI000171 Active INTI000171 UNIPROT:Q90Z80 ELM:LIG_WW_Pin1_4 7 12 UNIPROT:Q9I9K6 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S10 PMID: 17159919 SWTI000172 Active INTI000172 UNIPROT:P35210 ELM:LIG_WW_Pin1_4 651 656 UNIPROT:P22696 PFAM:PF00397 11 41 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S654 PMID: 19597489 SWTI000173 Active INTI000173 UNIPROT:O64645 ELM:LIG_WW_Pin1_4 192 197 UNIPROT:Q9SL42 PFAM:PF00639 11 119 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S195 PMID: 20129060 SWTI000174 Active INTI000174 UNIPROT:O64645 ELM:LIG_WW_Pin1_4 46 51 UNIPROT:Q9SL42 PFAM:PF00639 11 119 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S49 PMID: 20129060 SWTI000175 Active INTI000175 UNIPROT:O82794 ELM:LIG_WW_Pin1_4 199 204 UNIPROT:Q9SL42 PFAM:PF00639 11 119 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T202 PMID: 20129060 SWTI000176 Active INTI000176 UNIPROT:P34152-3 ELM:LIG_WW_Pin1_4 907 912 UNIPROT:Q9QUR7 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S910 PMID: 19595712 SWTI000177 Active INTI000177 UNIPROT:P31994 ELM:MOD_TYR_ITIM 290 295 UNIPROT:Q92835 PFAM:PF00017 5 86 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y292 GO:0009898 PMID: 7718892;PMID: 9052859 SWTI000178 Active INTI000178 UNIPROT:P43630 ELM:MOD_TYR_ITIM 396 401 UNIPROT:P29350 PFAM:PF00017 4;110 79;194 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y398 GO:0009898 PMID: 8986721 SWTI000179 Active INTI000179 UNIPROT:Q13291 ELM:MOD_TYR_ITSM 277 284 UNIPROT:Q06124 PFAM:PF00017 6;112 81;197 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y281 GO:0009898 PMID: 11313386 SWTI000180 Active INTI000180 UNIPROT:Q13291 ELM:MOD_TYR_ITSM 323 330 UNIPROT:Q06124 PFAM:PF00017 6;112 81;197 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y327 GO:0009898 PMID: 11313386 SWTI000181 Active INTI000181 UNIPROT:P35570 ELM:LIG_SH2_GRB2 895 898 UNIPROT:P62994 PFAM:PF00017 60 135 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y895 PMID: 7504175 SWTI000182 Active INTI000182 UNIPROT:P01106 ELM:LIG_SH3_2 60 65 UNIPROT:O00499 PFAM:PF07653 524 590 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 S62 UNIPROTFAM:GSK-3 subfamily PMID: 15992821 SWTI000183 Active INTI000183 UNIPROT:P09959 ELM:TRG_NLS_MonoExtN_4 161 167 UNIPROT:Q02821 PFAM:PF00514 119 457 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 S160 GO:0005829 PMID: 14998990 SWTI000184 Active INTI000184 UNIPROT:P07270 ELM:TRG_NLS_MonoExtC_3 156 161 UNIPROT:P32337 IPR:IPR016024 10 934 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 S152 UNIPROT:P17157 GO:0005829 PMID: 9732266 SWTI000185 Active INTI000185 UNIPROT:Q62318 ELM:LIG_HP1_1 486 490 UNIPROT:P83917 PFAM:PF01393 115 172 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 S473 UNIPROT:P28867 PMID: 18590578 SWTI000186 Active INTI000186 UNIPROT:P30307 ELM:TRG_NES_CRM1_1 188 203 UNIPROT:O14980 PFAM:PF08389 123 268 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 S198 UNIPROT:P53350 GO:0000086 GO:0005634 KEGGIN:hsa04110;REACTOMEIN:69275 PMID: 11897663 SWTI000187 Active INTI000187 UNIPROT:Q16665 ELM:LIG_TAZ1 792 795 UNIPROT:P45481 PFAM:PF02135 351 431 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00677 N803 UNIPROT:Q9NWT6 GO:0005634 KEGG:hsa04066;REACTOME:1234174 PMID: 11959977 SWTI000188 Active INTI000188 UNIPROT:P12272 ELM:TRG_NLS_Bipartite_1 124 144 UNIPROT:Q14974 PFAM:PF00514 399 437 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 T121 UNIPROT:P24941 GO:0005829 PMID: 21182795 SWTI000189 Active INTI000189 UNIPROT:P04049 ELM:LIG_14-3-3_1 256 261 UNIPROT:P63104 PFAM:PF00244 3 236 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 S257 PMID: 8601312 SWTI000190 Active INTI000190 UNIPROT:P30305 ELM:LIG_14-3-3_3 320 325 UNIPROT:P31946 PFAM:PF00244 5 238 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 S321 UNIPROT:P06493 KEGG:hsa04110 PMID: 20801879 SWTI000191 Active INTI000191 UNIPROT:Q9Y5X1 ELM:LIG_Glycolytic_Aldolase 165 169 UNIPROT:P04075 PFAM:PF00274 15 364 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 Y154;T159;S174;S175;S176;Y177;S181;S183 PMID: 15299020 SWTI000192 Active INTI000192 UNIPROT:O60331 ELM:LIG_PTB_Talin 650 653 UNIPROT:Q9Y490 PFAM:PF02174 310 401 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 S650 PMID: 15738269 SWTI000193 Active INTI000193 UNIPROT:P42574 ELM:CLV_C14_caspase-8-10 172 175 UNIPROT:Q14790 PFAM:PF00656 234 476 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 S176 UNIPROTFAM:CK2 subfamily GO:0005829 KEGG:hsa04210;REACTOMEIN:75153 PMID: 21558555 SWTI000194 Active INTI000194 UNIPROT:P60484 ELM:CLV_C14_Caspase3-7 381 385 UNIPROT:P42574 PFAM:PF00656 45 275 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 S385 UNIPROTFAM:CK2 subfamily PMID: 12788938 SWTI000195 Active INTI000195 UNIPROT:Q05586 ELM:TRG_ER_diArg_1 893 895 UNIPROT:P53618 PFAM:PF01602 18 539 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 S896 UNIPROTFAM:PKC subfamily PMID: 11312291;PMID: 14529714 SWTI000196 Active INTI000196 UNIPROT:O95644 ELM:TRG_NLS_MonoExtN_4 262 269 UNIPROT:P52292 PFAM:PF00514 108 449 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 S241;S290 UNIPROT:P49841;UNIPROT:P49841 GO:0005829 PMID: 12351631 SWTI000197 Active INTI000197 UNIPROT:Q13153 ELM:LIG_SH3_2 13 18 UNIPROT:P16333 PFAM:PF00018 112 157 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 S21 UNIPROTFAM:RAC subfamily PMID: 14585966 SWTI000198 Active INTI000198 UNIPROT:P10636 ELM:LIG_SH3_3 530 536 UNIPROT:P06241 PFAM:PF00018 88 135 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 S527 PMID: 18467332 SWTI000199 Active INTI000199 UNIPROT:P18827 ELM:LIG_PDZ_Class_2 305 310 UNIPROT:O00560 PFAM:PF00595 198 270 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 Y309 PMID: 19228696 SWTI000200 Active INTI000200 UNIPROT:O88602 ELM:LIG_PDZ_Class_1 318 323 UNIPROT:Q62108 PFAM:PF00595 160 244 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 T321 UNIPROTFAM:cAMP subfamily PMID: 11805122 SWTI000201 Active INTI000201 UNIPROT:P05067 ELM:LIG_PTB_Apo_2 756 763 UNIPROT:O00213 PFAM:PF00640 543 664 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 T743 PMID: 18833287 SWTI000202 Active INTI000202 UNIPROT:P05106 ELM:LIG_PTB_Phospho_1 779 785 UNIPROT:P29353 PFAM:PF00640 162 318 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 T779 PMID: 10896934;PMID: 20739287 SWTI000203 Active INTI000203 UNIPROT:Q99661 ELM:LIG_SxIP_EBH_1 93 104 UNIPROT:Q15691 PFAM:PF03271 209 248 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 S95;S109;S111 UNIPROT:Q96GD4;UNIPROT:Q96GD4;UNIPROT:Q96GD4 GO:0000236 GO:0005829 REACTOME:375302 PMID: 19632184;PMID: 15883193 SWTI000204 Active INTI000204 UNIPROT:O75122 ELM:LIG_SxIP_EBH_1 512 521 UNIPROT:Q15691 PFAM:PF03271 209 248 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 S525;S529;S533;S537;S541 UNIPROT:P49841;UNIPROT:P49841;UNIPROT:P49841;UNIPROT:P49841;UNIPROT:P49841 GO:0000236 GO:0005829 REACTOME:375302 PMID: 19289791;PMID: 15955847 SWTI000205 Active INTI000205 UNIPROT:Q9UKG1 ELM:LIG_RhoGAP_OCRL_1 403 415 UNIPROT:Q01968 PFAM:PF00620 735 878 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 S403 PMID: 17765681;PMID: 21666675 SWTI000206 Active INTI000206 UNIPROT:Q9UKG1 ELM:LIG_RhoGAP_OCRL_1 403 415 UNIPROT:Q01968 PFAM:PF00620 735 878 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 S410 PMID: 17765681;PMID: 21666675 SWTI000207 Active INTI000207 UNIPROT:P48050 ELM:LIG_PDZ_Class_1 440 445 UNIPROT:P78352 PFAM:PF00595 160 244 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 S443 UNIPROTFAM:cAMP subfamily PMID: 8893032 SWTI000208 Active INTI000208 UNIPROT:P07550 ELM:LIG_PDZ_Class_1 408 413 UNIPROT:O14745 PFAM:PF00595 16 91 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 S411 UNIPROT:P34947 PMID: 10499588 SWTI000209 Active INTI000209 UNIPROT:P11274 ELM:LIG_PDZ_Class_1 1266 1271 UNIPROT:P55196 PFAM:PF00595 1008 1090 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 T1269 PMID: 17473018;PMID: 17973281 SWTI000210 Active INTI000210 TRUE UNIPROT:P42768 ELM:LIG_GBD_WASP_1 466 476 UNIPROT:P42768 PFAM:PF00786 237 296 ID B Uncategorised Uncategorised PTM-dependent Reversible Negative Abrogation MOD:00696 Y291 UNIPROT:P06241,UNIPROT:P08631 PMID: 20533885;PMID: 12769846;PMID: 16293614;PMID: 12235133;PMID: 14707117 SWTI000211 Active INTI000211 TRUE UNIPROT:O00401 ELM:LIG_GBD_WASP_1 467 477 UNIPROT:O00401 PFAM:PF00786 202 261 ID B Uncategorised Uncategorised PTM-dependent Reversible Negative Abrogation MOD:00696 Y256 PMID: 16293614;PMID: 20533885;PMID: 16257963 SWTI000212 Active INTI000212 UNIPROT:P19814 ELM:TRG_ENDOCYTIC_2 350 353 UNIPROT:P84092 PFAM:PF00928 1 137 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18348 PMID: 20603002 SWTI000213 Active INTI000213 UNIPROT:P07766 ELM:LIG_SH3_5 184 188 UNIPROT:O43639 PFAM:PF00018 8 53 ID A Binary Allostery Effector binding Reversible Positive Induction TCR-CD3 ligand PMID: 12110186 SWTI000214 Active INTI000214 UNIPROT:Q8WUM4 ELM:LIG_ALG2 801 810 UNIPROT:O75340 PFAM:PF13499 91 155 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:29108 PMID: 18940611 SWTI000215 Active INTI000215 UNIPROT:Q12834 ELM:LIG_MAD2 129 137 UNIPROT:Q13257 PFAM:PF02301 12 191 ID B Binary Allostery Effector binding Reversible Positive Induction UNIPROT:Q13257 GO:0000089 GO:0005829 KEGG:hsa04110;REACTOME:69618 PMID: 16525508 SWTI000216 Active INTI000216 UNIPROT:P49407 ELM:TRG_AP2beta_CARGO_1 385 395 UNIPROT:P63010 PFAM:PF09066 826 936 ID A Binary Allostery Effector binding Reversible Positive Induction Ligand-activated GPCR PMID: 16516836 SWTI000217 Active INTI000217 UNIPROT:P01730 ELM:TRG_LysEnd_APsAcLL_1 434 439 UNIPROT:P53680 PFAM:PF01217 1 142 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18348 PMID: 20603002 SWTI000218 Active INTI000218 UNIPROT:P35222 ELM:LIG_PDZ_Class_1 776 781 UNIPROT:O14745 PFAM:PF00595 154 231 ID B Binary Allostery Effector binding Reversible Positive Induction UNIPROT:P15311 PMID: 20042604 SWTI000219 Active INTI000219 UNIPROT:P21457 ELM:MOD_NMyristoyl 1 7 GO:0016020 ID A Binary Allostery Effector binding Reversible Positive Induction CHEBI:29108 GO:0016020 PMID: 21465563;PMID: 7630423;PMID: 9296500 SWTI000220 Active INTI000220 UNIPROT:P17612 ELM:MOD_NMyristoyl 1 7 GO:0016020 ID A Binary Allostery PTM-dependent Reversible Positive Induction MOD:00696 S11 GO:0016020 PMID: 21740913;PMID: 8251932 SWTI000221 Active INTI000221 UNIPROT:P00533 ELM:TRG_ENDOCYTIC_2 998 1001 UNIPROT:Q96CW1 PFAM:PF00928 159 435 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18348 PMID: 10228163 SWTI000222 Active INTI000222 UNIPROT:P02786 ELM:TRG_ENDOCYTIC_2 20 23 UNIPROT:Q96CW1 PFAM:PF00928 159 435 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18348 PMID: 2327986;PMID: 2298808;PMID: 8408022 SWTI000223 Active INTI000223 UNIPROT:P03383 ELM:TRG_ENDOCYTIC_2 477 480 UNIPROT:Q96CW1 PFAM:PF00928 159 435 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18348 PMID: 20463077 SWTI000224 Active INTI000224 UNIPROT:P03522 ELM:TRG_ENDOCYTIC_2 501 504 UNIPROT:Q96CW1 PFAM:PF00928 159 435 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18348 PMID: 10637287 SWTI000225 Active INTI000225 UNIPROT:P04578 ELM:TRG_ENDOCYTIC_2 712 715 UNIPROT:Q96CW1 PFAM:PF00928 159 435 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18348 PMID: 9882340;PMID: 12768012 SWTI000226 Active INTI000226 UNIPROT:P05884 ELM:TRG_ENDOCYTIC_2 723 726 UNIPROT:Q4R706 PFAM:PF00928 159 435 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18348 PMID: 11208154 SWTI000227 Active INTI000227 UNIPROT:P07306 ELM:TRG_ENDOCYTIC_2 5 8 UNIPROT:Q96CW1 PFAM:PF00928 159 435 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18348 PMID: 1907285;PMID: 8407903 SWTI000228 Active INTI000228 UNIPROT:P11279 ELM:TRG_ENDOCYTIC_2 414 417 UNIPROT:Q96CW1 PFAM:PF00928 159 435 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18348 PMID: 11801736;PMID: 2391371;PMID: 7844146 SWTI000229 Active INTI000229 UNIPROT:P16410 ELM:TRG_ENDOCYTIC_2 201 204 UNIPROT:Q96CW1 PFAM:PF00928 159 435 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18348 PMID: 9175836 SWTI000230 Active INTI000230 UNIPROT:P32004 ELM:TRG_ENDOCYTIC_2 1176 1179 UNIPROT:Q96CW1 PFAM:PF00928 159 435 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18348 PMID: 18321067 SWTI000231 Active INTI000231 UNIPROT:P51519 ELM:TRG_ENDOCYTIC_2 487 490 UNIPROT:Q3ZC13 PFAM:PF00928 159 435 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18348 PMID: 15254202 SWTI000232 Active INTI000232 UNIPROT:Q9J3M8 ELM:TRG_ENDOCYTIC_2 582 585 UNIPROT:Q96CW1 PFAM:PF00928 159 435 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18348 PMID: 8947032 SWTI000233 Active INTI000233 UNIPROT:O15118 ELM:TRG_LysEnd_APsAcLL_1 1271 1276 UNIPROT:P53680 PFAM:PF01217 1 142 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18348 PMID: 9927649 SWTI000234 Active INTI000234 UNIPROT:P04233 ELM:TRG_LysEnd_APsAcLL_1 19 24 UNIPROT:P53680 PFAM:PF01217 1 142 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18348 PMID: 7592972;PMID: 7650016 SWTI000235 Active INTI000235 UNIPROT:P04235 ELM:TRG_LysEnd_APsAcLL_1 138 143 UNIPROT:P62743 PFAM:PF01217 1 142 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18348 PMID: 1535555 SWTI000236 Active INTI000236 UNIPROT:P04601 ELM:TRG_LysEnd_APsAcLL_1 160 165 UNIPROT:P53680 PFAM:PF01217 1 142 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18348 PMID: 9736718 SWTI000237 Active INTI000237 UNIPROT:P05855 ELM:TRG_LysEnd_APsAcLL_1 159 164 UNIPROT:P53680 PFAM:PF01217 1 142 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18348 PMID: 9811606;PMID: 9736718 SWTI000238 Active INTI000238 UNIPROT:P46938 ELM:LIG_14-3-3_1 109 114 UNIPROT:P62259 PFAM:PF00244 4 239 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S112 PMID:11118213;PMID:19900439 SWTI000239 Active INTI000239 UNIPROT:P11942 ELM:TRG_LysEnd_APsAcLL_1 149 154 UNIPROT:P62743 PFAM:PF01217 1 142 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18348 PMID: 1535555;PMID: 9230070;PMID: 15296492 SWTI000240 Active INTI000240 UNIPROT:P16070 ELM:TRG_LysEnd_APsAcLL_1 708 713 UNIPROT:P53680 PFAM:PF01217 1 142 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18348 PMID: 8647812 SWTI000241 Active INTI000241 UNIPROT:P41143 ELM:TRG_LysEnd_APsAcLL_1 241 246 UNIPROT:P53680 PFAM:PF01217 1 142 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18348 PMID: 12851402 SWTI000242 Active INTI000242 UNIPROT:P50895 ELM:TRG_LysEnd_APsAcLL_1 604 609 UNIPROT:P53680 PFAM:PF01217 1 142 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18348 PMID: 10542217 SWTI000243 Active INTI000243 UNIPROT:P51519 ELM:TRG_LysEnd_APsAcLL_1 463 468 UNIPROT:Q17QC5 PFAM:PF01217 1 142 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18348 PMID: 15254202 SWTI000244 Active INTI000244 UNIPROT:P56817 ELM:TRG_LysEnd_APsAcLL_1 495 500 UNIPROT:P53680 PFAM:PF01217 1 142 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18348 PMID: 15117318 SWTI000245 Active INTI000245 UNIPROT:Q04656 ELM:TRG_LysEnd_APsAcLL_1 1483 1488 UNIPROT:P53680 PFAM:PF01217 1 142 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18348 PMID: 15269005;PMID: 10484781 SWTI000246 Active INTI000246 UNIPROT:O75376 ELM:LIG_CORNRBOX 2051 2059 UNIPROT:P10276 PFAM:PF00104 207 406 ID B Binary Allostery Effector binding Reversible Negative Inhibition CHEBI:15367 GO:0005634 PMID: 20543827 SWTI000247 Active INTI000247 UNIPROT:O75376 ELM:LIG_CORNRBOX 2263 2271 UNIPROT:P10276 PFAM:PF00104 207 406 ID B Binary Allostery Effector binding Reversible Negative Inhibition CHEBI:15367 GO:0005634 PMID: 20543827 SWTI000248 Active INTI000248 UNIPROT:Q9Y618 ELM:LIG_CORNRBOX 2143 2151 UNIPROT:Q07869 PFAM:PF00104 241 450 ID B Binary Allostery Effector binding Reversible Negative Inhibition CHEBI:28666 GO:0005634 PMID: 11845213 SWTI000249 Active INTI000249 UNIPROT:Q9Y618 ELM:LIG_CORNRBOX 2350 2358 UNIPROT:Q07869 PFAM:PF00104 241 450 ID B Binary Allostery Effector binding Reversible Negative Inhibition CHEBI:28666 GO:0005634 PMID: 11845213 SWTI000250 Active INTI000250 UNIPROT:P48552 ELM:LIG_NRBOX 132 138 UNIPROT:P03372 PFAM:PF00104 325 543 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:50114 GO:0005634 PMID: 7641693 SWTI000251 Active INTI000251 UNIPROT:P48552 ELM:LIG_NRBOX 184 190 UNIPROT:P03372 PFAM:PF00104 325 543 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:50114 GO:0005634 PMID: 7641693 SWTI000252 Active INTI000252 UNIPROT:P48552 ELM:LIG_NRBOX 20 26 UNIPROT:P03372 PFAM:PF00104 325 543 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:50114 GO:0005634 PMID: 7641693 SWTI000253 Active INTI000253 UNIPROT:P48552 ELM:LIG_NRBOX 265 271 UNIPROT:P03372 PFAM:PF00104 325 543 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:50114 GO:0005634 PMID: 7641693 SWTI000254 Active INTI000254 UNIPROT:P48552 ELM:LIG_NRBOX 379 385 UNIPROT:P03372 PFAM:PF00104 325 543 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:50114 GO:0005634 PMID: 7641693 SWTI000255 Active INTI000255 UNIPROT:P48552 ELM:LIG_NRBOX 499 505 UNIPROT:P03372 PFAM:PF00104 325 543 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:50114 GO:0005634 PMID: 7641693 SWTI000256 Active INTI000256 UNIPROT:P48552 ELM:LIG_NRBOX 500 506 UNIPROT:P03372 PFAM:PF00104 325 543 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:50114 GO:0005634 PMID: 7641693 SWTI000257 Active INTI000257 UNIPROT:P48552 ELM:LIG_NRBOX 712 718 UNIPROT:P03372 PFAM:PF00104 325 543 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:50114 GO:0005634 PMID: 7641693 SWTI000258 Active INTI000258 UNIPROT:P48552 ELM:LIG_NRBOX 818 824 UNIPROT:P03372 PFAM:PF00104 325 543 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:50114 GO:0005634 PMID: 7641693 SWTI000259 Active INTI000259 UNIPROT:P48552 ELM:LIG_NRBOX 935 941 UNIPROT:P03372 PFAM:PF00104 325 543 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:50114 GO:0005634 PMID: 7641693 SWTI000260 Active INTI000260 UNIPROT:Q15596 ELM:LIG_NRBOX 640 646 UNIPROT:P04150 PFAM:PF00104 542 753 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:24261 GO:0005634 PMID: 9430642;PMID: 12151000 SWTI000261 Active INTI000261 UNIPROT:Q15596 ELM:LIG_NRBOX 689 695 UNIPROT:P04150 PFAM:PF00104 542 753 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:24261 GO:0005634 PMID: 9430642;PMID: 12151000 SWTI000262 Active INTI000262 UNIPROT:Q15596 ELM:LIG_NRBOX 744 750 UNIPROT:P04150 PFAM:PF00104 542 753 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:24261 GO:0005634 PMID: 9430642;PMID: 12151000 SWTI000263 Active INTI000263 UNIPROT:Q15648 ELM:LIG_NRBOX 603 609 UNIPROT:P10827 PFAM:PF00104 199 380 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18258 GO:0005634 PMID: 12556447;PMID: 9653119;PMID: 15340084 SWTI000264 Active INTI000264 UNIPROT:Q15648 ELM:LIG_NRBOX 644 650 UNIPROT:P10827 PFAM:PF00104 199 380 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:18258 GO:0005634 PMID: 12556447;PMID: 9653119;PMID: 15340084 SWTI000265 Active INTI000265 UNIPROT:Q9JL19 ELM:LIG_NRBOX 1494 1500 UNIPROT:P37238 PFAM:PF00104 294 493 ID B Binary Allostery Effector binding Reversible Positive Induction CHEBI:34159 GO:0005634 PMID: 12724417;PMID: 10788465 SWTI000266 Active INTI000266 TRUE UNIPROT:P42768 ELM:LIG_GBD_WASP_1 466 476 UNIPROT:P42768 PFAM:PF00786 237 296 ID B Binary Allostery Effector binding Reversible Negative Inhibition UNIPROT:P60953 PMID: 10724160;PMID: 20533885;PMID: 15066431;PMID: 15821030;PMID: 10995436;PMID: 11052943; PMID: 10360578 SWTI000267 Active INTI000267 TRUE UNIPROT:P42768 ELM:LIG_GBD_WASP_1 466 476 UNIPROT:P42768 PFAM:PF00786 237 296 ID B Binary Allostery Effector binding Reversible Negative Inhibition CHEBI:18348 PMID: 10995436;PMID: 20533885;PMID: 11052943;PMID: 10724160 SWTI000268 Active INTI000268 TRUE UNIPROT:O00401 ELM:LIG_GBD_WASP_1 467 477 UNIPROT:O00401 PFAM:PF00786 202 261 ID B Binary Allostery Effector binding Reversible Negative Inhibition UNIPROT:P60953 PMID: 12872157;PMID: 21676863;PMID: 20533885 SWTI000269 Active INTI000269 TRUE UNIPROT:O00401 ELM:LIG_GBD_WASP_1 467 477 UNIPROT:O00401 PFAM:PF00786 202 261 ID B Binary Allostery Effector binding Reversible Negative Inhibition CHEBI:18348 PMID: 10995436;PMID: 20533885;PMID: 11052943 SWTI000270 Active INTI000270 UNIPROT:P04637 ELM:LIG_PH_Tfb1 50 56 UNIPROT:P32780 PFAM:PF08567 9 81 ID A Cumulative Rheostatic PTM-dependent Reversible Positive Enhancement MOD:00696 S46;T55 PMID: 16793543 SWTI000271 Active INTI000271 UNIPROT:P00533 ELM:LIG_TKB 1069 1074 UNIPROT:P22681 IPR:IPR024159 47 351 ID A Cumulative Rheostatic PTM-dependent Reversible Negative Inhibition MOD:00696 S1070;S1071 PMID: 20877636 SWTI000272 Active INTI000272 UNIPROT:O43597 ELM:LIG_TKB 55 60 UNIPROT:P22681 IPR:IPR024159 47 351 ID A Cumulative Rheostatic PTM-dependent Reversible Negative Inhibition MOD:00696 T56 PMID: 20877636 SWTI000273 Active INTI000273 UNIPROT:P18887 ELM:LIG_FHA_2 517;521 523;527 UNIPROT:Q96T60 IPR:IPR008984 7 112 ID A Cumulative Rheostatic PTM-dependent Reversible Positive Enhancement MOD:00696 S518;T519;T523;S525 UNIPROT:P68400;UNIPROT:P68400;UNIPROT:P68400;UNIPROT:P68400 PMID: 19155274;PMID: 15066279;PMID: 15367657 SWTI000274 Active INTI000274 UNIPROT:P05067 ELM:LIG_SH2_GRB2 757 760 UNIPROT:P62993 PFAM:PF00017 60 135 ID A Cumulative Rheostatic PTM-dependent Reversible Positive Enhancement MOD:00696 Y757;T743 PMID: 19602287 SWTI000275 Active INTI000275 UNIPROT:P05106 ELM:LIG_PTB_Phospho_1 779 785 UNIPROT:P29353 PFAM:PF00640 162 318 ID A Cumulative Rheostatic PTM-dependent Reversible Positive Enhancement MOD:00696 Y785;Y773 PMID: 10964917;PMID: 20739287 SWTI000276 Active INTI000276 UNIPROT:P25054 ELM:LIG_SxIP_EBH_1 2801 2811 UNIPROT:Q15691 PFAM:PF03271 209 248 ID A Cumulative Rheostatic PTM-dependent Reversible Negative Inhibition MOD:00696 S2789;S2793 UNIPROT:P06493;UNIPROTFAM:GSK-3 subfamily PMID: 15616574;PMID: 19632184 SWTI000277 Active INTI000277 UNIPROT:P05106 ELM:LIG_PTB_Apo_2 767 774 UNIPROT:Q9Y490 PFAM:PF02174 310 401 ID A Specificity Altered binding specificity PTM-dependent Reversible Negative Inhibition MOD:00696 Y773 PMID: 18156175 SWTI000277 Active INTI000278 UNIPROT:P05106 ELM:LIG_PTB_Phospho_1 767 773 UNIPROT:Q99704 PFAM:PF02174 151 254 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 Y773 PMID: 18156175 SWTI000278 Active INTI000279 UNIPROT:P24864-3 ELM:MOD_GSK3_1 377 384 UNIPROT:P49841 PFAM:PF00069 56 340 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 S384 UNIPROT:P24941 PMID: 14536078 SWTI000278 Active INTI000280 UNIPROT:P24864-3 ELM:LIG_SCF_FBW7_1 378 384 UNIPROT:Q969H0 PFAM:PF00400 371;411;451;491;531;571;611 407;447;487;527;567;607;650 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 S380;S384 UNIPROT:P49841;UNIPROT:P24941 PMID: 14536078 SWTI000279 Active INTI000281 UNIPROT:P84022 ELM:LIG_WW_Pin1_4 176 181 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 T179 UNIPROTFAM:CDC2/CDKX subfamily PMID: 21685363 SWTI000279 Active INTI000282 UNIPROT:P84022 ELM:MOD_GSK3_1 201 208 UNIPROT:P49841 PFAM:PF00069 56 340 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 S208 UNIPROTFAM:CDC2/CDKX subfamily PMID: 21685363 SWTI000279 Active INTI000283 UNIPROT:P84022 ELM:LIG_WW_Nedd4L 203 210 UNIPROT:Q96PU5 PFAM:PF00397 499 528 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 S204;S208 UNIPROT:P49841;UNIPROTFAM:CDC2/CDKX subfamily PMID: 21685363 SWTI000279 Active INTI000284 UNIPROT:P84022 ELM:LIG_WW_1 181 184 UNIPROT:Q96PU5 PFAM:PF00397 387 416 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Enhancement MOD:00696 T179 UNIPROTFAM:CDC2/CDKX subfamily PMID: 21685363 SWTI000280 Active INTI000285 UNIPROT:P09793 ELM:TRG_ENDOCYTIC_2 201 204 UNIPROT:P84091 PFAM:PF00928 159 435 ID A Specificity Altered binding specificity PTM-dependent Reversible Negative Abrogation MOD:00696 Y201 PMID: 9175836 SWTI000280 Active INTI000286 UNIPROT:P09793 ELM:LIG_SH2_STAT5 201 204 UNIPROT:P35235 PFAM:PF00017 6;112 81;197 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 Y201 PMID: 9175836 SWTI000281 Active INTI000287 UNIPROT:Q14118 ELM:LIG_WW_1 889 892 UNIPROT:P11532 PFAM:PF00397 3057 3086 ID A Specificity Altered binding specificity PTM-dependent Reversible Negative Abrogation MOD:00696 Y892 PMID: 20163697;PMID: 11724572 SWTI000281 Active INTI000288 UNIPROT:Q14118 ELM:LIG_SH2_SRC 892 895 UNIPROT:P06241 PFAM:PF00017 149 231 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 Y892 PMID: 20163697;PMID: 11724572 SWTI000282 Active INTI000289 UNIPROT:P98174 ELM:MOD_GSK3_1 280 287 UNIPROT:P49841 PFAM:PF00069 56 340 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 S287 PMID: 15743413 SWTI000282 Active INTI000290 UNIPROT:P98174 ELM:LIG_SCF-TrCP1_1 282 287 UNIPROT:Q9Y297 PFAM:PF00400 297;333;373;416;456;496;545 329;369;409;452;492;532;581 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 S283;S287 UNIPROT:P49841; PMID: 15743413 SWTI000283 Active INTI000291 UNIPROT:Q5JSP0 ELM:MOD_GSK3_1 77 84 UNIPROT:P49841 PFAM:PF00069 56 340 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 S84 PMID: 18363964 SWTI000283 Active INTI000292 UNIPROT:Q5JSP0 ELM:MOD_GSK3_1 73 80 UNIPROT:P49841 PFAM:PF00069 56 340 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 S80 UNIPROT:P49841 PMID: 18363964 SWTI000283 Active INTI000293 UNIPROT:Q5JSP0 ELM:LIG_SCF-TrCP1_1 75 80 UNIPROT:Q9Y297 PFAM:PF00400 297;333;373;416;456;496;545 329;369;409;452;492;532;581 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 S76;S80 UNIPROT:P49841;UNIPROT:P49841 PMID: 18363964 SWTI000284 Active INTI000294 UNIPROT:Q9BYG3 ELM:MOD_CDK 235 241 UNIPROT:P06493 PFAM:PF00069 4 287 ID A Specificity Altered binding specificity Reversible PMID: 16244663 SWTI000284 Active INTI000295 UNIPROT:Q9BYG3 ELM:MOD_GSK3_1 231 238 UNIPROT:P49841 PFAM:PF00069 56 340 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 T238 UNIPROT:P06493 PMID: 16244663 SWTI000284 Active INTI000296 UNIPROT:Q9BYG3 ELM:MOD_GSK3_1 227 234 UNIPROT:P49841 PFAM:PF00069 56 340 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 T234 UNIPROT:P49841 PMID: 16244663 SWTI000284 Active INTI000297 UNIPROT:Q9BYG3 ELM:LIG_FHA_2 238 244 UNIPROT:P46013 PFAM:PF00498 27 91 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 S230;T234;T238 UNIPROT:P49841;UNIPROT:P49841;UNIPROT:P06493 PMID: 16244663 SWTI000285 Active INTI000298 UNIPROT:P01106 ELM:MOD_ProDKin_1 59 65 UNIPROT:P28482 PFAM:PF00069 25 313 ID A Specificity Altered binding specificity Reversible PMID: 15150404 SWTI000285 Active INTI000299 UNIPROT:P01106 ELM:MOD_GSK3_1 55 62 UNIPROT:P49841 PFAM:PF00069 56 340 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 S62 UNIPROT:P28482 PMID: 15150404 SWTI000285 Active INTI000300 UNIPROT:P01106 ELM:LIG_SCF_FBW7_1 56 62 UNIPROT:Q969H0 PFAM:PF00400 371;411;451;491;531;571;611 407;447;487;527;567;607;650 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 T58;S62 UNIPROT:P49841;UNIPROT:P28482 PMID: 15150404 SWTI000286 Active INTI000301 UNIPROT:P05412 ELM:MOD_GSK3_1 236 243 UNIPROT:P49841 PFAM:PF00069 56 340 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 S243 PMID: 16023596 SWTI000286 Active INTI000302 UNIPROT:P05412 ELM:LIG_SCF_FBW7_1 236 243 UNIPROT:Q969H0 PFAM:PF00400 371;411;451;491;531;571;611 407;447;487;527;567;607;650 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 T239;S243 UNIPROT:P49841; PMID: 16023596 SWTI000287 Active INTI000303 UNIPROT:P07766 ELM:LIG_SH3_5 184 188 UNIPROT:Q8TE68 PFAM:PF00018 486 529 ID A Specificity Altered binding specificity PTM-dependent Reversible Negative Abrogation MOD:00696 Y188 GO:0009898 PMID: 17617578 SWTI000287 Active INTI000304 UNIPROT:P07766 ELM:MOD_TYR_ITAM 185 202 UNIPROT:P43403 PFAM:PF00017 10;163 87;239 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 Y188;Y199 GO:0009898 PMID: 17617578 SWTI000288 Active INTI000305 UNIPROT:P05107 ELM:LIG_Filamin 753 763 UNIPROT:P21333 PFAM:PF00630 2235 2322 ID A Specificity Altered binding specificity PTM-dependent Reversible Negative Abrogation MOD:00696 T758 GO:0009898 PMID: 18550856 SWTI000288 Active INTI000306 UNIPROT:P05107 ELM:LIG_14-3-3_3 755 760 UNIPROT:P63104 PFAM:PF00244 3 236 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 T758 GO:0009898 PMID: 18550856 SWTI000289 Active INTI000307 UNIPROT:Q14118 ELM:LIG_WW_1 889 892 UNIPROT:P46939 PFAM:PF00397 2815 2843 ID A Specificity Altered binding specificity PTM-dependent Reversible Negative Abrogation MOD:00696 Y892 PMID: 10769203;PMID: 11724572 SWTI000289 Active INTI000308 UNIPROT:Q14118 ELM:LIG_SH2_SRC 892 895 UNIPROT:P41240 PFAM:PF00017 82 156 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 Y892 PMID: 10769203;PMID: 11724572 SWTI000290 Active INTI000309 UNIPROT:Q15303 ELM:LIG_WW_1 1053 1056 UNIPROT:Q96J02 PFAM:PF00397 328;360 357;389 ID A Specificity Altered binding specificity PTM-dependent Reversible Negative Abrogation MOD:00696 Y1056 PMID: 18334649;PMID: 19596786;PMID: 20943952 SWTI000290 Active INTI000310 UNIPROT:Q15303 ELM:LIG_SH2_STAT5 1056 1059 UNIPROT:P27986 PFAM:PF00017 333;624 408;698 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 Y1056 PMID: 8617750;PMID: 19596786;PMID: 20943952 SWTI000291 Active INTI000311 UNIPROT:P54253 ELM:LIG_ULM_U2AF65_1 770 775 UNIPROT:P26368 PFAM:PF00076 399 460 ID A Specificity Altered binding specificity PTM-dependent Reversible Negative Abrogation MOD:00696 S775 PMID: 20037628 SWTI000291 Active INTI000312 UNIPROT:P54253 ELM:LIG_14-3-3_1 772 777 UNIPROT:P63104 PFAM:PF00244 3 236 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 S775 PMID: 20037628 SWTI000292 Active INTI000313 UNIPROT:P05067 ELM:LIG_PTB_Apo_2 756 763 UNIPROT:O00213 PFAM:PF00640 543 664 ID A Specificity Altered binding specificity PTM-dependent Reversible Negative Abrogation MOD:00696 Y757 PMID: 19602287;PMID: 19221419 SWTI000292 Active INTI000314 UNIPROT:P05067 ELM:LIG_SH2_GRB2 757 760 UNIPROT:P62993 PFAM:PF00017 60 135 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 Y757 PMID: 19602287 SWTI000293 Active INTI000315 UNIPROT:P05106 ELM:LIG_PTB_Apo_2 779 786 UNIPROT:Q96AC1 PFAM:PF00373 281 573 ID A Specificity Altered binding specificity PTM-dependent Reversible Negative Abrogation MOD:00696 Y785 PMID: 20702409;PMID: 18458155 SWTI000293 Active INTI000316 UNIPROT:P05106 ELM:LIG_PTB_Phospho_1 779 785 UNIPROT:P29353 PFAM:PF00640 162 318 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 Y785 PMID: 20739287 SWTI000294 Active INTI000317 UNIPROT:P24864 ELM:MOD_GSK3_1 392 399 UNIPROT:P49841 PFAM:PF00069 56 340 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 S399 UNIPROT:P24941 PMID: 14536078;PMID: 17434132 SWTI000294 Active INTI000318 UNIPROT:P24864 ELM:LIG_SCF_FBW7_1 393 399 UNIPROT:Q969H0 PFAM:PF00400 371;411;451;491;531;571;611 407;447;487;527;567;607;650 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 T395;S399 UNIPROT:P49841;UNIPROT:P24941 PMID: 14536078;PMID: 17434132 SWTI000295 Active INTI000319 UNIPROT:P36956 ELM:MOD_GSK3_1 422 430 UNIPROT:P49841 PFAM:PF00069 56 340 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 S430 PMID: 16825193;PMID: 16054087 SWTI000295 Active INTI000320 UNIPROT:P36956 ELM:LIG_SCF_FBW7_1 425 430 UNIPROT:Q969H0 PFAM:PF00400 371;411;451;491;531;571;611 407;447;487;527;567;607;650 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 T426;S430 UNIPROT:P49841; PMID: 16825193;PMID: 16054087 SWTI000296 Active INTI000321 UNIPROT:P35222 ELM:MOD_GSK3_1 34 41 UNIPROT:P49841 PFAM:PF00069 56 340 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 T41 KEGG:hsa04310 PMID: 12820959;PMID: 12051714 SWTI000296 Active INTI000322 UNIPROT:P35222 ELM:MOD_GSK3_1 30 37 UNIPROT:P49841 PFAM:PF00069 56 340 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 S37 UNIPROT:P49841 KEGG:hsa04310 PMID: 12820959;PMID: 12051714 SWTI000296 Active INTI000323 UNIPROT:P35222 ELM:LIG_SCF-TrCP1_1 32 37 UNIPROT:Q9Y297 PFAM:PF00400 297;333;373;416;456;496;545 329;369;409;452;492;532;581 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 S33;S37 UNIPROT:P49841;UNIPROT:P49841 KEGG:hsa04310 PMID: 12820959;PMID: 12051714 SWTI000297 Active INTI000324 UNIPROT:O95863 ELM:MOD_GSK3_1 93 100 UNIPROT:P49841 PFAM:PF00069 56 340 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 S100 PMID: 19955572;PMID: 15448698 SWTI000297 Active INTI000325 UNIPROT:O95863 ELM:LIG_SCF-TrCP1_1 95 100 UNIPROT:Q9Y297 PFAM:PF00400 297;333;373;416;456;496;545 329;369;409;452;492;532;581 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 S96;S100 UNIPROT:P49841; PMID: 19955572;PMID: 15448698 SWTI000298 Active INTI000326 UNIPROT:P06756 PFAM:PF01839 252;306;370 286;341;406 UNIPROT:P05106 PFAM:PF00362 38 461 Pre-assembly Composite binding site formation Reversible GO:0005886 PMID: 9420328 SWTI000298 Active INTI000327 UNIPROT:O43854 ELM:LIG_RGD 96 98 INTI000326 Pre-assembly Composite binding site formation Reversible Positive Induction GO:0031012 PMID: 9420328 SWTI000299 Active INTI000328 UNIPROT:P08514 PFAM:PF01839 320 362 UNIPROT:P05106 PFAM:PF00362 38 461 Pre-assembly Composite binding site formation Reversible GO:0005886 PMID: 2191722 SWTI000299 Active INTI000329 UNIPROT:P62384 ELM:LIG_RGD 51 53 INTI000328 Pre-assembly Composite binding site formation Reversible Positive Induction GO:0031012 PMID: 2191722 SWTI000300 Active INTI000330 UNIPROT:P06756 PFAM:PF01839 252;306;370 286;341;406 UNIPROT:P05106 PFAM:PF00362 38 461 Pre-assembly Composite binding site formation Reversible GO:0005886 PMID: 6325925;PMID: 1694173 SWTI000300 Active INTI000331 UNIPROT:P02751 ELM:LIG_RGD 1524 1526 INTI000330 Pre-assembly Composite binding site formation Reversible Positive Induction GO:0031012 PMID: 6325925;PMID: 1694173 SWTI000301 Active INTI000332 UNIPROT:P06756 PFAM:PF01839 252;306;370 286;341;406 UNIPROT:P05106 PFAM:PF00362 38 461 Pre-assembly Composite binding site formation Reversible GO:0005886 PMID: 7533862 SWTI000301 Active INTI000333 UNIPROT:P03305 ELM:LIG_RGD 869 871 INTI000332 Pre-assembly Composite binding site formation Reversible Positive Induction GO:0031012 PMID: 7533862 SWTI000302 Active INTI000334 UNIPROT:P06756 PFAM:PF01839 252;306;370 286;341;406 UNIPROT:P05106 PFAM:PF00362 38 461 Pre-assembly Composite binding site formation Reversible GO:0005886 PMID: 10835423;PMID: 2447074 SWTI000302 Active INTI000335 UNIPROT:P04004 ELM:LIG_RGD 64 66 INTI000334 Pre-assembly Composite binding site formation Reversible Positive Induction GO:0031012 PMID: 10835423;PMID: 2447074 SWTI000303 Active INTI000336 UNIPROT:P06756 PFAM:PF01839 252;306;370 286;341;406 UNIPROT:P05106 PFAM:PF00362 38 461 Pre-assembly Composite binding site formation Reversible GO:0005886 PMID: 2447074 SWTI000303 Active INTI000337 UNIPROT:P04275 ELM:LIG_RGD 2507 2509 INTI000336 Pre-assembly Composite binding site formation Reversible Positive Induction GO:0031012 PMID: 2447074 SWTI000304 Active INTI000338 UNIPROT:P06756 PFAM:PF01839 252;306;370 286;341;406 UNIPROT:P05106 PFAM:PF00362 38 461 Pre-assembly Composite binding site formation Reversible GO:0005886 PMID: 12063036 SWTI000304 Active INTI000339 UNIPROT:P10451 ELM:LIG_RGD 159 161 INTI000338 Pre-assembly Composite binding site formation Reversible Positive Induction GO:0031012 PMID: 12063036 SWTI000305 Active INTI000340 UNIPROT:P11688 PFAM:PF01839 329;395;459 371;431;490 UNIPROT:P09055 PFAM:PF00362 34 464 Pre-assembly Composite binding site formation Reversible GO:0005886 PMID: 9533887 SWTI000305 Active INTI000341 UNIPROT:P11276 ELM:LIG_RGD 1614 1616 INTI000340 Pre-assembly Composite binding site formation Reversible Positive Induction GO:0031012 PMID: 9533887 SWTI000306 Active INTI000342 UNIPROT:P08514 PFAM:PF01839 320 362 UNIPROT:P05106 PFAM:PF00362 38 461 Pre-assembly Composite binding site formation Reversible GO:0005886 PMID: 2191722 SWTI000306 Active INTI000343 UNIPROT:P17349 ELM:LIG_RGD 459 461 INTI000342 Pre-assembly Composite binding site formation Reversible Positive Induction GO:0031012 PMID: 2191722 SWTI000307 Active INTI000344 UNIPROT:P08514 PFAM:PF01839 320 362 UNIPROT:P05106 PFAM:PF00362 38 461 Pre-assembly Composite binding site formation Reversible GO:0005886 PMID: 2653425 SWTI000307 Active INTI000345 UNIPROT:P17495 ELM:LIG_RGD 51 53 INTI000344 Pre-assembly Composite binding site formation Reversible Positive Induction GO:0031012 PMID: 2653425 SWTI000308 Active INTI000346 UNIPROT:P06756 PFAM:PF01839 252;306;370 286;341;406 UNIPROT:P18564 PFAM:PF00362 30 456 Pre-assembly Composite binding site formation Reversible GO:0005886 PMID: 15194773 SWTI000308 Active INTI000347 UNIPROT:P21404 ELM:LIG_RGD 858 860 INTI000346 Pre-assembly Composite binding site formation Reversible Positive Induction GO:0031012 PMID: 15194773 SWTI000309 Active INTI000348 UNIPROT:P43406 PFAM:PF01839 252;306 286;341 UNIPROT:O54890 PFAM:PF00362 37 460 Pre-assembly Composite binding site formation Reversible GO:0005886 PMID: 19118218 SWTI000309 Active INTI000349 UNIPROT:P29788 ELM:LIG_RGD 64 66 INTI000348 Pre-assembly Composite binding site formation Reversible Positive Induction GO:0031012 PMID: 19118218 SWTI000310 Active INTI000350 UNIPROT:P06756 PFAM:PF01839 252;306;370 286;341;406 UNIPROT:P18564 PFAM:PF00362 30 456 Pre-assembly Composite binding site formation Reversible GO:0005886 PMID: 20554778 SWTI000310 Active INTI000351 UNIPROT:Q66578 ELM:LIG_RGD 764 766 INTI000350 Pre-assembly Composite binding site formation Reversible Positive Induction GO:0031012 PMID: 20554778 SWTI000311 Active INTI000352 UNIPROT:P06756 PFAM:PF01839 252;306;370 286;341;406 UNIPROT:P05106 PFAM:PF00362 38 461 Pre-assembly Composite binding site formation Reversible GO:0005886 PMID: 18480047 SWTI000311 Active INTI000353 UNIPROT:P02751 ELM:LIG_Integrin_isoDGR_1 263 265 INTI000352 ID A Pre-assembly Composite binding site formation PTM-dependent Reversible Positive Induction MOD:00684 N263 GO:0031012 PMID: 18480047 SWTI000312 Active INTI000354 UNIPROT:P61024 PFAM:PF01111 5 74 UNIPROT:Q13309 PFAM:PF13855 205;230;255;309;335 229;254;284;334;359 Pre-assembly Composite binding site formation Reversible GO:0000084 GO:0005634 REACTOME:2676436;KEGG:hsa04110 PMID: 16209941 SWTI000312 Active INTI000355 UNIPROT:P46527 ELM:MOD_CDK_1 184 190 UNIPROT:P24941 PFAM:PF00069 4 286 ID A Pre-assembly Composite binding site formation Reversible GO:0000084 GO:0005634 REACTOME:2676436;KEGG:hsa04110 PMID: 16209941 SWTI000312 Active INTI000356 UNIPROT:P46527 ELM:LIG_SCF_Skp2-Cks1_1 183 190 INTI000354 ID A Pre-assembly Composite binding site formation PTM-dependent Reversible Positive Induction MOD:00696 T187 UNIPROT:P24941 GO:0000084 GO:0005634 REACTOME:2676436;KEGG:hsa04110 PMID: 16209941 SWTI000313 Active INTI000357 UNIPROT:P61024 PFAM:PF01111 5 74 UNIPROT:Q13309 PFAM:PF13855 205;230;255;309;335 229;254;284;334;359 Pre-assembly Composite binding site formation Reversible GO:0000084 GO:0005634 KEGG:hsa04110 PMID: 12925736 SWTI000313 Active INTI000358 UNIPROT:P49918 ELM:MOD_CDK_1 307 313 UNIPROT:P24941 PFAM:PF00069 4 286 ID A Pre-assembly Composite binding site formation Reversible GO:0000084 GO:0005634 KEGG:hsa04110 PMID: 12925736 SWTI000313 Active INTI000359 UNIPROT:P49918 ELM:LIG_SCF_Skp2-Cks1_1 306 313 INTI000357 ID A Pre-assembly Composite binding site formation PTM-dependent Reversible Positive Induction MOD:00696 T310 UNIPROT:P24941 GO:0000084 GO:0005634 KEGG:hsa04110 PMID: 12925736 SWTI000314 Active INTI000360 UNIPROT:P61025 PFAM:PF01111 5 74 UNIPROT:Q9Z0Z3 PFAM:PF13855 205;230;255;334 229;254;280;359 Pre-assembly Composite binding site formation Reversible GO:0000084 GO:0005634 KEGG:mmu04110 PMID: 12925736 SWTI000314 Active INTI000361 UNIPROT:P49919 ELM:MOD_CDK_1 339 345 UNIPROT:P97377 PFAM:PF00069 4;238 220;334 ID A Pre-assembly Composite binding site formation Reversible GO:0000084 GO:0005634 KEGG:mmu04110 PMID: 12925736 SWTI000314 Active INTI000362 UNIPROT:P49919 ELM:LIG_SCF_Skp2-Cks1_1 338 345 INTI000360 ID A Pre-assembly Composite binding site formation PTM-dependent Reversible Positive Induction MOD:00696 T342 UNIPROT:P97377 GO:0000084 GO:0005634 KEGG:mmu04110 PMID: 12925736 SWTI000315 Active INTI000363 UNIPROT:P03070 ELM:TRG_NLS_MonoExtN_4 126 132 UNIPROT:Q7Z569 coiled_coil;PFAM:Pfam-B_17154 438;500 507;590 ID A Specificity Motif hiding PTM-dependent Reversible Positive Induction MOD:00696 T124 GO:0005829 PMID: 20040518;PMID: 9497340 SWTI000315 Active INTI000364 UNIPROT:P03070 ELM:TRG_NLS_MonoExtN_4 126 132 UNIPROT:P52294 PFAM:PF00514 115 451 ID A Specificity Motif hiding Effector binding Reversible Negative Abrogation UNIPROT:Q7Z569 GO:0005829 PMID: 20040518;PMID: 9497340 SWTI000316 Active INTI000365 UNIPROT:P16790 ELM:TRG_NLS_MonoExtN_4 425 432 UNIPROT:Q7Z569 coiled_coil;PFAM:Pfam-B_17154 438;500 507;590 ID A Specificity Motif hiding PTM-dependent Reversible Positive Induction MOD:00696 T427 GO:0005829 PMID: 20040518;PMID: 9497340 SWTI000316 Active INTI000366 UNIPROT:P16790 ELM:TRG_NLS_MonoExtN_4 425 432 UNIPROT:P52294 PFAM:PF00514 115 451 ID A Specificity Motif hiding Effector binding Reversible Negative Abrogation UNIPROT:Q7Z569 GO:0005829 PMID: 20040518;PMID: 9497340 SWTI000317 Active INTI000367 UNIPROT:Q9P0K1 ELM:LIG_14-3-3_3 831;854 836;859 UNIPROT:P31946 PFAM:PF00244 5 238 ID A Specificity Motif hiding PTM-dependent Reversible Positive Induction MOD:00696 S834;S857 PMID: 16868027 SWTI000317 Active INTI000368 UNIPROT:Q9P0K1 ELM:TRG_ER_diArg_1 829;850;852 831;852;854 UNIPROT:P53618 PFAM:PF01602 18 539 ID A Specificity Motif hiding Effector binding Reversible Negative Abrogation UNIPROT:P31946 PMID: 16868027 SWTI000318 Active INTI000369 UNIPROT:Q8K4J6 ELM:LIG_Actin_RPEL_3 17;61;105 36;80;124 UNIPROT:P68134 PFAM:PF00022 4 377 Specificity Motif hiding Reversible GO:0005829 PMID: 20818336;PMID: 21673315 SWTI000318 Active INTI000370 UNIPROT:Q8K4J6 ELM:TRG_NLS_MonoExtN_4 62;95 67;101 UNIPROT:O35344 PFAM:PF00514 104 438 ID A Specificity Motif hiding Effector binding Reversible Negative Abrogation UNIPROT:P68134 GO:0005829 PMID: 20818336;PMID: 21673315 SWTI000319 Active INTI000371 UNIPROT:P49685 ELM:LIG_14-3-3_3 356 360 UNIPROT:P31946 PFAM:PF00244 5 238 ID A Specificity Motif hiding PTM-dependent Reversible Positive Induction MOD:00696 S359 PMID: 21189250 SWTI000319 Active INTI000372 UNIPROT:P49685 ELM:TRG_ER_diArg_1 352 354 UNIPROT:P53618 PFAM:PF01602 18 539 ID A Specificity Motif hiding Effector binding Reversible Negative Abrogation UNIPROT:P31946 PMID: 21189250 SWTI000320 Active INTI000373 UNIPROT:P04233 ELM:LIG_14-3-3_3 5 10 UNIPROT:P31946 PFAM:PF00244 5 238 ID A Specificity Motif hiding PTM-dependent Reversible Positive Induction MOD:00696 S8 PMID: 12437930 SWTI000320 Active INTI000374 UNIPROT:P04233 ELM:TRG_ER_diArg_1 3 5 UNIPROT:P53618 PFAM:PF01602 18 539 ID A Specificity Motif hiding Effector binding Reversible Negative Abrogation UNIPROT:P31946 PMID: 12437930 SWTI000321 Active INTI000375 UNIPROT:Q9UBS5 OTHER:coiled coil 881 922 UNIPROT:O75899 coiled coil 788 815 Specificity Motif hiding Reversible PMID: 16065065 SWTI000321 Active INTI000376 UNIPROT:Q9UBS5 ELM:TRG_ER_diArg_1 923 925 UNIPROT:P53618 PFAM:PF01602 18 539 ID A Specificity Motif hiding Effector binding Reversible Negative Abrogation UNIPROT:O75899 PMID: 16065065 SWTI000322 Active INTI000377 TRUE UNIPROT:Q8R4T5 ELM:LIG_PDZ_Class_1 389 394 UNIPROT:Q8R4T5 PFAM:PF00595 100 186 Specificity Motif hiding Reversible PMID: 17396155 SWTI000322 Active INTI000378 UNIPROT:Q8R4T5 ELM:LIG_PDZ_Class_1 389 394 UNIPROT:O88382 PFAM:PF00595 920 1007 ID A Specificity Motif hiding Effector binding Reversible Negative Abrogation UNIPROT:Q8R4T5 PMID: 17396155 SWTI000323 Active INTI000379 UNIPROT:Q96PU5-8 ELM:LIG_14-3-3_1 465 470 UNIPROT:Q04917 PFAM:PF00244 4 241 ID A Specificity Domain hiding PTM-dependent Reversible Positive Induction MOD:00696 S468 UNIPROT:O00141 PMID: 16716084 SWTI000323 Active INTI000380 UNIPROT:P51170 ELM:LIG_WW_1 624 627 UNIPROT:Q96PU5-8 PFAM:PF00397 235;407;519;570 264;436;548;599 ID B Specificity Domain hiding Effector binding Reversible Negative Abrogation UNIPROT:Q04917 PMID: 16716084 SWTI000324 Active INTI000381 TRUE UNIPROT:O00499-6 ELM:LIG_SH3_3 305 311 UNIPROT:O00499-6 PFAM:PF07653 413 479 Specificity Domain hiding Reversible PMID: 15992821 SWTI000324 Active INTI000382 UNIPROT:P01106 ELM:LIG_SH3_2 60 65 UNIPROT:O00499-6 PFAM:PF07653 413 479 ID B Specificity Domain hiding Effector binding Reversible Negative Abrogation UNIPROT:O00499-6 PMID: 15992821 SWTI000325 Active INTI000383 CHEBI:16618 UNIPROT:P27986 PFAM:PF00017 624 698 Specificity Domain hiding Reversible PMID: 8521499 SWTI000325 Active INTI000384 UNIPROT:P06213 ELM:LIG_SH2_STAT5 1361 1364 UNIPROT:P27986 PFAM:PF00017 624 698 ID B Specificity Domain hiding Effector binding Reversible Negative Abrogation CHEBI:16618 PMID: 8521499 SWTI000326 Active INTI000385 UNIPROT:P08965 ELM:LIG_14-3-3_3;ELM:LIG_14-3-3_2 435;523 440;529 UNIPROT:P42656 PFAM:PF00244 6 241 ID A Specificity Domain hiding PTM-dependent Reversible Positive Induction MOD:00696 S338;T527 PMID: 11818066 SWTI000326 Active INTI000386 ENA:D31852 UNIPROT:P08965 PFAM:PF00076;PFAM:PF04059 197;596 264;692 ID B Specificity Domain hiding Effector binding Reversible Negative Abrogation UNIPROT:P42656 PMID: 11818066 SWTI000327 Active INTI000387 TRUE UNIPROT:Q02410 ELM:LIG_PDZ_Class_2 832 837 UNIPROT:Q02410 PFAM:PF00595 656;747 740;820 Specificity Domain hiding Reversible PMID: 16007100;PMID: 11083918 SWTI000327 Active INTI000388 UNIPROT:P49768 ELM:LIG_PDZ_Class_2 462 467 UNIPROT:Q02410 PFAM:PF00595 656;747 740;820 ID B Specificity Domain hiding Effector binding Reversible Negative Abrogation UNIPROT:Q02410 PMID: 16007100;PMID: 11083918 SWTI000328 Active INTI000389 TRUE UNIPROT:O00499-8 ELM:LIG_SH3_8 265 268 UNIPROT:O00499-8 PFAM:PF07653 385 451 Specificity Domain hiding Reversible PMID: 15483625 SWTI000328 Active INTI000390 UNIPROT:P50570 ELM:LIG_SH3_2 829 834 UNIPROT:O00499-8 PFAM:PF07653 385 451 ID B Specificity Domain hiding Effector binding Reversible Negative Abrogation UNIPROT:O00499-8 PMID: 15483625 SWTI000329 Active INTI000391 TRUE UNIPROT:Q02821 ELM:TRG_NLS_Bipartite_1 44 58 UNIPROT:Q02821 PFAM:PF00514 119 457 Specificity Domain hiding Reversible PMID: 12672802 SWTI000329 Active INTI000392 UNIPROT:P03070 ELM:TRG_NLS_MonoExtN_4 126 132 UNIPROT:Q02821 PFAM:PF00514 119 457 ID B Specificity Domain hiding Effector binding Reversible Negative Abrogation UNIPROT:Q02821 PMID: 12672802 SWTI000330 Active INTI000393 UNIPROT:P46527 ELM:LIG_CYCLIN_1 30 33 UNIPROT:P20248 PFAM:PF00134 181 307 Specificity Domain hiding Reversible GO:0000084 GO:0005634 REACTOME:69242;KEGG:hsa04110 PMID: 21358637 SWTI000330 Active INTI000394 UNIPROT:Q99741 ELM:LIG_CYCLIN_1 94 98 UNIPROT:P20248 PFAM:PF00134 181 307 ID B Specificity Domain hiding Effector binding Reversible Negative Abrogation UNIPROT:P46527 GO:0000084 GO:0005634 REACTOME:69242;KEGG:hsa04110 PMID: 21358637 SWTI000331 Active INTI000395 UNIPROT:Q7M6U3 ELM:LIG_CEP55 791 797 UNIPROT:Q8BT07 PFAM:PF12180 171 205 Specificity Domain hiding Reversible PMID: 20176808 SWTI000331 Active INTI000396 UNIPROT:Q61187 ELM:LIG_CEP55 158 164 UNIPROT:Q8BT07 PFAM:PF12180 171 205 ID B Specificity Domain hiding Effector binding Reversible Negative Abrogation UNIPROT:Q7M6U3 PMID: 20176808 SWTI000332 Active INTI000397 UNIPROT:Q7M6U3 ELM:LIG_CEP55 791 797 UNIPROT:Q8BT07 PFAM:PF12180 171 205 Specificity Domain hiding Reversible PMID: 20176808 SWTI000332 Active INTI000398 UNIPROT:Q9WU78 ELM:LIG_CEP55 801 807 UNIPROT:Q8BT07 PFAM:PF12180 171 205 ID B Specificity Domain hiding Effector binding Reversible Negative Abrogation UNIPROT:Q7M6U3 PMID: 20176808 SWTI000333 Active INTI000399 TRUE UNIPROT:O14745 ELM:LIG_PDZ_Class_1 353 358 UNIPROT:O14745 PFAM:PF00595 154 231 Specificity Domain hiding Reversible PMID: 20042604 SWTI000333 Active INTI000400 UNIPROT:P35222 ELM:LIG_PDZ_Class_1 776 781 UNIPROT:O14745 PFAM:PF00595 154 231 ID B Specificity Domain hiding Effector binding Reversible Negative Abrogation UNIPROT:O14745 PMID: 20042604 SWTI000334 Active INTI000401 UNIPROT:P31424 ELM:LIG_PDZ_Class_1 1198 1203 UNIPROT:Q8R4T5 PFAM:PF00595 100 186 Specificity Domain hiding Reversible PMID: 17396155 SWTI000334 Active INTI000402 TRUE UNIPROT:Q8R4T5 ELM:LIG_PDZ_Class_1 389 394 UNIPROT:Q8R4T5 PFAM:PF00595 100 186 ID B Specificity Domain hiding Effector binding Reversible Negative Abrogation UNIPROT:P31424 PMID: 17396155 SWTI000335 Active INTI000403 UNIPROT:P26010 ELM:LIG_Talin 770 779 UNIPROT:Q9Y490 PFAM:PF02174 310 401 ID A Specificity Competition Effector binding Reversible Negative Inhibition UNIPROT:P21333 GO:0009898 PMID: 16455489 SWTI000335 Active INTI000404 UNIPROT:P26010 ELM:LIG_Filamin 776 787 UNIPROT:P21333 PFAM:PF00630 2235 2322 ID A Specificity Competition Effector binding Reversible Negative Inhibition UNIPROT:Q9Y490 GO:0009898 PMID: 16455489 SWTI000336 Active INTI000405 UNIPROT:Q14469 ELM:LIG_WRPW_1 275 280 UNIPROT:Q04724 PFAM:PF00400 477 767 ID B Specificity Competition Effector binding Reversible Negative Inhibition UNIPROT:P56915 GO:0005634 PMID: 16762837 SWTI000336 Active INTI000406 UNIPROT:P56915 ELM:LIG_EH1_1 5 13 UNIPROT:Q04724 PFAM:PF00400 477 767 ID B Specificity Competition Effector binding Reversible Negative Inhibition UNIPROT:Q14469 GO:0005634 PMID: 16762837 SWTI000337 Active INTI000407 UNIPROT:P06729 ELM:LIG_GYF 295 303 UNIPROT:O95400 PFAM:PF02213 281 338 ID A Specificity Competition Effector binding Reversible Negative Inhibition UNIPROT:P06241 GO:0009898 PMID: 12426371 SWTI000337 Active INTI000408 UNIPROT:P06729 ELM:LIG_SH3_3 294 300 UNIPROT:P06241 PFAM:PF00018 88 135 ID A Specificity Competition Effector binding Reversible Negative Inhibition UNIPROT:O95400 GO:0045121;GO:0009898 PMID: 12426371 SWTI000338 Active INTI000409 UNIPROT:P38936 ELM:LIG_CYCLIN_1 19 22 UNIPROT:P24864 PFAM:PF00134 115 242 ID B Specificity Competition Effector binding Reversible Negative Inhibition UNIPROT:P30304 GO:0000082 GO:0005634 KEGG:hsa04110;REACTOME:453279 PMID: 9234691 SWTI000338 Active INTI000410 UNIPROT:P30304 ELM:LIG_CYCLIN_1 11 15 UNIPROT:P24864 PFAM:PF00134 115 242 ID B Specificity Competition Effector binding Reversible Negative Inhibition UNIPROT:P38936 GO:0000082 GO:0005634 KEGG:hsa04110;REACTOME:453279 PMID: 9234691 SWTI000339 Active INTI000411 UNIPROT:P06400 ELM:LIG_CYCLIN_1 873 877 UNIPROT:P20248 PFAM:PF00134 181 307 ID A Specificity Competition Effector binding Reversible Negative Inhibition UNIPROT:P62136 PMID: 20694007 SWTI000339 Active INTI000412 UNIPROT:P06400 ELM:LIG_PP1 872 878 UNIPROT:P62136 PFAM:PF00149 57 252 ID A Specificity Competition Effector binding Reversible Negative Inhibition UNIPROT:P20248 PMID: 20694007 SWTI000340 Active INTI000413 UNIPROT:Q9Y5X1 ELM:LIG_Glycolytic_Aldolase 165 169 UNIPROT:P04075 PFAM:PF00274 15 364 ID B Specificity Competition Effector binding Reversible Negative Inhibition CHEBI:16905 PMID: 20129922;PMID: 15299020 SWTI000340 Active INTI000414 CHEBI:16905 UNIPROT:P04075 PFAM:PF00274 15 364 ID B Specificity Competition Effector binding Reversible Negative Inhibition UNIPROT:Q9Y5X1 PMID: 20129922;PMID: 15299020 SWTI000341 Active INTI000415 UNIPROT:Q14118 ELM:LIG_WW_1 889 892 UNIPROT:P11532 PFAM:PF00397 3057 3086 ID A Specificity Competition Effector binding Reversible Negative Inhibition UNIPROT:P62993 PMID: 10903901;PMID: 10932245;PMID: 20163697 SWTI000341 Active INTI000416 UNIPROT:Q14118 ELM:LIG_SH3_3 888 894 UNIPROT:P62993 PFAM:PF00018 4 50 ID A Specificity Competition Effector binding Reversible Negative Inhibition UNIPROT:P11532 PMID: 10903901;PMID: 10932245;PMID: 20163697 SWTI000342 Active INTI000417 UNIPROT:P13569 ELM:LIG_PDZ_Class_1 1475 1480 UNIPROT:O14745 PFAM:PF00595 16 91 ID A Specificity Competition Effector binding Reversible Negative Inhibition UNIPROT:Q9UPX8 PMID: 17244609 SWTI000342 Active INTI000418 UNIPROT:P13569 ELM:LIG_PDZ_Class_1 1475 1480 UNIPROT:Q9UPX8 PFAM:PF00595 247 338 ID A Specificity Competition Effector binding Reversible Negative Inhibition UNIPROT:O14745 PMID: 17244609 SWTI000343 Active INTI000419 UNIPROT:P18887 ELM:LIG_FHA_2 517 523 UNIPROT:Q96T60 IPR:IPR008984 7 112 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 T519 UNIPROT:P68400 PMID: 19155274;PMID: 15066279;PMID: 15367657 SWTI000343 Active INTI000420 UNIPROT:P18887 ELM:LIG_FHA_2 521 527 UNIPROT:Q96T60 IPR:IPR008984 7 112 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 T523 UNIPROT:P68400 PMID: 19155274;PMID: 15066279;PMID: 15367657 SWTI000344 Active INTI000421 UNIPROT:P20963 ELM:MOD_TYR_ITAM 69 86 UNIPROT:P43403 PFAM:PF00017 10 87 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 Y72;Y83 GO:0009898 KEGG:hsa04660;REACTOME:202403 PMID: 7761456;PMID: 9295038 SWTI000344 Active INTI000422 UNIPROT:P20963 ELM:MOD_TYR_ITAM 69 86 UNIPROT:P43403 PFAM:PF00017 163 239 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 Y72;Y83 GO:0009898 KEGG:hsa04660;REACTOME:202403 PMID: 7761456;PMID: 9295038 SWTI000345 Active INTI000423 UNIPROT:P11911 ELM:MOD_TYR_ITAM 179 196 UNIPROT:P48025 PFAM:PF00017 14 91 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 Y182;Y193 GO:0009898 KEGGIN:mmu04662;REACTOME:2676022 PMID: 7538118 SWTI000345 Active INTI000424 UNIPROT:P11911 ELM:MOD_TYR_ITAM 179 196 UNIPROT:P48025 PFAM:PF00017 167 243 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 Y182;Y193 GO:0009898 KEGGIN:mmu04662;REACTOME:2676022 PMID: 7538118 SWTI000346 Active INTI000425 UNIPROT:P07766 ELM:MOD_TYR_ITAM 185 202 UNIPROT:P43405 PFAM:PF00017 15 92 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 Y188;Y199 GO:0009898 PMID: 9698567 SWTI000346 Active INTI000426 UNIPROT:P07766 ELM:MOD_TYR_ITAM 185 202 UNIPROT:P43405 PFAM:PF00017 168 244 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 Y188;Y199 GO:0009898 PMID: 9698567 SWTI000347 Active INTI000427 UNIPROT:P20963 ELM:MOD_TYR_ITAM 108 126 UNIPROT:P43403 PFAM:PF00017 10 87 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 Y111;Y123 GO:0009898 KEGG:hsa04660;REACTOME:202403 PMID: 7589084;PMID: 7761456 SWTI000347 Active INTI000428 UNIPROT:P20963 ELM:MOD_TYR_ITAM 108 126 UNIPROT:P43403 PFAM:PF00017 163 239 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 Y111;Y123 GO:0009898 KEGG:hsa04660;REACTOME:202403 PMID: 7589084;PMID: 7761456 SWTI000348 Active INTI000429 UNIPROT:P20963 ELM:MOD_TYR_ITAM 139 156 UNIPROT:P43403 PFAM:PF00017 10 87 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 Y142;Y153 GO:0009898 KEGG:hsa04660;REACTOME:202403 PMID: 7761456 SWTI000348 Active INTI000430 UNIPROT:P20963 ELM:MOD_TYR_ITAM 139 156 UNIPROT:P43403 PFAM:PF00017 163 239 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 Y142;Y153 GO:0009898 KEGG:hsa04660;REACTOME:202403 PMID: 7761456 SWTI000349 Active INTI000431 UNIPROT:P09693 ELM:MOD_TYR_ITAM 157 174 UNIPROT:P43403 PFAM:PF00017 10 87 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 Y160;Y171 GO:0009898 KEGG:hsa04660;REACTOME:202403 PMID: 7761456 SWTI000349 Active INTI000432 UNIPROT:P09693 ELM:MOD_TYR_ITAM 157 174 UNIPROT:P43403 PFAM:PF00017 163 239 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 Y160;Y171 GO:0009898 KEGG:hsa04660;REACTOME:202403 PMID: 7761456 SWTI000350 Active INTI000433 UNIPROT:O43613 ELM:MOD_TYR_ITSM 79 86 UNIPROT:Q06124 PFAM:PF00017 6 81 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 Y83 GO:0009898 PMID: 19661287 SWTI000350 Active INTI000434 UNIPROT:O43613 ELM:MOD_TYR_ITIM 356 361 UNIPROT:Q06124 PFAM:PF00017 6 81 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 Y358 GO:0009898 PMID: 19661287 SWTI000351 Active INTI000435 UNIPROT:P12318 ELM:MOD_TYR_ITAM 285 307 UNIPROT:P43405 PFAM:PF00017 15 92 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 Y288;Y304 GO:0009898 KEGG:hsa04380;KEGG:hsa04666 PMID: 18818202 SWTI000351 Active INTI000436 UNIPROT:P12318 ELM:MOD_TYR_ITAM 285 307 UNIPROT:P43405 PFAM:PF00017 168 244 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 Y288;Y304 GO:0009898 KEGG:hsa04380;KEGG:hsa04666 PMID: 18818202 SWTI000352 Active INTI000437 UNIPROT:P30273 ELM:MOD_TYR_ITAM 62 79 UNIPROT:P43405 PFAM:PF00017 15 92 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 Y65;Y76 GO:0009898 KEGG:hsa04664;KEGG:hsa04650 PMID: 18818202 SWTI000352 Active INTI000438 UNIPROT:P30273 ELM:MOD_TYR_ITAM 62 79 UNIPROT:P43405 PFAM:PF00017 168 244 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 Y65;Y76 GO:0009898 KEGG:hsa04664;KEGG:hsa04650 PMID: 18818202 SWTI000353 Active INTI000439 UNIPROT:P63104 PFAM:PF00244 3 236 UNIPROT:P63104 PFAM:PF00244 3 236 Avidity-sensing Reversible PMID: 19662078 SWTI000353 Active INTI000440 UNIPROT:Q02156 ELM:LIG_14-3-3_3 343 348 INTI000439 PFAM:PF00244 3 236 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 S346 PMID: 19662078 SWTI000353 Active INTI000441 UNIPROT:Q02156 ELM:LIG_14-3-3_3 365 370 INTI000439 PFAM:PF00244 3 236 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 S368 PMID: 19662078 SWTI000354 Active INTI000442 UNIPROT:P63104 PFAM:PF00244 3 236 UNIPROT:P63104 PFAM:PF00244 3 236 Avidity-sensing Reversible GO:0005829 KEGGIN:hsa04151 PMID: 14688280;PMID: 10576742 SWTI000354 Active INTI000443 UNIPROT:P04049 ELM:LIG_14-3-3_1 256 261 INTI000442 PFAM:PF00244 3 236 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 S259 UNIPROT:P31749 GO:0005829 KEGGIN:hsa04151 PMID: 14688280;PMID: 10576742 SWTI000354 Active INTI000444 UNIPROT:P04049 ELM:LIG_14-3-3_1 618 623 INTI000442 PFAM:PF00244 3 236 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 S621 GO:0005829 KEGGIN:hsa04151 PMID: 14688280;PMID: 10576742 SWTI000355 Active INTI000445 UNIPROT:P31946 PFAM:PF00244 5 238 UNIPROT:P31946 PFAM:PF00244 5 238 Avidity-sensing Reversible KEGG:hsa04151 PMID: 16751106;PMID: 10102273 SWTI000355 Active INTI000446 UNIPROT:O43524 ELM:LIG_14-3-3_3 250 255 INTI000445 PFAM:PF00244 5 238 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 S253 UNIPROT:P31749 KEGG:hsa04151 PMID: 16751106;PMID: 10102273 SWTI000355 Active INTI000447 UNIPROT:O43524 ELM:LIG_14-3-3_3 29 34 INTI000445 PFAM:PF00244 5 238 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 T32 UNIPROT:P31749 KEGG:hsa04151 PMID: 16751106;PMID: 10102273 SWTI000356 Active INTI000448 UNIPROT:P31946 PFAM:PF00244 5 238 UNIPROT:P31946 PFAM:PF00244 5 238 Avidity-sensing Reversible PMID: 9341175 SWTI000356 Active INTI000449 UNIPROT:P26045 ELM:LIG_14-3-3_3 356 361 INTI000448 PFAM:PF00244 5 238 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 S359 UNIPROT:P27448 PMID: 9341175 SWTI000356 Active INTI000450 UNIPROT:P26045 ELM:LIG_14-3-3_3 832 837 INTI000448 PFAM:PF00244 5 238 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 S835 PMID: 9341175 SWTI000357 Active INTI000451 UNIPROT:Q9CQV8 PFAM:PF00244 5 238 UNIPROT:Q9CQV8 PFAM:PF00244 5 238 Avidity-sensing Reversible GO:0005829 KEGGIN:mmu04010;KEGGIN:mmu04151 PMID: 9858547;PMID: 11741534 SWTI000357 Active INTI000452 UNIPROT:Q61097 ELM:LIG_14-3-3_3 294 299 INTI000451 PFAM:PF00244 5 238 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 S297 UNIPROT:Q03141 GO:0005829 KEGGIN:mmu04010;KEGGIN:mmu04151 PMID: 9858547;PMID: 11741534 SWTI000357 Active INTI000453 UNIPROT:Q61097 ELM:LIG_14-3-3_3 389 394 INTI000451 PFAM:PF00244 5 238 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 S392 UNIPROT:Q03141 GO:0005829 KEGGIN:mmu04010;KEGGIN:mmu04151 PMID: 9858547;PMID: 11741534 SWTI000358 Active INTI000454 UNIPROT:P29310 PFAM:PF00244 6 239 UNIPROT:P29310 PFAM:PF00244 6 239 Avidity-sensing Reversible GO:0009898 PMID: 10230800 SWTI000358 Active INTI000455 UNIPROT:Q8IPH9 ELM:LIG_14-3-3_3 51 56 INTI000454 PFAM:PF00244 6 239 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 S54 UNIPROT:Q00168 GO:0009898 PMID: 10230800 SWTI000358 Active INTI000456 UNIPROT:Q8IPH9 ELM:LIG_14-3-3_3 76 81 INTI000454 PFAM:PF00244 6 239 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 S79 UNIPROT:Q00168 GO:0009898 PMID: 10230800 SWTI000359 Active INTI000457 UNIPROT:P62258 PFAM:PF00244 4 239 UNIPROT:P62258 PFAM:PF00244 4 239 Avidity-sensing Reversible PMID: 9312143 SWTI000359 Active INTI000458 UNIPROT:P35568 ELM:LIG_14-3-3_3 371 376 INTI000457 PFAM:PF00244 4 239 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 S374 PMID: 9312143 SWTI000359 Active INTI000459 UNIPROT:P35568 ELM:LIG_14-3-3_3 638 643 INTI000457 PFAM:PF00244 4 239 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 S641 PMID: 9312143 SWTI000360 Active INTI000460 UNIPROT:A9UF02 ELM:LIG_SH2_IC 174 180 UNIPROT:P62993 PFAM:PF00017 60 135 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y177 PMID:8673601 SWTI000361 Active INTI000461 UNIPROT:O15530 ELM:LIG_SH2_IC 376 379 UNIPROT:Q9HBL0 PFAM:PF00017 1463 1557 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y376 PMID:17256997 SWTI000362 Active INTI000462 UNIPROT:O43561 ELM:LIG_SH2_IC 198 203 UNIPROT:O89100 PFAM:PF00017 58 132 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y200 PMID:15029250 SWTI000363 Active INTI000463 UNIPROT:O43561 ELM:LIG_SH2_IC 218 223 UNIPROT:O89100 PFAM:PF00017 58 132 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y220 PMID:15029250 SWTI000364 Active INTI000464 UNIPROT:O54957 ELM:LIG_SH2_GRB2 175 178 UNIPROT:Q60631 PFAM:PF00017 60 135 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y175 PMID: 10811803 SWTI000365 Active INTI000465 UNIPROT:O54957 ELM:LIG_SH2_GRB2 195 198 UNIPROT:Q60631 PFAM:PF00017 60 135 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y195 PMID: 10811803 SWTI000366 Active INTI000466 UNIPROT:O54957 ELM:LIG_SH2_GRB2 235 238 UNIPROT:Q60631 PFAM:PF00017 60 135 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y235 PMID: 10811803 SWTI000367 Active INTI000467 UNIPROT:O60496 ELM:LIG_SH2_IC 402 405 UNIPROT:Q9HBL0 PFAM:PF00017 1463 1557 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y402 PMID:17256997 SWTI000368 Active INTI000468 UNIPROT:O60674 ELM:LIG_SH2_IIB 804 823 UNIPROT:Q9NRF2 PFAM:PF00017 527 604 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y813 PMID:15767667 SWTI000369 Active INTI000469 UNIPROT:O75553 ELM:LIG_SH2_IB 211 230 UNIPROT:P46108 PFAM:PF00017 13 104 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y220 PMID:15316068 SWTI000370 Active INTI000470 UNIPROT:P00533 ELM:LIG_SH2_IC 1092 1100 UNIPROT:P62993 PFAM:PF00017 60 135 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1092 GO:0009898 KEGG:hsa04012;KEGG:hsa04151;KEGG:hsa04010 PMID:7527391 SWTI000371 Active INTI000471 UNIPROT:P00533 ELM:LIG_SH2_IE 1011 1020 UNIPROT:Q13671 IPR:IPR000980 67 154 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1016 GO:0009898 PMID:12783862 SWTI000372 Active INTI000472 UNIPROT:P00533 ELM:LIG_SH2_IE 1191 1200 UNIPROT:Q13671 IPR:IPR000980 67 154 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1197 GO:0009898 PMID:12783862 SWTI000373 Active INTI000473 UNIPROT:P00533 ELM:LIG_SH2_IE 1008 1024 UNIPROT:P23458 IPR:IPR000980 437 532 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1016 GO:0009898 PMID:16273093 SWTI000374 Active INTI000474 UNIPROT:P00533 ELM:LIG_SH2_IE 1008 1024 UNIPROT:O60674 PFAM:PF00017 400 481 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1016 GO:0009898 PMID:16273093 SWTI000375 Active INTI000475 UNIPROT:P00533 ELM:LIG_SH2_ID 1008 1024 UNIPROT:Q8N5H7 PFAM:PF00017 220 300 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1016 GO:0009898 PMID:16273093 SWTI000376 Active INTI000476 UNIPROT:P00533 ELM:LIG_SH2_ID 1008 1024 UNIPROT:Q9BRG2 PFAM:PF00017 15 95 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1016 GO:0009898 PMID:16273093 SWTI000377 Active INTI000477 UNIPROT:P00533 ELM:LIG_SH2_III 1008 1024 UNIPROT:P42226 PFAM:PF00017 537 616 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1016 GO:0009898 PMID:16273093 SWTI000378 Active INTI000478 UNIPROT:P04626 ELM:LIG_SH2_IC 1135 1144 UNIPROT:Q14451 PFAM:PF00017 431 512 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1139 GO:0009898 PMID:12975581 SWTI000379 Active INTI000479 UNIPROT:P04626 ELM:LIG_SH2_IE 1015 1031 UNIPROT:P23458 IPR:IPR000980 437 532 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1023 GO:0009898 PMID:16273093 SWTI000380 Active INTI000480 UNIPROT:P04626 ELM:LIG_SH2_IE 1015 1031 UNIPROT:O60674 PFAM:PF00017 400 481 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1023 GO:0009898 PMID:16273093 SWTI000381 Active INTI000481 UNIPROT:P04626 ELM:LIG_SH2_ID 1131 1147 UNIPROT:O75815 PFAM:PF00017 154 234 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1139 GO:0009898 PMID:16273093 SWTI000382 Active INTI000482 UNIPROT:P04626 ELM:LIG_SH2_ID 1015 1031 UNIPROT:Q9BRG2 PFAM:PF00017 15 95 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1023 GO:0009898 PMID:16273093 SWTI000383 Active INTI000483 UNIPROT:P04626 ELM:LIG_SH2_III 1131 1147 UNIPROT:P42226 PFAM:PF00017 537 616 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1139 GO:0009898 PMID:16273093 SWTI000384 Active INTI000484 UNIPROT:P04629 ELM:LIG_SH2_IIB 782 796 UNIPROT:P29353 PFAM:PF00017 488 559 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y791 PMID:11159935 SWTI000385 Active INTI000485 UNIPROT:P04629 ELM:LIG_SH2_IB 783 796 UNIPROT:P42679 PFAM:PF00017 122 196 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y791 PMID:10329710 SWTI000386 Active INTI000486 UNIPROT:P07949 ELM:LIG_SH2_IIB 976 985 UNIPROT:Q9NRF2 PFAM:PF00017 527 604 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y981 PMID:17471236 SWTI000387 Active INTI000487 UNIPROT:P08581 ELM:LIG_SH2_IC 1351 1360 UNIPROT:P62993 PFAM:PF00017 60 135 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1356 PMID:14559966 SWTI000388 Active INTI000488 UNIPROT:P09619 ELM:LIG_SH2_IIA 751 755 UNIPROT:P27986 PFAM:PF00017 624 698 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y751 PMID:11567151 SWTI000389 Active INTI000489 UNIPROT:P09619 ELM:LIG_SH2_IIA 1018 1029 UNIPROT:P08487 PFAM:PF00017 550 639 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1021 PMID:8181064 SWTI000390 Active INTI000490 UNIPROT:P10912 ELM:LIG_SH2_IIA 591 600 UNIPROT:Q06124 PFAM:PF00017 112 197 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y595 PMID:10976913 SWTI000391 Active INTI000491 UNIPROT:P10912 ELM:LIG_SH2_III 428 444 UNIPROT:P51692 PFAM:PF00017 593 670 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y436 PMID:8923468 SWTI000392 Active INTI000492 UNIPROT:P14784 ELM:LIG_SH2_IA 409 428 UNIPROT:P06239 PFAM:PF00017 127 209 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y418 GO:0009898 PMID:10214954 SWTI000393 Active INTI000493 UNIPROT:P14784 ELM:LIG_SH2_III 531 540 UNIPROT:P42229 PFAM:PF00017 593 670 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y536 GO:0009898 PMID:10602027 SWTI000394 Active INTI000494 UNIPROT:P14784 ELM:LIG_SH2_IIB 361 370 UNIPROT:P29353 PFAM:PF00017 488 559 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y364 GO:0009898 PMID:10602027 SWTI000395 Active INTI000495 UNIPROT:P14784 ELM:LIG_SH2_III 528 544 UNIPROT:P51692 PFAM:PF00017 593 670 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y536 GO:0009898 PMID:10602027 SWTI000396 Active INTI000496 UNIPROT:P15260 ELM:LIG_SH2_III 457 461 UNIPROT:P42224 PFAM:PF00017 577 658 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y457 GO:0009898 PMID:15780933 SWTI000397 Active INTI000497 UNIPROT:P15498 ELM:LIG_SH2_IIB 165 180 UNIPROT:Q15464 PFAM:PF00017 410 485 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y174 PMID:12084069 SWTI000398 Active INTI000498 UNIPROT:P16234 ELM:LIG_SH2_IIB 705 729 UNIPROT:Q7M4L6 PFAM:PF00017 323 399 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y720 GO:0009898 PMID:11095946 SWTI000399 Active INTI000499 UNIPROT:P17181 ELM:LIG_SH2_IE 458 474 UNIPROT:P29597 IPR:IPR000980 452 539 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y466 GO:0009898 PMID:7526154 SWTI000400 Active INTI000500 UNIPROT:P17181 ELM:LIG_SH2_IE 473 489 UNIPROT:P29597 IPR:IPR000980 452 539 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y481 GO:0009898 PMID:7526154 SWTI000401 Active INTI000501 UNIPROT:P19235 ELM:LIG_SH2_III 360 376 UNIPROT:P51692 PFAM:PF00017 593 670 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y368 GO:0009898 PMID:9122198 SWTI000402 Active INTI000502 UNIPROT:P19235 ELM:LIG_SH2_III 418 434 UNIPROT:P51692 PFAM:PF00017 593 670 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y426 GO:0009898 PMID:11290583 SWTI000403 Active INTI000503 UNIPROT:P19235 ELM:LIG_SH2_III 496 508 UNIPROT:P51692 PFAM:PF00017 593 670 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y504 GO:0009898 PMID:11290583 SWTI000404 Active INTI000504 UNIPROT:P21860 ELM:LIG_SH2_ID 860 876 UNIPROT:O75815 PFAM:PF00017 154 234 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y868 GO:0009898 PMID:16273093 SWTI000405 Active INTI000505 UNIPROT:P21860 ELM:LIG_SH2_ID 1268 1284 UNIPROT:O75815 PFAM:PF00017 154 234 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1276 GO:0009898 PMID:16273093 SWTI000406 Active INTI000506 UNIPROT:P21860 ELM:LIG_SH2_ID 1281 1297 UNIPROT:O75815 PFAM:PF00017 154 234 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1289 GO:0009898 PMID:16273093 SWTI000407 Active INTI000507 UNIPROT:P21860 ELM:LIG_SH2_ID 1320 1336 UNIPROT:O75815 PFAM:PF00017 154 234 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1328 GO:0009898 PMID:16273093 SWTI000408 Active INTI000508 UNIPROT:P21860 ELM:LIG_SH2_ID 1320 1336 UNIPROT:Q9BRG2 PFAM:PF00017 15 95 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1328 GO:0009898 PMID:16273093 SWTI000409 Active INTI000509 UNIPROT:P21860 ELM:LIG_SH2_III 1320 1336 UNIPROT:P42226 PFAM:PF00017 537 616 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1328 GO:0009898 PMID:16273093 SWTI000410 Active INTI000510 UNIPROT:P22681 ELM:LIG_SH2_IB 770 780 UNIPROT:P46108 PFAM:PF00017 13 104 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y774 PMID:20627867 SWTI000411 Active INTI000511 UNIPROT:P24394 ELM:LIG_SH2_III 566 585 UNIPROT:P42226 PFAM:PF00017 537 616 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y575 GO:0009898 PMID:8804422;PMID:10358772 SWTI000412 Active INTI000512 UNIPROT:P24394 ELM:LIG_SH2_III 594 613 UNIPROT:P42226 PFAM:PF00017 537 616 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y603 GO:0009898 PMID:10358772 SWTI000413 Active INTI000513 UNIPROT:P24394 ELM:LIG_SH2_III 622 641 UNIPROT:P42226 PFAM:PF00017 537 616 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y631 GO:0009898 PMID:10358772 SWTI000414 Active INTI000514 UNIPROT:P24394 ELM:LIG_SH2_IIA 706 721 UNIPROT:Q06124 PFAM:PF00017 112 197 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y713 GO:0009898 PMID:11714803 SWTI000415 Active INTI000515 UNIPROT:P24394 ELM:LIG_SH2_IIB 706 721 UNIPROT:P29353 PFAM:PF00017 488 559 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y713 GO:0009898 PMID:11714803 SWTI000416 Active INTI000516 UNIPROT:P24394 ELM:LIG_SH2_IIB 706 721 UNIPROT:Q92835 PFAM:PF00017 5 86 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y713 GO:0009898 PMID:11714803 SWTI000417 Active INTI000517 UNIPROT:P29320 ELM:LIG_SH2_IA 597 606 UNIPROT:P16333 PFAM:PF00017 282 356 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y602 PMID:19505147 SWTI000418 Active INTI000518 UNIPROT:P29353 ELM:LIG_SH2_IC 423 435 UNIPROT:P62993 PFAM:PF00017 60 135 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y427 PMID:10356320 SWTI000419 Active INTI000519 UNIPROT:P30273 ELM:LIG_SH2_IA 75 79 UNIPROT:P43405 PFAM:PF00017 168 244 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y76 GO:0009898 KEGG:hsa04664;KEGG:hsa04650 PMID:8590001 SWTI000420 Active INTI000520 UNIPROT:Q8WU20 ELM:LIG_SH2_IC 191 200 UNIPROT:P62993 PFAM:PF00017 60 135 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y196 PMID:17901128 SWTI000421 Active INTI000521 UNIPROT:Q8WU20 ELM:LIG_SH2_IC 301 310 UNIPROT:P62993 PFAM:PF00017 60 135 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y306 PMID:17901128 SWTI000422 Active INTI000522 UNIPROT:Q8WU20 ELM:LIG_SH2_IC 345 355 UNIPROT:P62993 PFAM:PF00017 60 135 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y349 PMID:17901128 SWTI000423 Active INTI000523 UNIPROT:Q8WU20 ELM:LIG_SH2_IC 385 395 UNIPROT:P62993 PFAM:PF00017 60 135 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y392 PMID:17901128 SWTI000424 Active INTI000524 UNIPROT:Q8WU20 ELM:LIG_SH2_IIA 431 440 UNIPROT:Q06124 PFAM:PF00017 112 197 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y436 PMID:17901128 SWTI000425 Active INTI000525 UNIPROT:Q8WU20 ELM:LIG_SH2_IIA 465 475 UNIPROT:Q06124 PFAM:PF00017 112 197 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y471 PMID:17901128 SWTI000426 Active INTI000526 UNIPROT:Q92918 ELM:LIG_SH2_IIB 372 391 UNIPROT:Q8WV28 PFAM:PF00017 346 429 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y381 PMID:11487585 SWTI000427 Active INTI000527 UNIPROT:Q99062 ELM:LIG_SH2_IIA 747 758 UNIPROT:O14543 PFAM:PF00017 46 127 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y752 GO:0009898 PMID:12133942 SWTI000428 Active INTI000528 UNIPROT:Q99704 ELM:LIG_SH2_IIB 203 206 UNIPROT:Q92835 PFAM:PF00017 3 86 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y203 PMID:10822173 SWTI000429 Active INTI000529 UNIPROT:Q99704 ELM:LIG_SH2_IB 447 454 UNIPROT:O60880 PFAM:PF00017 4 87 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y449 PMID:10852966 SWTI000430 Active INTI000530 UNIPROT:Q05397 ELM:LIG_SH2_IA 389 405 UNIPROT:O43639 PFAM:PF00017 285 323 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y397 PMID:11950595 SWTI000431 Active INTI000531 UNIPROT:Q13094 ELM:LIG_SH2_IIB 105 118 UNIPROT:Q15464 PFAM:PF00017 410 485 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y113 PMID:12084069 SWTI000432 Active INTI000532 UNIPROT:Q13094 ELM:LIG_SH2_IIB 120 133 UNIPROT:Q15464 PFAM:PF00017 410 485 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y128 PMID:12084069 SWTI000433 Active INTI000533 UNIPROT:Q13094 ELM:LIG_SH2_IIB 137 150 UNIPROT:Q15464 PFAM:PF00017 410 485 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y145 PMID:12084069 SWTI000434 Active INTI000534 UNIPROT:Q13291 ELM:LIG_SH2_IB 276 286 UNIPROT:O60880 PFAM:PF00017 4 87 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y281 PMID:10549287 SWTI000435 Active INTI000535 UNIPROT:Q13291 ELM:LIG_SH2_IB 273 286 UNIPROT:O35324 PFAM:PF00017 5 86 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y281 PMID:11689425 SWTI000436 Active INTI000536 UNIPROT:Q14289 ELM:LIG_SH2_IB 394 410 UNIPROT:P42679 PFAM:PF00017 122 196 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y402 PMID:12063569 SWTI000437 Active INTI000537 UNIPROT:Q16620 ELM:LIG_SH2_IA 714 730 UNIPROT:O43639 PFAM:PF00017 285 323 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y727 PMID:12074588 SWTI000438 Active INTI000538 UNIPROT:Q60787 ELM:LIG_SH2_IA 143 148 UNIPROT:Q03526 PFAM:PF00017 245 328 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y145 PMID:16436281 SWTI000439 Active INTI000539 UNIPROT:Q62120 ELM:LIG_SH2_III 804 820 UNIPROT:P52632 PFAM:PF00017 593 670 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y813 PMID:15121872 SWTI000440 Active INTI000540 UNIPROT:P56945 ELM:LIG_SH2_IB 358 368 UNIPROT:P46108 PFAM:PF00017 13 104 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y362 PMID:20627867 SWTI000441 Active INTI000541 UNIPROT:P63245 ELM:LIG_SH2_IA 241 250 UNIPROT:P12931 PFAM:PF00017 151 233 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y246 PMID:15254245 SWTI000442 Active INTI000542 UNIPROT:P81605 ELM:LIG_SH2_IA 15 25 UNIPROT:P16333 PFAM:PF00017 282 356 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y20 PMID:21397687 SWTI000443 Active INTI000543 UNIPROT:P97318 ELM:LIG_SH2_IA 212 228 UNIPROT:O43639 PFAM:PF00017 285 323 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y220 PMID:14517291 SWTI000444 Active INTI000544 UNIPROT:Q00560 ELM:LIG_SH2_IIA 750 764 UNIPROT:O35718 PFAM:PF00017 46 127 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y757 PMID:16630890 SWTI000445 Active INTI000545 UNIPROT:P42229 ELM:LIG_SH2_III 686 702 UNIPROT:P51692 PFAM:PF00017 593 670 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y694 GO:0005829 KEGG:hsa04630;KEGG:hsa04012;REACTOME:982772 PMID:11290583 SWTI000446 Active INTI000546 UNIPROT:P43403 ELM:LIG_SH2_IIC 284 300 UNIPROT:Q13191 IPR:IPR000980 257 354 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y292 PMID:10074432 SWTI000447 Active INTI000547 UNIPROT:P43405 ELM:LIG_SH2_IIC 315 331 UNIPROT:Q13191 IPR:IPR000980 257 354 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y323 PMID:10022120 SWTI000448 Active INTI000548 UNIPROT:P54763 ELM:LIG_SH2_IB 601 610 UNIPROT:P46108 PFAM:PF00017 13 104 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y604 PMID:10644995 SWTI000449 Active INTI000549 UNIPROT:P54763 ELM:LIG_SH2_IB 606 620 UNIPROT:P46108 PFAM:PF00017 13 104 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y610 PMID:10644995 SWTI000450 Active INTI000550 UNIPROT:P48356 ELM:LIG_SH2_III 1129 1148 UNIPROT:P40763 PFAM:PF00017 584 674 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1138 PMID:10799542 SWTI000451 Active INTI000551 UNIPROT:P21860 ELM:LIG_SH2_IE 1320 1336 UNIPROT:P23458 IPR:IPR000980 437 532 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1328 GO:0009898 PMID:16273093 SWTI000452 Active INTI000552 UNIPROT:P21860 ELM:LIG_SH2_IE 1320 1336 UNIPROT:O60674 PFAM:PF00017 400 481 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1328 GO:0009898 PMID:16273093 SWTI000453 Active INTI000553 UNIPROT:P21860 ELM:LIG_SH2_IE 1268 1284 UNIPROT:O60674 PFAM:PF00017 400 481 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1276 GO:0009898 PMID:16273093 SWTI000454 Active INTI000554 UNIPROT:P21860 ELM:LIG_SH2_IE 1268 1284 UNIPROT:P52333 IPR:IPR000980 373 463 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1276 GO:0009898 PMID:16273093 SWTI000455 Active INTI000555 UNIPROT:P24394 ELM:LIG_SH2_IIA 706 721 UNIPROT:P29350 PFAM:PF00017 110 194 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y713 GO:0009898 PMID:11714803 SWTI000456 Active INTI000556 UNIPROT:P04637 ELM:LIG_MDM2 19 26 UNIPROT:Q00987 PFAM:PF02201 27 102 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 T18 UNIPROTFAM:Casein kinase I subfamily GO:0006977 KEGG:hsa04115;KEGG:hsa04110;REACTOMEIN:69580 PMID: 10734067;PMID: 8875929 SWTI000457 Active INTI000557 UNIPROT:P04637 ELM:LIG_TAZ2 19 25 UNIPROT:Q92793 PFAM:PF02135 1770 1843 ID A Cumulative Rheostatic PTM-dependent Reversible Positive Enhancement MOD:00696 S15;T18;S20;S33;S37;S46 GO:0031571 GO:0000790;GO:0005634 KEGG:hsa04110;REACTOMEIN:69615 PMID: 20962272;PMID: 19217391 SWTI000458 Active INTI000558 UNIPROT:Q9UER7 ELM:LIG_SUMO_SBM_1 733 740 UNIPROT:P63165 PFAM:PF11976 22 92 ID A Cumulative Rheostatic PTM-dependent Reversible Positive Enhancement MOD:00696 S737;S739 UNIPROTFAM:CK2 subfamily;UNIPROTFAM:CK2 subfamily PMID: 21474068 SWTI000459 Active INTI000559 UNIPROT:P42656 PFAM:PF00244 6 241 UNIPROT:P42656 PFAM:PF00244 6 241 Avidity-sensing Reversible PMID: 11818066;PMID: 12242289 SWTI000459 Active INTI000560 UNIPROT:P08965 ELM:LIG_14-3-3_3 435 440 INTI000559 PFAM:PF00244 6 241 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 S438 UNIPROT:P08092 PMID: 11818066;PMID: 12242289 SWTI000459 Active INTI000561 UNIPROT:P08965 ELM:LIG_14-3-3_2 523 529 INTI000559 PFAM:PF00244 6 241 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 T527 UNIPROT:P08092 PMID: 11818066;PMID: 12242289 SWTI000460 Active INTI000562 UNIPROT:Q9BYG3 ELM:LIG_FHA_2 238 244 UNIPROT:P46013 PFAM:PF00498 27 91 ID A Cumulative Rheostatic PTM-dependent Reversible Positive Enhancement MOD:00696 S230;T234 UNIPROT:P49841;UNIPROT:P49841 PMID: 16244663 SWTI000461 Active INTI000563 UNIPROT:P32004 ELM:TRG_ENDOCYTIC_2 1176 1180 UNIPROT:Q96CW1 PFAM:PF00928 159 435 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Inhibition MOD:00696 Y1176 UNIPROT:P12931 PMID:12082080 SWTI000462 Active INTI000564 UNIPROT:O43521-2 ELM:LIG_Dynein_DLC8_1 50 56 UNIPROT:P63167 PFAM:PF01221 1 89 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 T56 UNIPROT:P45983 PMID:12591950 SWTI000463 Active INTI000565 UNIPROT:Q4VCS5 ELM:LIG_WW_1 239 242 UNIPROT:P46937 PFAM:PF00397 171 204 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:21205866;PMID:18164266 SWTI000464 Active INTI000566 UNIPROT:Q4VCS5 ELM:LIG_WW_1 239 242 UNIPROT:Q9GZV5 PFAM:PF00397 124 157 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:21205866;PMID:18164266 SWTI000465 Active INTI000567 UNIPROT:Q05193-3 ELM:LIG_PP2B_1 844 849 UNIPROT:Q08209 PFAM:PF00149 83 285 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:21689596 SWTI000466 Active INTI000568 UNIPROT:Q9P0K1 ELM:LIG_PDZ_Class_1 901 906 UNIPROT:P78352 PFAM:PF00595 313 393 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:16990550 SWTI000467 Active INTI000569 UNIPROT:P30305 ELM:LIG_APCC_KENbox_2 191 195 UNIPROT:Q9UM11 PFAM:PF00400 182 480 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation GO:0007067 GO:0005829 KEGGIN:hsa04110 PMID:17599046 SWTI000468 Active INTI000570 UNIPROT:P51955 ELM:LIG_PP1 380 387 UNIPROT:P36873 PFAM:PF00149 57 252 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:10880350 SWTI000469 Active INTI000571 UNIPROT:P51955 ELM:LIG_PP1 380 387 UNIPROT:P62136 PFAM:PF00149 57 252 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:10880350 SWTI000470 Active INTI000572 UNIPROT:P51955 ELM:LIG_APCC_Dbox_3 423 445 UNIPROT:Q12834 PFAM:PF00400 182 480 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation GO:0007067 GO:0005829 REACTOME:174143 PMID:11742988 SWTI000471 Active INTI000573 UNIPROT:O43521 ELM:LIG_SCF-TrCP1_2 93 98 UNIPROT:Q9Y297 PFAM:PF00400 301 590 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:19150432 SWTI000472 Active INTI000574 UNIPROT:P43155 ELM:TRG_MLS 1 21 UNIPROT:O94826 PFAM:PF00515 114 578 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:20558530;PMID:7945262 SWTI000473 Active INTI000575 UNIPROT:P05556-5 ELM:LIG_Talin 775 785 UNIPROT:Q9Y490 PFAM:PF02174 310 401 ID A Binary Pre-translational Alternative splicing Irreversible Negative Inhibition GO:0009898 PMID:21134644 SWTI000474 Active INTI000576 UNIPROT:P05556-5 ELM:LIG_Talin 775 785 UNIPROT:Q9Y4G6 PFAM:PF02174 313 404 ID A Binary Pre-translational Alternative splicing Irreversible Negative Inhibition GO:0009898 PMID:21134644 SWTI000475 Active INTI000577 UNIPROT:P05556 ELM:LIG_Filamin_2 783 791 UNIPROT:P21333 PFAM:PF00630 2235 2322 ID A Binary Pre-translational Alternative splicing Irreversible Negative Inhibition GO:0009898 PMID:11807098;PMID:16455489 SWTI000476 Active INTI000578 UNIPROT:P05556 ELM:LIG_Filamin_2 783 791 UNIPROT:O75369 PFAM:PF00630 2285 2372 ID A Binary Pre-translational Alternative splicing Irreversible Negative Inhibition GO:0009898 PMID:11807098 SWTI000477 Active INTI000579 UNIPROT:O00499 ELM:LIG_Clathr_ClatBox_1 390 394 UNIPROT:Q00610 PFAM:PF01394 19 234 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:9603201 SWTI000478 Active INTI000580 UNIPROT:O00499 ELM:LIG_Clathr_ClatBox_2 415 420 UNIPROT:Q00610 PFAM:PF01394 19 234 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:9603201 SWTI000479 Active INTI000581 TRUE UNIPROT:O00499-8 ELM:LIG_SH3_8 265 268 UNIPROT:O00499-8 PFAM:PF07653 385 451 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:15483625 SWTI000480 Active INTI000582 UNIPROT:O00499-8 ELM:LIG_PI(4,5)P2 258 266 CHEBI:18348 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:15483625 SWTI000481 Active INTI000583 UNIPROT:Q16881 ELM:LIG_NRBOX 144 150 UNIPROT:P03372 PFAM:PF00104 325 543 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:15199063 SWTI000482 Active INTI000584 UNIPROT:Q16881 ELM:LIG_NRBOX 144 150 UNIPROT:Q92731 PFAM:PF00104 277 494 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:15199063 SWTI000483 Active INTI000585 UNIPROT:Q01814 ELM:LIG_PDZ_Class_1 1238 1243 UNIPROT:Q15599 PFAM:PF00595 11 90 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:11786550;PMID:20663896 SWTI000484 Active INTI000586 UNIPROT:P23634 ELM:LIG_PDZ_Class_1 1236 1241 UNIPROT:P29475 PFAM:PF00595 17 99 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:11591728 SWTI000485 Active INTI000587 UNIPROT:P23634 ELM:LIG_PDZ_Class_1 1236 1241 UNIPROT:Q92796 PFAM:PF00595 130 217 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:11274188 SWTI000486 Active INTI000588 UNIPROT:P23634 ELM:LIG_PDZ_Class_1 1236 1241 UNIPROT:Q12959 PFAM:PF00595 224 310 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:9430700 SWTI000487 Active INTI000589 UNIPROT:P23634 ELM:LIG_PDZ_Class_1 1236 1241 UNIPROT:O14936 PFAM:PF00595 489 564 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID: 12511555 SWTI000488 Active INTI000590 UNIPROT:P32004 ELM:TRG_ENDOCYTIC_2 1176 1180 UNIPROT:Q96CW1 PFAM:PF00928 159 435 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:9570805;PMID:12082080 SWTI000489 Active INTI000591 UNIPROT:Q13444 ELM:LIG_SH3_2 767 772 UNIPROT:P12931 PFAM:PF00018 90 137 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:19487280 SWTI000490 Active INTI000592 UNIPROT:Q15303 ELM:LIG_WW_1 1053 1056 UNIPROT:Q96J02 PFAM:PF00397 328 357 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:18334649 SWTI000491 Active INTI000593 UNIPROT:O00408 ELM:MOD_NMyristoyl 1 7 UNIPROT:P30419 PFAM:PF02799 308 495 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:19632989 SWTI000492 Active INTI000594 UNIPROT:Q01082-2 ELM:MOD_PKA_2 2157 2162 UNIPROT:P17612 PFAM:PF00069 44 298 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation MOD:00696 T2159 UNIPROT:P17612 PMID:17088250 SWTI000493 Active INTI000595 UNIPROT:Q05655 ELM:CLV_C14_Caspase3-7 326 330 UNIPROT:P42574 PFAM:PF00656 45 275 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation GO:0005829 REACTOME:75153 PMID:18092819 SWTI000494 Active INTI000596 UNIPROT:O43521 ELM:LIG_Dynein_DLC8_1 110 116 UNIPROT:P63167 PFAM:PF01221 1 89 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:10198631 SWTI000495 Active INTI000597 UNIPROT:P13051 ELM:TRG_NLS_MonoExtN_4 15 21 UNIPROT:P52294 PFAM:PF00514 115 451 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation GO:0005829 PMID:9753728 SWTI000496 Active INTI000598 UNIPROT:P23385 ELM:LIG_EVH1_2 1152 1156 UNIPROT:Q9Z214 PFAM:PF00568 1 107 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:9069287 SWTI000497 Active INTI000599 UNIPROT:P97288-2 ELM:LIG_PDZ_Class_1 382 387 UNIPROT:Q3UHD6 PFAM:PF00595 41 134 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:15466885 SWTI000498 Active INTI000600 UNIPROT:P97288-2 ELM:LIG_PDZ_Class_1 382 387 UNIPROT:P70441 PFAM:PF00595 14 94 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:15466885 SWTI000499 Active INTI000601 UNIPROT:P97288-3 ELM:LIG_PDZ_Class_2 368 371 UNIPROT:Q63ZW7 PFAM:PF00595 134;248;365;555 221;328;453;641 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:15466885 SWTI000500 Active INTI000602 UNIPROT:Q15303 ELM:LIG_SH2_IIA 1056 1059 UNIPROT:P27986 PFAM:PF00017 333 428 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation GO:0009898 PMID:16122376 SWTI000501 Active INTI000603 UNIPROT:P49023 ELM:LIG_FAT_LD_1 4 12 UNIPROT:Q05397 PFAM:PF03623 914 1052 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:16219691 SWTI000502 Active INTI000604 UNIPROT:P49023 ELM:LIG_SH2_IB 118 121 UNIPROT:P20936 PFAM:PF03623 181 272 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:16219691 SWTI000503 Active INTI000605 UNIPROT:P49023 ELM:LIG_SH2_IB 118 121 UNIPROT:P46108 PFAM:PF03623 13 118 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:16219691;PMID:10704446 SWTI000504 Active INTI000606 UNIPROT:P49023 ELM:LIG_SH2_IB 31 34 UNIPROT:P46108 PFAM:PF03623 13 118 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:16219691;PMID:10704446 SWTI000505 Active INTI000607 UNIPROT:O43426 ELM:LIG_EH_1 1393 1397 UNIPROT:P42566 IPR:IPR000261 15 104 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:10801423;PMID:17158794 SWTI000506 Active INTI000608 UNIPROT:O43426 ELM:LIG_EH_1 1403 1407 UNIPROT:P42566 IPR:IPR000261 15 104 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:10801423;PMID:17158794 SWTI000507 Active INTI000609 UNIPROT:O43426 ELM:LIG_EH_1 1414 1418 UNIPROT:P42566 IPR:IPR000261 15 104 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:10801423;PMID:17158794 SWTI000508 Active INTI000610 UNIPROT:O43426 ELM:LIG_AP2alpha_2 1323 1325 UNIPROT:O94973 PFAM:PF02296 826 934 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:10801423;PMID:17158794 SWTI000509 Active INTI000611 UNIPROT:O43426 ELM:LIG_AP2alpha_2 1555 1557 UNIPROT:O94973 PFAM:PF02296 826 934 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:10801423;PMID:17158794 SWTI000510 Active INTI000612 UNIPROT:Q8IPH9 ELM:LIG_14-3-3_3 76 81 UNIPROTFAM:14-3-3 family PFAM:PF00244 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:16339006 SWTI000511 Active INTI000613 UNIPROT:Q8VIM5 ELM:LIG_Actin_RPEL_3 20 39 UNIPROT:P68134 PFAM:PF00022 4 377 ID A Binary Pre-translational Alternative promoter usage Irreversible Negative Abrogation PMID:16818234 SWTI000512 Active INTI000614 UNIPROT:Q8VIM5 ELM:LIG_Actin_RPEL_3 64 83 UNIPROT:P68134 PFAM:PF00022 4 377 ID A Binary Pre-translational Alternative promoter usage Irreversible Negative Abrogation PMID:16818234 SWTI000513 Active INTI000615 UNIPROT:P11532-5 ELM:LIG_Actin_DMD 5 10 UNIPROT:P68133 PFAM:PF00022 4 377 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:9883911 SWTI000514 Active INTI000616 UNIPROT:Q92667 ELM:LIG_PP1 151 158 UNIPROTFAM:PP-1 subfamily PFAM:PF00149 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:10995432 SWTI000515 Active INTI000617 UNIPROT:Q9NR28 ELM:LIG_BIR_internal 56 59 UNIPROT:P98170 PFAM:PF00653 166 231 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:14523016 SWTI000516 Active INTI000618 UNIPROT:Q9NR28 ELM:TRG_MLS 1 55 UNIPROT:O94826 PFAM:PF00515 114 578 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:14523016 SWTI000517 Active INTI000619 UNIPROT:P04637 ELM:LIG_MDM2 19 26 UNIPROT:Q00987 PFAM:PF02201 27 102 ID A Binary Pre-translational Alternative promoter usage and alternative splicing Irreversible Negative Abrogation GO:0006977 KEGG:hsa04115;KEGG:hsa04110;REACTOMEIN:69580 PMID: 12360399;PMID:18854945 SWTI000518 Active INTI000620 UNIPROT:P04637 ELM:TRG_NES_CRM1_1 339 352 UNIPROT:O14980 PFAM:PF08389 123 268 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation GO:0005634 PMID:16131611;PMID:18854945 SWTI000519 Active INTI000621 UNIPROT:P04637 ELM:LIG_USP7_1 359 363 UNIPROT:Q93009 PFAM:PF12436 532 566 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:16131611 SWTI000520 Active INTI000622 UNIPROT:P04637 ELM:LIG_USP7_1 364 368 UNIPROT:Q93009 PFAM:PF12436 532 566 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:16131611 SWTI000521 Active INTI000623 UNIPROT:Q9UK53-2 ELM:LIG_PCNA_2 9 15 UNIPROT:P12004 PFAM:PF02747 127 254 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:11682605 SWTI000522 Active INTI000624 UNIPROT:P78381 ELM:TRG_ER_diLys_1 392 396 UNIPROT:P53621 PFAM:PF00400 1 277 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID: 15932921 SWTI000523 Active INTI000625 UNIPROT:P13051-2 ELM:TRG_MLS 1 44 UNIPROT:O94826 PFAM:PF00515 114 578 ID A Binary Pre-translational Alternative promoter usage Irreversible Negative Abrogation PMID:12799180 SWTI000524 Active INTI000626 UNIPROT:P20020-3 ELM:LIG_IQ_2 1114 1128 UNIPROT:P62158 PFAM:PF13499 8 73 ID A Binary Pre-translational Alternative splicing Irreversible Negative Inhibition PMID:11152753 SWTI000525 Active INTI000627 UNIPROT:P84022 ELM:LIG_WW_1 181 184 UNIPROT:Q96PU5 PFAM:PF00397 387 416 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 T179 UNIPROTFAM:CDC2/CDKX subfamily PMID: 21685363 SWTI000525 Active INTI000628 UNIPROT:P84022 ELM:LIG_WW_Nedd4L 203 210 UNIPROT:Q96PU5 PFAM:PF00397 499 528 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 S204;S208 UNIPROT:P49841;UNIPROTFAM:CDC2/CDKX subfamily PMID: 21685363 SWTI000526 Active INTI000629 UNIPROT:P84022 ELM:LIG_WW_Nedd4L 203 210 UNIPROT:Q96PU5 PFAM:PF00397 499 528 ID A Cumulative Rheostatic PTM-dependent Reversible Positive Enhancement MOD:00696 S204;S208 UNIPROT:P49841;UNIPROTFAM:CDC2/CDKX subfamily PMID: 21685363 SWTI000527 Active INTI000630 UNIPROT:P55211 ELM:LIG_BIR_III_2 315 319 UNIPROT:P98170 PFAM:PF00653 268 331 ID A Binary Physicochemical compatibility PTM-dependent Irreversible Positive Induction Proteolytic cleavage D315 PMID: 12620238 SWTI000528 Active INTI000631 UNIPROT:P55211 ELM:LIG_BIR_III_2 315 319 UNIPROT:Q13490 PFAM:PF00653 272 337 ID A Binary Physicochemical compatibility PTM-dependent Irreversible Positive Induction Proteolytic cleavage D315 PMID: 19153467 SWTI000529 Active INTI000632 UNIPROT:P55210 ELM:LIG_BIR_III_2 23 27 UNIPROT:Q13490 PFAM:PF00653 49 114 ID A Binary Physicochemical compatibility PTM-dependent Irreversible Positive Induction Proteolytic cleavage D23 GO:0005829 KEGG:hsa04210;REACTOMEIN:75153 PMID: 19258326 SWTI000530 Active INTI000633 UNIPROT:O02002 ELM:LIG_BIR_III_4 33 37 UNIPROT:Q24306 PFAM:PF00653 47 111 ID A Binary Physicochemical compatibility PTM-dependent Irreversible Positive Induction Proteolytic cleavage D33 PMID: 15580265 SWTI000531 Active INTI000634 UNIPROT:O01382 ELM:LIG_BIR_III_4 28 32 UNIPROT:Q24306 PFAM:PF00653 47 111 ID A Binary Physicochemical compatibility PTM-dependent Irreversible Positive Induction Proteolytic cleavage D28 PMID: 15580265 SWTI000532 Active INTI000635 UNIPROT:P48542 ELM:LIG_PDZ_Class_1 420 425 UNIPROT:Q3UHD6 PFAM:PF00595 41 134 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:17828261 SWTI000533 Active INTI000636 UNIPROT:P15791-3 ELM:TRG_NLS_MonoCore_2 327 332 UNIPROT:P52294 PFAM:PF00514 115 451 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:7519621 SWTI000534 Active INTI000637 UNIPROT:Q8C437-3 ELM:TRG_ENDOCYTIC_2 38 41 UNIPROT:P84091 PFAM:PF00928 159 435 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:19555649 SWTI000535 Active INTI000638 UNIPROT:Q8C437 ELM:TRG_LysEnd_APsAcLL_1 14 19 UNIPROT:P62743 PFAM:PF01217 1 142 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:19555649 SWTI000536 Active INTI000639 UNIPROT:Q9ULV5 ELM:MOD_SUMO 292 295 UNIPROT:P63279 PFAM:PF00179 8 152 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:16371476 SWTI000537 Active INTI000640 UNIPROT:Q9ULV5 ELM:MOD_SUMO 292 295 UNIPROT:P63279 PFAM:PF00179 8 152 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S298 PMID:16371476 SWTI000538 Active INTI000641 UNIPROT:O15350 ELM:LIG_WW_Pin1_4 479 484 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:15175157 SWTI000539 Active INTI000642 UNIPROT:O15350 ELM:LIG_WW_Pin1_4 439 444 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:15175157 SWTI000540 Active INTI000643 UNIPROT:O15350 ELM:LIG_WW_Pin1_4 409 414 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:15175157 SWTI000541 Active INTI000644 UNIPROT:Q9Y4I1 ELM:LIG_Dynein_DLC8_2 1286 1290 UNIPROT:Q96FJ2 PFAM:PF01221 1 89 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:17029413;PMID:16981716 SWTI000542 Active INTI000645 UNIPROT:Q13127 ELM:LIG_SCF-TrCP1_2 1008 1013 UNIPROT:Q9Y297 PFAM:PF00400 301 590 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:18354482 SWTI000543 Active INTI000646 UNIPROT:Q969H0 ELM:TRG_NLS_MonoCore_2 10 15 UNIPROT:P52294 PFAM:PF00514 115 451 ID A Binary Pre-translational Alternative splicing Irreversible Negative Inhibition GO:0005829 PMID:15498494 SWTI000544 Active INTI000647 UNIPROT:Q969H0-2 ELM:TRG_NES_CRM1_2 19 26 UNIPROT:O14980 PFAM:PF08389 123 268 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation GO:0005634 PMID:15498494 SWTI000545 Active INTI000648 UNIPROT:Q8WY21-4 ELM:TRG_LysEnd_APsAcLL_2 1136 1140 UNIPROT:P53680 PFAM:PF01217 1 142 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:18315530 SWTI000546 Active INTI000649 UNIPROT:Q8WY21-2 ELM:TRG_ENDOCYTIC_2 1132 1135 UNIPROT:Q96CW1 PFAM:PF00928 159 435 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:18315530 SWTI000547 Active INTI000650 UNIPROT:Q9NQ25 ELM:MOD_TYR_ITSM 280 287 UNIPROT:O60880 PFAM:PF00017 6 104 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:15368295 SWTI000548 Active INTI000651 UNIPROT:P60953 ELM:MOD_CAAXbox 188 191 UNIPROT:P49354 PFAM:PF01239 115 288 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:19092927 SWTI000549 Active INTI000652 UNIPROT:P60953-1 ELM:MOD_Spalmitoyl 188 191 UNIPROT:Q9Y397 PFAM:PF01529 80 263 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:19092927 SWTI000550 Active INTI000653 UNIPROT:P31809 ELM:CLV_CASPASE3_1 457 460 UNIPROT:P70677 PFAM:PF00656 45 275 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:12637508 SWTI000551 Active INTI000654 UNIPROT:O55207-3 ELM:LIG_PDZ_Class_1 1288 1293 UNIPROT:Q9WVJ4 PFAM:PF00595 13 100 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:10357812 SWTI000552 Active INTI000655 UNIPROT:Q9ES52 ELM:LIG_SH2_IIA 918 921 UNIPROT:P26450 PFAM:PF00017 333 428 ID A Binary Pre-translational Alternative splicing Irreversible Negative Inhibition PMID:10716940 SWTI000553 Active INTI000656 UNIPROT:P13285 ELM:LIG_WW_1 57 60 UNIPROT:Q8C863 PFAM:PF00397 319 352 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:17437719 SWTI000554 Active INTI000657 UNIPROT:P13285 ELM:LIG_WW_1 98 101 UNIPROT:Q8C863 PFAM:PF00397 319 352 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:17437719 SWTI000555 Active INTI000658 UNIPROT:Q60575-3 ELM:LIG_PDZ_Class_1 1145 1150 UNIPROT:Q9Z0G0 PFAM:PF00595 133 213 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:10198040 SWTI000556 Active INTI000659 UNIPROT:Q80TQ2 ELM:LIG_TRAF2_3 449 453 UNIPROT:P39429 PFAM:PF00917 358 498 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:17923499;PMID:18718859;PMID:12917691 SWTI000557 Active INTI000660 UNIPROT:Q91Y57 ELM:MOD_TYR_ITIM 430 435 UNIPROT:P29351 PFAM:PF00017 4 110 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:11278955 SWTI000558 Active INTI000661 UNIPROT:Q91Y57 ELM:MOD_TYR_ITIM 430 435 UNIPROT:P35235 PFAM:PF00017 6 102 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:11278955 SWTI000559 Active INTI000662 UNIPROT:Q86YW5 ELM:MOD_TYR_ITIM 279 284 UNIPROT:Q06124 PFAM:PF00017 6 81 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:15128762 SWTI000560 Active INTI000663 UNIPROT:P22756 ELM:LIG_PDZ_Class_1 945 949 UNIPROT:Q9EP80 PFAM:PF00595 22 105 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:12597860 SWTI000561 Active INTI000664 UNIPROT:P22756 ELM:LIG_PDZ_Class_1 945 949 UNIPROT:P97879 PFAM:PF00595 471;572;672;988 560;657;754;1070 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:12597860 SWTI000562 Active INTI000665 UNIPROT:P22756 ELM:TRG_ER_diArg_2 937 941 UNIPROT:P53618 PFAM:PF01602 18 539 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:14527949 SWTI000563 Active INTI000666 UNIPROT:Q5BJF6 ELM:MOD_CDK_1 817 823 UNIPROT:P06493 PFAM:PF00069 4 297 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation MOD:00696 S820 GO:0000086 GO:0005829 REACTOME:380287 PMID:19386263 SWTI000564 Active INTI000667 UNIPROT:P15246-2 ELM:TRG_ER_KDEL_1 225 228 UNIPROT:P24390 PFAM:PF00810 28 170 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:1627573 SWTI000565 Active INTI000668 UNIPROT:Q32P28 ELM:TRG_ER_KDEL_1 733 736 UNIPROT:P24390 PFAM:PF00810 28 170 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:19088120 SWTI000566 Active INTI000669 UNIPROT:Q13485 ELM:TRG_NES_CRM1_2 142 149 UNIPROT:O14980 PFAM:PF08389 123 268 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation GO:0005634 PMID:11074002 SWTI000567 Active INTI000670 UNIPROT:P15565 ELM:TRG_MLS 1 16 UNIPROT:O94826 PFAM:PF00515 114 578 ID A Binary Pre-translational Alternative initiation Irreversible Negative Abrogation PMID:1448094 SWTI000568 Active INTI000671 UNIPROT:Q80UN9 ELM:TRG_MLS 1 47 UNIPROT:O94826 PFAM:PF00515 114 578 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:8139535 SWTI000569 Active INTI000672 UNIPROT:Q15046-2 ELM:TRG_MLS 1 49 UNIPROT:O94826 PFAM:PF00515 114 578 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:10952987 SWTI000570 Active INTI000673 UNIPROT:Q9NS18 ELM:TRG_MLS 1 21 UNIPROT:O94826 PFAM:PF00515 114 578 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:11297543 SWTI000571 Active INTI000674 UNIPROT:O15527 ELM:TRG_NLS_MonoExtN_4 332 339 UNIPROT:P52294 PFAM:PF00514 115 451 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation GO:0005829 PMID:10233168 SWTI000572 Active INTI000675 UNIPROT:P33316 ELM:TRG_MLS 1 69 UNIPROT:O94826 PFAM:PF00515 114 578 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:9228092 SWTI000573 Active INTI000676 UNIPROT:P98082 ELM:LIG_AP2alpha_2 293 295 UNIPROT:O94973 PFAM:PF02296 826 934 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:11247302 SWTI000574 Active INTI000677 UNIPROT:P98082 ELM:LIG_AP2alpha_2 298 300 UNIPROT:O94973 PFAM:PF02296 826 934 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:11247302 SWTI000575 Active INTI000678 UNIPROT:P29590 ELM:TRG_NLS 476 490 UNIPROT:P52294 PFAM:PF00514 115 451 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation GO:0005829 PMID:1594241;PMID:9885291;PMID:21092142 SWTI000576 Active INTI000679 UNIPROT:P29590 ELM:MOD_SUMO 489 492 UNIPROT:P63279 PFAM:PF00179 8 152 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:1594241 SWTI000577 Active INTI000680 UNIPROT:P29590 ELM:TRG_NES_CRM1_1 702 716 UNIPROT:O14980 PFAM:PF08389 123 268 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation GO:0005634 PMID:10739668;PMID:1594241;PMID:21092142 SWTI000578 Active INTI000681 UNIPROT:P05710 ELM:TRG_LysEnd_APsAcLL_1 301 306 UNIPROT:P53680 PFAM:PF01217 1 142 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:12403840 SWTI000579 Active INTI000682 UNIPROT:Q9UHK6 ELM:TRG_PTS1 379 382 UNIPROT:P50542 PFAM:PF00515 488 589 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:14960364 SWTI000580 Active INTI000683 UNIPROT:P38398 ELM:TRG_NLS_MonoExtN_4 501 508 UNIPROT:P52294 PFAM:PF00514 115 451 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation GO:0005829 PMID:9010228;PMID:12890739 SWTI000581 Active INTI000684 UNIPROT:Q9Y2N7 ELM:LIG_ODPH_VHL_1 490 502 UNIPROT:P40337 PFAM:PF01847 58 213 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation GO:0005829 PMID:12538644 SWTI000582 Active INTI000685 UNIPROT:P42229 ELM:LIG_SH2_STAT5 694 697 UNIPROT:P42229 PFAM:PF00017 593 670 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:19788420 SWTI000583 Active INTI000686 UNIPROT:P54256-2 ELM:LIG_14-3-3_4 594 598 UNIPROT:P63102 PFAM:PF00244 3 236 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:17166838 SWTI000584 Active INTI000687 UNIPROT:Q702N8 ELM:LIG_EVH1_1 22 26 UNIPROT:Q8N8S7 PFAM:PF00568 1 108 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:16631741 SWTI000585 Active INTI000688 UNIPROT:Q702N8 ELM:LIG_EVH1_1 22 26 UNIPROT:P50552 PFAM:PF00568 1 110 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:16631741 SWTI000586 Active INTI000689 UNIPROT:Q9Y2T3 ELM:LIG_PDZ_Class_1 449 454 UNIPROT:Q92796 PFAM:PF00595 130 217 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:10542258 SWTI000587 Active INTI000690 UNIPROT:Q9GZV5 ELM:LIG_14-3-3_1 86 91 UNIPROT:P62258 PFAM:PF00244 4 239 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S89 PMID:11118213 SWTI000588 Active INTI000691 UNIPROT:Q05586-4 ELM:LIG_PDZ_Class_1 917 922 UNIPROT:P78352 PFAM:PF00595 65 151 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:11163274 SWTI000589 Active INTI000691 UNIPROT:Q05586-4 ELM:LIG_PDZ_Class_1 917 922 UNIPROT:P78352 PFAM:PF00595 65 151 ID A Specificity Motif hiding Reversible PMID:11163274 SWTI000589 Active INTI000692 UNIPROT:Q05586-4 ELM:TRG_ER_diArg_1 893 895 UNIPROT:P53618 PFAM:PF01602 18 539 ID A Specificity Motif hiding Effector binding Reversible Negative Abrogation UNIPROT:P78352 PMID:11163274 SWTI000590 Active INTI000693 UNIPROT:O55207-3 ELM:LIG_PDZ_Class_1 1288 1293 UNIPROT:Q9WVJ4 PFAM:PF00595 13 100 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:11498538 SWTI000591 Active INTI000694 UNIPROT:O55207 ELM:LIG_SH3_2 1120 1125 UNIPROT:O35964 PFAM:PF07653 306 365 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:11498538 SWTI000592 Active INTI000695 UNIPROT:P51790-2 ELM:LIG_PDZ_Class_1 861 866 UNIPROT:O14745 PFAM:PF00595 154 234 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:11967229 SWTI000593 Active INTI000696 UNIPROT:P19491 ELM:LIG_PDZ_Class_2 878 883 UNIPROT:Q9EP80 PFAM:PF00595 22 105 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:10340301 SWTI000594 Active INTI000697 UNIPROT:Q66T02 ELM:LIG_PDZ_Class_1 1068 1073 UNIPROT:Q9Z0G0 PFAM:PF00595 133 213 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:16467373 SWTI000595 Active INTI000698 UNIPROT:P38377 ELM:LIG_IQ 13 31 UNIPROT:P62161 PFAM:PF13499 14 73 ID B Binary Allostery Effector binding Reversible Positive Enhancement CHEBI:29108 PMID: 21102557 SWTI000597 Active INTI000700 UNIPROT:P97924-6 ELM:LIG_PDZ_Class_1 1649 1654 UNIPROT:P31016 PFAM:PF00595 65 151 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:11182094; PMID:18199770 SWTI000598 Active INTI000701 UNIPROT:Q9NQ66 ELM:LIG_PDZ_Class_1 1211 1216 UNIPROT:Q8TEW0 PFAM:PF00595 271 359 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:15782111; PMID:18390926 SWTI000599 Active INTI000702 UNIPROT:Q9Z1B3 ELM:LIG_PDZ_Class_1 1211 1216 UNIPROT:P70441 PFAM:PF00595 14 94 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:10980202 SWTI000600 Active INTI000703 UNIPROT:Q9NQ66-2 ELM:LIG_SH3_3 1162 1168 UNIPROT:Q9BYB0 PFAM:PF07653 472 531 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:21148417 SWTI000601 Active INTI000704 UNIPROT:O70161 ELM:TRG_ENDOCYTIC_2 644 647 UNIPROT:P84091 PFAM:PF00928 159 435 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:16707488; PMID:19287005 SWTI000602 Active INTI000705 UNIPROT:O70161 ELM:LIG_PTB_Talin 645 648 UNIPROT:P26039 PFAM:PF02174 310 401 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:12422220; PMID:12422219; PMID:19287005 SWTI000603 Active INTI000706 UNIPROT:O70161 ELM:LIG_PTB_Talin 645 648 UNIPROT:P26039 PFAM:PF02174 310 401 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Inhibition MOD:00696 S645 UNIPROT:P49615 PMID:19287005; PMID:17290217 SWTI000604 Active INTI000707 UNIPROT:O70161 ELM:LIG_PTB_Talin 645 648 UNIPROT:P26039 PFAM:PF02174 310 401 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Enhancement MOD:00696 Y644 PMID:15738269; PMID:14691141; PMID:16616931 SWTI000605 Active INTI000708 UNIPROT:O70161 ELM:TRG_AP2beta_CARGO_2 633 644 UNIPROT:Q9DBG3 PFAM:PF09066 826 936 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:19287005 SWTI000606 Active INTI000709 UNIPROT:O70161 ELM:TRG_AP2beta_CARGO_2 633 644 UNIPROT:Q9DBG3 PFAM:PF09066 826 936 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Inhibition MOD:00696 S645 UNIPROT:P49615 PMID:19287005 SWTI000607 Active INTI000710 UNIPROT:Q00987 ELM:TRG_NLS_MonoExtC_3 181 187 UNIPROT:P52294 PFAM:PF00514 115 451 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation GO:0005829 PMID:17426254 SWTI000608 Active INTI000711 UNIPROT:Q00987 ELM:TRG_NES_CRM1_2 190 202 UNIPROT:O14980 PFAM:PF08389 123 268 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation GO:0005634 PMID:14757843; PMID:17426254 SWTI000609 Active INTI000712 UNIPROT:O60716 ELM:TRG_NES_CRM1_1 942 956 UNIPROT:O14980 PFAM:PF08389 123 268 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation GO:0005634 PMID:10393933 SWTI000610 Active INTI000713 UNIPROT:Q14494 ELM:TRG_NES_CRM1_2 251 259 UNIPROT:O14980 PFAM:PF08389 123 268 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation GO:0005634 PMID:12729924 SWTI000611 Active INTI000714 UNIPROT:Q9UQB8-4 ELM:LIG_PDZ_Class_1 516 521 UNIPROT:Q92796 PFAM:PF00595 226 311 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:15255944 SWTI000612 Active INTI000715 UNIPROT:P27732 ELM:LIG_IQ 1650 1669 UNIPROT:P62161 PFAM:PF13499 8 146 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:17050708; PMID:21998309 SWTI000613 Active INTI000716 UNIPROT:O75925 ELM:LIG_SUMO_SBM_1 457 461 UNIPROT:P63165 PFAM:PF11976 22 92 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Enhancement MOD:00696 S466;S467;S468 UNIPROTFAM:CK2 subfamily;UNIPROTFAM:CK2 subfamily;UNIPROTFAM:CK2 subfamily PMID: 19217413 SWTI000614 Active INTI000717 UNIPROT:O60331 ELM:TRG_ENDOCYTIC_2 649 652 UNIPROT:Q96CW1 PFAM:PF00928 159 435 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Inhibition MOD:00696 S645 UNIPROT:P49615 PMID:19287005; PMID:17290217 SWTI000615 Active INTI000543 UNIPROT:P97318 ELM:LIG_SH2_IA 220 223 UNIPROT:O43639 PFAM:PF00017 285 323 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation MOD:00696 Y220 UNIPROT:P05480 PMID: 22586277;PMID: 11279201 SWTI000616 Active INTI000718 UNIPROT:P97318 ELM:LIG_SH2_IA 232 235 UNIPROT:O43639 PFAM:PF00017 285 323 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation MOD:00696 Y232 PMID:22586277 SWTI000617 Active INTI000719 UNIPROT:P97318 ELM:LIG_SH2_IA 220 223 UNIPROT:Q64010 PFAM:PF00017 13 118 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation MOD:00696 Y220 UNIPROT:P05480 PMID:22586277; PMID:15062102; PMID:15316068; PMID:15110774;PMID: 11279201 SWTI000618 Active INTI000720 UNIPROT:P97318 ELM:LIG_SH2_IA 232 235 UNIPROT:Q64010 PFAM:PF00017 13 118 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation MOD:00696 Y232 PMID:22586277; PMID:15062102; PMID:15316068; PMID:15110774 SWTI000619 Active INTI000721 UNIPROT:P97318 ELM:LIG_SH2_SRC 185 188 UNIPROT:P05480 PFAM:PF00017 156 253 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation MOD:00696 Y185 PMID:22586277 SWTI000620 Active INTI000722 UNIPROT:P97318 ELM:LIG_SH2_SRC 198 201 UNIPROT:P05480 PFAM:PF00017 156 253 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation MOD:00696 Y198 UNIPROT:P05480 PMID:22586277;PMID: 11279201 SWTI000621 Active INTI000718 UNIPROT:P97318 ELM:LIG_SH2_IA 232 235 UNIPROT:O43639 PFAM:PF00017 285 323 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y232 PMID:22586277; PMID:15062102; PMID:15316068; PMID:15110774 SWTI000622 Active INTI000720 UNIPROT:P97318 ELM:LIG_SH2_IA 232 235 UNIPROT:Q64010 PFAM:PF00017 13 118 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y232 PMID:22586277; PMID:15062102; PMID:15316068; PMID:15110774 SWTI000623 Active INTI000721 UNIPROT:P97318 ELM:LIG_SH2_SRC 185 188 UNIPROT:P05480 PFAM:PF00017 156 253 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y185 PMID:22586277 SWTI000624 Active INTI000722 UNIPROT:P97318 ELM:LIG_SH2_SRC 198 201 UNIPROT:P05480 PFAM:PF00017 156 253 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y198 UNIPROT:P05480 PMID:22586277;PMID: 11279201 SWTI000625 Active INTI000723 UNIPROT:P16471 ELM:LIG_SCF-TrCP1_1 348 353 UNIPROT:Q9UKB1 PFAM:PF00400 232 518 ID A Binary Pre-translational Alternative Splicing Irreversible Negative Abrogation PMID:15082796 SWTI000626 Active INTI000724 UNIPROT:P16471 ELM:LIG_SH2_STAT5 342 345 UNIPROT:P42229 PFAM:PF00017 589 686 ID A Binary Pre-translational Alternative Splicing Irreversible Negative Abrogation PMID:11518703 SWTI000627 Active INTI000725 UNIPROT:Q24546 ELM:MOD_PKA_1 3 9 UNIPROT:KAPC_DROME PFAM:PF00069 46 300 ID A Binary Pre-translational RNA editing Irreversible Negative Abrogation MOD:00696 S6 UNIPROT:P12370 PMID:17105647 SWTI000628 Active INTI000726 UNIPROT:P23634 ELM:LIG_PDZ_Class_1 1236 1241 UNIPROT:Q12959 PFAM:PF00595 319 405 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:9430700 SWTI000629 Active INTI000727 UNIPROT:P23634 ELM:LIG_PDZ_Class_1 1236 1241 UNIPROT:Q92796 PFAM:PF00595 226 311 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:11274188 SWTI000630 Active INTI000728 UNIPROT:P97924-6 ELM:LIG_PDZ_Class_1 1649 1654 UNIPROT:P31016 PFAM:PF00595 160 246 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:11182094; PMID:18199770 SWTI000631 Active INTI000729 UNIPROT:P97924-6 ELM:LIG_PDZ_Class_1 1649 1654 UNIPROT:P31016 PFAM:PF00595 313 393 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:11182094; PMID:18199770 SWTI000632 Active INTI000730 TRUE UNIPROT:P64897 ELM:LIG_FHA_1 20 26 UNIPROT:P64897 PFAM:PF00498 77 140 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T22 UNIPROT:P0A5S4 PMID: 19318624 SWTI000633 Active INTI000731 UNIPROT:P38377 ELM:LIG_IQ 13 31 UNIPROT:P62161 PFAM:PF13499 86 146 ID B Binary Allostery Effector binding Reversible Positive Enhancement CHEBI:29108 PMID: 21102557 SWTI000634 Active INTI000732 UNIPROT:Q05586-4 ELM:LIG_PDZ_Class_1 917 922 UNIPROT:P78352 PFAM:PF00595 160 246 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:11163274 SWTI000635 Active INTI000733 UNIPROT:Q05586-4 ELM:LIG_PDZ_Class_1 917 922 UNIPROT:P78352 PFAM:PF00595 160 246 ID A Specificity Motif hiding Reversible PMID:11163274 SWTI000635 Active INTI000734 UNIPROT:Q05586-4 ELM:TRG_ER_diArg_1 893 895 UNIPROT:P53618 PFAM:PF01602 18 539 ID A Specificity Motif hiding Reversible PMID:11163274 SWTI000636 Active INTI000735 UNIPROT:Q05586-4 ELM:LIG_PDZ_Class_1 917 922 UNIPROT:P78352 PFAM:PF00595 313 393 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:11163274 SWTI000637 Active INTI000736 UNIPROT:Q05586-4 ELM:LIG_PDZ_Class_1 917 922 UNIPROT:P78352 PFAM:PF00595 313 393 ID A Specificity Motif hiding Reversible PMID:11163274 SWTI000637 Active INTI000734 UNIPROT:Q05586-4 ELM:TRG_ER_diArg_1 893 895 UNIPROT:P53618 PFAM:PF01602 18 539 ID A Specificity Motif hiding Reversible PMID:11163274 SWTI000638 Active INTI000737 UNIPROT:Q9Y2T3 ELM:LIG_PDZ_Class_1 449 454 UNIPROT:Q92796 PFAM:PF00595 226 311 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:10542258 SWTI000639 Active INTI000738 UNIPROT:Q91Y57 ELM:MOD_TYR_ITIM 430 435 UNIPROT:P29351 PFAM:PF00017 110 213 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:11278955 SWTI000640 Active INTI000739 UNIPROT:Q91Y57 ELM:MOD_TYR_ITIM 430 435 UNIPROT:P35235 PFAM:PF00017 112 216 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:11278955 SWTI000641 Active INTI000740 UNIPROT:Q86YW5 ELM:MOD_TYR_ITIM 279 284 UNIPROT:Q06124 PFAM:PF00017 112 197 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:15128762 SWTI000642 Active INTI000741 UNIPROT:Q9ES52 ELM:LIG_SH2_IIA 918 921 UNIPROT:P26450 PFAM:PF00017 624 718 ID A Binary Pre-translational Alternative splicing Irreversible Negative Inhibition PMID:10716940 SWTI000643 Active INTI000742 UNIPROT:P13285 ELM:LIG_WW_1 57 60 UNIPROT:Q8C863 PFAM:PF00397 399 432 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:17437719 SWTI000644 Active INTI000743 UNIPROT:P55210 ELM:LIG_BIR_III_2 23 27 UNIPROT:Q13490 PFAM:PF00653 187 251 ID A Binary Physicochemical compatibility PTM-dependent Irreversible Positive Induction Proteolytic cleavage D23 GO:0005829 KEGG:hsa04210;REACTOMEIN:75153 PMID: 19258326 SWTI000645 Active INTI000744 UNIPROT:P55210 ELM:LIG_BIR_III_2 23 27 UNIPROT:Q13490 PFAM:PF00653 272 337 ID A Binary Physicochemical compatibility PTM-dependent Irreversible Positive Induction Proteolytic cleavage D23 GO:0005829 KEGG:hsa04210;REACTOMEIN:75153 PMID: 19258326 SWTI000646 Active INTI000745 UNIPROT:P20020-3 ELM:LIG_IQ_2 1114 1128 UNIPROT:P62158 PFAM:PF13499 85 146 ID A Binary Pre-translational Alternative splicing Irreversible Negative Inhibition PMID:11152753 SWTI000647 Active INTI000746 UNIPROT:Q9NR28 ELM:LIG_BIR_internal 56 59 UNIPROT:P98170 PFAM:PF00653 268 331 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:14523016 SWTI000648 Active INTI000747 UNIPROT:O43426 ELM:LIG_EH_1 1393 1397 UNIPROT:P42566 IPR:IPR000261 128 216 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:10801423;PMID:17158794 SWTI000649 Active INTI000748 UNIPROT:O43426 ELM:LIG_EH_1 1403 1407 UNIPROT:P42566 IPR:IPR000261 128 216 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:10801423;PMID:17158794 SWTI000650 Active INTI000749 UNIPROT:O43426 ELM:LIG_EH_1 1414 1418 UNIPROT:P42566 IPR:IPR000261 128 216 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:10801423;PMID:17158794 SWTI000651 Active INTI000750 UNIPROT:O43426 ELM:LIG_EH_1 1393 1397 UNIPROT:P42566 IPR:IPR000261 224 314 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:10801423;PMID:17158794 SWTI000652 Active INTI000751 UNIPROT:O43426 ELM:LIG_EH_1 1403 1407 UNIPROT:P42566 IPR:IPR000261 224 314 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:10801423;PMID:17158794 SWTI000653 Active INTI000752 UNIPROT:O43426 ELM:LIG_EH_1 1414 1418 UNIPROT:P42566 IPR:IPR000261 224 314 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:10801423;PMID:17158794 SWTI000654 Active INTI000753 UNIPROT:P49023 ELM:LIG_SH2_IB 118 121 UNIPROT:P20936 PFAM:PF03623 351 441 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:16219691 SWTI000655 Active INTI000754 UNIPROT:P97288-2 ELM:LIG_PDZ_Class_1 382 387 UNIPROT:P70441 PFAM:PF00595 149 229 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:15466885 SWTI000656 Active INTI000755 UNIPROT:Q15303 ELM:LIG_SH2_IIA 1056 1059 UNIPROT:P27986 PFAM:PF00017 624 718 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:16122376 SWTI000657 Active INTI000756 UNIPROT:Q15303 ELM:LIG_WW_1 1053 1056 UNIPROT:Q96J02 PFAM:PF00397 360 389 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:18334649 SWTI000658 Active INTI000757 UNIPROT:Q4VCS5 ELM:LIG_WW_1 239 242 UNIPROT:P46937 PFAM:PF00397 230 263 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:21205866;PMID:18164266 SWTI000659 Inactive INTI000758 UNIPROT:O43613 ELM:MOD_TYR_ITSM 79 86 UNIPROT:Q06124 PFAM:PF00017 112 197 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 Y83 GO:0009898 PMID: 19661287 SWTI000659 Inactive INTI000759 UNIPROT:O43613 ELM:MOD_TYR_ITIM 356 361 UNIPROT:Q06124 PFAM:PF00017 112 197 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 Y358 GO:0009898 PMID: 19661287 SWTI000660 Inactive INTI000760 UNIPROT:Q14118 ELM:LIG_WW_1 889 892 UNIPROT:P11532 PFAM:PF00397 3057 3086 ID A Specificity Competition Effector binding Reversible Negative Inhibition UNIPROT:P62993 PMID: 10903901;PMID: 10932245;PMID: 20163697 SWTI000660 Inactive INTI000761 UNIPROT:Q14118 ELM:LIG_SH3_3 888 894 UNIPROT:P62993 PFAM:PF00018 162 207 ID A Specificity Competition Effector binding Reversible Negative Inhibition UNIPROT:P11532 PMID: 10903901;PMID: 10932245;PMID: 20163697 SWTI000661 Active INTI000762 UNIPROT:Q969H0 ELM:LIG_WW_Pin1_4 202 207 UNIPROT:Q13526 PFAM:PF00397 7 37 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 T205 PMID:22608923 SWTI000662 Active INTI000763 UNIPROT:O75925 ELM:LIG_SUMO_SBM_1 457 461 UNIPROT:P61956 PFAM:PF11976 18 88 ID B Binary Physicochemical compatibility PTM-dependent Reversible Negative Induction MOD:00394 K33 PMID:22578841 SWTI000663 Active INTI000765 UNIPROT:O75925 ELM:LIG_SUMO_SBM_1 457 461 UNIPROT:P63165 PFAM:PF11976 22 92 ID B Binary Physicochemical compatibility PTM-dependent Reversible Negative Induction MOD:00394 K37 PMID:22578841 SWTI000664 Active INTI000766 UNIPROT:O75928 ELM:LIG_SUMO_SBM_1 467 471 UNIPROT:P61956 PFAM:PF11976 18 88 ID B Binary Physicochemical compatibility PTM-dependent Reversible Negative Induction MOD:00394 K33 PMID:22578841 SWTI000665 Active INTI000767 UNIPROT:O75928 ELM:LIG_SUMO_SBM_1 467 471 UNIPROT:P63165 PFAM:PF11976 22 92 ID B Binary Physicochemical compatibility PTM-dependent Reversible Negative Induction MOD:00394 K37 PMID:22578841 SWTI000668 Active INTI000770 UNIPROT:Q92731 ELM:MOD_GSK3_1 5 12 UNIPROT:P49841 PFAM:PF00069 56 340 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S12 PMID:22586270 SWTI000668 Active INTI000771 UNIPROT:Q92731 ELM:MOD_SUMO_PHOS 4 7 UNIPROT:P63279 PFAM:PF00179 8 152 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S6 PMID:22586270 SWTI000669 Active INTI000828 UNIPROT:Q92731 ELM:MOD_SUMO_PHOS 4 7 UNIPROT:P63279 PFAM:PF00179 8 152 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Inhibition MOD:00492 K4 PMID:22586270 SWTI000670 Active INTI000772 UNIPROT:Q13309 ELM:TRG_NLS_MonoExtN_4 65 72 UNIPROT:O15131 PFAM:PF00514 112 450 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Inhibition MOD:00394 K68;K71 UNIPROT:Q09472 GO:0005829 PMID:22770219 SWTI000671 Active INTI000773 UNIPROT:Q13309 ELM:TRG_NLS_MonoExtN_4 65 72 UNIPROT:O60684 PFAM:PF00514 156 450 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Inhibition MOD:00394 K68;K71 UNIPROT:Q09472 GO:0005829 PMID:22770219 SWTI000672 Active INTI000774 UNIPROT:Q8IWE5 ELM:LIG_TPR_Kinesin_1 236 240 UNIPROT:Q9H0B6 PFAM:PF13424 198 482 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:22172677 SWTI000673 Active INTI000775 UNIPROT:O35867 ELM:LIG_PP1 454 461 UNIPROT:P62138 PFAM:PF00149 57 252 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Inhibition MOD:00696 S461 UNIPROTFAM:cAMP subfamily PMID: 10504266 SWTI000674 Active INTI000776 UNIPROT:P09619 ELM:LIG_PDZ_Class_1 1101 1106 UNIPROT:O14745 PFAM:PF00595 16 91 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Inhibition MOD:00696 S1104 UNIPROT:P25098 PMID: 15271984 SWTI000675 Active INTI000777 UNIPROT:P49418 ELM:LIG_Clathr_ClatBox_1 351 355 UNIPROT:Q00610 PFAM:PF01394 19;148;198 56;187;234 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Inhibition MOD:00696 T350 UNIPROTFAM:CK2 subfamily GO:0030118 PMID: 16945112 SWTI000676 Active INTI000778 UNIPROT:P49418 ELM:LIG_Clathr_ClatBox_2 380 385 UNIPROT:Q00610 PFAM:PF01394 19;148;198 56;187;234 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Inhibition MOD:00696 T387 UNIPROTFAM:CK2 subfamily GO:0030118 PMID: 16945112 SWTI000677 Active INTI000779 UNIPROT:P49418 ELM:LIG_Clathr_ClatBox_1 351 355 UNIPROT:Q00610 PFAM:PF01394 19;148;198 56;187;234 ID A Avidity-sensing Reversible Positive Induction GO:0030118 PMID: 14981508 SWTI000677 Active INTI000780 UNIPROT:P49418 ELM:LIG_Clathr_ClatBox_2 380 385 UNIPROT:Q00610 PFAM:PF01394 19;148;198 56;187;234 ID A Avidity-sensing Reversible Positive Induction GO:0030118 PMID: 14981508 SWTI000678 Active INTI000781 UNIPROT:O15350 ELM:LIG_WW_1 484 487 UNIPROT:P46937 PFAM:PF00397 173;232 202;261 ID A Specificity Competition Effector binding Reversible Negative Inhibition UNIPROT:Q96J02 PMID: 17110958 SWTI000678 Active INTI000782 UNIPROT:O15350 ELM:LIG_WW_1 484 487 UNIPROT:Q96J02 PFAM:PF00397 328;360;440;480 357;389;469;509 ID A Specificity Competition Effector binding Reversible Negative Inhibition UNIPROT:P46937 PMID: 17110958 SWTI000679 Active INTI000783 UNIPROT:Q15054 ELM:LIG_PCNA_PIPBox_1 456 465 UNIPROT:P12004 PFAM:PF02747 127 254 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Inhibition MOD:00696 S458 UNIPROTFAM:cAMP subfamily GO:0000084 GO:0005634 REACTOME:69239;KEGG:ko03030;KEGG:ko03410;KEGG:ko03420;KEGG:ko03430 PMID: 22148433 SWTI000680 Active INTI000784 UNIPROT:P32004 ELM:TRG_ENDOCYTIC_2 1176 1179 UNIPROT:Q96CW1 PFAM:PF00928 159 435 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 Y1176 UNIPROT:P12931 GO:0005886 PMID: 12082080 SWTI000681 Active INTI000785 UNIPROT:O15151 ELM:LIG_USP7_1 398 402 UNIPROT:Q93009 PFAM:PF00917 57 197 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Inhibition MOD:00696 S403 UNIPROT:Q13315 PMID: 15916963;PMID: 15788536; PMID: 16163388 SWTI000682 Active INTI000786 UNIPROT:P63104 PFAM:PF00244 3 236 UNIPROT:P63104 PFAM:PF00244 3 236 Avidity-sensing Reversible PMID: 16943424 SWTI000682 Active INTI000787 UNIPROT:O15151 ELM:LIG_14-3-3_1 364 369 INTI000786 PFAM:PF00244 3 236 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 S367 UNIPROT:O96017 PMID: 16943424 SWTI000682 Active INTI000788 UNIPROT:O15151 ELM:LIG_14-3-3_3 339 344 INTI000786 PFAM:PF00244 3 236 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 S342 UNIPROT:O96017 PMID: 16943424 SWTI000683 Active INTI000789 UNIPROT:Q9WTQ5 ELM:LIG_CYCLIN_1 501 504 UNIPROT:P25322 PFAM:PF00134 26 153 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 S507 UNIPROTFAM:PKC subfamily GO:0005737 PMID: 10982843 SWTI000684 Active INTI000790 UNIPROT:P05627 ELM:LIG_WW_1 167 170 UNIPROT:Q8C863 PFAM:PF00397 289;321;401;441 318;350;430;470 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Abrogation MOD:00696 Y170 UNIPROT:P00520 GO:0005634 PMID: 16901904 SWTI000685 Active INTI000791 UNIPROT:O60566 ELM:LIG_APCC_KENbox_2 303 307 UNIPROT:Q12834 PFAM:PF00400 Specificity Domain hiding GO:0005829 KEGG:hsa04110 PMID: 22193957 SWTI000685 Active INTI000792 UNIPROT:P14635 ELM:LIG_APCC_Dbox_1 41 49 UNIPROT:Q12834 PFAM:PF00400 ID B Specificity Domain hiding Effector binding Reversible Negative Abrogation UNIPROT:O60566 GO:0051323 GO:0005829 KEGG:hsa04110 PMID: 22193957 SWTI000686 Active INTI000793 UNIPROT:O60566 ELM:LIG_APCC_KENbox_2 303 307 UNIPROT:Q12834 PFAM:PF00400 Specificity Domain hiding GO:0005829 KEGG:hsa04110 PMID: 22193957 SWTI000686 Active INTI000794 UNIPROT:O95997 ELM:LIG_APCC_Dbox_1 60 68 UNIPROT:Q12834 PFAM:PF00400 ID B Specificity Domain hiding Effector binding Reversible Negative Abrogation UNIPROT:O60566 GO:0051323 GO:0005829 KEGG:hsa04110 PMID: 22193957 SWTI000687 Active INTI000795 UNIPROT:Q08981 ELM:LIG_APCC_KENbox_2 97 101 UNIPROT:P53197 PFAM:PF00400 Specificity Domain hiding KEGG:sce04111 PMID: 21460798;PMID: 18596038 SWTI000687 Active INTI000796 UNIPROT:P24869 ELM:LIG_APCC_Dbox_1 99 103 UNIPROT:P53197 PFAM:PF00400 ID B Specificity Domain hiding Effector binding Reversible Negative Abrogation UNIPROT:Q08981 GO:0051322;GO:0051326;GO:0051318 KEGG:sce04111 PMID: 21460798;PMID: 18596038 SWTI000688 Active INTI000797 UNIPROT:Q08981 ELM:LIG_APCC_KENbox_2 97 101 UNIPROT:P53197 PFAM:PF00400 Specificity Domain hiding KEGG:sce04111 PMID: 21460798;PMID: 18596038 SWTI000688 Active INTI000798 UNIPROT:P27895 ELM:LIG_APCC_Dbox_1 931 935 UNIPROT:P53197 PFAM:PF00400 ID B Specificity Domain hiding Effector binding Reversible Negative Abrogation UNIPROT:Q08981 GO:0051322;GO:0051326;GO:0051318 KEGG:sce04111 PMID: 21460798;PMID: 18596038 SWTI000689 Active INTI000799 UNIPROT:Q08981 ELM:LIG_APCC_KENbox_2 97 101 UNIPROT:P53197 PFAM:PF00400 Specificity Domain hiding KEGG:sce04111 PMID: 21460798;PMID: 18596038 SWTI000689 Active INTI000800 UNIPROT:P34244 ELM:LIG_APCC_Dbox_1 774 778 UNIPROT:P53197 PFAM:PF00400 ID B Specificity Domain hiding Effector binding Reversible Negative Abrogation UNIPROT:Q08981 GO:0051322;GO:0051326;GO:0051318 KEGG:sce04111 PMID: 21460798;PMID: 18596038 SWTI000690 Active INTI000801 UNIPROT:P63104 PFAM:PF00244 3 236 UNIPROT:P63104 PFAM:PF00244 3 236 Avidity-sensing Reversible PMID: 14690436;PMID: 10518537 SWTI000690 Active INTI000802 UNIPROT:P98177 ELM:LIG_14-3-3_1 29 34 INTI000801 PFAM:PF00244 3 236 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 T32 UNIPROT:P31749 PMID: 14690436;PMID: 10518537 SWTI000690 Active INTI000803 UNIPROT:P98177 ELM:LIG_14-3-3_2 193 199 INTI000801 PFAM:PF00244 3 236 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 S197 UNIPROT:P31749 PMID: 14690436;PMID: 10518537 SWTI000691 Active INTI000804 UNIPROT:P46937-2 ELM:MOD_LATS_1 376 381 UNIPROT:O95835 PFAM:PF00069 705 1010 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 S381 PMID:20048001 SWTI000691 Active INTI000805 UNIPROT:P46937-2 ELM:MOD_CK1_1 381 387 UNIPROT:P49674 PFAM:PF00069 9 280 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 S384 PMID:20048001 SWTI000691 Active INTI000806 UNIPROT:P46937-2 ELM:MOD_CK1_1 384 390 UNIPROT:P49674 PFAM:PF00069 9 280 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 S387 PMID:20048001 SWTI000691 Active INTI000807 UNIPROT:P46937-2 ELM:LIG_SCF-TrCP1_2 383 387 UNIPROT:Q9Y297 PFAM:PF00400 301 590 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00696 S384;S387 PMID:20048001 SWTI000692 Active INTI000808 UNIPROT:P46527 ELM:TRG_NLS 152 166 UNIPROT:P52294 PFAM:PF00514 115 451 ID A Specificity Motif hiding Effector binding Reversible Negative Abrogation UNIPROT:P61981 GO:0005829 KEGGIN:hsa04110;KEGGIN:hsa04151 PMID: 12244301;PMID: 12244303;PMID: 15057270 SWTI000692 Active INTI000809 UNIPROT:P46527 ELM:LIG_14-3-3 154 159 UNIPROT:P61981 PFAM:PF00244 4 241 ID A Specificity Motif hiding PTM-dependent Reversible Positive Induction MOD:00696 T157 UNIPROT:P31749 KEGGIN:hsa04110;KEGGIN:hsa04151 PMID: 12244301;PMID: 12244303;PMID: 15057270 SWTI000693 Active INTI000810 UNIPROT:P61981 PFAM:PF00244 4 241 UNIPROT:P27348 PFAM:PF00244 3 236 Avidity-sensing KEGGIN:hsa04110;KEGGIN:hsa04151 PMID: 12042314;PMID: 12244303;PMID: 14504289;PMID: 15057270;PMID: 15280662 SWTI000693 Active INTI000811 UNIPROT:P46527 ELM:LIG_14-3-3 154 159 INTI000810 PFAM:PF00244 4 241 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 T157 UNIPROT:P31749 KEGGIN:hsa04110;KEGGIN:hsa04151 PMID: 12042314;PMID: 12244303;PMID: 14504289;PMID: 15057270;PMID: 15280662 SWTI000693 Active INTI000812 UNIPROT:P46527 ELM:LIG_14-3-3 193 198 INTI000810 PFAM:PF00244 3 236 ID A Avidity-sensing PTM-dependent Reversible Positive Induction MOD:00696 T198 UNIPROT:P31749, UNIPROT:Q15418, UNIPROT:P51812 KEGGIN:hsa04110;KEGGIN:hsa04151 PMID: 12042314;PMID: 12244303;PMID: 14504289;PMID: 15057270;PMID: 15280662 SWTI000694 Active INTI000813 UNIPROT:P38936 ELM:LIG_PCNA_PIPBox_1 144 153 UNIPROT:P12004 PFAM:PF02747 127 254 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Inhibition MOD:00696 T145 UNIPROT:P31749 GO:0000084 GO:0070557;GO:0005634 KEGGIN:hsa04110 PMID: 11463845 SWTI000695 Active INTI000814 UNIPROT:P38936 ELM:LIG_PCNA_PIPBox_1 144 153 UNIPROT:P12004 PFAM:PF02747 127 254 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Inhibition MOD:00696 S146 UNIPROTFAM:PKC subfamily GO:0000084 GO:0070557;GO:0005634 KEGGIN:hsa04110 PMID: 10753973 SWTI000696 Active INTI000815 UNIPROT:Q13541 ELM:LIG_eIF4E_1 54 60 UNIPROT:P06730 PFAM:PF01652 38 200 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Inhibition MOD:00696 S65 UNIPROT:P42345 GO:0005829 KEGG:hsa04151;KEGG:hsa04150;KEGG:hsa04910 PMID: 7939721;PMID: 10364159;PMID: 10779345;PMID: 10942774;PMID: 11297505;PMID: 11691836;PMID: 11799119;PMID: 12374276;PMID: 12747827 SWTI000697 Active INTI000816 UNIPROT:Q61337 ELM:14-3-3_1 133 138 UNIPROT:P68254 PFAM:PF00244 3 236 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 S136 UNIPROT:P31750 PMID: 8929531;PMID: 9346240;PMID: 10559890;PMID: 10949026 SWTI000698 Active INTI000817 UNIPROT:P00533 ELM:LIG_SH2_SRC 1016 1019 UNIPROT:P19174 PFAM:PF00017 550;668 639;741 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1016 GO:0009898 KEGG:hsa04012;KEGG:hsa04020 PMID: 16273093 SWTI000699 Active INTI000818 UNIPROT:P00533 ELM:LIG_SH2_SRC 1125 1128 UNIPROT:P46108 PFAM:PF00017 13 104 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1125 GO:0009898 KEGG:hsa04012 PMID: 16273093 SWTI000700 Active INTI000819 UNIPROT:P00533 ELM:LIG_SH2_SRC 1016 1019 UNIPROT:P16333 PFAM:PF00017 282 356 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1016 GO:0009898 KEGG:hsa04012 PMID: 16273093 SWTI000701 Active INTI000820 UNIPROT:P21860 ELM:LIG_SH2_GRB2 1262 1265 UNIPROT:P62993 PFAM:PF00017 60 135 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y1262 GO:0009898 KEGG:hsa04012 PMID: 16729043 SWTI000702 Active INTI000821 UNIPROT:Q05397 ELM:LIG_SH2_SRC 397 400 UNIPROT:P05480 PFAM:PF00017 156 238 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y397 KEGGIN:hsa04012 PMID: 21266176 SWTI000703 Active INTI000822 UNIPROT:Q13480 ELM:LIG_SH2_STAT5 472 475 UNIPROT:P27986 PFAM:PF00017 333;624 408;698 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y472 KEGG:hsa04012 PMID: 10978177 SWTI000704 Active INTI000823 UNIPROT:Q13480 ELM:LIG_SH2_STAT5 447 450 UNIPROT:P27986 PFAM:PF00017 333;624 408;698 ID A Binary Physicochemical compatibility PTM-dependent Reversible Positive Induction MOD:00696 Y447 KEGG:hsa04012 PMID: 10978177 SWTI000666 Active INTI000764 UNIPROT:P29590 ELM:MOD_SUMO 159 162 UNIPROT:P63279 PFAM:PF00179 8 152 ID A Uncategorised Uncategorised PTM-dependent Reversible Positive Induction MOD:01149 K160 PMID:22578841 SWTI000666 Active INTI000768 UNIPROT:Q9UER7 ELM:LIG_SUMO_SBM_1 733 740 UNIPROT:P61956 PFAM:PF11976 18 88 Uncategorised Uncategorised PTM-dependent Reversible Positive Induction MOD:01149 K160 PMID:22578841 SWTI000705 Active INTI000769 UNIPROT:Q9UER7 ELM:LIG_SUMO_SBM_1 733 740 UNIPROT:P61956 PFAM:PF11976 18 88 ID B Specificity Altered binding specificity PTM-dependent Reversible Negative Abrogation MOD:00394 K33 PMID:22578841 SWTI000705 Active INTI000824 UNIPROT:P61956 ELM:LIG_BROMO 33 33 UNIPROT:Q09472 PFAM:PF00439 1058 1144 ID A Specificity Altered binding specificity PTM-dependent Reversible Positive Induction MOD:00394 K33 PMID:22578841 SWTI000667 Active INTI000825 UNIPROT:P29590 ELM:MOD_SUMO 159 162 UNIPROT:P63279 PFAM:PF00179 8 152 ID A Uncategorised Uncategorised PTM-dependent Reversible Positive Induction MOD:01149 K160 PMID:22578841 SWTI000667 Active INTI000826 UNIPROT:Q9UER7 ELM:LIG_SUMO_SBM_1 733 740 UNIPROT:P63165 PFAM:PF11976 22 92 Uncategorised Uncategorised PTM-dependent Reversible Positive Induction MOD:01149 K160 PMID:22578841 SWTI000706 Active INTI000827 UNIPROT:Q9UER7 ELM:LIG_SUMO_SBM_1 733 740 UNIPROT:P63165 PFAM:PF11976 22 92 ID B Binary Physicochemical compatibility PTM-dependent Reversible Negative Inhibition MOD:00394 K37 PMID:22578841 SWTI000707 Active INTI000828 UNIPROT:P29590 ELM:LIG_SUMO_SBM_1 556 566 UNIPROT:P63165 PFAM:PF11976 22 92 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation PMID:23028697 SWTI000708 Active INTI000829 UNIPROT:O95644 ELM:MOD_SUMO 701 704 UNIPROT:P63279 PFAM:PF00179 8 152 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation MOD:01149 K702 PMID:19218564 SWTI000709 Active INTI000829 UNIPROT:O95644 ELM:MOD_SUMO 913 916 UNIPROT:P63279 PFAM:PF00179 8 152 ID A Binary Pre-translational Alternative splicing Irreversible Negative Abrogation MOD:01149 K914 PMID:19218564 SWTI000710 Active INTI000830 UNIPROT:P21192 ELM:TRG_NES 122 150 UNIPROT:P30822 PFAM:PF08389 111 256 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Inhibition MOD:00696 S137 UNIPROT:P53894 PMID:18715118 SWTI000711 Active INTI000830 UNIPROT:P21192 ELM:TRG_NES 122 150 UNIPROT:P30822 PFAM:PF08389 111 256 ID A Binary Physicochemical compatibility PTM-dependent Reversible Negative Inhibition MOD:00696 S122 UNIPROT:P53894 PMID:18715118