Switch ID Proteins Genes Reactome Pathways KEGG Pathways KEGG Pathways ID KEGG PathwayClasses KEGG Protein ID GO terms Process GO terms Process ID GO terms Compartment GO terms Compartment ID GO terms Function GO terms Function ID GO terms and ELM Compartment GO terms and ELM Compartment ID ELM Compartment ELM Compartment ID Modifying Enzymes Modifying Enzymes ID PhosphoELM PhosphoELM ID PhosphoELM Pos Phosphosite Phosphosite ID Phosphosite Pos SWTI000001 O43561, P19174 LAT, PLCG1 Immune System, DAP12 signaling, Hemostasis, Adaptive Immune System, Innate Immune System, Generation of second messenger molecules, DAP12 interactions, TCR signaling NF-kappa B signaling pathway, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Natural killer cell mediated cytotoxicity path:hsa04064, path:hsa04660, path:hsa04664, path:hsa04666, path:hsa04650 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Immune System hsa:27040, hsa:5335 P:T cell receptor signaling pathway GO:0050852 C:signalosome GO:0008180 cytosol GO:0005829 SWTI000002 P31749 AKT1 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Cellular Processes; Cell Communication, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:207 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 UNIPROT:P42345 P42345 ILK, PDK-1 Q13418, O15530 473, 473 TBK1, MAPKAPK2, ILK, DNA-PK, PIKFYVE, PKD1, PDK1, LRRK2, mTOR, ATM, PKCA, PKCB Q9UHD2, P49137, Q13418, P78527, Q9Y2I7, Q15139, O15530, Q5S007, P42345, NP_000042, P17252, P05771 473, 473, 473, 473, 473, 473, 473, 473, 473, 473, 473, 473 SWTI000003 P05771 PRKCB Environmental Information Processing; Signal Transduction, Human Diseases; Substance Dependence, Organismal Systems; Excretory System, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Digestive System, Cellular Processes; Cell Communication, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:5579 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 UNIPROT:P05771-2 P05771-2 SWTI000004 Q12800, Q13526 TFCP2, PIN1 hsa:7024, hsa:5300 nucleus, cytosol GO:0005634, GO:0005829 SWTI000005 P30307, P53350 CDC25C, PLK1 G2/M Transition, Cell Cycle, Polo-like kinase mediated events, Mitotic G2-G2/M phases, Cell Cycle, Mitotic, Cyclin A/B1 associated events during G2/M transition Cell cycle, Progesterone-mediated oocyte maturation, Oocyte meiosis path:hsa04110, path:hsa04914, path:hsa04114 Organismal Systems; Endocrine System, Cellular Processes; Cell Growth and Death hsa:995, hsa:5347 P:G2/M transition of mitotic cell cycle, P:cell proliferation GO:0000086, GO:0008283 C:cytosol, C:nucleoplasm GO:0005829, GO:0005654 UNIPROT:P06493 P06493 CDK1 P06493 130 CDK1 P06493 130 SWTI000006 P30305, P53350 CDC25B, PLK1 G2/M Transition, Cell Cycle, Mitotic G2-G2/M phases, Cell Cycle, Mitotic, Cyclin A/B1 associated events during G2/M transition Cell cycle, Progesterone-mediated oocyte maturation path:hsa04110, path:hsa04914 Organismal Systems; Endocrine System, Cellular Processes; Cell Growth and Death hsa:994, hsa:5347 P:G2/M transition of mitotic cell cycle GO:0000086 C:centrosome, C:cytosol, C:spindle pole, C:nucleoplasm GO:0005813, GO:0005829, GO:0000922, GO:0005654 UNIPROT:P06493 P06493 SWTI000007 P64897 garA mtc:MT1875 nucleus GO:0005634 UNIPROT:P65728 P65728 SWTI000008 P30307, P31946 CDC25C, YWHAB Cell cycle, Oocyte meiosis path:hsa04110, path:hsa04114 Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death hsa:995, hsa:7529 C:cytosol GO:0005829 C:cytosol GO:0005829 nucleus, cytosol, internal side of plasma membrane GO:0005634, GO:0005829, GO:0009898 UNIPROT:O14757 O14757 CHK2, CHK2, BRSK1 O96017, O96017, Q8TDC3 216, 216, 216 MAPKAPK2, Chk1, Chk2, MARK3, BRSK1 iso2 P49137, O14757, O96017, P27448, Q8TDC3-2 216, 216, 216, 216, 216 SWTI000009 Q96CW1, P11117 AP2M1, ACP2 Cellular Processes; Transport and Catabolism hsa:1173, hsa:53 C:lysosomal membrane GO:0005765 cytosol, clathrin-coated endocytic vesicle, plasma membrane GO:0005829, GO:0045334, GO:0005886 UNIPROT:Q2M2I8 Q2M2I8 AAK1, AAK1 Q2M2I8, Q2M2I8 156, 156 AAK1 Q2M2I8 156 SWTI000010 P12931 SRC Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Communication hsa:6714 cytosol GO:0005829 Csk P41240 530 Src, Src, CSK P12931, Q9WUD9, P41240 530, 530, 530 SWTI000011 P49841, O95644 GSK3B, NFATC1 Axon guidance, Wnt signaling pathway, T cell receptor signaling pathway, B cell receptor signaling pathway path:hsa04360, path:hsa04310, path:hsa04660, path:hsa04662 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Development, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:2932, hsa:4772 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol, nucleus GO:0005829, GO:0005634 UNIPROTFAM:cAMP subfamily UNIPROTFAM:cAMP subfamily PKA_group 294 PKACa P17612 294 SWTI000012 P49841, O95644 GSK3B, NFATC1 Axon guidance, Wnt signaling pathway, T cell receptor signaling pathway, B cell receptor signaling pathway path:hsa04360, path:hsa04310, path:hsa04660, path:hsa04662 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Development, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:2932, hsa:4772 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol, nucleus GO:0005829, GO:0005634 UNIPROTFAM:cAMP subfamily UNIPROTFAM:cAMP subfamily PKA_group 245 PKACa, PKACa P17612, P05132 245, 245 SWTI000013 P00533, P22681 EGFR, CBL Immune System, Signaling by FGFR in disease, Signal Transduction, Signaling by constitutively active EGFR, Signaling by EGFR, EGFR downregulation, Disease, Signaling by SCF-KIT, Signaling by the B Cell Receptor (BCR), Adaptive Immune System, Signaling by EGFR in Cancer, Signaling by FGFR Endocytosis, ErbB signaling pathway path:hsa04144, path:hsa04012 Environmental Information Processing; Signal Transduction, Cellular Processes; Transport and Catabolism, Human Diseases; Infectious Diseases, Cellular Processes; Cell Communication, Human Diseases; Cancers, Organismal Systems; Endocrine System hsa:1956, hsa:867 P:negative regulation of epidermal growth factor receptor signaling pathway, P:negative regulation of apoptotic process GO:0042059, GO:0043066 C:nucleus GO:0005634 SWTI000014 P22681, O43597 CBL, SPRY2 Sprouty lures membrane-bound CBL away from EGFR, Negative regulation of FGFR signaling, Spry regulation of FGF signaling, Signaling by FGFR, Signal Transduction, Signaling by EGFR, Signaling by FGFR in disease, EGFR downregulation, Disease, Signaling by EGFR in Cancer, Sprouty lures cytosolic CBL away from EGFR Jak-STAT signaling pathway path:hsa04630 Environmental Information Processing; Signal Transduction, Human Diseases; Cancers hsa:867, hsa:10253 P:fibroblast growth factor receptor signaling pathway, P:negative regulation of apoptotic process, P:epidermal growth factor receptor signaling pathway, P:negative regulation of epidermal growth factor receptor signaling pathway GO:0008543, GO:0043066, GO:0007173, GO:0042059 C:plasma membrane, C:cytosol GO:0005886, GO:0005829 SRC P12931 55 Src P12931 55 SWTI000015 P49841, P01106 GSK3B, MYC Signal Transduction Wnt signaling pathway, PI3K-Akt signaling pathway, ErbB signaling pathway, Cell cycle path:hsa04310, path:hsa04151, path:hsa04012, path:hsa04110 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:2932, hsa:4609 P:negative regulation of protein binding, P:canonical Wnt receptor signaling pathway, P:positive regulation of transcription from RNA polymerase II promoter, P:negative regulation of apoptotic process GO:0032091, GO:0060070, GO:0045944, GO:0043066 cytosol, nucleus GO:0005829, GO:0005634 UNIPROT:P28482 P28482 MAPK1 P28482 62 ERK2, CDK5, ERK2, mTOR, JNK2, JNK1, JNK3, ERK1 P28482, Q00535, NP_446294, P42345, P45984, P45983, P53779, P21708 62, 62, 62, 62, 62, 62, 62, 62 SWTI000016 P49841, P04637 GSK3B, TP53 Wnt signaling pathway, PI3K-Akt signaling pathway, Neurotrophin signaling pathway, Cell cycle path:hsa04310, path:hsa04151, path:hsa04722, path:hsa04110 Environmental Information Processing; Signal Transduction, Human Diseases; Neurodegenerative Diseases, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:2932, hsa:7157 P:ER overload response, P:positive regulation of transcription from RNA polymerase II promoter, P:negative regulation of apoptotic process GO:0006983, GO:0045944, GO:0043066 C:cytosol, C:nucleus GO:0005829, GO:0005634 F:ATP binding GO:0005524 C:cytosol, C:nucleus GO:0005829, GO:0005634 cytosol, nucleus GO:0005829, GO:0005634 UNIPROT:P78527 P78527 DNA-PK, DNA-PK, DNA-PK, DNA-PK, MAPKAPK5 P78527, P78527, P78527, P78527, Q8IW41 37, 37, 37, 37, 37 Chk1, Chk2, DNA-PK, MAPKAPK5, ATR O14757, O96017, P78527, Q8IW41, Q13535 37, 37, 37, 37, 37 SWTI000017 P49841, P05412 GSK3B, JUN Immune System, Innate Immune System Neurotrophin signaling pathway, Wnt signaling pathway, T cell receptor signaling pathway, B cell receptor signaling pathway, ErbB signaling pathway, Focal adhesion path:hsa04722, path:hsa04310, path:hsa04660, path:hsa04662, path:hsa04012, path:hsa04510 Environmental Information Processing; Signal Transduction, Human Diseases; Substance Dependence, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Development, Cellular Processes; Cell Communication, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:2932, hsa:3725 P:negative regulation of transcription, DNA-dependent, P:response to drug GO:0045892, GO:0042493 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol, nucleus GO:0005829, GO:0005634 CK2_group, GSK-3_alpha , P49840 243, 243 CK2-A1, GSK3B P68400, P49841 243, 243 SWTI000018 P49841, P24864 GSK3B, CCNE1 PI3K-Akt signaling pathway, Cell cycle path:hsa04151, path:hsa04110 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:2932, hsa:898 P:response to drug GO:0042493 C:centrosome, C:cytosol GO:0005813, GO:0005829 C:cytosol GO:0005829 cytosol, nucleus GO:0005829, GO:0005634 UNIPROT:P24941 P24941 CDK2 P24941 399 CDK2 P24941 399 SWTI000019 P49841, P54252 GSK3B, ATXN3 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Nervous System, Human Diseases; Cancers, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:2932, hsa:4287 cytosol, nucleus GO:0005829, GO:0005634 SWTI000020 P03070, Q969H0 None, FBXW7 hsa:55294 cytosol, nucleus GO:0005829, GO:0005634 SWTI000021 P46531, Q969H0 NOTCH1, FBXW7 NOTCH1 Intracellular Domain Regulates Transcription, Signal Transduction, Signaling by NOTCH1, Signaling by NOTCH hsa:4851, hsa:55294 C:nucleoplasm GO:0005654 F:sequence-specific DNA binding transcription factor activity GO:0003700 cytosol, nucleus GO:0005829, GO:0005634 SWTI000022 Q16665, P40337 HIF1A, VHL Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha, Cellular response to hypoxia, Regulation of Hypoxia-inducible Factor (HIF) by Oxygen, Cellular responses to stress, Destruction of Ubiquitinated HIF-alpha by the Proteasome, Nuclear Export of Ubiquitinated HIF-alpha:VHL:EloB/C:CUL2:RBX1 Complex HIF-1 signaling pathway path:hsa04066 Human Diseases; Cancers, Environmental Information Processing; Signal Transduction hsa:3091, hsa:7428 C:cytosol GO:0005829 C:cytosol GO:0005829 nucleus, cytosol GO:0005634, GO:0005829 UNIPROT:Q9GZT9 Q9GZT9 SWTI000023 Q16665, P40337 HIF1A, VHL Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha, Cellular response to hypoxia, Regulation of Hypoxia-inducible Factor (HIF) by Oxygen, Cellular responses to stress, Destruction of Ubiquitinated HIF-alpha by the Proteasome, Nuclear Export of Ubiquitinated HIF-alpha:VHL:EloB/C:CUL2:RBX1 Complex HIF-1 signaling pathway path:hsa04066 Human Diseases; Cancers, Environmental Information Processing; Signal Transduction hsa:3091, hsa:7428 C:cytosol GO:0005829 C:cytosol GO:0005829 nucleus, cytosol GO:0005634, GO:0005829 UNIPROT:Q9GZT9 Q9GZT9 SWTI000024 P40337, Q99814 VHL, EPAS1 Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha, Cellular response to hypoxia, Regulation of Hypoxia-inducible Factor (HIF) by Oxygen, Cellular responses to stress, Nuclear Export of Ubiquitinated HIF-alpha:VHL:EloB/C:CUL2:RBX1 Complex, Destruction of Ubiquitinated HIF-alpha by the Proteasome Human Diseases; Cancers hsa:7428, hsa:2034 C:cytosol GO:0005829 C:cytosol GO:0005829 nucleus, cytosol GO:0005634, GO:0005829 UNIPROT:Q9GZT9 Q9GZT9 SWTI000025 P40337, Q99814 VHL, EPAS1 Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha, Cellular response to hypoxia, Regulation of Hypoxia-inducible Factor (HIF) by Oxygen, Cellular responses to stress, Nuclear Export of Ubiquitinated HIF-alpha:VHL:EloB/C:CUL2:RBX1 Complex, Destruction of Ubiquitinated HIF-alpha by the Proteasome Human Diseases; Cancers hsa:7428, hsa:2034 C:cytosol GO:0005829 C:cytosol GO:0005829 nucleus, cytosol GO:0005634, GO:0005829 UNIPROT:Q9GZT9 Q9GZT9 SWTI000026 P40337, Q9Y2N7 VHL, HIF3A Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha, Cellular response to hypoxia, Regulation of Hypoxia-inducible Factor (HIF) by Oxygen, Cellular responses to stress, Nuclear Export of Ubiquitinated HIF-alpha:VHL:EloB/C:CUL2:RBX1 Complex, Destruction of Ubiquitinated HIF-alpha by the Proteasome Human Diseases; Cancers hsa:7428, hsa:64344 C:cytosol, C:nucleoplasm GO:0005829, GO:0005654 C:cytosol GO:0005829 nucleus, cytosol GO:0005634, GO:0005829 UNIPROT:Q9GZT9 Q9GZT9 SWTI000027 O15350, Q13526 TP73, PIN1 hsa:7161, hsa:5300 nucleus, cytosol GO:0005634, GO:0005829 SWTI000028 O15350, Q13526 TP73, PIN1 hsa:7161, hsa:5300 nucleus, cytosol GO:0005634, GO:0005829 SWTI000029 O15350, Q13526 TP73, PIN1 hsa:7161, hsa:5300 nucleus, cytosol GO:0005634, GO:0005829 SWTI000030 O54918, Q9QUR7 Bcl2l11, Pin1 mmu:12125, mmu:23988 nucleus, cytosol GO:0005634, GO:0005829 MAPK10, MAPK8, MAPK9 P53779, P45983, P45984 65, 65, 65 ERK2, ERK1, JNK3, JNK2, JNK1, JNK3, JNK2, JNK1 P63085, Q63844, Q61831, P45984, P45983, P53779, Q9WTU6, Q91Y86 65, 65, 65, 65, 65, 65, 65, 65 SWTI000031 P01101, Q9QUR7 Fos, Pin1 Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Nervous System, Organismal Systems; Immune System mmu:14281, mmu:23988 nucleus, cytosol GO:0005634, GO:0005829 FRK P42685 232 SWTI000032 P01101, Q9QUR7 Fos, Pin1 Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Nervous System, Organismal Systems; Immune System mmu:14281, mmu:23988 nucleus, cytosol GO:0005634, GO:0005829 SWTI000033 P01101, Q9QUR7 Fos, Pin1 Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Nervous System, Organismal Systems; Immune System mmu:14281, mmu:23988 nucleus, cytosol GO:0005634, GO:0005829 SWTI000034 P01101, Q9QUR7 Fos, Pin1 Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Nervous System, Organismal Systems; Immune System mmu:14281, mmu:23988 nucleus, cytosol GO:0005634, GO:0005829 SWTI000035 Q13526, P01106 PIN1, MYC Human Diseases; Cancers, Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases hsa:5300, hsa:4609 C:cytoplasm, C:nucleoplasm GO:0005737, GO:0005654 nucleus, cytosol GO:0005634, GO:0005829 GSK-3_group, GSK-3_beta, GSK-3_alpha, GSK-3_group , P49841, P49840, 58, 58, 58, 58 GSK3B, ERK2, GSK3A, GSK3B, JNK3 P49841, P28482, P49840, P18266, P53779 58, 58, 58, 58, 58 SWTI000036 P03409, Q13526 tax, PIN1 hsa:5300 nucleus, cytosol GO:0005634, GO:0005829 SWTI000037 Q13526, P04637 PIN1, TP53 Environmental Information Processing; Signal Transduction, Human Diseases; Neurodegenerative Diseases, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers hsa:5300, hsa:7157 P:negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 C:cytoplasm GO:0005737 nucleus, cytosol GO:0005634, GO:0005829 GSK-3_group, CDK_group, CDK7 , , P50613 33, 33, 33 CDK7, p38-alpha, CDK5, CDK9 P50613, Q16539, Q00535, P50750 33, 33, 33, 33 SWTI000038 Q13526, P04637 PIN1, TP53 Environmental Information Processing; Signal Transduction, Human Diseases; Neurodegenerative Diseases, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers hsa:5300, hsa:7157 P:negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 C:cytoplasm GO:0005737 nucleus, cytosol GO:0005634, GO:0005829 Aurora A O14965 315 AurA, CDK1, CDK2, CDK9 O14965, P06493, P24941, P50750 315, 315, 315, 315 SWTI000039 Q13526, P04637 PIN1, TP53 Environmental Information Processing; Signal Transduction, Human Diseases; Neurodegenerative Diseases, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers hsa:5300, hsa:7157 P:negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 C:cytoplasm GO:0005737 nucleus, cytosol GO:0005634, GO:0005829 JNK1 P45983 81 SWTI000040 P05412, Q13526 JUN, PIN1 Immune System, Innate Immune System Environmental Information Processing; Signal Transduction, Human Diseases; Substance Dependence, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Immune System hsa:3725, hsa:5300 P:innate immune response GO:0045087 C:nucleoplasm GO:0005654 nucleus, cytosol GO:0005634, GO:0005829 MAPK8, VRK1, MAPK8, MAPK9 P45983, Q99986, P45983, P45984 63, 63, 63, 63 CDK3, VRK1, PKD1, JNK2, JNK1, PLK3, ERK7 Q00526, Q99986, Q15139, P45984, P45983, Q9H4B4, Q8TD08 63, 63, 63, 63, 63, 63, 63 SWTI000041 P05412, Q13526 JUN, PIN1 Immune System, Innate Immune System Environmental Information Processing; Signal Transduction, Human Diseases; Substance Dependence, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Immune System hsa:3725, hsa:5300 P:innate immune response GO:0045087 C:nucleoplasm GO:0005654 nucleus, cytosol GO:0005634, GO:0005829 MAPK8, VRK1 P45983, Q99986 73, 73 CDK3, VRK1, JNK2, JNK1, PLK3, ERK7 Q00526, Q99986, P45984, P45983, Q9H4B4, Q8TD08 73, 73, 73, 73, 73, 73 SWTI000042 Q9QUR7, P06876 Pin1, Myb mmu:23988, mmu:17863 nucleus, cytosol GO:0005634, GO:0005829 SWTI000043 P10276, Q13526 RARA, PIN1 Human Diseases; Cancers hsa:5914, hsa:5300 C:cytoplasm, C:nucleoplasm GO:0005737, GO:0005654 nucleus, cytosol GO:0005634, GO:0005829 CDK7 P50613 77 CDK7 P50613 77 SWTI000044 P14598, Q13526 NCF1, PIN1 Immune System Organismal Systems; Immune System hsa:653361, hsa:5300 P:innate immune response GO:0045087 nucleus, cytosol GO:0005634, GO:0005829 MAPK14, MAPK3 Q16539, P27361 345, 345 ERK1, p38-alpha, ERK2, IRAK4 P27361, Q16539, P28482, Q9NWZ3 345, 345, 345, 345 SWTI000045 P22736, Q13526 NR4A1, PIN1 Immune System, Innate Immune System hsa:3164, hsa:5300 C:nucleoplasm GO:0005654 nucleus, cytosol GO:0005634, GO:0005829 SWTI000046 P22736, Q13526 NR4A1, PIN1 Immune System, Innate Immune System hsa:3164, hsa:5300 C:nucleoplasm GO:0005654 nucleus, cytosol GO:0005634, GO:0005829 ERK2 P28482 431 SWTI000047 P22736, Q13526 NR4A1, PIN1 Immune System, Innate Immune System hsa:3164, hsa:5300 C:nucleoplasm GO:0005654 nucleus, cytosol GO:0005634, GO:0005829 JNK1 P45983 95 SWTI000048 P25322, Q9QUR7 Ccnd1, Pin1 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers mmu:12443, mmu:23988 nucleus, cytosol GO:0005634, GO:0005829 GSK-3_beta, GSK-3_beta P49841, P49841 286, 286 GSK3B, DYRK1B Q9WV60, Q9Z188 286, 286 SWTI000049 P29590, Q13526 PML, PIN1 Interferon Signaling, Cytokine Signaling in Immune system, Immune System Human Diseases; Infectious Diseases, Human Diseases; Cancers hsa:5371, hsa:5300 C:cytoplasm GO:0005737 nucleus, cytosol GO:0005634, GO:0005829 ERK5 Q13164 403 SWTI000050 P29590, Q13526 PML, PIN1 Interferon Signaling, Cytokine Signaling in Immune system, Immune System Human Diseases; Infectious Diseases, Human Diseases; Cancers hsa:5371, hsa:5300 C:cytoplasm GO:0005737 nucleus, cytosol GO:0005634, GO:0005829 SWTI000051 P29590, Q13526 PML, PIN1 Interferon Signaling, Cytokine Signaling in Immune system, Immune System Human Diseases; Infectious Diseases, Human Diseases; Cancers hsa:5371, hsa:5300 C:cytoplasm GO:0005737 nucleus, cytosol GO:0005634, GO:0005829 SWTI000052 P29590, Q13526 PML, PIN1 Interferon Signaling, Cytokine Signaling in Immune system, Immune System Human Diseases; Infectious Diseases, Human Diseases; Cancers hsa:5371, hsa:5300 C:cytoplasm GO:0005737 nucleus, cytosol GO:0005634, GO:0005829 SWTI000053 P31749, Q13526 AKT1, PIN1 Immune System, Innate Immune System Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Cellular Processes; Cell Communication, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:207, hsa:5300 C:nucleoplasm GO:0005654 nucleus, cytosol GO:0005634, GO:0005829 mTOR P42345 450 SWTI000054 P31749, Q13526 AKT1, PIN1 Immune System, Innate Immune System Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Cellular Processes; Cell Communication, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:207, hsa:5300 C:nucleoplasm GO:0005654 nucleus, cytosol GO:0005634, GO:0005829 SWTI000055 Q9QUR7, P33242 Pin1, Nr5a1 mmu:23988, mmu:26423 nucleus, cytosol GO:0005634, GO:0005829 MAPK1 P28482 203 CDK7, ERK2, ERK2, ERK1 P50613, P63085, P28482, Q63844 203, 203, 203, 203 SWTI000056 P35222, Q13526 CTNNB1, PIN1 Human Diseases; Infectious Diseases, Human Diseases; Cancers, Cellular Processes; Cell Communication, Organismal Systems; Immune System hsa:1499, hsa:5300 nucleus, cytosol GO:0005634, GO:0005829 CDK5 Q00535 246 SWTI000057 P35568, Q13526 IRS1, PIN1 Immune System, Innate Immune System, Cytokine Signaling in Immune system Environmental Information Processing; Signal Transduction, Organismal Systems; Endocrine System hsa:3667, hsa:5300 nucleus, cytosol GO:0005634, GO:0005829 SWTI000058 Q9QUR7, P35991 Pin1, Btk Organismal Systems; Immune System mmu:23988, mmu:12229 nucleus, cytosol GO:0005634, GO:0005829 SWTI000059 Q9QUR7, P35991 Pin1, Btk Organismal Systems; Immune System mmu:23988, mmu:12229 nucleus, cytosol GO:0005634, GO:0005829 SWTI000060 P40763, Q13526 STAT3, PIN1 Immune System, Cytokine Signaling in Immune system Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Immune System hsa:6774, hsa:5300 C:nucleoplasm GO:0005654 nucleus, cytosol GO:0005634, GO:0005829 IRAK1, PKC_delta P51617, Q05655 727, 727 PKCD, IRAK1, JNK2 iso2, p38-alpha, mTOR, PKCE, JNK1, RSK2 Q05655, P51617, P45984-2, Q16539, Q9JLN9, Q02156, P45983, P51812 727, 727, 727, 727, 727, 727, 727, 727 SWTI000061 P46527, Q13526 CDKN1B, PIN1 Immune System, Innate Immune System Human Diseases; Cancers, Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases hsa:1027, hsa:5300 C:nucleoplasm GO:0005654 nucleus, cytosol GO:0005634, GO:0005829 CDK2 P24941 187 ERK1, CDK2, ERK2, CDK6, CDK2 P27361, P24941, P28482, Q00534, P97377 187, 187, 187, 187, 187 SWTI000062 P46531, Q13526 NOTCH1, PIN1 hsa:4851, hsa:5300 C:nucleoplasm GO:0005654 nucleus, cytosol GO:0005634, GO:0005829 SWTI000063 P46531, Q13526 NOTCH1, PIN1 hsa:4851, hsa:5300 C:nucleoplasm GO:0005654 nucleus, cytosol GO:0005634, GO:0005829 SWTI000064 P46531, Q13526 NOTCH1, PIN1 hsa:4851, hsa:5300 C:nucleoplasm GO:0005654 nucleus, cytosol GO:0005634, GO:0005829 SWTI000065 P54274, Q13526 TERF1, PIN1 hsa:7013, hsa:5300 C:cytoplasm, C:nucleoplasm GO:0005737, GO:0005654 nucleus, cytosol GO:0005634, GO:0005829 SWTI000066 P69713, Q13526 X, PIN1 hsa:5300 nucleus, cytosol GO:0005634, GO:0005829 SWTI000067 P78543, Q13526 BTG2, PIN1 hsa:7832, hsa:5300 nucleus, cytosol GO:0005634, GO:0005829 SWTI000068 P84022, Q13526 SMAD3, PIN1 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers hsa:4088, hsa:5300 P:negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 C:nucleoplasm GO:0005654 nucleus, cytosol GO:0005634, GO:0005829 CDK2, CDK4, MAPK1, MAPK1 P24941, P11802, P28482, P28482 179, 179, 179, 179 CDK4, ERK2, CDK4, CDK9, CDK8, CDK2 P30285, P28482, P11802, P50750, P49336, P97377 179, 179, 179, 179, 179, 179 SWTI000069 P84022, Q13526 SMAD3, PIN1 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers hsa:4088, hsa:5300 P:negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 C:nucleoplasm GO:0005654 nucleus, cytosol GO:0005634, GO:0005829 MAPK1, MAPK1, MAPK1 P28482, P28482, P28482 204, 204, 204 ERK2, CDK4, MELK P28482, P11802, Q61846 204, 204, 204 SWTI000070 P84022, Q13526 SMAD3, PIN1 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers hsa:4088, hsa:5300 P:negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 C:nucleoplasm GO:0005654 nucleus, cytosol GO:0005634, GO:0005829 MAPK1, MAPK1, MAPK1 P28482, P28482, P28482 208, 208, 208 ERK2, CDK4, CDK9, CDK8 P28482, P11802, P50750, P49336 208, 208, 208, 208 SWTI000071 P84022, Q13526 SMAD3, PIN1 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers hsa:4088, hsa:5300 P:negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 C:nucleoplasm GO:0005654 nucleus, cytosol GO:0005634, GO:0005829 CDK2, CDK4, MAPK1 P24941, P11802, P28482 213, 213, 213 CDK4, ERK2, CDK4, CDK9, CDK8, CDK2 P30285, P28482, P11802, P50750, P49336, P97377 213, 213, 213, 213, 213, 213 SWTI000072 Q01860, Q13526 POU5F1, PIN1 hsa:5460, hsa:5300 C:nucleoplasm GO:0005654 nucleus, cytosol GO:0005634, GO:0005829 SWTI000073 Q04206, Q13526 RELA, PIN1 Immune System, Innate Immune System, RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways RIG-I-like receptor signaling pathway path:hsa04622 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Immune System hsa:5970, hsa:5300 P:cytokine-mediated signaling pathway, P:innate immune response GO:0019221, GO:0045087 nucleus, cytosol GO:0005634, GO:0005829 SWTI000074 Q05397, Q13526 PTK2, PIN1 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Immune System hsa:5747, hsa:5300 nucleus, cytosol GO:0005634, GO:0005829 CDK5 Q00535 910 SWTI000075 Q14653, Q13526 IRF3, PIN1 Antiviral mechanism by IFN-stimulated genes, PIN1 mediated IRF3 degradation, Immune System, Negative regulators of RIG-I/MDA5 signaling, Innate Immune System, ISG15 antiviral mechanism, Interferon Signaling, Cytokine Signaling in Immune system, RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways RIG-I-like receptor signaling pathway path:hsa04622 Organismal Systems; Immune System, Human Diseases; Infectious Diseases hsa:3661, hsa:5300 P:negative regulation of type I interferon production GO:0032480 C:nucleoplasm GO:0005654 nucleus, cytosol GO:0005634, GO:0005829 SWTI000076 Q9QUR7, Q3U182 Pin1, Crtc2 mmu:23988, mmu:74343 C:cytoplasm GO:0005737 nucleus, cytosol GO:0005634, GO:0005829 SWTI000077 Q61457, Q9QUR7 Ccne1, Pin1 Human Diseases; Cancers, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death mmu:12447, mmu:23988 P:cell cycle GO:0007049 nucleus, cytosol GO:0005634, GO:0005829 SWTI000078 Q9QUR7, Q80Z64 Pin1, Nanog mmu:23988, mmu:71950 nucleus, cytosol GO:0005634, GO:0005829 SWTI000079 Q9QUR7, Q80Z64 Pin1, Nanog mmu:23988, mmu:71950 nucleus, cytosol GO:0005634, GO:0005829 SWTI000080 Q9QUR7, Q8BT07 Pin1, Cep55 mmu:23988, mmu:74107 C:midbody GO:0030496 nucleus, cytosol GO:0005634, GO:0005829 SWTI000081 Q9QUR7, Q8BT07 Pin1, Cep55 mmu:23988, mmu:74107 C:midbody GO:0030496 nucleus, cytosol GO:0005634, GO:0005829 SWTI000082 Q9QUR7, Q8BUV3 Pin1, Gphn mmu:23988, mmu:268566 C:cytoplasm GO:0005737 nucleus, cytosol GO:0005634, GO:0005829 SWTI000083 Q9QUR7, Q8BUV3 Pin1, Gphn mmu:23988, mmu:268566 C:cytoplasm GO:0005737 nucleus, cytosol GO:0005634, GO:0005829 SWTI000084 Q9QUR7, Q8BUV3 Pin1, Gphn mmu:23988, mmu:268566 C:cytoplasm GO:0005737 nucleus, cytosol GO:0005634, GO:0005829 SWTI000085 Q8CFN5, Q9QUR7 Mef2c, Pin1 mmu:17260, mmu:23988 C:cytoplasm, C:nuclear speck GO:0005737, GO:0016607 nucleus, cytosol GO:0005634, GO:0005829 SWTI000086 Q8CFN5, Q9QUR7 Mef2c, Pin1 mmu:17260, mmu:23988 C:cytoplasm, C:nuclear speck GO:0005737, GO:0016607 nucleus, cytosol GO:0005634, GO:0005829 SWTI000087 Q92945, Q13526 KHSRP, PIN1 hsa:8570, hsa:5300 C:nucleoplasm GO:0005654 nucleus, cytosol GO:0005634, GO:0005829 SWTI000088 Q9QUR7, Q99K48 Pin1, Nono mmu:23988, mmu:53610 C:nuclear speck GO:0016607 nucleus, cytosol GO:0005634, GO:0005829 SWTI000089 Q9QUR7, Q99K48 Pin1, Nono mmu:23988, mmu:53610 C:nuclear speck GO:0016607 nucleus, cytosol GO:0005634, GO:0005829 SWTI000090 Q9QUR7, Q99K48 Pin1, Nono mmu:23988, mmu:53610 C:nuclear speck GO:0016607 nucleus, cytosol GO:0005634, GO:0005829 SWTI000091 Q9QUR7, Q99MK8 Pin1, Adrbk1 mmu:23988 nucleus, cytosol GO:0005634, GO:0005829 SWTI000092 Q9BR01, Q13526 SULT4A1, PIN1 hsa:25830, hsa:5300 nucleus, cytosol GO:0005634, GO:0005829 SWTI000093 Q9BR01, Q13526 SULT4A1, PIN1 hsa:25830, hsa:5300 nucleus, cytosol GO:0005634, GO:0005829 ERK1 P27361 11 SWTI000094 Q9QUR7, Q9ERA0 Pin1, Tfcp2 mmu:23988, mmu:21422 nucleus, cytosol GO:0005634, GO:0005829 SWTI000095 Q9QUR7, Q9ERA0 Pin1, Tfcp2 mmu:23988, mmu:21422 nucleus, cytosol GO:0005634, GO:0005829 SWTI000096 Q9QUR7, Q9ERA0 Pin1, Tfcp2 mmu:23988, mmu:21422 nucleus, cytosol GO:0005634, GO:0005829 SWTI000097 Q9HC98, Q13526 NEK6, PIN1 hsa:10783, hsa:5300 C:cytoplasm, C:nuclear speck GO:0005737, GO:0016607 nucleus, cytosol GO:0005634, GO:0005829 SWTI000098 Q9HC98, Q13526 NEK6, PIN1 hsa:10783, hsa:5300 C:cytoplasm, C:nuclear speck GO:0005737, GO:0016607 nucleus, cytosol GO:0005634, GO:0005829 SWTI000099 Q9NY61, Q13526 AATF, PIN1 hsa:26574, hsa:5300 nucleus, cytosol GO:0005634, GO:0005829 SWTI000100 Q13526, Q9UER7 PIN1, DAXX hsa:5300, hsa:1616 nucleus, cytosol GO:0005634, GO:0005829 SWTI000101 Q9Y618, Q13526 NCOR2, PIN1 hsa:9612, hsa:5300 nucleus, cytosol GO:0005634, GO:0005829 SWTI000102 Q9Y618, Q13526 NCOR2, PIN1 hsa:9612, hsa:5300 nucleus, cytosol GO:0005634, GO:0005829 SWTI000103 Q9Y6H5, Q13526 SNCAIP, PIN1 hsa:9627, hsa:5300 C:cytoplasm GO:0005737 nucleus, cytosol GO:0005634, GO:0005829 SWTI000104 Q9Y6H5, Q13526 SNCAIP, PIN1 hsa:9627, hsa:5300 C:cytoplasm GO:0005737 nucleus, cytosol GO:0005634, GO:0005829 SWTI000105 P31946, O35147 YWHAB, Bad Environmental Information Processing; Signal Transduction, Human Diseases; Neurodegenerative Diseases, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers hsa:7529, rno:64639 P:induction of apoptosis by intracellular signals, P:activation of pro-apoptotic gene products GO:0008629, GO:0008633 C:cytosol GO:0005829 C:cytosol GO:0005829 nucleus, cytosol, internal side of plasma membrane GO:0005634, GO:0005829, GO:0009898 UNIPROT:P47196 P47196 Akt1, p70S6K, p70S6K, PKACa P47196, P67999, P23443, P27791 137, 137, 137, 137 SWTI000106 P63104, P03076 YWHAZ, None Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death hsa:7534 nucleus, cytosol, internal side of plasma membrane GO:0005634, GO:0005829, GO:0009898 SWTI000107 P63104, P54253 YWHAZ, ATXN1 Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death hsa:7534, hsa:6310 C:nucleoplasm GO:0005654 nucleus, cytosol, internal side of plasma membrane GO:0005634, GO:0005829, GO:0009898 UNIPROT:P31749 P31749 PKACa, Akt1 P17612, P31749 775, 775 SWTI000108 P63104, Q99683 YWHAZ, MAP3K5 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death hsa:7534, hsa:4217 nucleus, cytosol, internal side of plasma membrane GO:0005634, GO:0005829, GO:0009898 MAP3K5 Q99683 966 PDK1, ASK1 O15530, Q99683 966, 966 SWTI000109 A2ALK8, Q9CQV8 Ptpn3, Ywhab Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death mmu:545622, mmu:54401 cytosol, internal side of plasma membrane, nucleus, mitochondrion GO:0005829, GO:0009898, GO:0005634, GO:0005739 SWTI000110 P32418, P62258 SLC8A1, YWHAE Environmental Information Processing; Signal Transduction, Cellular Processes; Cell Growth and Death, Organismal Systems; Digestive System, Human Diseases; Cardiovascular Diseases hsa:6546, hsa:7531 C:mitochondrion GO:0005739 C:mitochondrion GO:0005739 cytosol, internal side of plasma membrane, nucleus, mitochondrion GO:0005829, GO:0009898, GO:0005634, GO:0005739 SWTI000111 P63104, P98177 YWHAZ, FOXO4 Immune System, Adaptive Immune System Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death hsa:7534, hsa:4303 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol, internal side of plasma membrane, nucleus, mitochondrion GO:0005829, GO:0009898, GO:0005634, GO:0005739 UNIPROT:P31749 P31749 PKB_group 197 Akt1 P31749 197 SWTI000112 Q04206, Q04917 RELA, YWHAH PI3K-Akt signaling pathway path:hsa04151 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers, Organismal Systems; Immune System hsa:5970, hsa:7533 cytosol, internal side of plasma membrane, nucleus, mitochondrion GO:0005829, GO:0009898, GO:0005634, GO:0005739 UNIPROTFAM:I-kappa-B kinase subfamily UNIPROTFAM:I-kappa-B kinase subfamily SWTI000113 P63104, Q14432 YWHAZ, PDE3A Hemostasis Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Organismal Systems; Endocrine System hsa:7534, hsa:5139 P:response to drug GO:0042493 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol, internal side of plasma membrane, nucleus, mitochondrion GO:0005829, GO:0009898, GO:0005634, GO:0005739 UNIPROTFAM:PKC subfamily UNIPROTFAM:PKC subfamily PKCA P17252 428 SWTI000114 Q63572, P35213 Tesk1, Ywhab Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death rno:29460, rno:56011 cytosol, internal side of plasma membrane, nucleus, mitochondrion GO:0005829, GO:0009898, GO:0005634, GO:0005739 SWTI000115 P43565, P34730 RIM15, BMH2 sce:YFL033C, sce:YDR099W C:cytoplasm, C:nucleus GO:0005737, GO:0005634 C:nucleus GO:0005634 nucleus, cytosol, internal side of plasma membrane GO:0005634, GO:0005829, GO:0009898 UNIPROT:P17157 P17157 SWTI000116 P31946, P56524 YWHAB, HDAC4 Signal Transduction Human Diseases; Infectious Diseases, Human Diseases; Cancers, Cellular Processes; Cell Growth and Death hsa:7529, hsa:9759 C:transcriptional repressor complex GO:0017053 nucleus, cytosol, internal side of plasma membrane GO:0005634, GO:0005829, GO:0009898 CaM-KIV Q16566 632 SWTI000117 P38398, Q13085 BRCA1, ACACA Metabolism; Carbohydrate Metabolism hsa:672, hsa:31 P:fatty acid biosynthetic process GO:0006633 nucleus, BRCA1-BARD1 complex GO:0005634, GO:0031436 SWTI000118 P38398, Q6UWZ7 BRCA1, FAM175A hsa:672, hsa:84142 P:G2/M transition DNA damage checkpoint, P:response to ionizing radiation, P:positive regulation of DNA repair GO:0031572, GO:0010212, GO:0045739 C:BRCA1-A complex GO:0070531 nucleus, BRCA1-BARD1 complex GO:0005634, GO:0031436 SWTI000119 P38398, Q8WXE1 BRCA1, ATRIP Cell Cycle Fanconi anemia pathway path:hsa03460 Genetic Information Processing; Replication and Repair hsa:672, hsa:84126 C:nucleoplasm GO:0005654 nucleus, BRCA1-BARD1 complex GO:0005634, GO:0031436 CDK2 P24941 239 SWTI000120 P38398, Q99708 BRCA1, RBBP8 Meiotic Recombination, Meiosis hsa:672, hsa:5932 P:G2/M transition DNA damage checkpoint, P:double-strand break repair via homologous recombination GO:0031572, GO:0000724 nucleus, BRCA1-BARD1 complex GO:0005634, GO:0031436 SWTI000121 P38398, Q9BX63 BRCA1, BRIP1 Fanconi anemia pathway path:hsa03460 Genetic Information Processing; Replication and Repair hsa:672, hsa:83990 nucleus, BRCA1-BARD1 complex GO:0005634, GO:0031436 SWTI000122 P38398, Q9BX63 BRCA1, BRIP1 Fanconi anemia pathway path:hsa03460 Genetic Information Processing; Replication and Repair hsa:672, hsa:83990 nucleus, BRCA1-BARD1 complex GO:0005634, GO:0031436 SWTI000123 Q14676, P16104 MDC1, H2AFX Double-Strand Break Repair, DNA Repair, Homologous recombination repair of replication-independent double-strand breaks, ATM mediated response to DNA double-strand break, ATM mediated phosphorylation of repair proteins, Recruitment of repair and signaling proteins to double-strand breaks, Homologous Recombination Repair hsa:9656, hsa:3014 P:double-strand break repair via homologous recombination GO:0000724 C:nucleoplasm GO:0005654 nucleus GO:0005634 UNIPROT:Q13315, UNIPROT:P78527 P78527, Q13315 ATM Q13315 140 DNA-PK, MST1 P78527, Q13043 140, 140 SWTI000124 O96017 CHEK2 Cellular Processes; Cell Growth and Death hsa:11200 nucleus GO:0005634 ATM, CHK2, PLK1, TTK Q13315, O96017, P53350, P33981 68, 68, 68, 68 Chk2, DNA-PK, PLK1, ATR, ATM, TTK, ZAK O96017, P78527, P53350, Q13535, NP_000042, P33981, Q9NYL2 68, 68, 68, 68, 68, 68, 68 SWTI000125 P22216, P14737 RAD53, RAD9 Meiosis, Cell cycle path:sce04113, path:sce04111 Cellular Processes; Cell Growth and Death sce:YPL153C, sce:YDR217C P:cell cycle GO:0007049 C:nucleus GO:0005634 C:nucleus GO:0005634 nucleus GO:0005634 SWTI000126 P22216, P34217 RAD53, PIN4 Cellular Processes; Cell Growth and Death sce:YPL153C, sce:YBL051C P:DNA damage checkpoint GO:0000077 nucleus GO:0005634 SWTI000127 P46014, Q9SYQ8 KAPP, CLV1 ath:AT5G19280, ath:AT1G75820 P:regulation of meristem structural organization GO:0009934 C:integral to membrane, C:plasma membrane GO:0016021, GO:0005886 nucleus GO:0005634 SWTI000128 P22216, P14737 RAD53, RAD9 Meiosis, Cell cycle path:sce04113, path:sce04111 Cellular Processes; Cell Growth and Death sce:YPL153C, sce:YDR217C P:cell cycle GO:0007049 C:nucleus GO:0005634 C:nucleus GO:0005634 nucleus, Replication fork GO:0005634, GO:0005657 SWTI000129 P22216, P14737 RAD53, RAD9 Meiosis, Cell cycle path:sce04113, path:sce04111 Cellular Processes; Cell Growth and Death sce:YPL153C, sce:YDR217C P:cell cycle GO:0007049 C:nucleus GO:0005634 C:nucleus GO:0005634 nucleus, Replication fork GO:0005634, GO:0005657 SWTI000130 P18887, Q7Z2E3 XRCC1, APTX hsa:7515, hsa:54840 P:single strand break repair GO:0000012 C:nucleoplasm GO:0005654 F:damaged DNA binding GO:0003684 nucleus, Replication fork GO:0005634, GO:0005657 UNIPROT:P68400 P68400 CK2_alpha P68400 523 CK2-A1, CK2-A2 P68400, P19784 523, 523 SWTI000131 Q13426, Q96T60 XRCC4, PNKP hsa:7518, hsa:11284 nucleus, Replication fork GO:0005634, GO:0005657 UNIPROT:P68400 P68400 CK2-A1 P68400 233 SWTI000132 Q924T3, Q9JLV6 Xrcc4, Pnkp mmu:108138 nucleus, Replication fork GO:0005634, GO:0005657 SWTI000133 Q09170, Q9P7T4 cds1, mrc1 Cell cycle path:spo04111 Cellular Processes; Cell Growth and Death spo:SPCC18B5.11c, spo:SPAC694.06c P:mitotic cell cycle DNA replication checkpoint, P:intra-S DNA damage checkpoint, P:signal transduction GO:0033314, GO:0031573, GO:0007165 nucleus, Replication fork GO:0005634, GO:0005657 SWTI000134 P00533, Q99704 EGFR, DOK1 Signal Transduction Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Communication, Human Diseases; Cancers hsa:1956, hsa:1796 C:perinuclear region of cytoplasm GO:0048471 integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex GO:0008305, GO:0016023, GO:0005829, GO:0009898, GO:0043235 EGFR P00533 1110 EGFR P00533 1110 SWTI000135 P29353, P21860 SHC1, ERBB3 Signaling by ERBB4, Signaling by ERBB2, NGF signalling via TRKA from the plasma membrane, Immune System, Downstream signaling of activated FGFR, Signaling by FGFR, Signalling by NGF, Signal Transduction, Signaling by EGFR, Signaling by FGFR in disease, Disease, Signaling by the B Cell Receptor (BCR), Adaptive Immune System, Signaling by EGFR in Cancer, SHC1 events in ERBB2 signaling ErbB signaling pathway path:hsa04012 Environmental Information Processing; Signal Transduction, Human Diseases; Cancers, Organismal Systems; Immune System hsa:6464, hsa:2065 P:heart development GO:0007507 C:nucleus GO:0005634 integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex GO:0008305, GO:0016023, GO:0005829, GO:0009898, GO:0043235 SWTI000136 P14784, P29353 IL2RB, SHC1 Immune System, SHC1 mediates cytokine-induced phosphorylation of GAB2, Interleukin-3, 5 and GM-CSF signaling, Phosphorylated SHC1 recruits GRB2:GAB2, Signaling by Interleukins, Cytokine Signaling in Immune system, Interleukin-2 signaling, Interleukin receptor SHC signaling Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Immune System hsa:3560, hsa:6464 integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex GO:0008305, GO:0016023, GO:0005829, GO:0009898, GO:0043235 SWTI000137 P35568, P24394 IRS1, IL4R PI3K-Akt signaling pathway path:hsa04151 Environmental Information Processing; Signal Transduction, Organismal Systems; Endocrine System hsa:3667, hsa:3566 integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex GO:0008305, GO:0016023, GO:0005829, GO:0009898, GO:0043235 SWTI000138 P29353, P06213 SHC1, INSR Signal Transduction, Insulin receptor signalling cascade, SHC-related events, Signal attenuation, Signaling by Insulin receptor, SHC activation Insulin signaling pathway path:hsa04910 Environmental Information Processing; Signal Transduction, Human Diseases; Cancers, Cellular Processes; Cell Communication, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:6464, hsa:3643 P:activation of MAPK activity, P:response to glucocorticoid stimulus, P:positive regulation of DNA replication, P:positive regulation of cell proliferation GO:0000187, GO:0051384, GO:0045740, GO:0008284 C:cytosol, C:nucleus, C:endosome membrane GO:0005829, GO:0005634, GO:0010008 C:cytosol GO:0005829 integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex GO:0008305, GO:0016023, GO:0005829, GO:0009898, GO:0043235 INSR, INSR, INSR P06213, P06213, P06213 999, 999, 999 InsR P06213 999 SWTI000139 Q99704, P05106 DOK1, ITGB3 Signal Transduction Human Diseases; Cardiovascular Diseases hsa:1796, hsa:3690 integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex GO:0008305, GO:0016023, GO:0005829, GO:0009898, GO:0043235 SRC, SRC P12931, P12931 773, 773 Src P12931 773 SWTI000140 P29353, P05106 SHC1, ITGB3 Hemostasis, Integrin cell surface interactions, Signal Transduction, Integrin alphaIIb beta3 signaling, Platelet activation, signaling and aggregation, Cell surface interactions at the vascular wall, SHC1 dissociates from integrin alphaIIb beta3, Platelet Aggregation (Plug Formation), SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow Focal adhesion path:hsa04510 Environmental Information Processing; Signal Transduction, Human Diseases; Cancers, Cellular Processes; Cell Communication, Human Diseases; Cardiovascular Diseases, Organismal Systems; Immune System hsa:6464, hsa:3690 P:leukocyte migration GO:0050900 integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex GO:0008305, GO:0016023, GO:0005829, GO:0009898, GO:0043235 SYK, SRC P43405, P12931 785, 785 Src P12931 785 SWTI000141 P29353, P16144 SHC1, ITGB4 Integrin cell surface interactions, Signal Transduction Focal adhesion path:hsa04510 Environmental Information Processing; Signal Transduction, Human Diseases; Cancers, Cellular Processes; Cell Communication, Human Diseases; Cardiovascular Diseases, Organismal Systems; Immune System hsa:6464, hsa:3691 integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex GO:0008305, GO:0016023, GO:0005829, GO:0009898, GO:0043235 SWTI000142 P29353, Q07954 SHC1, LRP1 Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Immune System hsa:6464, hsa:4035 C:nucleus GO:0005634 integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex GO:0008305, GO:0016023, GO:0005829, GO:0009898, GO:0043235 SRC P12931 4507 Src P12931 4507 SWTI000143 P03077, P98083 None, Shc1 Human Diseases; Cancers, Organismal Systems; Immune System mmu:20416 integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex GO:0008305, GO:0016023, GO:0005829, GO:0009898, GO:0043235 SWTI000144 Q61006, Q18PE0 Musk, Dok7 mmu:18198, mmu:231134 C:neuromuscular junction, C:cell junction GO:0031594, GO:0030054 integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex GO:0008305, GO:0016023, GO:0005829, GO:0009898, GO:0043235 SWTI000145 P29353, P04629 SHC1, NTRK1 NGF signalling via TRKA from the plasma membrane, Signalling to ERKs, Signalling by NGF, Signal Transduction, Signalling to RAS Neurotrophin signaling pathway path:hsa04722 Environmental Information Processing; Signal Transduction, Human Diseases; Cancers, Organismal Systems; Nervous System, Organismal Systems; Immune System hsa:6464, hsa:4914 P:Ras protein signal transduction GO:0007265 integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex GO:0008305, GO:0016023, GO:0005829, GO:0009898, GO:0043235 TRKA, TRKA P04629, P04629 496, 496 TrkA P04629 496 SWTI000146 P35546, P97465 Ret, Dok1 Human Diseases; Cancers mmu:19713, mmu:13448 P:MAPK cascade, P:transmembrane receptor protein tyrosine kinase signaling pathway GO:0000165, GO:0007169 integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex GO:0008305, GO:0016023, GO:0005829, GO:0009898, GO:0043235 Ret P35546 1063 SWTI000147 P29353, Q92835 SHC1, INPP5D Immune System, Interleukin-3, 5 and GM-CSF signaling, Hemostasis, Signaling by Interleukins, Interleukin receptor SHC signaling, Interleukin-2 signaling, Cytokine Signaling in Immune system, Cell surface interactions at the vascular wall, Adaptive Immune System Environmental Information Processing; Signal Transduction, Human Diseases; Cancers, Organismal Systems; Immune System hsa:6464, hsa:3635 P:leukocyte migration GO:0050900 C:cytosol GO:0005829 C:cytosol GO:0005829 integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex GO:0008305, GO:0016023, GO:0005829, GO:0009898, GO:0043235 SWTI000148 P29353, Q92835 SHC1, INPP5D Immune System, Interleukin-3, 5 and GM-CSF signaling, Hemostasis, Signaling by Interleukins, Interleukin receptor SHC signaling, Interleukin-2 signaling, Cytokine Signaling in Immune system, Cell surface interactions at the vascular wall, Adaptive Immune System Environmental Information Processing; Signal Transduction, Human Diseases; Cancers, Organismal Systems; Immune System hsa:6464, hsa:3635 P:leukocyte migration GO:0050900 C:cytosol GO:0005829 C:cytosol GO:0005829 integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex GO:0008305, GO:0016023, GO:0005829, GO:0009898, GO:0043235 SWTI000149 O00141 SGK1 hsa:6446 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 UNIPROT:P42345 P42345 PDK-1, PDK-2, NEK6 O15530, , Q9HC98 422, 422, 422 mTOR, NEK6 P42345, Q9HC98 422, 422 SWTI000150 P11792 SCH9 sce:YHR205W cytosol, internal side of plasma membrane GO:0005829, GO:0009898 UNIPROT:P35169 P35169 SWTI000151 P18654 Rps6ka3 Environmental Information Processing; Signal Transduction, Organismal Systems; Nervous System mmu:110651 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 Rps6ka3 P18654 ERK1, PDK1, RSK2 Q63844, Q9Z2A0, P18654 386, 386, 386 SWTI000152 P31751 AKT2 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Cellular Processes; Cell Communication, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:208 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000153 P67999 Rps6kb1 Environmental Information Processing; Signal Transduction rno:83840 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 mTOR, NEK6, PDK1 P42345, Q9HC98, O55173 412, 412, 412 SWTI000154 Q13464 ROCK1 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Immune System hsa:6093 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000155 Q96BR1 SGK3 hsa:100533105 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000156 Q9ERE3 Sgk3 mmu:170755 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000157 Q9Y297, O00221 BTRC, NFKBIE Ubiquitination of IkB by SCF-beta-TrCP, Immune System, Downstream Signaling Events Of B Cell Receptor (BCR), Signaling by the B Cell Receptor (BCR), Activation of NF-kappaB in B Cells, Adaptive Immune System Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Immune System hsa:8945, hsa:4794 C:cytosol GO:0005829 C:cytosol GO:0005829 nucleoplasm, nucleus, Chromosome, cytosol GO:0005654, GO:0005634, GO:0005694, GO:0005829 SWTI000158 P03230, Q9UKB1 LMP1, FBXW11 Environmental Information Processing; Signal Transduction hsa:23291 nucleoplasm, nucleus, Chromosome, cytosol GO:0005654, GO:0005634, GO:0005694, GO:0005829 SWTI000159 Q9Y297, P05923 BTRC, vpu Host Interactions of HIV factors, HIV Infection, Vpu mediated degradation of CD4, Disease, Degradation of ubiquitinated CD4 Environmental Information Processing; Signal Transduction hsa:8945 C:cytosol GO:0005829 C:cytosol GO:0005829 nucleoplasm, nucleus, Chromosome, cytosol GO:0005654, GO:0005634, GO:0005694, GO:0005829 SWTI000160 P16471, Q9UKB1 PRLR, FBXW11 Immune System Environmental Information Processing; Signal Transduction, Environmental Information Processing; Signaling Molecules and Interaction hsa:5618, hsa:23291 nucleoplasm, nucleus, Chromosome, cytosol GO:0005654, GO:0005634, GO:0005694, GO:0005829 SWTI000161 Q9Y297, P18848 BTRC, ATF4 Disease Environmental Information Processing; Signal Transduction, Human Diseases; Substance Dependence, Human Diseases; Infectious Diseases, Genetic Information Processing; Folding, Sorting and Degradation, Organismal Systems; Nervous System, Human Diseases; Cancers hsa:8945, hsa:468 nucleoplasm, nucleus, Chromosome, cytosol GO:0005654, GO:0005634, GO:0005694, GO:0005829 SWTI000162 P19838, Q9Y297 NFKB1, BTRC Interleukin-1 signaling, Immune System, Downstream Signaling Events Of B Cell Receptor (BCR), Signal Transduction, Signaling by Interleukins, Signaling by the B Cell Receptor (BCR), Activation of NF-kappaB in B Cells, Adaptive Immune System, Cytokine Signaling in Immune system, Ubiquitination of IkB by SCF-beta-TrCP Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers, Organismal Systems; Immune System hsa:4790, hsa:8945 P:positive regulation of transcription, DNA-dependent GO:0045893 C:cytosol GO:0005829 C:cytosol GO:0005829 nucleoplasm, nucleus, Chromosome, cytosol GO:0005654, GO:0005634, GO:0005694, GO:0005829 IKK_group, IKK_alpha, IKK_group, IKK_alpha, IKK_beta, IKK_alpha , O15111, , O15111, O14920, O15111 927, 927, 927, 927, 927, 927 IKK-alpha, IKK-beta, IKK-alpha, IKK-beta O15111, O14920, O15111, O14920 927, 927, 932, 932 SWTI000163 Q9Y297, P25963 BTRC, NFKBIA Immune System, Downstream Signaling Events Of B Cell Receptor (BCR), Signal Transduction, Signaling by the B Cell Receptor (BCR), Activation of NF-kappaB in B Cells, Adaptive Immune System, Ubiquitination of IkB by SCF-beta-TrCP Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers, Organismal Systems; Immune System hsa:8945, hsa:4792 P:virus-host interaction GO:0019048 C:cytosol, C:nucleus GO:0005829, GO:0005634 C:cytosol, C:nucleus GO:0005829, GO:0005634 nucleoplasm, nucleus, Chromosome, cytosol GO:0005654, GO:0005634, GO:0005694, GO:0005829 CK2_group, IKK_group, IKK_group, CK2_group, IKK_group, IKK_group , , , , , 32, 32, 32, 36, 36, 36 CK2-A1, SGK1, IKK-epsilon, IKK-alpha, p90RSK, Nik, IKK-beta, RSK2, CK2-A1, IKK-epsilon, IKK-alpha, Nik, IKK-beta P68400, O00141, Q14164, O15111, Q15418, Q99558, O14920, P51812, P68400, Q14164, O15111, Q99558, O14920 32, 32, 32, 32, 32, 32, 32, 32, 36, 36, 36, 36, 36 SWTI000164 Q9Y297, Q12959 BTRC, DLG1 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases hsa:8945, hsa:1739 P:virus-host interaction GO:0019048 C:nucleus, C:cytosol GO:0005634, GO:0005829 C:nucleus, C:cytosol GO:0005634, GO:0005829 nucleoplasm, nucleus, Chromosome, cytosol GO:0005654, GO:0005634, GO:0005694, GO:0005829 SWTI000165 Q15653, Q9Y297 NFKBIB, BTRC Immune System, Downstream Signaling Events Of B Cell Receptor (BCR), Signaling by the B Cell Receptor (BCR), Activation of NF-kappaB in B Cells, Adaptive Immune System, Ubiquitination of IkB by SCF-beta-TrCP Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Immune System hsa:4793, hsa:8945 C:cytosol, C:nucleus GO:0005829, GO:0005634 C:cytosol, C:nucleus GO:0005829, GO:0005634 nucleoplasm, nucleus, Chromosome, cytosol GO:0005654, GO:0005634, GO:0005694, GO:0005829 RSK-1, RSK-1 Q15418, Q15418 19, 23 SWTI000166 Q9Y297, Q53EL6 BTRC, PDCD4 Environmental Information Processing; Signal Transduction hsa:8945, hsa:27250 P:negative regulation of transcription, DNA-dependent GO:0045892 C:cytosol, C:nucleus GO:0005829, GO:0005634 C:cytosol, C:nucleus GO:0005829, GO:0005634 nucleoplasm, nucleus, Chromosome, cytosol GO:0005654, GO:0005634, GO:0005694, GO:0005829 SWTI000167 Q9Y297, Q6PGQ7 BTRC, BORA Environmental Information Processing; Signal Transduction hsa:8945, hsa:79866 nucleoplasm, nucleus, Chromosome, cytosol GO:0005654, GO:0005634, GO:0005694, GO:0005829 PLK1, PLK1 P53350, P53350 497, 501 SWTI000168 Q9Y297, Q9HAW4 BTRC, CLSPN Cell Cycle Environmental Information Processing; Signal Transduction hsa:8945, hsa:63967 nucleoplasm, nucleus, Chromosome, cytosol GO:0005654, GO:0005634, GO:0005694, GO:0005829 PLK1 P53350 30 SWTI000169 Q9Y297, Q9UKT4 BTRC, FBXO5 Cell Cycle, SCF-beta-TrCP mediated degradation of Emi1, SCF-mediated degradation of Emi1, Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, Cell Cycle, Mitotic, APC/C-mediated degradation of cell cycle proteins Oocyte meiosis path:hsa04114 Environmental Information Processing; Signal Transduction, Cellular Processes; Cell Growth and Death hsa:8945, hsa:26271 P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0051437, GO:0031145 C:cytosol GO:0005829 C:cytosol GO:0005829 nucleoplasm, nucleus, Chromosome, cytosol GO:0005654, GO:0005634, GO:0005694, GO:0005829 PLK1, PLK1 P53350, P53350 145, 149 SWTI000170 Q8QGV2, Q9I9K6 wee1-b, pin1 xla:399355, xla:399385 nucleus, cytosol GO:0005634, GO:0005829 SWTI000171 Q90Z80, Q9I9K6 fbxo5-a, pin1 xla:398237, xla:399385 nucleus, cytosol GO:0005634, GO:0005829 SWTI000172 P22696, P35210 ESS1, SPT23 sce:YJR017C, sce:YKL020C C:nucleus GO:0005634 C:nucleus GO:0005634 nucleus, cytosol GO:0005634, GO:0005829 SWTI000173 Q9SL42, O64645 PIN1, SOC1 ath:AT2G18040, ath:AT2G45660 nucleus, cytosol GO:0005634, GO:0005829 SWTI000174 Q9SL42, O64645 PIN1, SOC1 ath:AT2G18040, ath:AT2G45660 nucleus, cytosol GO:0005634, GO:0005829 SWTI000175 O82794, Q9SL42 AGL24, PIN1 ath:AT4G24540, ath:AT2G18040 nucleus, cytosol GO:0005634, GO:0005829 SWTI000176 P34152, Q9QUR7 Ptk2, Pin1 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Immune System mmu:14083, mmu:23988 nucleus, cytosol GO:0005634, GO:0005829 SWTI000177 P31994, Q92835 FCGR2B, INPP5D Adaptive Immune System, Immune System B cell receptor signaling pathway, Fc gamma R-mediated phagocytosis path:hsa04662, path:hsa04666 Human Diseases; Infectious Diseases, Organismal Systems; Immune System hsa:2213, hsa:3635 C:plasma membrane GO:0005886 cytosol GO:0005829 Lyn, BLK P07948, P51451 292, 292 Fyn, Blk, Lyn P06241, P51451, P07948 292, 292, 292 SWTI000178 P43630, P29350 KIR3DL2, PTPN6 Immune System, Adaptive Immune System Natural killer cell mediated cytotoxicity path:hsa04650 Organismal Systems; Immune System hsa:3812, hsa:5777 cytosol GO:0005829 SWTI000179 Q13291, Q06124 SLAMF1, PTPN11 Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Immune System hsa:6504, hsa:5781 cytosol GO:0005829 Fyn P06241 281 Fyn P06241 281 SWTI000180 Q13291, Q06124 SLAMF1, PTPN11 Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Immune System hsa:6504, hsa:5781 cytosol GO:0005829 Fyn, Lyn P06241, P07948 327, 327 Fyn, Lyn P06241, P07948 327, 327 SWTI000181 P62994, P35570 Grb2, Irs1 SOS-mediated signalling, Signal Transduction, Insulin receptor signalling cascade, Signaling by Insulin receptor, Cytokine Signaling in Immune system, Immune System, IRS-related events, IRS-mediated signalling PI3K-Akt signaling pathway, Neurotrophin signaling pathway, Insulin signaling pathway path:rno04151, path:rno04722, path:rno04910 Environmental Information Processing; Signal Transduction, Organismal Systems; Endocrine System, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Development, Cellular Processes; Cell Communication, Organismal Systems; Nervous System, Organismal Systems; Immune System rno:81504, rno:25467 P:insulin receptor signaling pathway, P:protein heterooligomerization GO:0008286, GO:0051291 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol GO:0005829 INSR, IGF1R, INSR P06213, P08069, P06213 895, 895, 895 Fyn, InsR P39688, P15127 895, 895 SWTI000182 O00499, P01106 BIN1, MYC Human Diseases; Cancers, Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases hsa:274, hsa:4609 C:cytoplasm GO:0005737 cytosol, focal adhesion, plasma membrane GO:0005829, GO:0005925, GO:0005886 UNIPROTFAM:GSK-3 subfamily UNIPROTFAM:GSK-3 subfamily MAPK1 P28482 62 ERK2, CDK5, ERK2, mTOR, JNK2, JNK1, JNK3, ERK1 P28482, Q00535, NP_446294, P42345, P45984, P45983, P53779, P21708 62, 62, 62, 62, 62, 62, 62, 62 SWTI000183 Q02821, P09959 SRP1, SWI6 Cellular Processes; Cell Growth and Death sce:YNL189W, sce:YLR182W C:cytoplasm GO:0005737 Nuclear pore, nucleus, NLS-dependent protein nuclear import complex GO:0005643, GO:0005634, GO:0042564 SWTI000184 P07270, P32337 PHO4, PSE1 sce:YFR034C, sce:YMR308C C:cytoplasm, C:nucleus GO:0005737, GO:0005634 C:nucleus GO:0005634 Nuclear pore, nucleus, NLS-dependent protein nuclear import complex GO:0005643, GO:0005634, GO:0042564 UNIPROT:P17157 P17157 SWTI000185 Q62318, P83917 Trim28, Cbx1 mmu:21849, mmu:12412 heterochromatin, nucleus GO:0000792, GO:0005634 UNIPROT:P28867 P28867 PKCD Q05655 473 SWTI000186 P30307, O14980 CDC25C, XPO1 Cell Cycle, Cell Cycle, Mitotic Genetic Information Processing; Translation, Cellular Processes; Cell Growth and Death, Human Diseases; Infectious Diseases hsa:995, hsa:7514 P:virus-host interaction GO:0019048 C:cytosol, C:nucleoplasm GO:0005829, GO:0005654 C:cytosol GO:0005829 nucleus, cytosol GO:0005634, GO:0005829 UNIPROT:P53350 P53350 PLK1, PLK3 P53350, Q9H4B4 198, 198 PLK1, PLK3 P53350, Q9H4B4 198, 198 SWTI000187 Q16665, P45481 HIF1A, Crebbp Human Diseases; Cancers, Environmental Information Processing; Signal Transduction hsa:3091 C:transcription factor complex GO:0005667 UNIPROT:Q9NWT6 Q9NWT6 SWTI000188 Q14974, P12272 KPNB1, PTHLH hsa:3837, hsa:5744 Nuclear pore, nucleus, NLS-dependent protein nuclear import complex GO:0005643, GO:0005634, GO:0042564 UNIPROT:P24941 P24941 CDK2 P24941 121 SWTI000189 P63104, P04049 YWHAZ, RAF1 Immune System, GP1b-IX-V activation signalling, Hemostasis, Rap1 signalling, Signaling by Interleukins, Platelet activation, signaling and aggregation, Adaptive Immune System, Cytokine Signaling in Immune system PI3K-Akt signaling pathway path:hsa04151 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers, Cellular Processes; Cell Communication, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:7534, hsa:5894 P:platelet activation GO:0030168 C:cytosol GO:0005829 C:cytosol GO:0005829 nucleus, cytosol, internal side of plasma membrane GO:0005634, GO:0005829, GO:0009898 SWTI000190 P31946, P30305 YWHAB, CDC25B Cell cycle path:hsa04110 Human Diseases; Infectious Diseases, Environmental Information Processing; Signal Transduction, Cellular Processes; Cell Growth and Death hsa:7529, hsa:994 C:centrosome, C:cytosol GO:0005813, GO:0005829 C:cytosol GO:0005829 nucleus, cytosol, internal side of plasma membrane GO:0005634, GO:0005829, GO:0009898 UNIPROT:P06493 P06493 CDK1 P06493 321 SWTI000191 P04075, Q9Y5X1 ALDOA, SNX9 Metabolism; Carbohydrate Metabolism hsa:226, hsa:51429 SWTI000192 Q9Y490, O60331 TLN1, PIP5K1C Axon guidance, Developmental Biology, Semaphorin interactions, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Focal adhesion path:hsa04510 Cellular Processes; Cell Communication hsa:7094, hsa:23396 P:axon guidance GO:0007411 C:cytosol, C:focal adhesion, C:ruffle membrane GO:0005829, GO:0005925, GO:0032587 SWTI000193 P42574, Q14790 CASP3, CASP8 Intrinsic Pathway for Apoptosis, Apoptotic cleavage of cellular proteins, Apoptosis, Apoptotic execution phase, Caspase-mediated cleavage of cytoskeletal proteins Apoptosis, p53 signaling pathway path:hsa04210, path:hsa04115 Human Diseases; Neurodegenerative Diseases, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers, Human Diseases; Cardiovascular Diseases, Organismal Systems; Immune System hsa:836, hsa:841 P:induction of apoptosis by extracellular signals, P:induction of apoptosis by intracellular signals, P:response to tumor necrosis factor, P:heart development GO:0008624, GO:0008629, GO:0034612, GO:0007507 C:cytosol GO:0005829 F:cysteine-type endopeptidase activity GO:0004197 UNIPROTFAM:CK2 subfamily UNIPROTFAM:CK2 subfamily SWTI000194 P60484, P42574 PTEN, CASP3 Signalling by NGF, Signal Transduction p53 signaling pathway path:hsa04115 Environmental Information Processing; Signal Transduction, Human Diseases; Neurodegenerative Diseases, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers, Cellular Processes; Cell Communication hsa:5728, hsa:836 P:nerve growth factor receptor signaling pathway, P:negative regulation of apoptotic process, P:heart development GO:0048011, GO:0043066, GO:0007507 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol, nucleus GO:0005829, GO:0005634 UNIPROTFAM:CK2 subfamily UNIPROTFAM:CK2 subfamily CK2_group, CK2_group, CK2_alpha , , P68400 385, 385, 385 CK2-A1 P68400 385 SWTI000195 Q05586, P53618 GRIN1, COPB1 Human Diseases; Substance Dependence, Human Diseases; Neurodegenerative Diseases, Organismal Systems; Nervous System hsa:2902, hsa:1315 rough endoplasmic reticulum, endoplasmic reticulum cisterna, cytosol, endoplasmic reticulum membrane, endoplasmic reticulum membrane, integral protein, ER-Golgi transport vesicle membrane, Golgi-ER transport vesicle membrane GO:0005791, GO:0016022, GO:0005829, GO:0005789, GO:0030176, GO:0012507, GO:0012508 UNIPROTFAM:PKC subfamily UNIPROTFAM:PKC subfamily PKC_group 896 SWTI000196 O95644, P52292 NFATC1, KPNA2 Human Diseases; Infectious Diseases, Environmental Information Processing; Signal Transduction, Organismal Systems; Development, Organismal Systems; Immune System hsa:4772, hsa:3838 C:cytosol GO:0005829 Nuclear pore, nucleus, NLS-dependent protein nuclear import complex GO:0005643, GO:0005634, GO:0042564 UNIPROT:P49841, UNIPROT:P49841 P49841 SWTI000197 Q13153, P16333 PAK1, NCK1 Axon guidance, TCR signaling, Immune System, Developmental Biology, Signaling by Robo receptor, Generation of second messenger molecules, Activation of Rac, Adaptive Immune System, Cell-Cell communication Axon guidance, T cell receptor signaling pathway, ErbB signaling pathway path:hsa04360, path:hsa04660, path:hsa04012 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Development, Organismal Systems; Immune System hsa:5058, hsa:4690 P:axon guidance, P:T cell receptor signaling pathway GO:0007411, GO:0050852 C:cytosol, C:plasma membrane GO:0005829, GO:0005886 C:cytosol, C:plasma membrane GO:0005829, GO:0005886 cytosol, focal adhesion, plasma membrane GO:0005829, GO:0005925, GO:0005886 UNIPROTFAM:RAC subfamily UNIPROTFAM:RAC subfamily PKG1 iso2 Q13976-2 21 SWTI000198 P10636, P06241 MAPT, FYN Human Diseases; Neurodegenerative Diseases, Human Diseases; Infectious Diseases, Organismal Systems; Development, Cellular Processes; Cell Communication, Organismal Systems; Immune System hsa:4137, hsa:2534 P:neuron migration GO:0001764 C:cytosol, C:plasma membrane GO:0005829, GO:0005886 C:cytosol, C:plasma membrane GO:0005829, GO:0005886 cytosol, focal adhesion, plasma membrane GO:0005829, GO:0005925, GO:0005886 SWTI000199 O00560, P18827 SDCBP, SDC1 Environmental Information Processing; Signaling Molecules and Interaction hsa:6386, hsa:6382 C:focal adhesion GO:0005925 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000200 Q62108, O88602 Dlg4, Cacng2 Human Diseases; Cardiovascular Diseases mmu:13385, mmu:12300 C:alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex GO:0032281 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 UNIPROTFAM:cAMP subfamily UNIPROTFAM:cAMP subfamily PKACa P05132 321 SWTI000201 P05067, O00213 APP, APBB1 Human Diseases; Neurodegenerative Diseases hsa:351, hsa:322 P:visual learning, P:extracellular matrix organization GO:0008542, GO:0030198 C:dendritic spine, C:synapse GO:0043197, GO:0045202 integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex GO:0008305, GO:0016023, GO:0005829, GO:0009898, GO:0043235 GSK-3_beta P49841 743 CDK1 P06493 743 SWTI000202 P29353, P05106 SHC1, ITGB3 Hemostasis, Integrin cell surface interactions, Signal Transduction, Integrin alphaIIb beta3 signaling, Platelet activation, signaling and aggregation, Cell surface interactions at the vascular wall, SHC1 dissociates from integrin alphaIIb beta3, Platelet Aggregation (Plug Formation), SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow Focal adhesion path:hsa04510 Environmental Information Processing; Signal Transduction, Human Diseases; Cancers, Cellular Processes; Cell Communication, Human Diseases; Cardiovascular Diseases, Organismal Systems; Immune System hsa:6464, hsa:3690 P:leukocyte migration GO:0050900 integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex GO:0008305, GO:0016023, GO:0005829, GO:0009898, GO:0043235 PDK-1 O15530 779 SWTI000203 Q15691, Q99661 MAPRE1, KIF2C Mitotic Prometaphase, DNA Replication, M Phase, Cell Cycle, Mitotic, Cell Cycle, Mitotic M-M/G1 phases hsa:22919, hsa:11004 P:cell proliferation, P:mitotic prometaphase, P:cell division GO:0008283, GO:0000236, GO:0051301 C:cytosol, C:microtubule GO:0005829, GO:0005874 C:cytosol, C:microtubule GO:0005829, GO:0005874 cytosol, microtubule GO:0005829, GO:0005874 UNIPROT:Q96GD4, UNIPROT:Q96GD4, UNIPROT:Q96GD4 Q96GD4 Aurora B Q96GD4 95 AurB, AurB, AurB Q96GD4, Q96GD4, Q96GD4 95, 109, 111 SWTI000204 O75122, Q15691 CLASP2, MAPRE1 Mitotic Prometaphase, Developmental Biology, DNA Replication, Axon guidance, M Phase, Role of Abl in Robo-Slit signaling, Cell Cycle, Mitotic, Cell Cycle, Signaling by Robo receptor, Mitotic M-M/G1 phases hsa:23122, hsa:22919 P:mitotic prometaphase, P:cell division GO:0000236, GO:0051301 C:Golgi apparatus, C:cytosol, C:cytoplasmic microtubule GO:0005794, GO:0005829, GO:0005881 C:cytosol GO:0005829 cytosol, microtubule GO:0005829, GO:0005874 UNIPROT:P49841, UNIPROT:P49841, UNIPROT:P49841, UNIPROT:P49841, UNIPROT:P49841 P49841 CDK1 P06493 541 SWTI000205 Q01968, Q9UKG1 OCRL, APPL1 Human Diseases; Cancers hsa:4952, hsa:26060 C:cytosol, C:early endosome membrane GO:0005829, GO:0031901 SWTI000206 Q01968, Q9UKG1 OCRL, APPL1 Human Diseases; Cancers hsa:4952, hsa:26060 C:cytosol, C:early endosome membrane GO:0005829, GO:0031901 PKACa P17612 410 SWTI000207 P48050, P78352 KCNJ4, DLG4 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, Transmission across Chemical Synapses, Neuronal System Organismal Systems; Nervous System hsa:3761, hsa:1742 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 UNIPROTFAM:cAMP subfamily UNIPROTFAM:cAMP subfamily SWTI000208 O14745, P07550 SLC9A3R1, ADRB2 hsa:9368, hsa:154 C:apical plasma membrane GO:0016324 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 UNIPROT:P34947 P34947 GRK-5 P34947 411 GRK5 P34947 411 SWTI000209 P55196, P11274 MLLT4, BCR Human Diseases; Cancers, Cellular Processes; Cell Communication hsa:4301, hsa:613 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000210 P42768 WAS Organismal Systems; Immune System, Human Diseases; Infectious Diseases hsa:7454 UNIPROT:P06241, UNIPROT:P08631 P08631, P06241 BTK, HCK Q06187, P08631 291, 291 Abl, Lck, Hck, Ack, Lyn P00519, P06239, P08103, Q07912, P07948 291, 291, 291, 291, 291 SWTI000211 O00401 WASL Organismal Systems; Immune System, Human Diseases; Infectious Diseases hsa:8976 Arg Q4JIM5 256 SWTI000212 P19814, P84092 Ttgn1, Ap2m1 rno:192152, rno:116563 cytosol, clathrin-coated endocytic vesicle, plasma membrane GO:0005829, GO:0045334, GO:0005886 SWTI000213 P07766, O43639 CD3E, NCK2 T cell receptor signaling pathway path:hsa04660 Organismal Systems; Immune System, Human Diseases; Infectious Diseases hsa:916, hsa:8440 P:T cell activation, P:positive regulation of T cell proliferation, P:signal complex assembly GO:0042110, GO:0042102, GO:0007172 cytosol, plasma membrane GO:0005829, GO:0005886 SWTI000214 Q8WUM4, O75340 PDCD6IP, PDCD6 hsa:10015, hsa:10016 SWTI000215 Q13257, Q12834 MAD2L1, CDC20 Degradation of multiubiquitinated Nek2A, Degradation multiubiquitinated Cyclin A, M Phase, Cell Cycle, Mitotic Spindle Checkpoint, Mitotic Prometaphase, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Regulation of APC/C activators between G1/S and early anaphase, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Regulation of mitotic cell cycle, Cell Cycle, Mitotic, Cell Cycle Checkpoints, APC-Cdc20 mediated degradation of Nek2A, APC/C:Cdc20 mediated degradation of mitotic proteins, Mitotic M-M/G1 phases, DNA Replication, Inactivation of APC/C via direct inhibition of the APC/C complex, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, APC/C-mediated degradation of cell cycle proteins Cell cycle, Oocyte meiosis path:hsa04110, path:hsa04114 Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death hsa:4085, hsa:991 P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, P:mitotic prometaphase, P:mitotic cell cycle spindle assembly checkpoint, P:cell division GO:0031145, GO:0000236, GO:0007094, GO:0051301 C:cytosol, C:spindle pole, C:perinuclear region of cytoplasm GO:0005829, GO:0000922, GO:0048471 nucleus, anaphase-promoting complex GO:0005634, GO:0005680 SWTI000216 P63010, P49407 AP2B1, ARRB1 Signal Transduction Endocytosis path:hsa04144 Cellular Processes; Transport and Catabolism hsa:163, hsa:408 C:cytosol, C:coated pit, C:plasma membrane GO:0005829, GO:0005905, GO:0005886 C:cytosol GO:0005829 cytosol, extrinsic to endosome membrane GO:0005829, GO:0031313 SWTI000217 P53680, P01730 AP2S1, CD4 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters, Host Interactions of HIV factors, Immune System, Nef Mediated CD4 Down-regulation, HIV Infection, The role of Nef in HIV-1 replication and disease pathogenesis, Disease, Degradation of CD4, Adaptive Immune System Organismal Systems; Immune System hsa:1175, hsa:920 P:regulation of defense response to virus by virus GO:0050690 Endocytic vesicle, cytosol GO:0030139, GO:0005829 SWTI000218 O14745, P35222 SLC9A3R1, CTNNB1 Human Diseases; Infectious Diseases, Human Diseases; Cancers, Cellular Processes; Cell Communication hsa:9368, hsa:1499 P:negative regulation of cell proliferation GO:0008285 C:centrosome, C:microvillus membrane GO:0005813, GO:0031528 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000219 P21457 RCVRN bta:281447 anchored to plasma membrane, cytosol GO:0046658, GO:0005829 SWTI000220 P17612 PRKACA Environmental Information Processing; Signal Transduction, Human Diseases; Substance Dependence, Organismal Systems; Excretory System, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Organismal Systems; Digestive System, Organismal Systems; Nervous System, Organismal Systems; Sensory System, Organismal Systems; Endocrine System hsa:5566 anchored to plasma membrane, cytosol GO:0046658, GO:0005829 SWTI000221 P00533, Q96CW1 EGFR, AP2M1 Axon guidance, NGF signalling via TRKA from the plasma membrane, Immune System, Signalling by NGF, Signal Transduction, Signaling by EGFR, Signal transduction by L1, L1CAM interactions, EGFR downregulation, Developmental Biology, Disease, Adaptive Immune System, Signaling by EGFR in Cancer Endocytosis path:hsa04144 Environmental Information Processing; Signal Transduction, Cellular Processes; Transport and Catabolism, Human Diseases; Infectious Diseases, Cellular Processes; Cell Communication, Human Diseases; Cancers hsa:1956, hsa:1173 P:negative regulation of epidermal growth factor receptor signaling pathway, P:axon guidance GO:0042059, GO:0007411 cytosol, clathrin-coated endocytic vesicle, plasma membrane GO:0005829, GO:0045334, GO:0005886 SWTI000222 Q96CW1, P02786 AP2M1, TFRC Membrane Trafficking Endocytosis path:hsa04144 Cellular Processes; Transport and Catabolism hsa:1173, hsa:7037 cytosol, clathrin-coated endocytic vesicle, plasma membrane GO:0005829, GO:0045334, GO:0005886 SWTI000223 Q96CW1, P03383 AP2M1, env hsa:1173 cytosol, clathrin-coated endocytic vesicle, plasma membrane GO:0005829, GO:0045334, GO:0005886 SWTI000224 P03522, Q96CW1 G, AP2M1 hsa:1173 cytosol, clathrin-coated endocytic vesicle, plasma membrane GO:0005829, GO:0045334, GO:0005886 SWTI000225 P04578, Q96CW1 env, AP2M1 Immune System, HIV Infection, Disease hsa:1173 cytosol, clathrin-coated endocytic vesicle, plasma membrane GO:0005829, GO:0045334, GO:0005886 SWTI000226 P05884, Q4R706 env, AP2M1 cytosol, clathrin-coated endocytic vesicle, plasma membrane GO:0005829, GO:0045334, GO:0005886 SWTI000227 Q96CW1, P07306 AP2M1, ASGR1 hsa:1173, hsa:432 cytosol, clathrin-coated endocytic vesicle, plasma membrane GO:0005829, GO:0045334, GO:0005886 SWTI000228 P11279, Q96CW1 LAMP1, AP2M1 Cellular Processes; Transport and Catabolism hsa:3916, hsa:1173 C:lysosomal membrane GO:0005765 cytosol, clathrin-coated endocytic vesicle, plasma membrane GO:0005829, GO:0045334, GO:0005886 SWTI000229 Q96CW1, P16410 AP2M1, CTLA4 Immune System, Adaptive Immune System Human Diseases; Immune Diseases hsa:1173, hsa:1493 cytosol, clathrin-coated endocytic vesicle, plasma membrane GO:0005829, GO:0045334, GO:0005886 SWTI000230 Q96CW1, P32004 AP2M1, L1CAM Axon guidance, Signal transduction by L1, L1CAM interactions, Developmental Biology, Recycling pathway of L1 hsa:1173, hsa:3897 P:axon guidance GO:0007411 C:plasma membrane GO:0005886 C:plasma membrane GO:0005886 cytosol, clathrin-coated endocytic vesicle, plasma membrane GO:0005829, GO:0045334, GO:0005886 SWTI000231 P51519, Q3ZC13 env, AP2M1 bta:517446 cytosol, clathrin-coated endocytic vesicle, plasma membrane GO:0005829, GO:0045334, GO:0005886 SWTI000232 Q9J3M8, Q96CW1 gE, AP2M1 hsa:1173 cytosol, clathrin-coated endocytic vesicle, plasma membrane GO:0005829, GO:0045334, GO:0005886 SWTI000233 O15118, P53680 NPC1, AP2S1 Cellular Processes; Transport and Catabolism hsa:4864, hsa:1175 Endocytic vesicle, cytosol GO:0030139, GO:0005829 SWTI000234 P53680, P04233 AP2S1, CD74 Internalization of MHC II:Ii clathrin coated vesicle, Immune System, MHC class II antigen presentation, Adaptive Immune System Human Diseases; Infectious Diseases hsa:1175, hsa:972 P:intracellular protein transport, P:antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0006886, GO:0019886 Endocytic vesicle, cytosol GO:0030139, GO:0005829 SWTI000235 P04235, P62743 Cd3d, Ap2s1 Human Diseases; Infectious Diseases, Organismal Systems; Immune System mmu:12500, mmu:232910 Endocytic vesicle, cytosol GO:0030139, GO:0005829 SWTI000236 P04601, P53680 nef, AP2S1 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters, Host Interactions of HIV factors, Nef Mediated CD4 Down-regulation, Nef Mediated CD8 Down-regulation, HIV Infection, The role of Nef in HIV-1 replication and disease pathogenesis, Disease, Degradation of CD4, Degradation of CD8 hsa:1175 P:regulation of defense response to virus by virus, P:viral reproduction GO:0050690, GO:0016032 C:cytosol GO:0005829 C:cytosol GO:0005829 Endocytic vesicle, cytosol GO:0030139, GO:0005829 SWTI000237 P05855, P53680 nef, AP2S1 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters, Host Interactions of HIV factors, Nef Mediated CD4 Down-regulation, HIV Infection, Nef Mediated CD8 Down-regulation, The role of Nef in HIV-1 replication and disease pathogenesis, Disease, Degradation of CD4, Degradation of CD8 hsa:1175 P:regulation of defense response to virus by virus, P:viral reproduction GO:0050690, GO:0016032 C:cytosol GO:0005829 C:cytosol GO:0005829 Endocytic vesicle, cytosol GO:0030139, GO:0005829 SWTI000238 P46938, P62259 Yap1, Ywhae Cellular Processes; Cell Growth and Death mmu:22601, mmu:22627 nucleus, cytosol, internal side of plasma membrane GO:0005634, GO:0005829, GO:0009898 SWTI000239 P11942, P62743 Cd3g, Ap2s1 Human Diseases; Infectious Diseases, Organismal Systems; Immune System mmu:12502, mmu:232910 Endocytic vesicle, cytosol GO:0030139, GO:0005829 SWTI000240 P16070, P53680 CD44, AP2S1 Immune System, Disease Human Diseases; Infectious Diseases hsa:960, hsa:1175 Endocytic vesicle, cytosol GO:0030139, GO:0005829 SWTI000241 P41143, P53680 OPRD1, AP2S1 Signal Transduction hsa:4985, hsa:1175 Endocytic vesicle, cytosol GO:0030139, GO:0005829 SWTI000242 P50895, P53680 BCAM, AP2S1 hsa:4059, hsa:1175 Endocytic vesicle, cytosol GO:0030139, GO:0005829 SWTI000243 Q17QC5, P51519 AP2S1, env bta:536553 Endocytic vesicle, cytosol GO:0030139, GO:0005829 SWTI000244 P56817, P53680 BACE1, AP2S1 Human Diseases; Neurodegenerative Diseases hsa:23621, hsa:1175 Endocytic vesicle, cytosol GO:0030139, GO:0005829 SWTI000245 Q04656, P53680 ATP7A, AP2S1 hsa:538, hsa:1175 C:cytosol GO:0005829 C:cytosol GO:0005829 Endocytic vesicle, cytosol GO:0030139, GO:0005829 SWTI000246 P10276, O75376 RARA, NCOR1 Gene Expression, Generic Transcription Pathway Human Diseases; Cancers hsa:5914, hsa:9611 P:transcription initiation from RNA polymerase II promoter GO:0006367 C:nuclear chromatin GO:0000790 F:transcription corepressor activity GO:0003714 nucleus GO:0005634 SWTI000247 P10276, O75376 RARA, NCOR1 Gene Expression, Generic Transcription Pathway Human Diseases; Cancers hsa:5914, hsa:9611 P:transcription initiation from RNA polymerase II promoter GO:0006367 C:nuclear chromatin GO:0000790 F:transcription corepressor activity GO:0003714 nucleus GO:0005634 SWTI000248 Q9Y618, Q07869 NCOR2, PPARA Fatty acid, triacylglycerol, and ketone body metabolism, Gene Expression, Metabolism, Metabolism of lipids and lipoproteins, Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), Generic Transcription Pathway Organismal Systems; Endocrine System, Human Diseases; Infectious Diseases hsa:9612, hsa:5465 P:negative regulation of transcription from RNA polymerase II promoter, P:transcription initiation from RNA polymerase II promoter GO:0000122, GO:0006367 nucleus GO:0005634 SWTI000249 Q9Y618, Q07869 NCOR2, PPARA Fatty acid, triacylglycerol, and ketone body metabolism, Gene Expression, Metabolism, Metabolism of lipids and lipoproteins, Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), Generic Transcription Pathway Organismal Systems; Endocrine System, Human Diseases; Infectious Diseases hsa:9612, hsa:5465 P:negative regulation of transcription from RNA polymerase II promoter, P:transcription initiation from RNA polymerase II promoter GO:0000122, GO:0006367 nucleus GO:0005634 SWTI000250 P48552, P03372 NRIP1, ESR1 hsa:8204, hsa:2099 P:positive regulation of transcription from RNA polymerase II promoter GO:0045944 nucleus GO:0005634 SWTI000251 P48552, P03372 NRIP1, ESR1 hsa:8204, hsa:2099 P:positive regulation of transcription from RNA polymerase II promoter GO:0045944 nucleus GO:0005634 SWTI000252 P48552, P03372 NRIP1, ESR1 hsa:8204, hsa:2099 P:positive regulation of transcription from RNA polymerase II promoter GO:0045944 nucleus GO:0005634 SWTI000253 P48552, P03372 NRIP1, ESR1 hsa:8204, hsa:2099 P:positive regulation of transcription from RNA polymerase II promoter GO:0045944 nucleus GO:0005634 SWTI000254 P48552, P03372 NRIP1, ESR1 hsa:8204, hsa:2099 P:positive regulation of transcription from RNA polymerase II promoter GO:0045944 nucleus GO:0005634 SWTI000255 P48552, P03372 NRIP1, ESR1 hsa:8204, hsa:2099 P:positive regulation of transcription from RNA polymerase II promoter GO:0045944 nucleus GO:0005634 SWTI000256 P48552, P03372 NRIP1, ESR1 hsa:8204, hsa:2099 P:positive regulation of transcription from RNA polymerase II promoter GO:0045944 nucleus GO:0005634 SWTI000257 P48552, P03372 NRIP1, ESR1 hsa:8204, hsa:2099 P:positive regulation of transcription from RNA polymerase II promoter GO:0045944 nucleus GO:0005634 SWTI000258 P48552, P03372 NRIP1, ESR1 hsa:8204, hsa:2099 P:positive regulation of transcription from RNA polymerase II promoter GO:0045944 nucleus GO:0005634 SWTI000259 P48552, P03372 NRIP1, ESR1 hsa:8204, hsa:2099 P:positive regulation of transcription from RNA polymerase II promoter GO:0045944 nucleus GO:0005634 SWTI000260 Q15596, P04150 NCOA2, NR3C1 hsa:10499, hsa:2908 C:nucleoplasm, C:postsynaptic density GO:0005654, GO:0014069 F:chromatin binding GO:0003682 nucleus GO:0005634 SWTI000261 Q15596, P04150 NCOA2, NR3C1 hsa:10499, hsa:2908 C:nucleoplasm, C:postsynaptic density GO:0005654, GO:0014069 F:chromatin binding GO:0003682 nucleus GO:0005634 SWTI000262 Q15596, P04150 NCOA2, NR3C1 hsa:10499, hsa:2908 C:nucleoplasm, C:postsynaptic density GO:0005654, GO:0014069 F:chromatin binding GO:0003682 nucleus GO:0005634 SWTI000263 Q15648, P10827 MED1, THRA Nuclear Receptor transcription pathway, Gene Expression, Generic Transcription Pathway hsa:5469, hsa:7067 P:transcription initiation from RNA polymerase II promoter, P:positive regulation of transcription from RNA polymerase II promoter GO:0006367, GO:0045944 nucleus GO:0005634 SWTI000264 Q15648, P10827 MED1, THRA Nuclear Receptor transcription pathway, Gene Expression, Generic Transcription Pathway hsa:5469, hsa:7067 P:transcription initiation from RNA polymerase II promoter, P:positive regulation of transcription from RNA polymerase II promoter GO:0006367, GO:0045944 nucleus GO:0005634 SWTI000265 Q9JL19, P37238 Ncoa6, Pparg Human Diseases; Cancers mmu:19016 nucleus GO:0005634 SWTI000266 P42768 WAS Organismal Systems; Immune System, Human Diseases; Infectious Diseases hsa:7454 SWTI000267 P42768 WAS Organismal Systems; Immune System, Human Diseases; Infectious Diseases hsa:7454 SWTI000268 O00401 WASL Organismal Systems; Immune System, Human Diseases; Infectious Diseases hsa:8976 SWTI000269 O00401 WASL Organismal Systems; Immune System, Human Diseases; Infectious Diseases hsa:8976 SWTI000270 P32780, P04637 GTF2H1, TP53 RNA Pol II CTD phosphorylation and interaction with CE Environmental Information Processing; Signal Transduction, Human Diseases; Neurodegenerative Diseases, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers hsa:2965, hsa:7157 P:positive regulation of transcription from RNA polymerase II promoter GO:0045944 HIPK2, ATM, DYRK2, DYRK2, HIPK2, MAPK_group Q9H2X6, Q13315, Q92630, Q92630, Q9H2X6, 46, 46, 46, 46, 46, 55 PKCD, DNA-PK, p38-alpha, CDK5, HIPK2, DYRK2, ATM, TAF1, GRK5, ERK2 Q05655, P78527, Q16539, Q00535, Q9H2X6, Q92630, NP_000042, P21675, P34947, P28482 46, 46, 46, 46, 46, 46, 46, 55, 55, 55 SWTI000271 P00533, P22681 EGFR, CBL Immune System, Signaling by FGFR in disease, Signal Transduction, Signaling by constitutively active EGFR, Signaling by EGFR, EGFR downregulation, Disease, Signaling by SCF-KIT, Signaling by the B Cell Receptor (BCR), Adaptive Immune System, Signaling by EGFR in Cancer, Signaling by FGFR Endocytosis, ErbB signaling pathway path:hsa04144, path:hsa04012 Environmental Information Processing; Signal Transduction, Cellular Processes; Transport and Catabolism, Human Diseases; Infectious Diseases, Cellular Processes; Cell Communication, Human Diseases; Cancers, Organismal Systems; Endocrine System hsa:1956, hsa:867 P:negative regulation of epidermal growth factor receptor signaling pathway, P:negative regulation of apoptotic process GO:0042059, GO:0043066 C:nucleus GO:0005634 CaM-KII_alpha, CaM-KII_alpha Q9UQM7, Q9UQM7 1070, 1071 CaMK2-alpha, CaMK2-alpha P11275, P11275 1070, 1071 SWTI000272 P22681, O43597 CBL, SPRY2 Sprouty lures membrane-bound CBL away from EGFR, Negative regulation of FGFR signaling, Spry regulation of FGF signaling, Signaling by FGFR, Signal Transduction, Signaling by EGFR, Signaling by FGFR in disease, EGFR downregulation, Disease, Signaling by EGFR in Cancer, Sprouty lures cytosolic CBL away from EGFR Jak-STAT signaling pathway path:hsa04630 Environmental Information Processing; Signal Transduction, Human Diseases; Cancers hsa:867, hsa:10253 P:fibroblast growth factor receptor signaling pathway, P:negative regulation of apoptotic process, P:epidermal growth factor receptor signaling pathway, P:negative regulation of epidermal growth factor receptor signaling pathway GO:0008543, GO:0043066, GO:0007173, GO:0042059 C:plasma membrane, C:cytosol GO:0005886, GO:0005829 SWTI000273 P18887, Q96T60 XRCC1, PNKP hsa:7515, hsa:11284 F:damaged DNA binding GO:0003684 nucleus, Replication fork GO:0005634, GO:0005657 UNIPROT:P68400, UNIPROT:P68400, UNIPROT:P68400, UNIPROT:P68400 P68400 CK2_alpha, CK2_alpha, CK2_alpha, CK2_alpha P68400, P68400, P68400, P68400 518, 519, 523, 525 CK2-A1, CK2-A2, CK2-A1, CK2-A2, CK2-A1, CK2-A2, CK2-A1 P68400, P19784, P68400, P19784, P68400, P19784, P68400 518, 518, 519, 519, 523, 523, 525 SWTI000274 P05067, P62993 APP, GRB2 Innate Immune System, Gastrin-CREB signalling pathway via PKC and MAPK, Signal Transduction, Signaling by GPCR, Immune System, Disease, Platelet activation, signaling and aggregation, Hemostasis Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Development, Cellular Processes; Cell Communication, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:351, hsa:2885 P:platelet activation GO:0030168 C:Golgi apparatus, C:cytosol GO:0005794, GO:0005829 C:cytosol GO:0005829 cytosol GO:0005829 GSK-3_beta P49841 743 CDK1, Fyn P06493, P06241 743, 757 SWTI000275 P29353, P05106 SHC1, ITGB3 Hemostasis, Integrin cell surface interactions, Signal Transduction, Integrin alphaIIb beta3 signaling, Platelet activation, signaling and aggregation, Cell surface interactions at the vascular wall, SHC1 dissociates from integrin alphaIIb beta3, Platelet Aggregation (Plug Formation), SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow Focal adhesion path:hsa04510 Environmental Information Processing; Signal Transduction, Human Diseases; Cancers, Cellular Processes; Cell Communication, Human Diseases; Cardiovascular Diseases, Organismal Systems; Immune System hsa:6464, hsa:3690 P:leukocyte migration GO:0050900 integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex GO:0008305, GO:0016023, GO:0005829, GO:0009898, GO:0043235 SRC, SRC, SYK, SRC P12931, P12931, P43405, P12931 773, 773, 785, 785 Src, Src P12931, P12931 773, 785 SWTI000276 P25054, Q15691 APC, MAPRE1 Human Diseases; Cancers hsa:324, hsa:22919 C:centrosome, C:cytosol, C:cytoplasmic microtubule, C:microtubule plus end GO:0005813, GO:0005829, GO:0005881, GO:0035371 C:cytosol GO:0005829 cytosol, microtubule GO:0005829, GO:0005874 UNIPROT:P06493, UNIPROTFAM:GSK-3 subfamily UNIPROTFAM:GSK-3 subfamily, P06493 SWTI000277 Q99704, P05106, Q9Y490 DOK1, ITGB3, TLN1 Axon guidance, GRB2:SOS provides linkage to MAPK signaling for Intergrins, Response to elevated platelet cytosolic Ca2+, Integrin cell surface interactions, Signal Transduction, Developmental Biology, Integrin alphaIIb beta3 signaling, p130Cas linkage to MAPK signaling for integrins, Platelet activation, signaling and aggregation, Hemostasis, SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow, SHC1 dissociates from integrin alphaIIb beta3, Platelet Aggregation (Plug Formation), Platelet degranulation Focal adhesion path:hsa04510 Human Diseases; Infectious Diseases, Cellular Processes; Cell Communication, Human Diseases; Cardiovascular Diseases hsa:1796, hsa:3690, hsa:7094 P:axon guidance, P:platelet degranulation GO:0007411, GO:0002576 C:cytosol GO:0005829 C:cytosol GO:0005829 integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex, integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex GO:0008305, GO:0016023, GO:0005829, GO:0009898, GO:0043235, GO:0008305, GO:0016023, GO:0005829, GO:0009898, GO:0043235 SRC, SRC P12931, P12931 773, 773 Src P12931 773 SWTI000278 P49841, P24864, Q969H0 GSK3B, CCNE1, FBXW7 Immune System, Signal Transduction, Adaptive Immune System PI3K-Akt signaling pathway, Cell cycle path:hsa04151, path:hsa04110 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:2932, hsa:898, hsa:55294 P:response to drug GO:0042493 C:centrosome, C:cytosol, C:nucleoplasm GO:0005813, GO:0005829, GO:0005654 C:cytosol GO:0005829 cytosol, nucleus, nucleus, cytosol GO:0005829, GO:0005634, GO:0005634, GO:0005829 UNIPROT:P24941, UNIPROT:P24941, GSK3B P49841, P24941 SWTI000279 P49841, P84022, Q13526, Q96PU5 GSK3B, SMAD3, PIN1, NEDD4L Immune System, Downregulation of SMAD2/3:SMAD4 transcriptional activity, Signal Transduction, TGF-beta receptor signaling activates SMADs, Downregulation of TGF-beta receptor signaling, Gene Expression, Innate Immune System, Developmental Biology, Adaptive Immune System, Generic Transcription Pathway, Signaling by TGF-beta Receptor Complex, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Wnt signaling pathway, Cell cycle, Endocytosis path:hsa04310, path:hsa04110, path:hsa04144 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers, Cellular Processes; Cell Communication, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System, Cellular Processes; Transport and Catabolism hsa:2932, hsa:4088, hsa:5300, hsa:23327 P:negative regulation of transforming growth factor beta receptor signaling pathway, P:transforming growth factor beta receptor signaling pathway, P:transcription initiation from RNA polymerase II promoter, P:negative regulation of transcription from RNA polymerase II promoter, P:positive regulation of transcription from RNA polymerase II promoter, P:negative regulation of apoptotic process GO:0030512, GO:0007179, GO:0006367, GO:0000122, GO:0045944, GO:0043066 C:cytosol, C:nucleoplasm, C:plasma membrane GO:0005829, GO:0005654, GO:0005886 C:cytosol GO:0005829 nucleus, cytosol, cytosol, nucleus, cytosol, integral membrane protein, integral plasma membrane protein GO:0005634, GO:0005829, GO:0005829, GO:0005634, GO:0005829, GO:0016021, GO:0005887 UNIPROTFAM:CDC2/CDKX subfamily, UNIPROTFAM:CDC2/CDKX subfamily, UNIPROTFAM:CDC2/CDKX subfamily, UNIPROTFAM:CDC2/CDKX subfamily, GSK3B P49841, UNIPROTFAM:CDC2/CDKX subfamily CDK2, CDK4, MAPK1, MAPK1 P24941, P11802, P28482, P28482 179, 179, 179, 179 CDK4, ERK2, CDK4, CDK9, CDK8, CDK2 P30285, P28482, P11802, P50750, P49336, P97377 179, 179, 179, 179, 179, 179 SWTI000280 P09793, P84091, P35235 Ctla4, Ap2m1, Ptpn11 Human Diseases; Immune Diseases, Human Diseases; Cancers, Organismal Systems; Nervous System, Organismal Systems; Immune System mmu:12477, mmu:11773, mmu:19247 C:mitochondrion GO:0005739 cytosol, clathrin-coated endocytic vesicle, plasma membrane, cytosol GO:0005829, GO:0045334, GO:0005886, GO:0005829 JAK2, Lck O60674, P06239 201, 201 Fyn, JAK2, Lck P39688, O60674, P06240 201, 201, 201 SWTI000281 Q14118, P06241, P11532 DAG1, FYN, DMD Human Diseases; Infectious Diseases, Organismal Systems; Development, Cellular Processes; Cell Communication, Human Diseases; Cardiovascular Diseases, Organismal Systems; Immune System hsa:1605, hsa:2534, hsa:1756 P:virus-host interaction GO:0019048 C:cytoskeleton, C:sarcolemma, C:cytosol, C:dystrophin-associated glycoprotein complex, C:costamere GO:0005856, GO:0042383, GO:0005829, GO:0016010, GO:0043034 F:structural constituent of muscle GO:0008307 C:cytosol GO:0005829 cytosol, integral membrane protein, integral plasma membrane protein, cytosol GO:0005829, GO:0016021, GO:0005887, GO:0005829 SRC P12931 892 SWTI000282 Q9Y297, P49841, P98174 BTRC, GSK3B, FGD1 Signaling by ERBB4, Immune System, Downstream Signaling Events Of B Cell Receptor (BCR), Signalling by NGF, Signal Transduction, Degradation of ubiquitinated -beta catenin by the proteasome, Degradation of beta-catenin by the destruction complex, Disease, Signaling by the B Cell Receptor (BCR), Adaptive Immune System, Signaling by Wnt Wnt signaling pathway, Hedgehog signaling pathway path:hsa04310, path:hsa04340 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:8945, hsa:2932, hsa:2245 P:nerve growth factor receptor signaling pathway, P:organ morphogenesis, P:negative regulation of transcription, DNA-dependent GO:0048011, GO:0009887, GO:0045892 C:cytosol, C:plasma membrane, C:nucleus GO:0005829, GO:0005886, GO:0005634 C:cytosol, C:nucleus GO:0005829, GO:0005634 cytosol, nucleus, nucleoplasm, nucleus, Chromosome, cytosol GO:0005829, GO:0005634, GO:0005654, GO:0005634, GO:0005694, GO:0005829 , GSK3B , P49841 SWTI000283 Q9Y297, P49841, Q5JSP0 BTRC, GSK3B, FGD3 Signaling by ERBB4, Immune System, Downstream Signaling Events Of B Cell Receptor (BCR), Signalling by NGF, Signal Transduction, Degradation of ubiquitinated -beta catenin by the proteasome, Degradation of beta-catenin by the destruction complex, Disease, Signaling by the B Cell Receptor (BCR), Adaptive Immune System, Signaling by Wnt Wnt signaling pathway, Hedgehog signaling pathway path:hsa04310, path:hsa04340 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:8945, hsa:2932, hsa:89846 P:nerve growth factor receptor signaling pathway, P:negative regulation of transcription, DNA-dependent GO:0048011, GO:0045892 C:cytosol, C:nucleus GO:0005829, GO:0005634 C:cytosol, C:nucleus GO:0005829, GO:0005634 cytosol, nucleus, cytosol, nucleus, nucleoplasm, nucleus, Chromosome, cytosol GO:0005829, GO:0005634, GO:0005829, GO:0005634, GO:0005654, GO:0005634, GO:0005694, GO:0005829 UNIPROT:P49841, UNIPROT:P49841, GSK3B P49841 SWTI000284 P49841, Q9BYG3, P06493, P46013 GSK3B, MKI67IP, CDK1, MKI67 Signaling by ERBB4, Signaling by ERBB2, DAP12 signaling, Signaling by PDGF, Developmental Biology, NGF signalling via TRKA from the plasma membrane, Signal Transduction, DAP12 interactions, Signaling by EGFR in Cancer, Downstream signaling of activated FGFR, Signaling by FGFR, Signaling by EGFR, Signaling by FGFR in disease, Innate Immune System, Downstream signal transduction, Axon guidance, Signalling by NGF, Disease, Signaling by SCF-KIT, Immune System Cell cycle path:hsa04110 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers, Cellular Processes; Cell Communication, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:2932, hsa:84365, hsa:983, hsa:4288 P:organ regeneration, P:epidermal growth factor receptor signaling pathway, P:cell migration, P:nerve growth factor receptor signaling pathway, P:axon guidance, P:fibroblast growth factor receptor signaling pathway, P:response to drug, P:anti-apoptosis, P:protein complex assembly GO:0031100, GO:0007173, GO:0016477, GO:0048011, GO:0007411, GO:0008543, GO:0042493, GO:0006916, GO:0006461 C:cytoplasm, C:nucleolus, C:nucleoplasm, C:cytosol GO:0005737, GO:0005730, GO:0005654, GO:0005829 F:ATP binding GO:0005524 cytosol, nucleus, cytosol, nucleus, nucleus, Replication fork GO:0005829, GO:0005634, GO:0005829, GO:0005634, GO:0005634, GO:0005657 UNIPROT:P49841, UNIPROT:P49841, UNIPROT:P06493, GSK3B, CDK1 P49841, P06493 GSK-3_beta, GSK-3_alpha, GSK-3_beta, GSK-3_alpha P49841, P49840, P49841, P49840 230, 230, 234, 234 GSK3B, GSK3A, GSK3B, GSK3A, CDK1 P49841, P49840, P49841, P49840, P06493 230, 230, 234, 234, 238 SWTI000285 P49841, P28482, Q969H0, P01106 GSK3B, MAPK1, FBXW7, MYC Signaling by ERBB4, Signaling by ERBB2, DAP12 signaling, Signaling by PDGF, Developmental Biology, Signaling by NOTCH1, Signaling by NOTCH, NGF signalling via TRKA from the plasma membrane, Signaling by FGFR in disease, Signal Transduction, DAP12 interactions, Signaling by EGFR in Cancer, Signaling by FGFR, Downstream signaling of activated FGFR, Signaling by SCF-KIT, Signaling by EGFR, Innate Immune System, Downstream signal transduction, Axon guidance, Immune System, NOTCH1 Intracellular Domain Regulates Transcription, Signalling by NGF, Disease, Adaptive Immune System Axon guidance, PI3K-Akt signaling pathway, Wnt signaling pathway, Focal adhesion, T cell receptor signaling pathway, B cell receptor signaling pathway, TGF-beta signaling pathway, Chemokine signaling pathway, Neurotrophin signaling pathway, Insulin signaling pathway, Melanogenesis, ErbB signaling pathway, MAPK signaling pathway, Cell cycle path:hsa04360, path:hsa04151, path:hsa04310, path:hsa04510, path:hsa04660, path:hsa04662, path:hsa04350, path:hsa04062, path:hsa04722, path:hsa04910, path:hsa04916, path:hsa04012, path:hsa04010, path:hsa04110 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Neurodegenerative Diseases, Human Diseases; Cancers, Organismal Systems; Development, Cellular Processes; Cell Communication, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:2932, hsa:5594, hsa:55294, hsa:4609 P:positive regulation of peptidyl-threonine phosphorylation, P:Notch signaling pathway, P:epidermal growth factor receptor signaling pathway, P:negative regulation of protein binding, P:canonical Wnt receptor signaling pathway, P:nerve growth factor receptor signaling pathway, P:cellular response to UV, P:axon guidance, P:fibroblast growth factor receptor signaling pathway, P:positive regulation of transcription from RNA polymerase II promoter, P:peptidyl-serine phosphorylation, P:virus-host interaction, P:negative regulation of apoptotic process, P:response to DNA damage stimulus GO:0010800, GO:0007219, GO:0007173, GO:0032091, GO:0060070, GO:0048011, GO:0034644, GO:0007411, GO:0008543, GO:0045944, GO:0018105, GO:0019048, GO:0043066, GO:0006974 C:nucleolus, C:nucleoplasm, C:Golgi apparatus, C:protein complex, C:cytosol GO:0005730, GO:0005654, GO:0005794, GO:0043234, GO:0005829 F:sequence-specific DNA binding transcription factor activity, F:ATP binding GO:0003700, GO:0005524 C:cytosol GO:0005829 nucleus, cytosol, cytosol, nucleus, nucleus, cytosol GO:0005634, GO:0005829, GO:0005829, GO:0005634, GO:0005634, GO:0005829 UNIPROT:P28482, GSK3B, MAPK1 P49841, P28482 GSK-3_group, GSK-3_beta, GSK-3_alpha, GSK-3_group, MAPK1 , P49841, P49840, , P28482 58, 58, 58, 58, 62 GSK3B, ERK2, GSK3A, GSK3B, JNK3, ERK2, CDK5, ERK2, mTOR, JNK2, JNK1, JNK3, ERK1 P49841, P28482, P49840, P18266, P53779, P28482, Q00535, NP_446294, P42345, P45984, P45983, P53779, P21708 58, 58, 58, 58, 58, 62, 62, 62, 62, 62, 62, 62, 62 SWTI000286 P49841, P05412, Q969H0 GSK3B, JUN, FBXW7 Immune System, Signal Transduction, Adaptive Immune System, Innate Immune System Neurotrophin signaling pathway, Wnt signaling pathway, T cell receptor signaling pathway, B cell receptor signaling pathway, ErbB signaling pathway, Focal adhesion path:hsa04722, path:hsa04310, path:hsa04660, path:hsa04662, path:hsa04012, path:hsa04510 Environmental Information Processing; Signal Transduction, Human Diseases; Substance Dependence, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Development, Cellular Processes; Cell Communication, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:2932, hsa:3725, hsa:55294 P:negative regulation of transcription, DNA-dependent, P:response to drug GO:0045892, GO:0042493 C:cytosol, C:nucleoplasm GO:0005829, GO:0005654 C:cytosol GO:0005829 cytosol, nucleus, nucleus, cytosol GO:0005829, GO:0005634, GO:0005634, GO:0005829 , GSK3B , P49841 GSK-3_group, GSK-3_alpha, GSK-3_group, GSK-3_alpha, CK2_group, GSK-3_alpha , P49840, , P49840, , P49840 239, 239, 239, 239, 243, 243 GSK3B, CK2-A1, GSK3B P49841, P68400, P49841 239, 243, 243 SWTI000287 P43403, P07766, Q8TE68 ZAP70, CD3E, EPS8L1 Adaptive Immune System, TCR signaling, Translocation of ZAP-70 to Immunological synapse, Immune System, Generation of second messenger molecules T cell receptor signaling pathway path:hsa04660 Human Diseases; Immune Diseases, Organismal Systems; Immune System, Human Diseases; Infectious Diseases hsa:7535, hsa:916, hsa:54869 P:positive regulation of calcium-mediated signaling, P:T cell receptor signaling pathway, P:positive regulation of alpha-beta T cell proliferation, P:negative thymic T cell selection GO:0050850, GO:0050852, GO:0046641, GO:0045060 C:T cell receptor complex, C:immunological synapse GO:0042101, GO:0001772 cytosol, plasma membrane, cytosol GO:0005829, GO:0005886, GO:0005829 Fyn, Fyn P06241, P06241 188, 199 SWTI000288 P63104, P05107, P21333 YWHAZ, ITGB2, FLNA Immune System, GP1b-IX-V activation signalling, Hemostasis, Platelet activation, signaling and aggregation, Adaptive Immune System Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Organismal Systems; Immune System hsa:7534, hsa:3689, hsa:2316 P:platelet activation GO:0030168 C:cytosol GO:0005829 C:cytosol GO:0005829 nucleus, cytosol, internal side of plasma membrane GO:0005634, GO:0005829, GO:0009898 PKC_group, PKC_alpha, PKC_delta, PKC_eta , P17252, Q05655, P24723 758, 758, 758, 758 PKCD, PKCB iso2, PKCH, PKCA, PKCB Q05655, P05771-2, P24723, P17252, P05771 758, 758, 758, 758, 758 SWTI000289 P46939, P41240, Q14118 UTRN, CSK, DAG1 Human Diseases; Cardiovascular Diseases hsa:7402, hsa:1445, hsa:1605 C:cytoplasm, C:cytoskeleton, C:plasma membrane GO:0005737, GO:0005856, GO:0005886 F:calcium ion binding GO:0005509 cytosol, integral membrane protein, integral plasma membrane protein, cytosol GO:0005829, GO:0016021, GO:0005887, GO:0005829 SRC P12931 892 SWTI000290 P27986, Q15303, Q96J02 PIK3R1, ERBB4, ITCH Signaling by ERBB4, Signaling by ERBB2, DAP12 signaling, PI3K events in ERBB2 signaling, Signaling by PDGF, Constitutive PI3K/AKT Signaling in Cancer, PIP3 activates AKT signaling, PI3K/AKT Signaling in Cancer, NGF signalling via TRKA from the plasma membrane, Downstream Signaling Events Of B Cell Receptor (BCR), Downregulation of ERBB4 signaling, Signal Transduction, Signaling by FGFR, DAP12 interactions, Signaling by EGFR in Cancer, PI-3K cascade, PI3K events in ERBB4 signaling, Downstream signaling of activated FGFR, Signaling by SCF-KIT, Signaling by EGFR, Signaling by FGFR in disease, Signaling by the B Cell Receptor (BCR), Innate Immune System, Downstream signal transduction, Immune System, GAB1 signalosome, Signalling by NGF, Disease, PI3K/AKT activation, Adaptive Immune System Endocytosis, ErbB signaling pathway path:hsa04144, path:hsa04012 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System, Cellular Processes; Transport and Catabolism hsa:5295, hsa:2066, hsa:83737 P:positive regulation of glucose import, P:negative regulation of apoptotic process, P:apoptotic process GO:0046326, GO:0043066, GO:0006915 C:plasma membrane, C:cytosol GO:0005886, GO:0005829 C:cytosol GO:0005829 cytosol, integral membrane protein, integral plasma membrane protein, cytosol GO:0005829, GO:0016021, GO:0005887, GO:0005829 HER4 Q15303 1056 SWTI000291 P63104, P26368, P54253 YWHAZ, U2AF2, ATXN1 Gene Expression Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death hsa:7534, hsa:11338, hsa:6310 C:nucleoplasm GO:0005654 nucleus, spliceosome complex, nucleus, cytosol, internal side of plasma membrane GO:0005634, GO:0005681, GO:0005634, GO:0005829, GO:0009898 PKACa, Akt1 P17612, P31749 775, 775 SWTI000292 P05067, P62993, O00213 APP, GRB2, APBB1 Innate Immune System, Gastrin-CREB signalling pathway via PKC and MAPK, Signal Transduction, Signaling by GPCR, Immune System, Disease, Platelet activation, signaling and aggregation, Hemostasis Environmental Information Processing; Signal Transduction, Human Diseases; Neurodegenerative Diseases, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Development, Cellular Processes; Cell Communication, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:351, hsa:2885, hsa:322 P:axon guidance, P:visual learning, P:platelet activation, P:extracellular matrix organization GO:0007411, GO:0008542, GO:0030168, GO:0030198 C:Golgi apparatus, C:dendritic spine, C:cytosol, C:synapse GO:0005794, GO:0043197, GO:0005829, GO:0045202 C:cytosol GO:0005829 integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex, cytosol GO:0008305, GO:0016023, GO:0005829, GO:0009898, GO:0043235, GO:0005829 Fyn P06241 757 SWTI000293 P29353, P05106, Q96AC1 SHC1, ITGB3, FERMT2 Hemostasis, Integrin cell surface interactions, Signal Transduction, Integrin alphaIIb beta3 signaling, Platelet activation, signaling and aggregation, Cell surface interactions at the vascular wall, SHC1 dissociates from integrin alphaIIb beta3, Platelet Aggregation (Plug Formation), SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow Focal adhesion path:hsa04510 Environmental Information Processing; Signal Transduction, Human Diseases; Cancers, Cellular Processes; Cell Communication, Human Diseases; Cardiovascular Diseases, Organismal Systems; Immune System hsa:6464, hsa:3690, hsa:10979 P:leukocyte migration GO:0050900 C:cytosol, C:nucleus GO:0005829, GO:0005634 F:phospholipid binding GO:0005543 C:cytosol GO:0005829 integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex, integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex GO:0008305, GO:0016023, GO:0005829, GO:0009898, GO:0043235, GO:0008305, GO:0016023, GO:0005829, GO:0009898, GO:0043235 SYK, SRC P43405, P12931 785, 785 Src P12931 785 SWTI000294 P49841, P24864, Q969H0 GSK3B, CCNE1, FBXW7 Immune System, Signal Transduction, Adaptive Immune System PI3K-Akt signaling pathway, Cell cycle path:hsa04151, path:hsa04110 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:2932, hsa:898, hsa:55294 P:response to drug GO:0042493 C:centrosome, C:cytosol, C:nucleoplasm GO:0005813, GO:0005829, GO:0005654 C:cytosol GO:0005829 cytosol, nucleus, nucleus, cytosol GO:0005829, GO:0005634, GO:0005634, GO:0005829 UNIPROT:P24941, UNIPROT:P24941, GSK3B P49841, P24941 CDK2, GSK-3_beta, GSK-3_alpha, CDK2 P24941, P49841, P49840, P24941 395, 395, 395, 399 GSK3B, CDK2, GSK3A, CDK2 P49841, P24941, P49840, P24941 395, 395, 395, 399 SWTI000295 P49841, P36956, Q969H0 GSK3B, SREBF1, FBXW7 Signal Transduction, SREBP1A/1C/2 is retained in the endoplasmic reticulum by SCAP:cholesterol:INSIG, Immune System, Adaptive Immune System Insulin signaling pathway path:hsa04910 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:2932, hsa:6720, hsa:55294 P:positive regulation of transcription from RNA polymerase II promoter GO:0045944 C:endoplasmic reticulum, C:nucleus GO:0005783, GO:0005634 F:sequence-specific DNA binding transcription factor activity GO:0003700 C:nucleus GO:0005634 cytosol, nucleus, nucleus, cytosol GO:0005829, GO:0005634, GO:0005634, GO:0005829 , GSK3B , P49841 GSK3B, GSK3B P49841, P49841 426, 430 SWTI000296 Q9Y297, P49841, P35222 BTRC, GSK3B, CTNNB1 Signaling by ERBB4, Beta-catenin phosphorylation cascade, Degradation of ubiquitinated -beta catenin by the proteasome, Downstream Signaling Events Of B Cell Receptor (BCR), Signal Transduction, Degradation of beta-catenin by the destruction complex, Developmental Biology, Disease, Signaling by the B Cell Receptor (BCR), Immune System, Adaptive Immune System, Signaling by Wnt Wnt signaling pathway, Melanogenesis, Focal adhesion, Hedgehog signaling pathway path:hsa04310, path:hsa04916, path:hsa04510, path:hsa04340 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers, Cellular Processes; Cell Communication, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:8945, hsa:2932, hsa:1499 P:negative regulation of transcription, DNA-dependent, P:cellular response to organic cyclic compound, P:response to drug, P:positive regulation of transcription from RNA polymerase II promoter, P:epithelial to mesenchymal transition GO:0045892, GO:0071407, GO:0042493, GO:0045944, GO:0001837 C:centrosome, C:nucleus, C:Axin-APC-beta-catenin-GSK3B complex, C:dendritic shaft, C:cytosol GO:0005813, GO:0005634, GO:0034747, GO:0043198, GO:0005829 C:nucleus, C:cytosol GO:0005634, GO:0005829 cytosol, nucleus, cytosol, nucleus, nucleoplasm, nucleus, Chromosome, cytosol GO:0005829, GO:0005634, GO:0005829, GO:0005634, GO:0005654, GO:0005634, GO:0005694, GO:0005829 UNIPROT:P49841, UNIPROT:P49841, GSK3B P49841 GSK-3_group, GSK-3_group , 33, 37 GSK3B, IKK-alpha, GSK3A, JNK1, GSK3B, IKK-alpha, GSK3A, JNK1 P49841, O15111, P49840, P45983, P49841, O15111, P49840, P45983 33, 33, 33, 33, 37, 37, 37, 37 SWTI000297 Q9Y297, O95863, P49841 BTRC, SNAI1, GSK3B Signaling by ERBB4, Immune System, Downstream Signaling Events Of B Cell Receptor (BCR), Signal Transduction, Degradation of ubiquitinated -beta catenin by the proteasome, Degradation of beta-catenin by the destruction complex, Disease, Signaling by the B Cell Receptor (BCR), Adaptive Immune System, Signaling by Wnt Wnt signaling pathway, Hedgehog signaling pathway path:hsa04310, path:hsa04340 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers, Cellular Processes; Cell Communication, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:8945, hsa:6615, hsa:2932 P:negative regulation of apoptotic process, P:cell migration, P:positive regulation of transcription, DNA-dependent, P:epithelial to mesenchymal transition, P:negative regulation of transcription, DNA-dependent GO:0043066, GO:0016477, GO:0045893, GO:0001837, GO:0045892 C:nucleus, C:cytosol GO:0005634, GO:0005829 C:nucleus, C:cytosol GO:0005634, GO:0005829 cytosol, nucleus, nucleoplasm, nucleus, Chromosome, cytosol GO:0005829, GO:0005634, GO:0005654, GO:0005634, GO:0005694, GO:0005829 , GSK3B , P49841 GSK3B, GSK3B P49841, P49841 96, 100 SWTI000298 O43854, P05106, P06756 EDIL3, ITGB3, ITGAV Axon guidance, PECAM1 interactions, Signal transduction by L1, Hemostasis, Integrin cell surface interactions, Signal Transduction, L1CAM interactions, Developmental Biology, Cell surface interactions at the vascular wall Phagosome, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, ECM-receptor interaction, Focal adhesion path:hsa04145, path:hsa04151, path:hsa04810, path:hsa04512, path:hsa04510 Environmental Information Processing; Signal Transduction, Cellular Processes; Transport and Catabolism, Environmental Information Processing; Signaling Molecules and Interaction, Human Diseases; Cancers, Cellular Processes; Cell Communication, Cellular Processes; Cell Motility, Human Diseases; Cardiovascular Diseases hsa:10085, hsa:3690, hsa:3685 P:negative regulation of lipoprotein metabolic process, P:leukocyte migration, P:axon guidance, P:negative regulation of macrophage derived foam cell differentiation, P:cell-matrix adhesion, P:negative regulation of lipid transport, P:integrin-mediated signaling pathway, P:negative regulation of low-density lipoprotein particle receptor biosynthetic process, P:negative regulation of lipid storage GO:0050748, GO:0050900, GO:0007411, GO:0010745, GO:0007160, GO:0032369, GO:0007229, GO:0045715, GO:0010888 C:integrin complex GO:0008305 C:integrin complex GO:0008305 integrin, extracellular GO:0008305, GO:0005576 SWTI000299 P05106, P62384, P08514 ITGB3, None, ITGA2B Signal transduction by L1, GRB2:SOS provides linkage to MAPK signaling for Intergrins, Developmental Biology, Signal Transduction, Hemostasis, Integrin cell surface interactions, SHC1 dissociates from integrin alphaIIb beta3, Axon guidance, Response to elevated platelet cytosolic Ca2+, Integrin alphaIIb beta3 signaling, L1CAM interactions, p130Cas linkage to MAPK signaling for integrins, Platelet Aggregation (Plug Formation), Platelet activation, signaling and aggregation, Platelet degranulation, SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Hematopoietic cell lineage, ECM-receptor interaction, Focal adhesion path:hsa04151, path:hsa04810, path:hsa04640, path:hsa04512, path:hsa04510 Environmental Information Processing; Signal Transduction, Environmental Information Processing; Signaling Molecules and Interaction, Human Diseases; Cancers, Cellular Processes; Cell Communication, Cellular Processes; Cell Motility, Human Diseases; Cardiovascular Diseases, Organismal Systems; Immune System hsa:3690, hsa:3674 P:axon guidance, P:platelet degranulation, P:cell adhesion, P:cell-matrix adhesion, P:integrin-mediated signaling pathway GO:0007411, GO:0002576, GO:0007155, GO:0007160, GO:0007229 C:platelet alpha granule membrane, C:integrin complex GO:0031092, GO:0008305 C:integrin complex GO:0008305 integrin, extracellular GO:0008305, GO:0005576 SWTI000300 P05106, P02751, P06756 ITGB3, FN1, ITGAV Axon guidance, PECAM1 interactions, Signal transduction by L1, GRB2:SOS provides linkage to MAPK signaling for Intergrins, Hemostasis, Integrin cell surface interactions, Signal Transduction, Response to elevated platelet cytosolic Ca2+, L1CAM interactions, Developmental Biology, Integrin alphaIIb beta3 signaling, p130Cas linkage to MAPK signaling for integrins, Platelet activation, signaling and aggregation, Cell surface interactions at the vascular wall, Platelet Aggregation (Plug Formation), Platelet degranulation Phagosome, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, ECM-receptor interaction, Focal adhesion path:hsa04145, path:hsa04151, path:hsa04810, path:hsa04512, path:hsa04510 Environmental Information Processing; Signal Transduction, Cellular Processes; Transport and Catabolism, Human Diseases; Infectious Diseases, Environmental Information Processing; Signaling Molecules and Interaction, Human Diseases; Cancers, Cellular Processes; Cell Communication, Cellular Processes; Cell Motility, Human Diseases; Cardiovascular Diseases hsa:3690, hsa:2335, hsa:3685 P:negative regulation of lipoprotein metabolic process, P:leukocyte migration, P:axon guidance, P:angiogenesis, P:platelet degranulation, P:negative regulation of macrophage derived foam cell differentiation, P:cell-matrix adhesion, P:negative regulation of lipid transport, P:integrin-mediated signaling pathway, P:negative regulation of low-density lipoprotein particle receptor biosynthetic process, P:negative regulation of lipid storage GO:0050748, GO:0050900, GO:0007411, GO:0001525, GO:0002576, GO:0010745, GO:0007160, GO:0032369, GO:0007229, GO:0045715, GO:0010888 C:integrin complex GO:0008305 C:integrin complex GO:0008305 integrin, extracellular GO:0008305, GO:0005576 SWTI000301 P03305, P05106, P06756 None, ITGB3, ITGAV Axon guidance, PECAM1 interactions, Signal transduction by L1, Hemostasis, Integrin cell surface interactions, Signal Transduction, L1CAM interactions, Developmental Biology, Cell surface interactions at the vascular wall Phagosome, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, ECM-receptor interaction, Focal adhesion path:hsa04145, path:hsa04151, path:hsa04810, path:hsa04512, path:hsa04510 Environmental Information Processing; Signal Transduction, Cellular Processes; Transport and Catabolism, Environmental Information Processing; Signaling Molecules and Interaction, Human Diseases; Cancers, Cellular Processes; Cell Communication, Cellular Processes; Cell Motility, Human Diseases; Cardiovascular Diseases hsa:3690, hsa:3685 P:negative regulation of lipoprotein metabolic process, P:leukocyte migration, P:axon guidance, P:negative regulation of macrophage derived foam cell differentiation, P:cell-matrix adhesion, P:negative regulation of lipid transport, P:integrin-mediated signaling pathway, P:negative regulation of low-density lipoprotein particle receptor biosynthetic process, P:negative regulation of lipid storage GO:0050748, GO:0050900, GO:0007411, GO:0010745, GO:0007160, GO:0032369, GO:0007229, GO:0045715, GO:0010888 C:integrin complex GO:0008305 C:integrin complex GO:0008305 integrin, extracellular GO:0008305, GO:0005576 SWTI000302 P04004, P05106, P06756 VTN, ITGB3, ITGAV Axon guidance, PECAM1 interactions, Signal transduction by L1, Hemostasis, Integrin cell surface interactions, Signal Transduction, L1CAM interactions, Developmental Biology, Cell surface interactions at the vascular wall Phagosome, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, ECM-receptor interaction, Focal adhesion path:hsa04145, path:hsa04151, path:hsa04810, path:hsa04512, path:hsa04510 Environmental Information Processing; Signal Transduction, Cellular Processes; Transport and Catabolism, Environmental Information Processing; Signaling Molecules and Interaction, Human Diseases; Cancers, Cellular Processes; Cell Communication, Cellular Processes; Cell Motility, Human Diseases; Cardiovascular Diseases hsa:7448, hsa:3690, hsa:3685 P:negative regulation of lipoprotein metabolic process, P:leukocyte migration, P:axon guidance, P:negative regulation of macrophage derived foam cell differentiation, P:cell-matrix adhesion, P:negative regulation of lipid transport, P:positive regulation of peptidyl-tyrosine phosphorylation, P:positive regulation of vascular endothelial growth factor receptor signaling pathway, P:integrin-mediated signaling pathway, P:negative regulation of low-density lipoprotein particle receptor biosynthetic process, P:negative regulation of lipid storage GO:0050748, GO:0050900, GO:0007411, GO:0010745, GO:0007160, GO:0032369, GO:0050731, GO:0030949, GO:0007229, GO:0045715, GO:0010888 C:integrin complex, C:alphav-beta3 integrin-vitronectin complex GO:0008305, GO:0071062 C:integrin complex GO:0008305 integrin, extracellular GO:0008305, GO:0005576 SWTI000303 P05106, P04275, P06756 ITGB3, VWF, ITGAV Axon guidance, PECAM1 interactions, Signal transduction by L1, GRB2:SOS provides linkage to MAPK signaling for Intergrins, Hemostasis, Integrin cell surface interactions, Signal Transduction, Response to elevated platelet cytosolic Ca2+, L1CAM interactions, Developmental Biology, Integrin alphaIIb beta3 signaling, p130Cas linkage to MAPK signaling for integrins, Platelet activation, signaling and aggregation, Cell surface interactions at the vascular wall, Platelet Aggregation (Plug Formation), Platelet degranulation Phagosome, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, ECM-receptor interaction, Focal adhesion path:hsa04145, path:hsa04151, path:hsa04810, path:hsa04512, path:hsa04510 Environmental Information Processing; Signal Transduction, Cellular Processes; Transport and Catabolism, Environmental Information Processing; Signaling Molecules and Interaction, Cellular Processes; Cell Communication, Cellular Processes; Cell Motility, Human Diseases; Cancers, Organismal Systems; Immune System, Human Diseases; Cardiovascular Diseases hsa:3690, hsa:7450, hsa:3685 P:negative regulation of lipoprotein metabolic process, P:leukocyte migration, P:axon guidance, P:platelet degranulation, P:negative regulation of macrophage derived foam cell differentiation, P:cell-matrix adhesion, P:negative regulation of lipid transport, P:integrin-mediated signaling pathway, P:negative regulation of low-density lipoprotein particle receptor biosynthetic process, P:negative regulation of lipid storage GO:0050748, GO:0050900, GO:0007411, GO:0002576, GO:0010745, GO:0007160, GO:0032369, GO:0007229, GO:0045715, GO:0010888 C:external side of plasma membrane, C:integrin complex GO:0009897, GO:0008305 C:integrin complex GO:0008305 integrin, extracellular GO:0008305, GO:0005576 SWTI000304 P05106, P10451, P06756 ITGB3, SPP1, ITGAV Axon guidance, PECAM1 interactions, Signal transduction by L1, Hemostasis, Integrin cell surface interactions, Signal Transduction, L1CAM interactions, Developmental Biology, Cell surface interactions at the vascular wall Phagosome, PI3K-Akt signaling pathway, ECM-receptor interaction, Regulation of actin cytoskeleton, Focal adhesion path:hsa04145, path:hsa04151, path:hsa04512, path:hsa04810, path:hsa04510 Environmental Information Processing; Signal Transduction, Cellular Processes; Transport and Catabolism, Environmental Information Processing; Signaling Molecules and Interaction, Cellular Processes; Cell Communication, Cellular Processes; Cell Motility, Human Diseases; Cancers, Organismal Systems; Immune System, Human Diseases; Cardiovascular Diseases hsa:3690, hsa:6696, hsa:3685 P:cell-matrix adhesion, P:leukocyte migration, P:axon guidance, P:negative regulation of macrophage derived foam cell differentiation, P:negative regulation of lipoprotein metabolic process, P:negative regulation of lipid transport, P:integrin-mediated signaling pathway, P:negative regulation of low-density lipoprotein particle receptor biosynthetic process, P:negative regulation of lipid storage GO:0007160, GO:0050900, GO:0007411, GO:0010745, GO:0050748, GO:0032369, GO:0007229, GO:0045715, GO:0010888 C:integrin complex GO:0008305 C:integrin complex GO:0008305 integrin, extracellular GO:0008305, GO:0005576 SWTI000305 P11688, P11276, P09055 Itga5, Fn1, Itgb1 Regulation of actin cytoskeleton, Phagosome, PI3K-Akt signaling pathway, ECM-receptor interaction, Focal adhesion path:mmu04810, path:mmu04145, path:mmu04151, path:mmu04512, path:mmu04510 Environmental Information Processing; Signal Transduction, Cellular Processes; Transport and Catabolism, Human Diseases; Cancers, Human Diseases; Infectious Diseases, Environmental Information Processing; Signaling Molecules and Interaction, Cellular Processes; Cell Communication, Cellular Processes; Cell Motility, Human Diseases; Cardiovascular Diseases, Organismal Systems; Immune System mmu:16402, mmu:16412 P:leukocyte cell-cell adhesion, P:positive regulation of peptidyl-tyrosine phosphorylation, P:integrin-mediated signaling pathway, P:cell-cell adhesion mediated by integrin GO:0007159, GO:0050731, GO:0007229, GO:0033631 C:external side of plasma membrane, C:ruffle membrane, C:focal adhesion GO:0009897, GO:0032587, GO:0005925 integrin, extracellular GO:0008305, GO:0005576 SWTI000306 P05106, P08514, P17349 ITGB3, ITGA2B, None Signal transduction by L1, GRB2:SOS provides linkage to MAPK signaling for Intergrins, Developmental Biology, Signal Transduction, Hemostasis, Integrin cell surface interactions, SHC1 dissociates from integrin alphaIIb beta3, Axon guidance, Response to elevated platelet cytosolic Ca2+, Integrin alphaIIb beta3 signaling, L1CAM interactions, p130Cas linkage to MAPK signaling for integrins, Platelet Aggregation (Plug Formation), Platelet activation, signaling and aggregation, Platelet degranulation, SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Hematopoietic cell lineage, ECM-receptor interaction, Focal adhesion path:hsa04151, path:hsa04810, path:hsa04640, path:hsa04512, path:hsa04510 Environmental Information Processing; Signal Transduction, Environmental Information Processing; Signaling Molecules and Interaction, Human Diseases; Cancers, Cellular Processes; Cell Communication, Cellular Processes; Cell Motility, Human Diseases; Cardiovascular Diseases, Organismal Systems; Immune System hsa:3690, hsa:3674 P:axon guidance, P:platelet degranulation, P:cell adhesion, P:cell-matrix adhesion, P:integrin-mediated signaling pathway GO:0007411, GO:0002576, GO:0007155, GO:0007160, GO:0007229 C:platelet alpha granule membrane, C:integrin complex GO:0031092, GO:0008305 C:integrin complex GO:0008305 integrin, extracellular GO:0008305, GO:0005576 SWTI000307 P05106, P08514, P17495 ITGB3, ITGA2B, None Signal transduction by L1, GRB2:SOS provides linkage to MAPK signaling for Intergrins, Developmental Biology, Signal Transduction, Hemostasis, Integrin cell surface interactions, SHC1 dissociates from integrin alphaIIb beta3, Axon guidance, Response to elevated platelet cytosolic Ca2+, Integrin alphaIIb beta3 signaling, L1CAM interactions, p130Cas linkage to MAPK signaling for integrins, Platelet Aggregation (Plug Formation), Platelet activation, signaling and aggregation, Platelet degranulation, SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Hematopoietic cell lineage, ECM-receptor interaction, Focal adhesion path:hsa04151, path:hsa04810, path:hsa04640, path:hsa04512, path:hsa04510 Environmental Information Processing; Signal Transduction, Environmental Information Processing; Signaling Molecules and Interaction, Human Diseases; Cancers, Cellular Processes; Cell Communication, Cellular Processes; Cell Motility, Human Diseases; Cardiovascular Diseases, Organismal Systems; Immune System hsa:3690, hsa:3674 P:axon guidance, P:platelet degranulation, P:cell adhesion, P:cell-matrix adhesion, P:integrin-mediated signaling pathway GO:0007411, GO:0002576, GO:0007155, GO:0007160, GO:0007229 C:platelet alpha granule membrane, C:integrin complex GO:0031092, GO:0008305 C:integrin complex GO:0008305 integrin, extracellular GO:0008305, GO:0005576 SWTI000308 P18564, P21404, P06756 ITGB6, None, ITGAV Integrin cell surface interactions, Signal Transduction PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, ECM-receptor interaction, Focal adhesion path:hsa04151, path:hsa04810, path:hsa04512, path:hsa04510 Environmental Information Processing; Signal Transduction, Human Diseases; Cancers, Environmental Information Processing; Signaling Molecules and Interaction, Cellular Processes; Cell Communication, Cellular Processes; Cell Motility, Human Diseases; Cardiovascular Diseases hsa:3694, hsa:3685 P:cell-matrix adhesion, P:integrin-mediated signaling pathway GO:0007160, GO:0007229 C:integrin complex GO:0008305 C:integrin complex GO:0008305 integrin, extracellular GO:0008305, GO:0005576 SWTI000309 P43406, P29788, O54890 Itgav, Vtn, Itgb3 Regulation of actin cytoskeleton, Phagosome, PI3K-Akt signaling pathway, ECM-receptor interaction, Focal adhesion path:mmu04810, path:mmu04145, path:mmu04151, path:mmu04512, path:mmu04510 Environmental Information Processing; Signal Transduction, Cellular Processes; Transport and Catabolism, Environmental Information Processing; Signaling Molecules and Interaction, Human Diseases; Cancers, Cellular Processes; Cell Communication, Cellular Processes; Cell Motility, Human Diseases; Cardiovascular Diseases mmu:16410, mmu:22370, mmu:16416 P:positive regulation of cell migration, P:integrin-mediated signaling pathway, P:positive regulation of osteoblast proliferation, P:cell-matrix adhesion GO:0030335, GO:0007229, GO:0033690, GO:0007160 C:external side of plasma membrane GO:0009897 integrin, extracellular GO:0008305, GO:0005576 SWTI000310 Q66578, P18564, P06756 None, ITGB6, ITGAV Integrin cell surface interactions, Signal Transduction PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, ECM-receptor interaction, Focal adhesion path:hsa04151, path:hsa04810, path:hsa04512, path:hsa04510 Environmental Information Processing; Signal Transduction, Human Diseases; Cancers, Environmental Information Processing; Signaling Molecules and Interaction, Cellular Processes; Cell Communication, Cellular Processes; Cell Motility, Human Diseases; Cardiovascular Diseases hsa:3694, hsa:3685 P:virus-host interaction, P:cell-matrix adhesion, P:integrin-mediated signaling pathway GO:0019048, GO:0007160, GO:0007229 C:integrin complex GO:0008305 C:integrin complex GO:0008305 integrin, extracellular GO:0008305, GO:0005576 SWTI000311 P05106, P02751, P06756 ITGB3, FN1, ITGAV Axon guidance, PECAM1 interactions, Signal transduction by L1, GRB2:SOS provides linkage to MAPK signaling for Intergrins, Hemostasis, Integrin cell surface interactions, Signal Transduction, Response to elevated platelet cytosolic Ca2+, L1CAM interactions, Developmental Biology, Integrin alphaIIb beta3 signaling, p130Cas linkage to MAPK signaling for integrins, Platelet activation, signaling and aggregation, Cell surface interactions at the vascular wall, Platelet Aggregation (Plug Formation), Platelet degranulation Phagosome, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, ECM-receptor interaction, Focal adhesion path:hsa04145, path:hsa04151, path:hsa04810, path:hsa04512, path:hsa04510 Environmental Information Processing; Signal Transduction, Cellular Processes; Transport and Catabolism, Human Diseases; Infectious Diseases, Environmental Information Processing; Signaling Molecules and Interaction, Human Diseases; Cancers, Cellular Processes; Cell Communication, Cellular Processes; Cell Motility, Human Diseases; Cardiovascular Diseases hsa:3690, hsa:2335, hsa:3685 P:negative regulation of lipoprotein metabolic process, P:leukocyte migration, P:axon guidance, P:angiogenesis, P:platelet degranulation, P:negative regulation of macrophage derived foam cell differentiation, P:cell-matrix adhesion, P:negative regulation of lipid transport, P:integrin-mediated signaling pathway, P:negative regulation of low-density lipoprotein particle receptor biosynthetic process, P:negative regulation of lipid storage GO:0050748, GO:0050900, GO:0007411, GO:0001525, GO:0002576, GO:0010745, GO:0007160, GO:0032369, GO:0007229, GO:0045715, GO:0010888 C:integrin complex GO:0008305 extracellular GO:0005576 SWTI000312 P61024, P46527, P24941, Q13309 CKS1B, CDKN1B, CDK2, SKP2 Mitotic G1-G1/S phases, Cyclin D associated events in G1, Removal of licensing factors from origins, Cell Cycle, Immune System, G1/S DNA Damage Checkpoints, SCF(Skp2)-mediated degradation of p27/p21, Regulation of DNA replication, Orc1 removal from chromatin, Regulation of mitotic cell cycle, G1/S Transition, Cell Cycle, Mitotic, S Phase, Switching of origins to a post-replicative state, Cell Cycle Checkpoints, Degradation of ubiquitinated p27/p21 by the 26S proteasome, p53-Dependent G1/S DNA damage checkpoint, G1 Phase, Cyclin E associated events during G1/S transition, Adaptive Immune System, p53-Dependent G1 DNA Damage Response, DNA Replication, Cyclin A:Cdk2-associated events at S phase entry, Synthesis of DNA, APC/C-mediated degradation of cell cycle proteins PI3K-Akt signaling pathway, Cell cycle path:hsa04151, path:hsa04110 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers hsa:1163, hsa:1027, hsa:1017, hsa:6502 P:G2/M transition of mitotic cell cycle, P:S phase of mitotic cell cycle, P:G1/S transition of mitotic cell cycle, P:G1 phase of mitotic cell cycle, P:cell division, P:cell proliferation, P:positive regulation of cell proliferation, P:potassium ion transport, P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, P:regulation of cyclin-dependent protein kinase activity GO:0000086, GO:0000084, GO:0000082, GO:0000080, GO:0051301, GO:0008283, GO:0008284, GO:0006813, GO:0031145, GO:0006977, GO:0000079 C:cytosol, C:nucleoplasm, C:endosome GO:0005829, GO:0005654, GO:0005768 C:cytosol GO:0005829 nucleus, cytosol, cycloplasmic cyclin-dependent protein kinase holoenzyme complex, nucleus, cytosol, SCF ubiquitin ligase complex GO:0005634, GO:0005829, GO:0000308, GO:0005634, GO:0005829, GO:0019005 CDK2 P24941 CDK2 P24941 187 ERK1, CDK2, ERK2, CDK6, CDK2 P27361, P24941, P28482, Q00534, P97377 187, 187, 187, 187, 187 SWTI000313 P61024, P49918, Q13309, P24941 CKS1B, CDKN1C, SKP2, CDK2 Mitotic G1-G1/S phases, Cyclin D associated events in G1, Cell Cycle, SCF(Skp2)-mediated degradation of p27/p21, Regulation of mitotic cell cycle, G1/S Transition, Cell Cycle, Mitotic, Degradation of ubiquitinated p27/p21 by the 26S proteasome, S Phase, G1 Phase, Cyclin E associated events during G1/S transition, Cyclin A:Cdk2-associated events at S phase entry, APC/C-mediated degradation of cell cycle proteins Cell cycle path:hsa04110 Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers hsa:1163, hsa:1028, hsa:6502, hsa:1017 P:G2/M transition of mitotic cell cycle, P:S phase of mitotic cell cycle, P:G1/S transition of mitotic cell cycle, P:G1 phase of mitotic cell cycle, P:cell division, P:cell proliferation, P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, P:regulation of cyclin-dependent protein kinase activity, P:positive regulation of transcription, DNA-dependent GO:0000086, GO:0000084, GO:0000082, GO:0000080, GO:0051301, GO:0008283, GO:0031145, GO:0000079, GO:0045893 C:cytosol, C:nucleoplasm GO:0005829, GO:0005654 C:cytosol GO:0005829 nucleus, cytosol, cycloplasmic cyclin-dependent protein kinase holoenzyme complex, nucleus, cytosol, SCF ubiquitin ligase complex GO:0005634, GO:0005829, GO:0000308, GO:0005634, GO:0005829, GO:0019005 CDK2 P24941 SWTI000314 P61025, Q9Z0Z3, P97377, P49919 Cks1b, Skp2, Cdk2, Cdkn1c Cell cycle path:mmu04110 Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers mmu:54124, mmu:27401, mmu:12566, mmu:12577 P:cell division GO:0051301 nucleus, cytosol, cycloplasmic cyclin-dependent protein kinase holoenzyme complex, nucleus, cytosol, SCF ubiquitin ligase complex GO:0005634, GO:0005829, GO:0000308, GO:0005634, GO:0005829, GO:0019005 Cdk2 P97377 SWTI000315 P52294, P03070, Q7Z569 KPNA1, None, BRAP hsa:3836, hsa:8315 F:nuclear localization sequence binding GO:0008139 Nuclear pore, nucleus, NLS-dependent protein nuclear import complex, Nuclear pore, nucleus, NLS-dependent protein nuclear import complex GO:0005643, GO:0005634, GO:0042564, GO:0005643, GO:0005634, GO:0042564 SWTI000316 P52294, Q7Z569, P16790 KPNA1, BRAP, UL44 hsa:3836, hsa:8315 F:nuclear localization sequence binding GO:0008139 Nuclear pore, nucleus, NLS-dependent protein nuclear import complex, Nuclear pore, nucleus, NLS-dependent protein nuclear import complex GO:0005643, GO:0005634, GO:0042564, GO:0005643, GO:0005634, GO:0042564 SWTI000317 P31946, Q9P0K1, P53618 YWHAB, ADAM22, COPB1 Membrane Trafficking Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death hsa:7529, hsa:53616, hsa:1315 C:cytosol GO:0005829 C:cytosol GO:0005829 nucleus, cytosol, internal side of plasma membrane, rough endoplasmic reticulum, endoplasmic reticulum cisterna, cytosol, endoplasmic reticulum membrane, endoplasmic reticulum membrane, integral protein, ER-Golgi transport vesicle membrane, Golgi-ER transport vesicle membrane GO:0005634, GO:0005829, GO:0009898, GO:0005791, GO:0016022, GO:0005829, GO:0005789, GO:0030176, GO:0012507, GO:0012508 SWTI000318 P68134, Q8K4J6, O35344 Acta1, Mkl1, Kpna3 mmu:11459, mmu:223701, mmu:16648 C:cytoplasm, C:nucleus GO:0005737, GO:0005634 C:nucleus GO:0005634 cytosol, Nuclear pore, nucleus, NLS-dependent protein nuclear import complex GO:0005829, GO:0005643, GO:0005634, GO:0042564 SWTI000319 P31946, P53618, P49685 YWHAB, COPB1, GPR15 Membrane Trafficking Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death hsa:7529, hsa:1315, hsa:2838 C:cytosol GO:0005829 C:cytosol GO:0005829 nucleus, cytosol, internal side of plasma membrane, rough endoplasmic reticulum, endoplasmic reticulum cisterna, cytosol, endoplasmic reticulum membrane, endoplasmic reticulum membrane, integral protein, ER-Golgi transport vesicle membrane, Golgi-ER transport vesicle membrane GO:0005634, GO:0005829, GO:0009898, GO:0005791, GO:0016022, GO:0005829, GO:0005789, GO:0030176, GO:0012507, GO:0012508 SWTI000320 P31946, P53618, P04233 YWHAB, COPB1, CD74 Membrane Trafficking, Immune System, Adaptive Immune System Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death hsa:7529, hsa:1315, hsa:972 P:intracellular protein transport GO:0006886 C:plasma membrane, C:cytosol GO:0005886, GO:0005829 C:cytosol GO:0005829 nucleus, cytosol, internal side of plasma membrane, rough endoplasmic reticulum, endoplasmic reticulum cisterna, cytosol, endoplasmic reticulum membrane, endoplasmic reticulum membrane, integral protein, ER-Golgi transport vesicle membrane, Golgi-ER transport vesicle membrane GO:0005634, GO:0005829, GO:0009898, GO:0005791, GO:0016022, GO:0005829, GO:0005789, GO:0030176, GO:0012507, GO:0012508 SWTI000321 O75899, Q9UBS5, P53618 GABBR2, GABBR1, COPB1 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, Potassium Channels, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits, GPCR downstream signaling, GABA receptor activation, G alpha (i) signalling events, Inwardly rectifying K+ channels, Activation of GABAB receptors, Signal Transduction, GPCR ligand binding, Signaling by GPCR, Transmission across Chemical Synapses, G protein gated Potassium channels, Activation of G protein gated Potassium channels, Class C/3 (Metabotropic glutamate/pheromone receptors), Neuronal System, GABA B receptor activation Neuroactive ligand-receptor interaction, GABAergic synapse path:hsa04080, path:hsa04727 Environmental Information Processing; Signaling Molecules and Interaction, Human Diseases; Substance Dependence, Organismal Systems; Nervous System hsa:9568, hsa:2550, hsa:1315 P:gamma-aminobutyric acid signaling pathway, P:synaptic transmission, P:negative regulation of adenylate cyclase activity GO:0007214, GO:0007268, GO:0007194 C:integral to plasma membrane, C:postsynaptic membrane, C:cell junction GO:0005887, GO:0045211, GO:0030054 F:G-protein coupled GABA receptor activity GO:0004965 rough endoplasmic reticulum, endoplasmic reticulum cisterna, cytosol, endoplasmic reticulum membrane, endoplasmic reticulum membrane, integral protein, ER-Golgi transport vesicle membrane, Golgi-ER transport vesicle membrane GO:0005791, GO:0016022, GO:0005829, GO:0005789, GO:0030176, GO:0012507, GO:0012508 SWTI000322 Q8R4T5, O88382 Grasp, Magi2 rno:192254, rno:113970 C:perinuclear region of cytoplasm GO:0048471 cytosol, internal side of plasma membrane, cytosol, internal side of plasma membrane GO:0005829, GO:0009898, GO:0005829, GO:0009898 SWTI000323 Q96PU5, Q04917, P51170 NEDD4L, YWHAH, SCNN1G Aldosterone-regulated sodium reabsorption path:hsa04960 Cellular Processes; Cell Growth and Death, Organismal Systems; Excretory System hsa:23327, hsa:7533, hsa:6340 P:excretion GO:0007588 F:sodium channel regulator activity GO:0017080 nucleus, cytosol, internal side of plasma membrane, cytosol, integral membrane protein, integral plasma membrane protein GO:0005634, GO:0005829, GO:0009898, GO:0005829, GO:0016021, GO:0005887 UNIPROT:O00141 O00141 SWTI000324 P01106, O00499 MYC, BIN1 Human Diseases; Cancers, Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases hsa:4609, hsa:274 C:cytoplasm GO:0005737 cytosol, focal adhesion, plasma membrane, cytosol, focal adhesion, plasma membrane GO:0005829, GO:0005925, GO:0005886, GO:0005829, GO:0005925, GO:0005886 SWTI000325 P27986, P06213 PIK3R1, INSR Insulin receptor signalling cascade, Signal Transduction, Signaling by Insulin receptor, IRS-mediated signalling, PI3K Cascade, IRS-related events PI3K-Akt signaling pathway, Aldosterone-regulated sodium reabsorption, HIF-1 signaling pathway, Insulin signaling pathway path:hsa04151, path:hsa04960, path:hsa04066, path:hsa04910 Human Diseases; Endocrine and Metabolic Diseases, Environmental Information Processing; Signal Transduction, Organismal Systems; Excretory System, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Cellular Processes; Cell Communication, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:5295, hsa:3643 P:positive regulation of glucose import GO:0046326 F:insulin binding GO:0043559 cytosol GO:0005829 SWTI000326 P08965, P42656 mei2, rad24 spo:SPAC27D7.03c, spo:SPAC8E11.02c C:cytosol GO:0005829 SWTI000327 Q02410, P49768 APBA1, PSEN1 Environmental Information Processing; Signal Transduction hsa:320, hsa:5663 cytosol, internal side of plasma membrane, cytosol, internal side of plasma membrane GO:0005829, GO:0009898, GO:0005829, GO:0009898 SWTI000328 O00499, P50570 BIN1, DNM2 hsa:274, hsa:1785 C:nucleus GO:0005634 cytosol, focal adhesion, plasma membrane GO:0005829, GO:0005925, GO:0005886 SWTI000329 Q02821, P03070 SRP1, None sce:YNL189W Nuclear pore, nucleus, NLS-dependent protein nuclear import complex, Nuclear pore, nucleus, NLS-dependent protein nuclear import complex GO:0005643, GO:0005634, GO:0042564, GO:0005643, GO:0005634, GO:0042564 SWTI000330 Q99741, P46527, P20248 CDC6, CDKN1B, CCNA2 Mitotic G1-G1/S phases, Removal of licensing factors from origins, Cell Cycle, G0 and Early G1, SCF(Skp2)-mediated degradation of p27/p21, Regulation of DNA replication, Orc1 removal from chromatin, G1/S Transition, Cell Cycle, Mitotic, S Phase, Switching of origins to a post-replicative state, Cell Cycle Checkpoints, Degradation of ubiquitinated p27/p21 by the 26S proteasome, Cyclin E associated events during G1/S transition, DNA Replication, Cyclin A:Cdk2-associated events at S phase entry, Synthesis of DNA Cell cycle path:hsa04110 Human Diseases; Cancers, Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death hsa:990, hsa:1027, hsa:890 P:S phase of mitotic cell cycle, P:mitosis, P:cell division, P:negative regulation of cell proliferation, P:regulation of cyclin-dependent protein kinase activity GO:0000084, GO:0007067, GO:0051301, GO:0008285, GO:0000079 C:cytosol, C:nucleoplasm GO:0005829, GO:0005654 C:cytosol GO:0005829 nucleus, cytosol, nucleus, cytosol GO:0005634, GO:0005829, GO:0005634, GO:0005829 SWTI000331 Q61187, Q8BT07, Q7M6U3 Tsg101, Cep55, Tex14 mmu:22088, mmu:74107, mmu:83560 P:cell division GO:0051301 C:cytoplasm, C:intercellular bridge, C:midbody GO:0005737, GO:0045171, GO:0030496 SWTI000332 Q9WU78, Q8BT07, Q7M6U3 Pdcd6ip, Cep55, Tex14 mmu:18571, mmu:74107, mmu:83560 P:cell division GO:0051301 C:intercellular bridge, C:midbody GO:0045171, GO:0030496 SWTI000333 O14745, P35222 SLC9A3R1, CTNNB1 Human Diseases; Infectious Diseases, Human Diseases; Cancers, Cellular Processes; Cell Communication hsa:9368, hsa:1499 P:negative regulation of cell proliferation GO:0008285 C:centrosome, C:microvillus membrane GO:0005813, GO:0031528 cytosol, internal side of plasma membrane, cytosol, internal side of plasma membrane GO:0005829, GO:0009898, GO:0005829, GO:0009898 SWTI000334 P31424, Q8R4T5 Grm5, Grasp Organismal Systems; Nervous System rno:24418, rno:192254 C:postsynaptic membrane, C:plasma membrane GO:0045211, GO:0005886 cytosol, internal side of plasma membrane, cytosol, internal side of plasma membrane GO:0005829, GO:0009898, GO:0005829, GO:0009898 SWTI000335 P21333, P26010, Q9Y490 FLNA, ITGB7, TLN1 Response to elevated platelet cytosolic Ca2+, Hemostasis, Integrin cell surface interactions, Signal Transduction, Platelet activation, signaling and aggregation, Platelet degranulation Focal adhesion path:hsa04510 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Environmental Information Processing; Signaling Molecules and Interaction, Cellular Processes; Cell Communication, Human Diseases; Cardiovascular Diseases hsa:2316, hsa:3695, hsa:7094 P:platelet degranulation, P:cell adhesion, P:platelet activation GO:0002576, GO:0007155, GO:0030168 C:actin cytoskeleton, C:cytosol, C:extracellular region GO:0015629, GO:0005829, GO:0005576 SWTI000336 Q04724, Q14469, P56915 TLE1, HES1, GSC Signal Transduction, Signaling by NOTCH1, Signaling by NOTCH, NOTCH1 Intracellular Domain Regulates Transcription hsa:7088, hsa:3280, hsa:145258 P:negative regulation of Wnt receptor signaling pathway, P:Notch signaling pathway GO:0030178, GO:0007219 C:nucleus, C:transcription factor complex GO:0005634, GO:0005667 F:sequence-specific DNA binding GO:0043565 C:nucleus GO:0005634 nucleus, nucleus GO:0005634, GO:0005634 SWTI000337 P06729, O95400, P06241 CD2, CD2BP2, FYN Hemostasis, Cell surface interactions at the vascular wall Human Diseases; Infectious Diseases, Organismal Systems; Development, Cellular Processes; Cell Communication, Organismal Systems; Immune System hsa:914, hsa:10421, hsa:2534 P:leukocyte migration GO:0050900 cytosol, cytosol, focal adhesion, plasma membrane GO:0005829, GO:0005829, GO:0005925, GO:0005886 SWTI000338 P24864, P30304, P38936 CCNE1, CDC25A, CDKN1A G1/S-Specific Transcription, Mitotic G1-G1/S phases, Cell Cycle, G0 and Early G1, G1/S DNA Damage Checkpoints, SCF(Skp2)-mediated degradation of p27/p21, G1/S Transition, Cell Cycle, Mitotic, p53-Dependent G1/S DNA damage checkpoint, Cell Cycle Checkpoints, Degradation of ubiquitinated p27/p21 by the 26S proteasome, E2F mediated regulation of DNA replication, S Phase, Activation of E2F target genes at G1/S, Cyclin E associated events during G1/S transition, p53-Dependent G1 DNA Damage Response, Cyclin A:Cdk2-associated events at S phase entry PI3K-Akt signaling pathway, Cell cycle, p53 signaling pathway path:hsa04151, path:hsa04110, path:hsa04115 Human Diseases; Infectious Diseases, Human Diseases; Cancers, Environmental Information Processing; Signal Transduction, Cellular Processes; Cell Growth and Death hsa:898, hsa:993, hsa:1026 P:G2/M transition of mitotic cell cycle, P:S phase of mitotic cell cycle, P:G1/S transition of mitotic cell cycle, P:response to corticosterone stimulus, P:cell division, P:organ regeneration, P:regulation of cyclin-dependent protein kinase activity, P:response to drug, P:response to organic nitrogen GO:0000086, GO:0000084, GO:0000082, GO:0051412, GO:0051301, GO:0031100, GO:0000079, GO:0042493, GO:0010243 C:nucleoplasm, C:cytosol, C:cyclin-dependent protein kinase holoenzyme complex GO:0005654, GO:0005829, GO:0000307 C:cytosol GO:0005829 nucleus, cytosol, nucleus, cytosol GO:0005634, GO:0005829, GO:0005634, GO:0005829 SWTI000339 P20248, P06400, P62136 CCNA2, RB1, PPP1CA Mitotic G1-G1/S phases, Removal of licensing factors from origins, Cell Cycle, Regulation of DNA replication, Orc1 removal from chromatin, G1/S Transition, Cell Cycle, Mitotic, Switching of origins to a post-replicative state, S Phase, Cyclin E associated events during G1/S transition, DNA Replication, Cyclin A:Cdk2-associated events at S phase entry, Synthesis of DNA Cell cycle path:hsa04110 Human Diseases; Substance Dependence, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers, Organismal Systems; Nervous System, Organismal Systems; Endocrine System hsa:890, hsa:5925, hsa:5499 P:cell division, P:positive regulation of transcription, DNA-dependent, P:Ras protein signal transduction GO:0051301, GO:0045893, GO:0007265 nucleus, cytosol, nucleus, cytosol, protein phosphatase type 1 complex GO:0005634, GO:0005829, GO:0005634, GO:0005829, GO:0000164 SWTI000340 P04075, Q9Y5X1 ALDOA, SNX9 Metabolism; Carbohydrate Metabolism hsa:226, hsa:51429 SWTI000341 P62993, Q14118, P11532 GRB2, DAG1, DMD Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Development, Cellular Processes; Cell Communication, Human Diseases; Cancers, Human Diseases; Cardiovascular Diseases, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:2885, hsa:1605, hsa:1756 P:virus-host interaction GO:0019048 C:cytoskeleton, C:sarcolemma, C:cytosol, C:dystrophin-associated glycoprotein complex, C:costamere GO:0005856, GO:0042383, GO:0005829, GO:0016010, GO:0043034 F:structural constituent of muscle GO:0008307 C:cytosol GO:0005829 cytosol, integral membrane protein, integral plasma membrane protein, cytosol, focal adhesion, plasma membrane GO:0005829, GO:0016021, GO:0005887, GO:0005829, GO:0005925, GO:0005886 SWTI000342 P13569, Q9UPX8, O14745 CFTR, SHANK2, SLC9A3R1 Organismal Systems; Digestive System hsa:1080, hsa:22941, hsa:9368 C:apical plasma membrane GO:0016324 cytosol, internal side of plasma membrane, cytosol, internal side of plasma membrane GO:0005829, GO:0009898, GO:0005829, GO:0009898 SWTI000343 P18887, Q96T60 XRCC1, PNKP hsa:7515, hsa:11284 F:damaged DNA binding GO:0003684 nucleus, Replication fork, nucleus, Replication fork GO:0005634, GO:0005657, GO:0005634, GO:0005657 UNIPROT:P68400, UNIPROT:P68400 P68400 CK2_alpha P68400 523 CK2-A1, CK2-A2 P68400, P19784 523, 523 SWTI000344 P20963, P43403 CD247, ZAP70 Adaptive Immune System, TCR signaling, Translocation of ZAP-70 to Immunological synapse, Immune System, Generation of second messenger molecules T cell receptor signaling pathway, Natural killer cell mediated cytotoxicity path:hsa04660, path:hsa04650 Organismal Systems; Immune System hsa:919, hsa:7535 P:T cell receptor signaling pathway GO:0050852 C:T cell receptor complex GO:0042101 cytosol, cytosol GO:0005829, GO:0005829 SWTI000345 P11911, P48025 Cd79a, Syk B cell receptor signaling pathway path:mmu04662 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Immune System mmu:12518, mmu:20963 P:B cell receptor signaling pathway GO:0050853 C:B cell receptor complex GO:0019815 cytosol, cytosol GO:0005829, GO:0005829 SWTI000346 P43405, P07766 SYK, CD3E Immune System, Adaptive Immune System Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Immune System hsa:6850, hsa:916 P:positive regulation of calcium-mediated signaling, P:positive regulation of alpha-beta T cell proliferation, P:positive regulation of peptidyl-tyrosine phosphorylation GO:0050850, GO:0046641, GO:0050731 C:T cell receptor complex GO:0042101 cytosol, cytosol GO:0005829, GO:0005829 Fyn, Fyn P06241, P06241 188, 199 SWTI000347 P20963, P43403 CD247, ZAP70 Adaptive Immune System, TCR signaling, Translocation of ZAP-70 to Immunological synapse, Immune System, Generation of second messenger molecules T cell receptor signaling pathway, Natural killer cell mediated cytotoxicity path:hsa04660, path:hsa04650 Organismal Systems; Immune System hsa:919, hsa:7535 P:T cell receptor signaling pathway GO:0050852 C:T cell receptor complex GO:0042101 cytosol, cytosol GO:0005829, GO:0005829 Fyn, Fyn P06241, P06241 111, 123 SWTI000348 P20963, P43403 CD247, ZAP70 Adaptive Immune System, TCR signaling, Translocation of ZAP-70 to Immunological synapse, Immune System, Generation of second messenger molecules T cell receptor signaling pathway, Natural killer cell mediated cytotoxicity path:hsa04660, path:hsa04650 Organismal Systems; Immune System hsa:919, hsa:7535 P:T cell receptor signaling pathway GO:0050852 C:T cell receptor complex GO:0042101 cytosol, cytosol GO:0005829, GO:0005829 Lck P06239 142 SWTI000349 P43403, P09693 ZAP70, CD3G Adaptive Immune System, TCR signaling, Translocation of ZAP-70 to Immunological synapse, Immune System, Generation of second messenger molecules T cell receptor signaling pathway path:hsa04660 Human Diseases; Infectious Diseases, Organismal Systems; Immune System hsa:7535, hsa:917 P:T cell receptor signaling pathway GO:0050852 C:T cell receptor complex GO:0042101 cytosol, cytosol GO:0005829, GO:0005829 SWTI000350 O43613, Q06124 HCRTR1, PTPN11 Signal Transduction Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Immune System hsa:3061, hsa:5781 cytosol, cytosol GO:0005829, GO:0005829 Src P12931 358 SWTI000351 P43405, P12318 SYK, FCGR2A Osteoclast differentiation, Fc gamma R-mediated phagocytosis path:hsa04380, path:hsa04666 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Development, Organismal Systems; Immune System hsa:6850, hsa:2212 cytosol, cytosol GO:0005829, GO:0005829 Fyn, Lyn, SYK, BLK, Fyn, Lyn, SYK, BLK P06241, P07948, P43405, P51451, P06241, P07948, P43405, P51451 288, 288, 288, 288, 304, 304, 304, 304 Fyn, Blk, Fyn, Syk, Blk, Lyn, Lyn P06241, P51451, P39688, P43405, P51451, P07948, P25911 288, 288, 304, 304, 304, 304, 304 SWTI000352 P30273, P43405 FCER1G, SYK GPVI-mediated activation cascade, Hemostasis, GPVI stimulates PI3K beta, gamma, Platelet activation, signaling and aggregation Fc epsilon RI signaling pathway, Natural killer cell mediated cytotoxicity path:hsa04664, path:hsa04650 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Immune System hsa:2207, hsa:6850 P:defense response to bacterium, P:neutrophil activation involved in immune response, P:positive regulation of mast cell degranulation, P:serotonin secretion by platelet, P:neutrophil chemotaxis, P:platelet activation, P:integrin-mediated signaling pathway GO:0042742, GO:0002283, GO:0043306, GO:0002554, GO:0030593, GO:0030168, GO:0007229 cytosol, cytosol GO:0005829, GO:0005829 SWTI000353 P63104, Q02156 YWHAZ, PRKCE Immune System, Hemostasis, Platelet activation, signaling and aggregation Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Organismal Systems; Immune System hsa:7534, hsa:5581 P:platelet activation GO:0030168 C:cytosol, C:mitochondrion, C:perinuclear region of cytoplasm GO:0005829, GO:0005739, GO:0048471 C:cytosol GO:0005829 nucleus, cytosol, internal side of plasma membrane, nucleus, cytosol, internal side of plasma membrane GO:0005634, GO:0005829, GO:0009898, GO:0005634, GO:0005829, GO:0009898 PKCE, PKCA Q02156, P17252 368, 368 SWTI000354 P63104, P04049 YWHAZ, RAF1 Immune System, GP1b-IX-V activation signalling, Hemostasis, Rap1 signalling, Signaling by Interleukins, Platelet activation, signaling and aggregation, Adaptive Immune System, Cytokine Signaling in Immune system PI3K-Akt signaling pathway path:hsa04151 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers, Cellular Processes; Cell Communication, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:7534, hsa:5894 P:platelet activation GO:0030168 C:cytosol GO:0005829 C:cytosol GO:0005829 nucleus, cytosol, internal side of plasma membrane, nucleus, cytosol, internal side of plasma membrane GO:0005634, GO:0005829, GO:0009898, GO:0005634, GO:0005829, GO:0009898 UNIPROT:P31749 P31749 PKA_group 621 AMPKA1, Raf1, PKACa, PKACa Q5EG47, P04049, P17612, P05132 621, 621, 621, 621 SWTI000355 P31946, O43524 YWHAB, FOXO3 Signaling by ERBB4, Signaling by ERBB2, Downstream signal transduction, NGF signalling via TRKA from the plasma membrane, Immune System, Downstream signaling of activated FGFR, DAP12 signaling, Signalling by NGF, Signal Transduction, Signaling by EGFR, Signaling by FGFR in disease, Signaling by PDGF, Developmental Biology, Disease, Signaling by SCF-KIT, Adaptive Immune System, Innate Immune System, DAP12 interactions, Signaling by EGFR in Cancer, Signaling by FGFR PI3K-Akt signaling pathway path:hsa04151 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers hsa:7529, hsa:2309 P:fibroblast growth factor receptor signaling pathway, P:insulin receptor signaling pathway, P:epidermal growth factor receptor signaling pathway, P:nerve growth factor receptor signaling pathway GO:0008543, GO:0008286, GO:0007173, GO:0048011 C:cytosol GO:0005829 C:cytosol GO:0005829 nucleus, cytosol, internal side of plasma membrane, nucleus, cytosol, internal side of plasma membrane GO:0005634, GO:0005829, GO:0009898, GO:0005634, GO:0005829, GO:0009898 UNIPROT:P31749, UNIPROT:P31749 P31749 PKB_group, SGK_group , 32, 32 Akt1, Pim1, Akt1 P47196, P11309, P31749 32, 32, 32 SWTI000356 P31946, P26045 YWHAB, PTPN3 Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death hsa:7529, hsa:5774 nucleus, cytosol, internal side of plasma membrane, nucleus, cytosol, internal side of plasma membrane GO:0005634, GO:0005829, GO:0009898, GO:0005634, GO:0005829, GO:0009898 UNIPROT:P27448 P27448 SWTI000357 Q61097, Q9CQV8 Ksr1, Ywhab Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death mmu:16706, mmu:54401 nucleus, cytosol, internal side of plasma membrane, nucleus, cytosol, internal side of plasma membrane GO:0005634, GO:0005829, GO:0009898, GO:0005634, GO:0005829, GO:0009898 UNIPROT:Q03141, UNIPROT:Q03141 Q03141 NM23, TAK1 P15531, Q62073 392, 392 SWTI000358 Q8IPH9, P29310 Slob, 14-3-3zeta dme:Dmel_CG6772, dme:Dmel_CG17870 C:cytoplasm GO:0005737 nucleus, cytosol, internal side of plasma membrane, nucleus, cytosol, internal side of plasma membrane GO:0005634, GO:0005829, GO:0009898, GO:0005634, GO:0005829, GO:0009898 UNIPROT:Q00168, UNIPROT:Q00168 Q00168 SWTI000359 P35568, P62258 IRS1, YWHAE Signalling by NGF, Signal Transduction PI3K-Akt signaling pathway, Neurotrophin signaling pathway path:hsa04151, path:hsa04722 Environmental Information Processing; Signal Transduction, Organismal Systems; Endocrine System, Cellular Processes; Cell Growth and Death, Organismal Systems; Nervous System hsa:3667, hsa:7531 P:nerve growth factor receptor signaling pathway GO:0048011 C:cytosol GO:0005829 C:cytosol GO:0005829 nucleus, cytosol, internal side of plasma membrane, nucleus, cytosol, internal side of plasma membrane GO:0005634, GO:0005829, GO:0009898, GO:0005634, GO:0005829, GO:0009898 SWTI000360 A9UF02, P62993 None, GRB2 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Development, Cellular Processes; Cell Communication, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:2885 SWTI000361 O15530, Q9HBL0 PDPK1, TNS1 Human Diseases; Cancers, Environmental Information Processing; Signal Transduction, Organismal Systems; Endocrine System hsa:5170, hsa:7145 C:focal adhesion GO:0005925 SRC P12931 376 Src, IGF1R P12931, P08069 376, 376 SWTI000362 O89100, O43561 Grap2, LAT Organismal Systems; Immune System mmu:17444, hsa:27040 SWTI000363 O89100, O43561 Grap2, LAT Organismal Systems; Immune System mmu:17444, hsa:27040 SWTI000364 O54957, Q60631 Lat, Grb2 Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway path:mmu04650, path:mmu04660, path:mmu04664 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Development, Cellular Processes; Cell Communication, Organismal Systems; Immune System, Organismal Systems; Endocrine System mmu:16797, mmu:14784 P:Ras protein signal transduction GO:0007265 cytosol GO:0005829 ZAP70 P43403 175 ZAP70 P43404 175 SWTI000365 O54957, Q60631 Lat, Grb2 Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway path:mmu04650, path:mmu04660, path:mmu04664 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Development, Cellular Processes; Cell Communication, Organismal Systems; Immune System, Organismal Systems; Endocrine System mmu:16797, mmu:14784 P:Ras protein signal transduction GO:0007265 cytosol GO:0005829 ZAP70 P43403 195 ZAP70 P43404 195 SWTI000366 O54957, Q60631 Lat, Grb2 Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway path:mmu04650, path:mmu04660, path:mmu04664 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Development, Cellular Processes; Cell Communication, Organismal Systems; Immune System, Organismal Systems; Endocrine System mmu:16797, mmu:14784 P:Ras protein signal transduction GO:0007265 cytosol GO:0005829 ZAP70 P43403 235 ZAP70 P43404 235 SWTI000367 O60496, Q9HBL0 DOK2, TNS1 hsa:9046, hsa:7145 SWTI000368 Q9NRF2, O60674 SH2B1, JAK2 Signaling by ERBB4, Nuclear signaling by ERBB4, Immune System, Hemostasis, Signal Transduction, Prolactin receptor signaling, Cytokine Signaling in Immune system, Factors involved in megakaryocyte development and platelet production Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Nervous System hsa:25970, hsa:3717 P:blood coagulation GO:0007596 C:cytosol, C:nucleus GO:0005829, GO:0005634 SWTI000369 P46108, O75553 CRK, DAB1 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Immune System hsa:1398, hsa:1600 SWTI000370 P00533, P62993 EGFR, GRB2 Signaling by ERBB4, Signaling by ERBB2, GRB2 events in EGFR signaling, DAP12 signaling, PI3K events in ERBB2 signaling, Signaling by constitutively active EGFR, Signaling by PDGF, Innate Immune System, EGFR downregulation, Developmental Biology, Constitutive PI3K/AKT Signaling in Cancer, Gastrin-CREB signalling pathway via PKC and MAPK, PIP3 activates AKT signaling, PI3K/AKT Signaling in Cancer, NGF signalling via TRKA from the plasma membrane, Downstream Signaling Events Of B Cell Receptor (BCR), GRB2 events in ERBB2 signaling, Signal Transduction, Signaling by GPCR, EGFR Transactivation by Gastrin, Signaling by FGFR, DAP12 interactions, Signaling by EGFR in Cancer, PI-3K cascade, PI3K events in ERBB4 signaling, Downstream signaling of activated FGFR, SHC1 events in ERBB2 signaling, Signaling by EGFR, Signaling by FGFR in disease, Signaling by the B Cell Receptor (BCR), PI3K/AKT activation, Downstream signal transduction, Axon guidance, Immune System, GAB1 signalosome, SHC1 events in EGFR signaling, Signalling by NGF, Disease, Signaling by SCF-KIT, Adaptive Immune System PI3K-Akt signaling pathway, Dorso-ventral axis formation, Focal adhesion, Gap junction, GnRH signaling pathway, ErbB signaling pathway, MAPK signaling pathway path:hsa04151, path:hsa04320, path:hsa04510, path:hsa04540, path:hsa04912, path:hsa04012, path:hsa04010 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Development, Cellular Processes; Cell Communication, Human Diseases; Cancers, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:1956, hsa:2885 P:negative regulation of epidermal growth factor receptor signaling pathway, P:axon guidance GO:0042059, GO:0007411 C:endosome GO:0005768 EGFR P00533 1092 Src, Abl, EGFR P05480, P00519, P00533 1092, 1092, 1092 SWTI000371 P00533, Q13671 EGFR, RIN1 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Communication, Human Diseases; Cancers hsa:1956, hsa:9610 SRC P12931 1016 Src, Abl, EGFR P12931, P00519, P00533 1016, 1016, 1016 SWTI000372 P00533, Q13671 EGFR, RIN1 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Communication, Human Diseases; Cancers hsa:1956, hsa:9610 EGFR P00533 1197 Abl, EGFR P00519, P00533 1197, 1197 SWTI000373 P00533, P23458 EGFR, JAK1 Immune System PI3K-Akt signaling pathway path:hsa04151 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Development, Cellular Processes; Cell Communication, Human Diseases; Cancers hsa:1956, hsa:3716 C:nucleus GO:0005634 F:ATP binding GO:0005524 SRC P12931 1016 Src, Abl, EGFR P12931, P00519, P00533 1016, 1016, 1016 SWTI000374 P00533, O60674 EGFR, JAK2 Signaling by ERBB4, Immune System, Signal Transduction, Signaling by SCF-KIT PI3K-Akt signaling pathway path:hsa04151 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Communication, Human Diseases; Cancers, Organismal Systems; Endocrine System hsa:1956, hsa:3717 P:positive regulation of nitric oxide biosynthetic process, P:protein autophosphorylation, P:positive regulation of cell migration GO:0045429, GO:0046777, GO:0030335 C:nucleus GO:0005634 F:ATP binding GO:0005524 SRC P12931 1016 Src, Abl, EGFR P12931, P00519, P00533 1016, 1016, 1016 SWTI000375 P00533, Q8N5H7 EGFR, SH2D3C Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Communication, Human Diseases; Cancers hsa:1956, hsa:10044 SRC P12931 1016 Src, Abl, EGFR P12931, P00519, P00533 1016, 1016, 1016 SWTI000376 P00533, Q9BRG2 EGFR, SH2D3A Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Communication, Human Diseases; Cancers hsa:1956, hsa:10045 SRC P12931 1016 Src, Abl, EGFR P12931, P00519, P00533 1016, 1016, 1016 SWTI000377 P00533, P42226 EGFR, STAT6 Downstream signal transduction, Signal Transduction, Signaling by PDGF Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Communication, Human Diseases; Cancers hsa:1956, hsa:6778 C:nucleus GO:0005634 SRC P12931 1016 Src, Abl, EGFR P12931, P00519, P00533 1016, 1016, 1016 SWTI000378 P04626, Q14451 ERBB2, GRB7 Signaling by ERBB2, Downstream signal transduction, Signal Transduction, Signaling by PDGF, Signaling by SCF-KIT, GRB7 events in ERBB2 signaling Human Diseases; Cancers, Environmental Information Processing; Signal Transduction, Cellular Processes; Cell Communication hsa:2064, hsa:2886 ErbB2 P04626 1139 HER2 P04626 1139 SWTI000379 P04626, P23458 ERBB2, JAK1 Immune System Human Diseases; Infectious Diseases, Human Diseases; Cancers, Environmental Information Processing; Signal Transduction, Cellular Processes; Cell Communication hsa:2064, hsa:3716 C:nucleus GO:0005634 F:ATP binding GO:0005524 HER2 P04626 1023 SWTI000380 P04626, O60674 ERBB2, JAK2 Signaling by ERBB4, Immune System, Signal Transduction, Signaling by SCF-KIT Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Cellular Processes; Cell Communication hsa:2064, hsa:3717 P:protein autophosphorylation GO:0046777 C:nucleus GO:0005634 F:ATP binding GO:0005524 HER2 P04626 1023 SWTI000381 P04626, O75815 ERBB2, BCAR3 Human Diseases; Cancers, Environmental Information Processing; Signal Transduction, Cellular Processes; Cell Communication hsa:2064, hsa:8412 ErbB2 P04626 1139 HER2 P04626 1139 SWTI000382 P04626, Q9BRG2 ERBB2, SH2D3A Human Diseases; Cancers, Environmental Information Processing; Signal Transduction, Cellular Processes; Cell Communication hsa:2064, hsa:10045 HER2 P04626 1023 SWTI000383 P04626, P42226 ERBB2, STAT6 Downstream signal transduction, Signal Transduction, Signaling by PDGF Human Diseases; Cancers, Environmental Information Processing; Signal Transduction, Cellular Processes; Cell Communication hsa:2064, hsa:6778 P:transcription, DNA-dependent GO:0006351 C:nucleus GO:0005634 ErbB2 P04626 1139 HER2 P04626 1139 SWTI000384 P29353, P04629 SHC1, NTRK1 NGF signalling via TRKA from the plasma membrane, Signalling to ERKs, Signalling by NGF, Signal Transduction, Signalling to RAS Neurotrophin signaling pathway path:hsa04722 Environmental Information Processing; Signal Transduction, Human Diseases; Cancers, Organismal Systems; Nervous System, Organismal Systems; Immune System hsa:6464, hsa:4914 P:Ras protein signal transduction GO:0007265 TRKA, TRKA P04629, P04629 791, 791 SWTI000385 P42679, P04629 MATK, NTRK1 Signal Transduction Neurotrophin signaling pathway path:hsa04722 Organismal Systems; Nervous System, Human Diseases; Cancers hsa:4145, hsa:4914 F:ATP binding GO:0005524 TRKA, TRKA P04629, P04629 791, 791 SWTI000386 Q9NRF2, P07949 SH2B1, RET Human Diseases; Cancers hsa:25970, hsa:5979 RET, RET P07949, P07949 981, 981 Ret P07949 981 SWTI000387 P62993, P08581 GRB2, MET Developmental Biology, Axon guidance PI3K-Akt signaling pathway, Focal adhesion path:hsa04151, path:hsa04510 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Development, Cellular Processes; Cell Communication, Human Diseases; Cancers, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:2885, hsa:4233 P:axon guidance GO:0007411 Met, Met, Met P08581, P08581, P08581 1356, 1356, 1356 Abl, Ron, Met P00519, Q04912, P08581 1356, 1356, 1356 SWTI000388 P27986, P09619 PIK3R1, PDGFRB Signaling by ERBB4, Signaling by ERBB2, Downstream signal transduction, NGF signalling via TRKA from the plasma membrane, PI-3K cascade, Signaling by PDGF, PI3K events in ERBB4 signaling, Immune System, Downstream signaling of activated FGFR, Downstream Signaling Events Of B Cell Receptor (BCR), GAB1 signalosome, DAP12 signaling, Signalling by NGF, Signal Transduction, Signaling by EGFR, Signaling by FGFR in disease, Constitutive PI3K/AKT Signaling in Cancer, PIP3 activates AKT signaling, Disease, Signaling by SCF-KIT, Signaling by the B Cell Receptor (BCR), PI3K/AKT Signaling in Cancer, Signaling by EGFR in Cancer, PI3K events in ERBB2 signaling, PI3K/AKT activation, Adaptive Immune System, Innate Immune System, DAP12 interactions, Signaling by FGFR PI3K-Akt signaling pathway, Focal adhesion, Regulation of actin cytoskeleton path:hsa04151, path:hsa04510, path:hsa04810 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Cellular Processes; Cell Communication, Organismal Systems; Nervous System, Cellular Processes; Cell Motility, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:5295, hsa:5159 PDGFR_beta, PDGFR_group P09619, 751, 751 PDGFRb P09619 751 SWTI000389 P08487, P09619 PLCG1, PDGFRB Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Cellular Processes; Cell Communication, Organismal Systems; Immune System bta:281987, hsa:5159 P:in utero embryonic development GO:0001701 PDGFR_beta P09619 1021 PDGFRb P09619 1021 SWTI000390 P10912, Q06124 GHR, PTPN11 Signaling by ERBB4, Signal Transduction, Nuclear signaling by ERBB4, Immune System, Prolactin receptor signaling, Cytokine Signaling in Immune system Jak-STAT signaling pathway path:hsa04630 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Environmental Information Processing; Signaling Molecules and Interaction, Human Diseases; Cancers, Organismal Systems; Immune System hsa:2690, hsa:5781 P:activation of MAPK activity, P:hormone-mediated signaling pathway GO:0000187, GO:0009755 C:mitochondrion GO:0005739 SWTI000391 P10912, P51692 GHR, STAT5B Signaling by ERBB4, Nuclear signaling by ERBB4, Immune System, Growth hormone receptor signaling, Signal Transduction, Prolactin receptor signaling, Cytokine Signaling in Immune system Jak-STAT signaling pathway path:hsa04630 Human Diseases; Cancers, Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Environmental Information Processing; Signaling Molecules and Interaction hsa:2690, hsa:6777 P:fatty acid metabolic process, P:cytokine-mediated signaling pathway, P:isoleucine metabolic process, P:creatinine metabolic process, P:succinate metabolic process, P:allantoin metabolic process, P:creatine metabolic process, P:response to estradiol stimulus, P:taurine metabolic process, P:valine metabolic process, P:JAK-STAT cascade involved in growth hormone signaling pathway, P:oxaloacetate metabolic process, P:citrate metabolic process, P:2-oxoglutarate metabolic process, P:positive regulation of multicellular organism growth GO:0006631, GO:0019221, GO:0006549, GO:0046449, GO:0006105, GO:0000255, GO:0006600, GO:0032355, GO:0019530, GO:0006573, GO:0060397, GO:0006107, GO:0006101, GO:0006103, GO:0040018 SWTI000392 P14784, P06239 IL2RB, LCK Immune System, Signaling by Interleukins, Cytokine Signaling in Immune system, Interleukin-2 signaling Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Immune System hsa:3560, hsa:3932 P:virus-host interaction GO:0019048 Lck P06239 418 Lck P06239 418 SWTI000393 P42229, P14784 STAT5A, IL2RB Immune System, Interleukin-3, 5 and GM-CSF signaling, Signaling by Interleukins, Cytokine Signaling in Immune system, Interleukin-2 signaling Jak-STAT signaling pathway path:hsa04630 Environmental Information Processing; Signal Transduction, Human Diseases; Cancers, Human Diseases; Infectious Diseases hsa:6776, hsa:3560 P:positive regulation of survival gene product expression GO:0045885 Lck P06239 536 Lck P06239 536 SWTI000394 P14784, P29353 IL2RB, SHC1 Immune System, SHC1 mediates cytokine-induced phosphorylation of GAB2, Interleukin-3, 5 and GM-CSF signaling, Phosphorylated SHC1 recruits GRB2:GAB2, Signaling by Interleukins, Cytokine Signaling in Immune system, Interleukin-2 signaling, Interleukin receptor SHC signaling Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Immune System hsa:3560, hsa:6464 SWTI000395 P14784, P51692 IL2RB, STAT5B Immune System, Interleukin-3, 5 and GM-CSF signaling, Signaling by Interleukins, Cytokine Signaling in Immune system, Interleukin-2 signaling Jak-STAT signaling pathway path:hsa04630 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers hsa:3560, hsa:6777 P:positive regulation of survival gene product expression GO:0045885 Lck P06239 536 Lck P06239 536 SWTI000396 P15260, P42224 IFNGR1, STAT1 Regulation of IFNG signaling, Immune System, Interferon gamma signaling, Interferon Signaling, Cytokine Signaling in Immune system Jak-STAT signaling pathway, Osteoclast differentiation path:hsa04630, path:hsa04380 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Development, Organismal Systems; Immune System hsa:3459, hsa:6772 P:response to virus, P:regulation of interferon-gamma-mediated signaling pathway GO:0009615, GO:0060334 JAK1 P23458 457 SWTI000397 Q15464, P15498 SHB, VAV1 GPVI-mediated activation cascade, Hemostasis, Platelet activation, signaling and aggregation Organismal Systems; Immune System hsa:6461, hsa:7409 P:apoptotic process GO:0006915 C:plasma membrane GO:0005886 Lck P06239 174 SWTI000398 Q7M4L6, P16234 SHF, PDGFRA Environmental Information Processing; Signal Transduction, Cellular Processes; Cell Communication, Human Diseases; Cancers hsa:5156 SWTI000399 P17181, P29597 IFNAR1, TYK2 Interferon Signaling, Regulation of IFNA signaling, Interferon alpha/beta signaling, Cytokine Signaling in Immune system, Immune System Jak-STAT signaling pathway, Osteoclast differentiation path:hsa04630, path:hsa04380 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Development, Organismal Systems; Immune System hsa:3454, hsa:7297 P:type I interferon-mediated signaling pathway, P:regulation of type I interferon-mediated signaling pathway GO:0060337, GO:0060338 Tyk2, Tyk2 P29597, P29597 466, 466 Tyk2 P29597 466 SWTI000400 P17181, P29597 IFNAR1, TYK2 Interferon Signaling, Regulation of IFNA signaling, Interferon alpha/beta signaling, Cytokine Signaling in Immune system, Immune System Jak-STAT signaling pathway, Osteoclast differentiation path:hsa04630, path:hsa04380 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Development, Organismal Systems; Immune System hsa:3454, hsa:7297 P:type I interferon-mediated signaling pathway, P:regulation of type I interferon-mediated signaling pathway GO:0060337, GO:0060338 Tyk2 P29597 481 Tyk2 P29597 481 SWTI000401 P51692, P19235 STAT5B, EPOR Jak-STAT signaling pathway path:hsa04630 Human Diseases; Cancers, Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Immune System hsa:6777, hsa:2057 Lyn, JAK2 P07948, O60674 368, 368 SWTI000402 P51692, P19235 STAT5B, EPOR Jak-STAT signaling pathway path:hsa04630 Human Diseases; Cancers, Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Immune System hsa:6777, hsa:2057 SWTI000403 P51692, P19235 STAT5B, EPOR Jak-STAT signaling pathway path:hsa04630 Human Diseases; Cancers, Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Immune System hsa:6777, hsa:2057 SWTI000404 O75815, P21860 BCAR3, ERBB3 Environmental Information Processing; Signal Transduction hsa:8412, hsa:2065 P:response to drug GO:0042493 SWTI000405 O75815, P21860 BCAR3, ERBB3 Environmental Information Processing; Signal Transduction hsa:8412, hsa:2065 P:response to drug GO:0042493 SWTI000406 O75815, P21860 BCAR3, ERBB3 Environmental Information Processing; Signal Transduction hsa:8412, hsa:2065 P:response to drug GO:0042493 SWTI000407 O75815, P21860 BCAR3, ERBB3 Environmental Information Processing; Signal Transduction hsa:8412, hsa:2065 P:response to drug GO:0042493 SWTI000408 Q9BRG2, P21860 SH2D3A, ERBB3 Environmental Information Processing; Signal Transduction hsa:10045, hsa:2065 SWTI000409 P21860, P42226 ERBB3, STAT6 Downstream signal transduction, Signal Transduction, Signaling by PDGF Environmental Information Processing; Signal Transduction hsa:2065, hsa:6778 C:nucleus GO:0005634 SWTI000410 P22681, P46108 CBL, CRK Immune System, Signal Transduction, Signaling by Interleukins, Interleukin-3, 5 and GM-CSF signaling, Regulation of signaling by CBL, Cytokine Signaling in Immune system Insulin signaling pathway, ErbB signaling pathway path:hsa04910, path:hsa04012 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:867, hsa:1398 C:cytosol, C:nucleus, C:plasma membrane GO:0005829, GO:0005634, GO:0005886 Fyn, SYK, Yes P06241, P43405, P07947 774, 774, 774 Syk, InsR, Src, Abl, Lck, Fyn P43405, P15127, P12931, P00520, P06239, P06241 774, 774, 774, 774, 774, 774 SWTI000411 P24394, P42226 IL4R, STAT6 Jak-STAT signaling pathway path:hsa04630 Environmental Information Processing; Signal Transduction hsa:3566, hsa:6778 SWTI000412 P24394, P42226 IL4R, STAT6 Jak-STAT signaling pathway path:hsa04630 Environmental Information Processing; Signal Transduction hsa:3566, hsa:6778 SWTI000413 P24394, P42226 IL4R, STAT6 Jak-STAT signaling pathway path:hsa04630 Environmental Information Processing; Signal Transduction hsa:3566, hsa:6778 SWTI000414 P24394, Q06124 IL4R, PTPN11 Jak-STAT signaling pathway path:hsa04630 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Immune System hsa:3566, hsa:5781 SWTI000415 P29353, P24394 SHC1, IL4R Environmental Information Processing; Signal Transduction, Human Diseases; Cancers, Organismal Systems; Immune System hsa:6464, hsa:3566 SWTI000416 P24394, Q92835 IL4R, INPP5D Environmental Information Processing; Signal Transduction, Organismal Systems; Immune System hsa:3566, hsa:3635 SWTI000417 P16333, P29320 NCK1, EPHA3 Axon guidance path:hsa04360 Organismal Systems; Development hsa:4690, hsa:2042 EphA3 P29320 602 SWTI000418 P29353, P62993 SHC1, GRB2 Signaling by ERBB4, Signaling by ERBB2, Signaling by constitutively active EGFR, Phosphorylated SHC1 recruits GRB2:GAB2, Integrin alphaIIb beta3 signaling, Signal attenuation, Cytokine Signaling in Immune system, NGF signalling via TRKA from the plasma membrane, SHC1 mediates cytokine-induced phosphorylation of GAB2, Hemostasis, Signal Transduction, Insulin receptor signalling cascade, Interleukin-2 signaling, Cell surface interactions at the vascular wall, SHC-mediated cascade, Signaling by Insulin receptor, Signaling by EGFR in Cancer, SHC1 events in ERBB4 signaling, Signalling to ERKs, Downstream signaling of activated FGFR, Tie2 Signaling, Signaling by FGFR, SHC1 events in ERBB2 signaling, Signaling by EGFR, Signaling by FGFR in disease, Interleukin-3, 5 and GM-CSF signaling, Assembly of Signalosomes at the Activated BCR, Signaling by the B Cell Receptor (BCR), SHC-mediated signalling, SHC-related events, Interleukin receptor SHC signaling, Platelet Aggregation (Plug Formation), Immune System, SHC1 events in EGFR signaling, Signalling by NGF, Integrin cell surface interactions, Signaling by Interleukins, Antigen Activates B Cell Receptor Leading to Generation of Second Messengers, Signalling to RAS, Disease, Platelet activation, signaling and aggregation, Adaptive Immune System Chemokine signaling pathway, Insulin signaling pathway, Neurotrophin signaling pathway, ErbB signaling pathway, Natural killer cell mediated cytotoxicity, Focal adhesion path:hsa04062, path:hsa04910, path:hsa04722, path:hsa04012, path:hsa04650, path:hsa04510 Environmental Information Processing; Signal Transduction, Human Diseases; Substance Dependence, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Development, Cellular Processes; Cell Communication, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:6464, hsa:2885 P:leukocyte migration, P:fibroblast growth factor receptor signaling pathway, P:insulin receptor signaling pathway, P:epidermal growth factor receptor signaling pathway, P:nerve growth factor receptor signaling pathway, P:Ras protein signal transduction, P:platelet activation, P:aging GO:0050900, GO:0008543, GO:0008286, GO:0007173, GO:0048011, GO:0007265, GO:0030168, GO:0007568 C:cytosol GO:0005829 SYK, ZAP70, FLT4 P43405, P43403, P35916 427, 427, 427 Src, Met P12931, P08581 427, 427 SWTI000419 P30273, P43405 FCER1G, SYK GPVI-mediated activation cascade, Hemostasis, GPVI stimulates PI3K beta, gamma, Platelet activation, signaling and aggregation Fc epsilon RI signaling pathway, Natural killer cell mediated cytotoxicity path:hsa04664, path:hsa04650 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Immune System hsa:2207, hsa:6850 P:defense response to bacterium, P:neutrophil activation involved in immune response, P:positive regulation of mast cell degranulation, P:serotonin secretion by platelet, P:neutrophil chemotaxis, P:platelet activation, P:integrin-mediated signaling pathway GO:0042742, GO:0002283, GO:0043306, GO:0002554, GO:0030593, GO:0030168, GO:0007229 SWTI000420 Q8WU20, P62993 FRS2, GRB2 Signaling by ERBB4, Signaling by ERBB2, DAP12 signaling, PI3K events in ERBB2 signaling, Signaling by PDGF, IRS-mediated signalling, Constitutive PI3K/AKT Signaling in Cancer, PI3K/AKT Signaling in Cancer, Signaling by FGFR mutants, IRS-related events, FRS2-mediated cascade, NGF signalling via TRKA from the plasma membrane, Downstream Signaling Events Of B Cell Receptor (BCR), Signal Transduction, Insulin receptor signalling cascade, Signaling by FGFR, Signaling by Insulin receptor, PI3K Cascade, DAP12 interactions, Signaling by EGFR in Cancer, Negative regulation of FGFR signaling, PI-3K cascade, PI3K events in ERBB4 signaling, Signalling to ERKs, Downstream signaling of activated FGFR, Signaling by SCF-KIT, Signaling by EGFR, Signaling by FGFR in disease, Signaling by the B Cell Receptor (BCR), PI3K/AKT activation, Innate Immune System, Downstream signal transduction, Immune System, GAB1 signalosome, Signalling by NGF, PIP3 activates AKT signaling, Disease, Adaptive Immune System Neurotrophin signaling pathway path:hsa04722 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Development, Cellular Processes; Cell Communication, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:10818, hsa:2885 P:fibroblast growth factor receptor signaling pathway, P:insulin receptor signaling pathway, P:nerve growth factor receptor signaling pathway GO:0008543, GO:0008286, GO:0048011 C:endosome GO:0005768 SWTI000421 Q8WU20, P62993 FRS2, GRB2 Signaling by ERBB4, Signaling by ERBB2, DAP12 signaling, PI3K events in ERBB2 signaling, Signaling by PDGF, IRS-mediated signalling, Constitutive PI3K/AKT Signaling in Cancer, PI3K/AKT Signaling in Cancer, Signaling by FGFR mutants, IRS-related events, FRS2-mediated cascade, NGF signalling via TRKA from the plasma membrane, Downstream Signaling Events Of B Cell Receptor (BCR), Signal Transduction, Insulin receptor signalling cascade, Signaling by FGFR, Signaling by Insulin receptor, PI3K Cascade, DAP12 interactions, Signaling by EGFR in Cancer, Negative regulation of FGFR signaling, PI-3K cascade, PI3K events in ERBB4 signaling, Signalling to ERKs, Downstream signaling of activated FGFR, Signaling by SCF-KIT, Signaling by EGFR, Signaling by FGFR in disease, Signaling by the B Cell Receptor (BCR), PI3K/AKT activation, Innate Immune System, Downstream signal transduction, Immune System, GAB1 signalosome, Signalling by NGF, PIP3 activates AKT signaling, Disease, Adaptive Immune System Neurotrophin signaling pathway path:hsa04722 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Development, Cellular Processes; Cell Communication, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:10818, hsa:2885 P:fibroblast growth factor receptor signaling pathway, P:insulin receptor signaling pathway, P:nerve growth factor receptor signaling pathway GO:0008543, GO:0008286, GO:0048011 C:endosome GO:0005768 SWTI000422 Q8WU20, P62993 FRS2, GRB2 Signaling by ERBB4, Signaling by ERBB2, DAP12 signaling, PI3K events in ERBB2 signaling, Signaling by PDGF, IRS-mediated signalling, Constitutive PI3K/AKT Signaling in Cancer, PI3K/AKT Signaling in Cancer, Signaling by FGFR mutants, IRS-related events, FRS2-mediated cascade, NGF signalling via TRKA from the plasma membrane, Downstream Signaling Events Of B Cell Receptor (BCR), Signal Transduction, Insulin receptor signalling cascade, Signaling by FGFR, Signaling by Insulin receptor, PI3K Cascade, DAP12 interactions, Signaling by EGFR in Cancer, Negative regulation of FGFR signaling, PI-3K cascade, PI3K events in ERBB4 signaling, Signalling to ERKs, Downstream signaling of activated FGFR, Signaling by SCF-KIT, Signaling by EGFR, Signaling by FGFR in disease, Signaling by the B Cell Receptor (BCR), PI3K/AKT activation, Innate Immune System, Downstream signal transduction, Immune System, GAB1 signalosome, Signalling by NGF, PIP3 activates AKT signaling, Disease, Adaptive Immune System Neurotrophin signaling pathway path:hsa04722 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Development, Cellular Processes; Cell Communication, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:10818, hsa:2885 P:fibroblast growth factor receptor signaling pathway, P:insulin receptor signaling pathway, P:nerve growth factor receptor signaling pathway GO:0008543, GO:0008286, GO:0048011 C:endosome GO:0005768 SWTI000423 Q8WU20, P62993 FRS2, GRB2 Signaling by ERBB4, Signaling by ERBB2, DAP12 signaling, PI3K events in ERBB2 signaling, Signaling by PDGF, IRS-mediated signalling, Constitutive PI3K/AKT Signaling in Cancer, PI3K/AKT Signaling in Cancer, Signaling by FGFR mutants, IRS-related events, FRS2-mediated cascade, NGF signalling via TRKA from the plasma membrane, Downstream Signaling Events Of B Cell Receptor (BCR), Signal Transduction, Insulin receptor signalling cascade, Signaling by FGFR, Signaling by Insulin receptor, PI3K Cascade, DAP12 interactions, Signaling by EGFR in Cancer, Negative regulation of FGFR signaling, PI-3K cascade, PI3K events in ERBB4 signaling, Signalling to ERKs, Downstream signaling of activated FGFR, Signaling by SCF-KIT, Signaling by EGFR, Signaling by FGFR in disease, Signaling by the B Cell Receptor (BCR), PI3K/AKT activation, Innate Immune System, Downstream signal transduction, Immune System, GAB1 signalosome, Signalling by NGF, PIP3 activates AKT signaling, Disease, Adaptive Immune System Neurotrophin signaling pathway path:hsa04722 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Development, Cellular Processes; Cell Communication, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:10818, hsa:2885 P:fibroblast growth factor receptor signaling pathway, P:insulin receptor signaling pathway, P:nerve growth factor receptor signaling pathway GO:0008543, GO:0008286, GO:0048011 C:endosome GO:0005768 SWTI000424 Q8WU20, Q06124 FRS2, PTPN11 Signaling by ERBB4, Signal Transduction, Negative regulation of FGFR signaling, FRS2-mediated cascade, Downstream signal transduction, NGF signalling via TRKA from the plasma membrane, PI-3K cascade, PI3K events in ERBB4 signaling, Immune System, Downstream signaling of activated FGFR, Downstream Signaling Events Of B Cell Receptor (BCR), Signaling by PDGF, GAB1 signalosome, DAP12 signaling, Signalling by NGF, PI3K events in ERBB2 signaling, Insulin receptor signalling cascade, Signaling by EGFR, Signaling by FGFR in disease, Innate Immune System, Constitutive PI3K/AKT Signaling in Cancer, PIP3 activates AKT signaling, Disease, Signaling by ERBB2, Signaling by SCF-KIT, Signaling by the B Cell Receptor (BCR), PI3K/AKT Signaling in Cancer, Signaling by EGFR in Cancer, PI3K/AKT activation, Adaptive Immune System, IRS-mediated signalling, Signaling by Insulin receptor, PI3K Cascade, DAP12 interactions, IRS-related events, Signaling by FGFR Neurotrophin signaling pathway path:hsa04722 Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Nervous System, Organismal Systems; Immune System hsa:10818, hsa:5781 P:activation of MAPK activity, P:fibroblast growth factor receptor signaling pathway, P:insulin receptor signaling pathway, P:nerve growth factor receptor signaling pathway GO:0000187, GO:0008543, GO:0008286, GO:0048011 SWTI000425 Q8WU20, Q06124 FRS2, PTPN11 Signaling by ERBB4, Signal Transduction, Negative regulation of FGFR signaling, FRS2-mediated cascade, Downstream signal transduction, NGF signalling via TRKA from the plasma membrane, PI-3K cascade, PI3K events in ERBB4 signaling, Immune System, Downstream signaling of activated FGFR, Downstream Signaling Events Of B Cell Receptor (BCR), Signaling by PDGF, GAB1 signalosome, DAP12 signaling, Signalling by NGF, PI3K events in ERBB2 signaling, Insulin receptor signalling cascade, Signaling by EGFR, Signaling by FGFR in disease, Innate Immune System, Constitutive PI3K/AKT Signaling in Cancer, PIP3 activates AKT signaling, Disease, Signaling by ERBB2, Signaling by SCF-KIT, Signaling by the B Cell Receptor (BCR), PI3K/AKT Signaling in Cancer, Signaling by EGFR in Cancer, PI3K/AKT activation, Adaptive Immune System, IRS-mediated signalling, Signaling by Insulin receptor, PI3K Cascade, DAP12 interactions, IRS-related events, Signaling by FGFR Neurotrophin signaling pathway path:hsa04722 Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Nervous System, Organismal Systems; Immune System hsa:10818, hsa:5781 P:activation of MAPK activity, P:fibroblast growth factor receptor signaling pathway, P:insulin receptor signaling pathway, P:nerve growth factor receptor signaling pathway GO:0000187, GO:0008543, GO:0008286, GO:0048011 SWTI000426 Q92918, Q8WV28 MAP4K1, BLNK Environmental Information Processing; Signal Transduction hsa:11184, hsa:29760 SYK P43405 381 SWTI000427 Q99062, O14543 CSF3R, SOCS3 Jak-STAT signaling pathway path:hsa04630 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Endocrine System hsa:1441, hsa:9021 SWTI000428 Q99704, Q92835 DOK1, INPP5D Organismal Systems; Immune System hsa:1796, hsa:3635 C:cytosol GO:0005829 SWTI000429 Q99704, O60880 DOK1, SH2D1A Human Diseases; Infectious Diseases hsa:1796, hsa:4068 SWTI000430 Q05397, O43639 PTK2, NCK2 Axon guidance, Signal Transduction, Developmental Biology, Cell-Cell communication Axon guidance, ErbB signaling pathway path:hsa04360, path:hsa04012 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Development, Organismal Systems; Immune System hsa:5747, hsa:8440 P:axon guidance, P:signal complex assembly GO:0007411, GO:0007172 C:cytosol GO:0005829 FAK Q05397 397 Src, Fgr, Met, FAK P12931, P09769, P08581, Q05397 397, 397, 397, 397 SWTI000431 Q15464, Q13094 SHB, LCP2 Organismal Systems; Immune System hsa:6461, hsa:3937 ZAP70, SYK, ZAP70, Lck, ZAP70 P43403, P43405, P43403, P06239, P43403 113, 113, 113, 113, 113 Syk, ZAP70, Lck P43405, P43403, P06239 113, 113, 113 SWTI000432 Q15464, Q13094 SHB, LCP2 Organismal Systems; Immune System hsa:6461, hsa:3937 ZAP70, SYK, ZAP70, Lck, ZAP70 P43403, P43405, P43403, P06239, P43403 128, 128, 128, 128, 128 Syk, ZAP70, Lck P43405, P43403, P06239 128, 128, 128 SWTI000433 Q15464, Q13094 SHB, LCP2 Organismal Systems; Immune System hsa:6461, hsa:3937 TXK, ZAP70 P42681, P43403 145, 145 ZAP70, Lck P43403, P06239 145, 145 SWTI000434 O60880, Q13291 SH2D1A, SLAMF1 Human Diseases; Infectious Diseases hsa:4068, hsa:6504 Fyn P06241 281 Fyn P06241 281 SWTI000435 O35324, Q13291 Sh2d1b, SLAMF1 hsa:6504 Fyn P06241 281 Fyn P06241 281 SWTI000436 P42679, Q14289 MATK, PTK2B Organismal Systems; Immune System hsa:4145, hsa:2185 P:positive regulation of cell proliferation GO:0008284 C:cytosol, C:nucleus GO:0005829, GO:0005634 F:non-membrane spanning protein tyrosine kinase activity, F:ATP binding GO:0004715, GO:0005524 SYK, PYK2 P43405, Q14289 402, 402 Src, Pyk2 P12931, Q14289 402, 402 SWTI000437 Q16620, O43639 NTRK2, NCK2 Signal Transduction Environmental Information Processing; Signal Transduction hsa:4915, hsa:8440 C:cytosol GO:0005829 SWTI000438 Q03526, Q60787 Itk, Lcp2 T cell receptor signaling pathway path:mmu04660 Organismal Systems; Immune System mmu:16428, mmu:16822 SWTI000439 P52632, Q62120 Stat5b, Jak2 Immune System, Cytokine Signaling in Immune system Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Immune System rno:25126, mmu:16452 P:positive regulation of inflammatory response, P:JAK-STAT cascade involved in growth hormone signaling pathway, P:response to lipopolysaccharide GO:0050729, GO:0060397, GO:0032496 C:cytosol GO:0005829 JAK2 O60674 813 JAK2 Q62120 813 SWTI000440 P56945, P46108 BCAR1, CRK Downstream signal transduction, Signaling by PDGF, Hemostasis, Integrin cell surface interactions, Signal Transduction, Integrin alphaIIb beta3 signaling, p130Cas linkage to MAPK signaling for integrins, Platelet activation, signaling and aggregation, Platelet Aggregation (Plug Formation) Chemokine signaling pathway, Regulation of actin cytoskeleton, Focal adhesion path:hsa04062, path:hsa04810, path:hsa04510 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Cellular Processes; Cell Communication, Cellular Processes; Cell Motility, Organismal Systems; Immune System hsa:9564, hsa:1398 P:nerve growth factor receptor signaling pathway, P:insulin receptor signaling pathway, P:platelet activation GO:0048011, GO:0008286, GO:0030168 C:cytosol GO:0005829 SWTI000441 P12931, P63245 SRC, Gnb2l1 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Communication hsa:6714, rno:83427 P:cell cycle GO:0007049 C:cytoskeleton, C:nucleus GO:0005856, GO:0005634 SWTI000442 P81605, P16333 DCD, NCK1 hsa:117159, hsa:4690 SWTI000443 O43639, P97318 NCK2, Dab1 hsa:8440, mmu:13131 SRC P12931 220 Src, Src, Abl P12931, P05480, P00519 220, 220, 220 SWTI000444 O35718, Q00560 Socs3, Il6st Jak-STAT signaling pathway path:mmu04630 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Endocrine System mmu:12702, mmu:16195 SWTI000445 P42229, P51692 STAT5A, STAT5B Signaling by ERBB4, p(Y449)-IL7RA mediates STAT5 activation, Interleukin-2 signaling, Interleukin-3, 5 and GM-CSF signaling, Growth hormone receptor signaling, Signaling by FGFR1 mutants, Downstream signal transduction, Signal Transduction, Disease, Prolactin receptor signaling, Signaling by SCF-KIT, Signaling by Interleukins, Signaling by FGFR in disease, Cytokine Signaling in Immune system, Interleukin-7 signaling, Immune System, Nuclear signaling by ERBB4, Signaling by PDGF, Phosphorylation of STATs, Signaling by FGFR1 fusion mutants, Signaling by FGFR mutants Jak-STAT signaling pathway, ErbB signaling pathway path:hsa04630, path:hsa04012 Human Diseases; Cancers, Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases hsa:6776, hsa:6777 P:fatty acid metabolic process, P:cytokine-mediated signaling pathway, P:lactation, P:regulation of cell adhesion, P:development of secondary female sexual characteristics, P:positive regulation of survival gene product expression, P:lipid storage, P:positive regulation of gamma-delta T cell differentiation, P:succinate metabolic process, P:positive regulation of inflammatory response, P:isoleucine metabolic process, P:negative regulation of erythrocyte differentiation, P:transcription from RNA polymerase II promoter, P:T cell homeostasis, P:positive regulation of natural killer cell differentiation, P:positive regulation of natural killer cell mediated cytotoxicity, P:regulation of epithelial cell differentiation, P:regulation of steroid metabolic process, P:creatinine metabolic process, P:positive regulation of mitotic cell cycle, P:allantoin metabolic process, P:development of secondary male sexual characteristics, P:T cell differentiation in thymus, P:positive regulation of activated T cell proliferation, P:creatine metabolic process, P:positive regulation of interleukin-2 biosynthetic process, P:luteinization, P:positive regulation of transcription from RNA polymerase II promoter, P:natural killer cell differentiation, P:taurine metabolic process, P:valine metabolic process, P:regulation of multicellular organism growth, P:response to ethanol, P:female pregnancy, P:JAK-STAT cascade involved in growth hormone signaling pathway, P:positive regulation of B cell differentiation, P:oxaloacetate metabolic process, P:citrate metabolic process, P:2-oxoglutarate metabolic process, P:positive regulation of multicellular organism growth, P:Peyer's patch development GO:0006631, GO:0019221, GO:0007595, GO:0030155, GO:0046543, GO:0045885, GO:0019915, GO:0045588, GO:0006105, GO:0050729, GO:0006549, GO:0045647, GO:0006366, GO:0043029, GO:0032825, GO:0045954, GO:0030856, GO:0019218, GO:0046449, GO:0045931, GO:0000255, GO:0046544, GO:0033077, GO:0042104, GO:0006600, GO:0045086, GO:0001553, GO:0045944, GO:0001779, GO:0019530, GO:0006573, GO:0040014, GO:0045471, GO:0007565, GO:0060397, GO:0045579, GO:0006107, GO:0006101, GO:0006103, GO:0040018, GO:0048541 C:nucleoplasm, C:cytosol GO:0005654, GO:0005829 F:sequence-specific DNA binding transcription factor activity, F:double-stranded DNA binding, F:RNA polymerase II core promoter sequence-specific DNA binding, F:calcium ion binding, F:signal transducer activity GO:0003700, GO:0003690, GO:0000979, GO:0005509, GO:0004871 Lyn, SRC, JAK2 P07948, P12931, O60674 694, 694, 694 Syk, Src, Lck, JAK2, JAK3, Lyn P43405, P12931, P06239, O60674, P52333, P25911 694, 694, 694, 694, 694, 694 SWTI000446 P43403, Q13191 ZAP70, CBLB Adaptive Immune System, Immune System T cell receptor signaling pathway path:hsa04660 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Immune System hsa:7535, hsa:868 C:cytosol GO:0005829 Lck, ZAP70, Lck, ZAP70 P06239, P43403, P06239, P43403 292, 292, 292, 292 ZAP70, Lck P43403, P06239 292, 292 SWTI000447 P43405, Q13191 SYK, CBLB Immune System, Antigen Activates B Cell Receptor Leading to Generation of Second Messengers, Assembly of Signalosomes at the Activated BCR, Signaling by the B Cell Receptor (BCR), Adaptive Immune System Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Immune System hsa:6850, hsa:868 C:cytosol GO:0005829 SWTI000448 P46108, P54763 CRK, Ephb2 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Immune System hsa:1398 EphB2 P29323 604 EphB2 P54763 604 SWTI000449 P46108, P54763 CRK, Ephb2 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Immune System hsa:1398 EphB2, EphB2, EphB2 P29323, P29323, P29323 610, 610, 610 EphB2 P54763 610 SWTI000450 P48356, P40763 Lepr, STAT3 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Environmental Information Processing; Signaling Molecules and Interaction, Human Diseases; Cancers, Organismal Systems; Endocrine System mmu:16847, hsa:6774 SWTI000451 P21860, P23458 ERBB3, JAK1 Immune System Human Diseases; Infectious Diseases, Human Diseases; Cancers, Environmental Information Processing; Signal Transduction hsa:2065, hsa:3716 C:nucleus GO:0005634 F:ATP binding GO:0005524 SWTI000452 O60674, P21860 JAK2, ERBB3 Signaling by ERBB4, Immune System, Signal Transduction, Signaling by SCF-KIT Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases hsa:3717, hsa:2065 P:positive regulation of phosphatidylinositol 3-kinase cascade GO:0014068 C:nucleus GO:0005634 F:ATP binding GO:0005524 SWTI000453 O60674, P21860 JAK2, ERBB3 Signaling by ERBB4, Immune System, Signal Transduction, Signaling by SCF-KIT Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases hsa:3717, hsa:2065 P:positive regulation of phosphatidylinositol 3-kinase cascade GO:0014068 C:nucleus GO:0005634 F:ATP binding GO:0005524 SWTI000454 P21860, P52333 ERBB3, JAK3 Immune System Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases hsa:2065, hsa:3718 F:ATP binding GO:0005524 SWTI000455 P29350, P24394 PTPN6, IL4R Jak-STAT signaling pathway path:hsa04630 Environmental Information Processing; Signal Transduction, Organismal Systems; Immune System hsa:5777, hsa:3566 SWTI000456 Q00987, P04637 MDM2, TP53 Cell Cycle, G1/S DNA Damage Checkpoints, Stabilization of p53, p53-Dependent G1/S DNA damage checkpoint, Cell Cycle Checkpoints, p53-Dependent G1 DNA Damage Response PI3K-Akt signaling pathway, Cell cycle, p53 signaling pathway path:hsa04151, path:hsa04110, path:hsa04115 Environmental Information Processing; Signal Transduction, Human Diseases; Neurodegenerative Diseases, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers hsa:4193, hsa:7157 P:virus-host interaction, P:response to antibiotic, P:negative regulation of transcription from RNA polymerase II promoter, P:negative regulation of apoptotic process, P:cellular response to hypoxia, P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0019048, GO:0046677, GO:0000122, GO:0043066, GO:0071456, GO:0006977 C:nucleolus, C:cytosol GO:0005730, GO:0005829 F:zinc ion binding GO:0008270 C:cytosol GO:0005829 nucleus, cytosol GO:0005634, GO:0005829 UNIPROTFAM:Casein kinase I subfamily UNIPROTFAM:Casein kinase I subfamily CK1_group, VRK1, VRK1, TTK , Q99986, Q99986, P33981 18, 18, 18, 18 AMPKA1, Chk1, CK1-D, VRK1, Chk2, DNA-PK, DAPK1, CK1-A Q13131, O14757, P48730, Q99986, O96017, P78527, P53355, P48729 18, 18, 18, 18, 18, 18, 18, 18 SWTI000457 Q92793, P04637 CREBBP, TP53 Wnt signaling pathway, Cell cycle path:hsa04310, path:hsa04110 Environmental Information Processing; Signal Transduction, Human Diseases; Neurodegenerative Diseases, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers, Organismal Systems; Nervous System hsa:1387, hsa:7157 P:virus-host interaction GO:0019048 C:cytoplasm, C:nuclear chromatin GO:0005737, GO:0000790 F:zinc ion binding GO:0008270 ATM, DNA-PK, CK1_group, VRK1, VRK1, TTK, CHK2, CHK1, DAPK1, GSK-3_group, CDK_group, CDK7, DNA-PK, DNA-PK, DNA-PK, DNA-PK, MAPKAPK5, HIPK2, ATM, DYRK2, DYRK2, HIPK2 Q13315, P78527, , Q99986, Q99986, P33981, O96017, O14757, P53355, , , P50613, P78527, P78527, P78527, P78527, Q8IW41, Q9H2X6, Q13315, Q92630, Q92630, Q9H2X6 15, 15, 18, 18, 18, 18, 20, 20, 20, 33, 33, 33, 37, 37, 37, 37, 37, 46, 46, 46, 46, 46 Chk1, ERK1, Chk2, DNA-PK, SMG1, LKB1, ERK2, p38-alpha, ERK2, DYRK1A, CDK5, ATR, ATM, ATM, PRPK, NuaK1, AMPKA1, Chk1, CK1-D, VRK1, Chk2, DNA-PK, DAPK1, CK1-A, AMPKA1, MAPKAPK2, Chk1, CK1-D, Chk2, DNA-PK, DAPK1, CDK5, CK1-A, JNK2, ATM, JNK1, PLK3, DAPK3, DRAK1, CDK7, p38-alpha, CDK5, CDK9, Chk1, Chk2, DNA-PK, MAPKAPK5, ATR, PKCD, DNA-PK, p38-alpha, CDK5, HIPK2, DYRK2, ATM O14757, P27361, O96017, P78527, Q96Q15, Q15831, P63085, Q16539, P28482, Q13627, Q00535, Q13535, NP_000042, Q62388, Q96S44, O60285, Q13131, O14757, P48730, Q99986, O96017, P78527, P53355, P48729, Q13131, P49137, O14757, P48730, O96017, P78527, P53355, Q00535, P48729, P45984, NP_000042, P45983, Q9H4B4, O43293, Q9UEE5, P50613, Q16539, Q00535, P50750, O14757, O96017, P78527, Q8IW41, Q13535, Q05655, P78527, Q16539, Q00535, Q9H2X6, Q92630, NP_000042 15, 15, 15, 15, 15, 15, 15, 15, 15, 15, 15, 15, 15, 15, 15, 15, 18, 18, 18, 18, 18, 18, 18, 18, 20, 20, 20, 20, 20, 20, 20, 20, 20, 20, 20, 20, 20, 20, 20, 33, 33, 33, 33, 37, 37, 37, 37, 37, 46, 46, 46, 46, 46, 46, 46 SWTI000458 P63165, Q9UER7 SUMO1, DAXX hsa:7341, hsa:1616 P:negative regulation of transcription, DNA-dependent GO:0045892 UNIPROTFAM:CK2 subfamily, UNIPROTFAM:CK2 subfamily UNIPROTFAM:CK2 subfamily CK2-A1, CK2-A1 P68400, P68400 737, 739 SWTI000459 P08965, P42656 mei2, rad24 spo:SPAC27D7.03c, spo:SPAC8E11.02c C:cytosol GO:0005829 C:cytosol GO:0005829 nucleus, cytosol, internal side of plasma membrane, cytosol, internal side of plasma membrane, nucleus, mitochondrion GO:0005634, GO:0005829, GO:0009898, GO:0005829, GO:0009898, GO:0005634, GO:0005739 UNIPROT:P08092, UNIPROT:P08092 P08092 SWTI000460 Q9BYG3, P46013 MKI67IP, MKI67 hsa:84365, hsa:4288 C:cytoplasm, C:nucleolus GO:0005737, GO:0005730 nucleus, Replication fork GO:0005634, GO:0005657 UNIPROT:P49841, UNIPROT:P49841 P49841 GSK-3_beta, GSK-3_alpha, GSK-3_beta, GSK-3_alpha P49841, P49840, P49841, P49840 230, 230, 234, 234 GSK3B, GSK3A, GSK3B, GSK3A P49841, P49840, P49841, P49840 230, 230, 234, 234 SWTI000461 Q96CW1, P32004 AP2M1, L1CAM Axon guidance, Signal transduction by L1, L1CAM interactions, Developmental Biology, Recycling pathway of L1 hsa:1173, hsa:3897 P:axon guidance GO:0007411 C:plasma membrane GO:0005886 C:plasma membrane GO:0005886 cytosol, clathrin-coated endocytic vesicle, plasma membrane GO:0005829, GO:0045334, GO:0005886 UNIPROT:P12931 P12931 Src P12931 1176 SWTI000462 P63167, O43521 DYNLL1, BCL2L11 Intrinsic Pathway for Apoptosis, Apoptosis, Activation of BH3-only proteins, Activation of BIM and translocation to mitochondria hsa:8655, hsa:10018 P:induction of apoptosis by intracellular signals, P:activation of pro-apoptotic gene products GO:0008629, GO:0008633 C:cytosol, C:plasma membrane GO:0005829, GO:0005886 C:cytosol GO:0005829 dynein complex, cytosol, cytoplasmic dynein complex GO:0030286, GO:0005829, GO:0005868 UNIPROT:P45983 P45983 SWTI000463 Q4VCS5, P46937 AMOT, YAP1 Signal Transduction, Signaling by Hippo hsa:154796, hsa:10413 P:vasculogenesis, P:hippo signaling cascade GO:0001570, GO:0035329 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol, integral membrane protein, integral plasma membrane protein GO:0005829, GO:0016021, GO:0005887 SWTI000464 Q4VCS5, Q9GZV5 AMOT, WWTR1 Signal Transduction, Signaling by Hippo hsa:154796, hsa:25937 P:hippo signaling cascade GO:0035329 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol, integral membrane protein, integral plasma membrane protein GO:0005829, GO:0016021, GO:0005887 SWTI000465 Q05193, Q08209 DNM1, PPP3CA Signal Transduction Environmental Information Processing; Signal Transduction, Human Diseases; Neurodegenerative Diseases, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Organismal Systems; Development, Organismal Systems; Nervous System, Organismal Systems; Immune System hsa:1759, hsa:5530 cytosol, extrinsic to internal side of plasma membrane, extrinsic to endoplasmic reticulum membrane, intrinsic to internal side of plasma membrane, nucleus, calcineurin complex GO:0005829, GO:0031234, GO:0042406, GO:0031235, GO:0005634, GO:0005955 SWTI000466 P78352, Q9P0K1 DLG4, ADAM22 hsa:1742, hsa:53616 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000467 P30305, Q9UM11 CDC25B, FZR1 Cell Cycle, Cell Cycle, Mitotic, S Phase, Cyclin A:Cdk2-associated events at S phase entry Cell cycle, Progesterone-mediated oocyte maturation path:hsa04110, path:hsa04914 Organismal Systems; Endocrine System, Cellular Processes; Cell Growth and Death hsa:994, hsa:51343 P:mitosis, P:cell division, P:positive regulation of cell proliferation GO:0007067, GO:0051301, GO:0008284 C:nucleoplasm, C:cytosol GO:0005654, GO:0005829 C:cytosol GO:0005829 cytosol, nucleus GO:0005829, GO:0005634 SWTI000468 P36873, P51955 PPP1CC, NEK2 Cell Cycle, Cell Cycle, Mitotic Human Diseases; Substance Dependence, Organismal Systems; Nervous System hsa:5501, hsa:4751 P:cell division GO:0051301 C:nucleolus, C:cytosol, C:midbody, C:condensed chromosome kinetochore GO:0005730, GO:0005829, GO:0030496, GO:0000777 F:metal ion binding GO:0046872 C:cytosol GO:0005829 nucleus, cytosol, protein phosphatase type 1 complex GO:0005634, GO:0005829, GO:0000164 SWTI000469 P62136, P51955 PPP1CA, NEK2 Human Diseases; Substance Dependence, Organismal Systems; Nervous System hsa:5499, hsa:4751 P:cell division GO:0051301 C:nucleolus, C:cytosol GO:0005730, GO:0005829 F:metal ion binding GO:0046872 C:cytosol GO:0005829 nucleus, cytosol, protein phosphatase type 1 complex GO:0005634, GO:0005829, GO:0000164 SWTI000470 Q12834, P51955 CDC20, NEK2 Degradation of multiubiquitinated Nek2A, Cell Cycle, Cell Cycle, Mitotic, APC-Cdc20 mediated degradation of Nek2A Cellular Processes; Cell Growth and Death hsa:991, hsa:4751 P:cell division GO:0051301 C:centrosome, C:cytosol, C:spindle pole GO:0005813, GO:0005829, GO:0000922 SWTI000471 Q9Y297, O43521 BTRC, BCL2L11 Signal Transduction Environmental Information Processing; Signal Transduction hsa:8945, hsa:10018 C:cytosol GO:0005829 SWTI000472 O94826, P43155 TOMM70A, CRAT hsa:9868, hsa:1384 SWTI000473 P05556, Q9Y490 ITGB1, TLN1 Axon guidance, Hemostasis, Integrin cell surface interactions, Signal Transduction, Developmental Biology, Semaphorin interactions Focal adhesion path:hsa04510 Human Diseases; Infectious Diseases, Environmental Information Processing; Signaling Molecules and Interaction, Cellular Processes; Cell Communication, Human Diseases; Cancers, Human Diseases; Cardiovascular Diseases hsa:3688, hsa:7094 P:axon guidance GO:0007411 C:focal adhesion, C:ruffle GO:0005925, GO:0001726 SWTI000474 P05556, Q9Y4G6 ITGB1, TLN2 Focal adhesion path:hsa04510 Human Diseases; Infectious Diseases, Environmental Information Processing; Signaling Molecules and Interaction, Cellular Processes; Cell Communication, Human Diseases; Cancers, Human Diseases; Cardiovascular Diseases hsa:3688, hsa:83660 C:focal adhesion, C:ruffle GO:0005925, GO:0001726 SWTI000475 P05556, P21333 ITGB1, FLNA Cell junction organization, Hemostasis, Cell-extracellular matrix interactions, Cell-Cell communication Focal adhesion path:hsa04510 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Environmental Information Processing; Signaling Molecules and Interaction, Cellular Processes; Cell Communication, Human Diseases; Cancers, Human Diseases; Cardiovascular Diseases hsa:3688, hsa:2316 P:cell junction assembly GO:0034329 SWTI000476 P05556, O75369 ITGB1, FLNB Immune System Focal adhesion path:hsa04510 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Environmental Information Processing; Signaling Molecules and Interaction, Cellular Processes; Cell Communication, Human Diseases; Cancers, Human Diseases; Cardiovascular Diseases hsa:3688, hsa:2317 SWTI000477 O00499, Q00610 BIN1, CLTC Cellular Processes; Transport and Catabolism hsa:274, hsa:1213 cytoskeleton, Golgi apparatus, cytosol, Golgi trans-face, clathrin-coated endocytic vesicle GO:0005856, GO:0005794, GO:0005829, GO:0005802, GO:0045334 SWTI000478 O00499, Q00610 BIN1, CLTC Cellular Processes; Transport and Catabolism hsa:274, hsa:1213 cytoskeleton, cytosol, clathrin-coated endocytic vesicle GO:0005856, GO:0005829, GO:0045334 SWTI000479 O00499 BIN1 hsa:274 SWTI000480 O00499 BIN1 hsa:274 SWTI000481 P03372, Q16881 ESR1, TXNRD1 hsa:2099, hsa:7296 nucleus GO:0005634 SWTI000482 Q92731, Q16881 ESR2, TXNRD1 hsa:2100, hsa:7296 C:mitochondrion GO:0005739 nucleus GO:0005634 SWTI000483 Q01814, Q15599 ATP2B2, SLC9A3R2 Organismal Systems; Digestive System hsa:491, hsa:9351 C:cytoplasm, C:apical plasma membrane, C:plasma membrane GO:0005737, GO:0016324, GO:0005886 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000484 P29475, P23634 NOS1, ATP2B4 Hemostasis, Platelet homeostasis Salivary secretion, Calcium signaling pathway path:hsa04970, path:hsa04020 Environmental Information Processing; Signal Transduction, Human Diseases; Neurodegenerative Diseases, Organismal Systems; Digestive System hsa:4842, hsa:493 P:blood coagulation GO:0007596 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000485 P23634, Q92796 ATP2B4, DLG3 Organismal Systems; Digestive System hsa:493, hsa:1741 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000486 P23634, Q12959 ATP2B4, DLG1 Organismal Systems; Digestive System hsa:493, hsa:1739 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000487 O14936, P23634 CASK, ATP2B4 Organismal Systems; Digestive System hsa:8573, hsa:493 F:ATP binding GO:0005524 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000488 Q96CW1, P32004 AP2M1, L1CAM Axon guidance, Signal transduction by L1, L1CAM interactions, Developmental Biology, Recycling pathway of L1 hsa:1173, hsa:3897 P:axon guidance GO:0007411 C:plasma membrane GO:0005886 C:plasma membrane GO:0005886 cytosol, clathrin-coated endocytic vesicle, plasma membrane GO:0005829, GO:0045334, GO:0005886 SWTI000489 Q13444, P12931 ADAM15, SRC Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Communication hsa:8751, hsa:6714 cytosol, focal adhesion, plasma membrane GO:0005829, GO:0005925, GO:0005886 SWTI000490 Q15303, Q96J02 ERBB4, ITCH Signaling by ERBB4, Immune System, Downregulation of ERBB4 signaling, Signal Transduction, Innate Immune System, Adaptive Immune System Endocytosis path:hsa04144 Environmental Information Processing; Signal Transduction, Cellular Processes; Transport and Catabolism hsa:2066, hsa:83737 P:negative regulation of apoptotic process, P:apoptotic process GO:0043066, GO:0006915 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol, integral membrane protein, integral plasma membrane protein GO:0005829, GO:0016021, GO:0005887 SWTI000491 P30419, O00408 NMT1, PDE2A hsa:4836, hsa:5138 C:cytosol, C:plasma membrane GO:0005829, GO:0005886 C:cytosol GO:0005829 anchored to plasma membrane, cytosol GO:0046658, GO:0005829 SWTI000492 P17612, Q01082 PRKACA, SPTBN1 Axon guidance, Developmental Biology, NCAM signaling for neurite out-growth Environmental Information Processing; Signal Transduction, Human Diseases; Substance Dependence, Organismal Systems; Excretory System, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Organismal Systems; Digestive System, Organismal Systems; Nervous System, Organismal Systems; Sensory System, Organismal Systems; Endocrine System hsa:5566, hsa:6711 C:cytosol, C:plasma membrane GO:0005829, GO:0005886 C:cytosol GO:0005829 cAMP-dependent protein kinase complex, nucleus, cytosol GO:0005952, GO:0005634, GO:0005829 PRKACA P17612 SWTI000493 P42574, Q05655 CASP3, PRKCD Apoptotic cleavage of cellular proteins, Signalling by NGF, Apoptosis, Signal Transduction, Apoptotic execution phase Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Neurodegenerative Diseases, Human Diseases; Cancers, Organismal Systems; Nervous System, Organismal Systems; Immune System hsa:836, hsa:5580 P:nerve growth factor receptor signaling pathway GO:0048011 C:cytosol, C:mitochondrion, C:nucleoplasm, C:plasma membrane GO:0005829, GO:0005739, GO:0005654, GO:0005886 C:cytosol GO:0005829 cytosol, nucleus GO:0005829, GO:0005634 SWTI000494 P63167, O43521 DYNLL1, BCL2L11 Intrinsic Pathway for Apoptosis, Apoptosis, Activation of BH3-only proteins, Activation of BIM and translocation to mitochondria hsa:8655, hsa:10018 P:induction of apoptosis by intracellular signals, P:activation of pro-apoptotic gene products GO:0008629, GO:0008633 C:cytosol, C:plasma membrane GO:0005829, GO:0005886 C:cytosol GO:0005829 dynein complex, cytosol, cytoplasmic dynein complex GO:0030286, GO:0005829, GO:0005868 SWTI000495 P52294, P13051 KPNA1, UNG hsa:3836, hsa:7374 P:virus-host interaction GO:0019048 Nuclear pore, nucleus, NLS-dependent protein nuclear import complex GO:0005643, GO:0005634, GO:0042564 SWTI000496 Q9Z214, P23385 Homer1, Grm1 Glutamatergic synapse path:rno04724 Organismal Systems; Nervous System rno:29546, rno:24414 C:postsynaptic density GO:0014069 cytosol, plasma membrane GO:0005829, GO:0005886 SWTI000497 P97288, Q3UHD6 Htr4, Snx27 mmu:15562, mmu:76742 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000498 P70441, P97288 Slc9a3r1, Htr4 mmu:26941, mmu:15562 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000499 Q63ZW7, P97288 Inadl, Htr4 mmu:12695, mmu:15562 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000500 P27986, Q15303 PIK3R1, ERBB4 Signaling by ERBB4, Signaling by ERBB2, Downstream signal transduction, NGF signalling via TRKA from the plasma membrane, PI-3K cascade, Signaling by PDGF, PI3K events in ERBB4 signaling, Immune System, Downstream signaling of activated FGFR, Downstream Signaling Events Of B Cell Receptor (BCR), GAB1 signalosome, DAP12 signaling, Signalling by NGF, Signal Transduction, Signaling by EGFR, Signaling by FGFR in disease, Constitutive PI3K/AKT Signaling in Cancer, PIP3 activates AKT signaling, Disease, Signaling by SCF-KIT, Signaling by the B Cell Receptor (BCR), PI3K/AKT Signaling in Cancer, Signaling by EGFR in Cancer, PI3K events in ERBB2 signaling, PI3K/AKT activation, Adaptive Immune System, Innate Immune System, DAP12 interactions, Signaling by FGFR ErbB signaling pathway path:hsa04012 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:5295, hsa:2066 P:positive regulation of glucose import GO:0046326 SWTI000501 Q05397, P49023 PTK2, PXN Signal Transduction, Cell-Cell communication VEGF signaling pathway, Chemokine signaling pathway, Regulation of actin cytoskeleton, Leukocyte transendothelial migration, Focal adhesion path:hsa04370, path:hsa04062, path:hsa04810, path:hsa04670, path:hsa04510 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Cellular Processes; Cell Communication, Cellular Processes; Cell Motility, Organismal Systems; Immune System hsa:5747, hsa:5829 P:signal complex assembly, P:growth hormone receptor signaling pathway GO:0007172, GO:0060396 C:lamellipodium, C:cell cortex, C:focal adhesion GO:0030027, GO:0005938, GO:0005925 C:focal adhesion GO:0005925 cytosol, focal adhesion, plasma membrane, intracellular GO:0005829, GO:0005925, GO:0005886, GO:0005622 SWTI000502 P49023, P20936 PXN, RASA1 Signal Transduction Environmental Information Processing; Signal Transduction, Organismal Systems; Immune System hsa:5829, hsa:5921 SWTI000503 P49023, P46108 PXN, CRK Signal Transduction Chemokine signaling pathway, Regulation of actin cytoskeleton, Focal adhesion path:hsa04062, path:hsa04810, path:hsa04510 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Cellular Processes; Cell Communication, Cellular Processes; Cell Motility, Organismal Systems; Immune System hsa:5829, hsa:1398 SWTI000504 P49023, P46108 PXN, CRK Signal Transduction Chemokine signaling pathway, Regulation of actin cytoskeleton, Focal adhesion path:hsa04062, path:hsa04810, path:hsa04510 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Cellular Processes; Cell Communication, Cellular Processes; Cell Motility, Organismal Systems; Immune System hsa:5829, hsa:1398 SWTI000505 P42566, O43426 EPS15, SYNJ1 hsa:2060, hsa:8867 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol, plasma membrane GO:0005829, GO:0005886 SWTI000506 P42566, O43426 EPS15, SYNJ1 hsa:2060, hsa:8867 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol, plasma membrane GO:0005829, GO:0005886 SWTI000507 P42566, O43426 EPS15, SYNJ1 hsa:2060, hsa:8867 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol, plasma membrane GO:0005829, GO:0005886 SWTI000508 O94973, O43426 AP2A2, SYNJ1 hsa:161, hsa:8867 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol, clathrin-coated endocytic vesicle GO:0005829, GO:0045334 SWTI000509 O94973, O43426 AP2A2, SYNJ1 hsa:161, hsa:8867 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol, clathrin-coated endocytic vesicle GO:0005829, GO:0045334 SWTI000510 Q8IPH9 Slob dme:Dmel_CG6772 nucleus, cytosol, internal side of plasma membrane GO:0005634, GO:0005829, GO:0009898 SWTI000511 P68134, Q8VIM5 Acta1, Myocd mmu:11459, mmu:214384 cytosol GO:0005829 SWTI000512 P68134, Q8VIM5 Acta1, Myocd mmu:11459, mmu:214384 cytosol GO:0005829 SWTI000513 P68133, P11532 ACTA1, DMD Human Diseases; Cardiovascular Diseases hsa:58, hsa:1756 P:muscle filament sliding GO:0030049 C:cytosol GO:0005829 F:structural constituent of cytoskeleton GO:0005200 SWTI000514 Q92667 AKAP1 hsa:8165 nucleus, cytosol, protein phosphatase type 1 complex GO:0005634, GO:0005829, GO:0000164 SWTI000515 P98170, Q9NR28 XIAP, DIABLO Intrinsic Pathway for Apoptosis, Apoptosis, SMAC-mediated apoptotic response, SMAC binds to IAPs, Apoptotic factor-mediated response, SMAC-mediated dissociation of IAP:caspase complexes Human Diseases; Infectious Diseases, Human Diseases; Cancers hsa:331, hsa:56616 P:induction of apoptosis by intracellular signals GO:0008629 C:cytosol GO:0005829 SWTI000516 O94826, Q9NR28 TOMM70A, DIABLO hsa:9868, hsa:56616 SWTI000517 Q00987, P04637 MDM2, TP53 Cell Cycle, G1/S DNA Damage Checkpoints, Stabilization of p53, p53-Dependent G1/S DNA damage checkpoint, Cell Cycle Checkpoints, p53-Dependent G1 DNA Damage Response PI3K-Akt signaling pathway, Cell cycle, p53 signaling pathway path:hsa04151, path:hsa04110, path:hsa04115 Environmental Information Processing; Signal Transduction, Human Diseases; Neurodegenerative Diseases, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers hsa:4193, hsa:7157 P:virus-host interaction, P:response to antibiotic, P:negative regulation of transcription from RNA polymerase II promoter, P:negative regulation of apoptotic process, P:cellular response to hypoxia, P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0019048, GO:0046677, GO:0000122, GO:0043066, GO:0071456, GO:0006977 C:nucleolus, C:cytosol GO:0005730, GO:0005829 F:zinc ion binding GO:0008270 C:cytosol GO:0005829 nucleus, cytosol GO:0005634, GO:0005829 SWTI000518 O14980, P04637 XPO1, TP53 Cell Cycle Genetic Information Processing; Translation, Environmental Information Processing; Signal Transduction, Human Diseases; Neurodegenerative Diseases, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers hsa:7514, hsa:7157 P:virus-host interaction, P:negative regulation of transcription from RNA polymerase II promoter, P:negative regulation of transforming growth factor beta receptor signaling pathway, P:transforming growth factor beta receptor signaling pathway GO:0019048, GO:0000122, GO:0030512, GO:0007179 C:nucleolus, C:cytosol GO:0005730, GO:0005829 C:cytosol GO:0005829 nucleus, cytosol GO:0005634, GO:0005829 SWTI000519 Q93009, P04637 USP7, TP53 Environmental Information Processing; Signal Transduction, Human Diseases; Neurodegenerative Diseases, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers hsa:7874, hsa:7157 P:virus-host interaction GO:0019048 C:PML body, C:cytosol, C:nucleus GO:0016605, GO:0005829, GO:0005634 C:nucleus GO:0005634 nucleus GO:0005634 SWTI000520 Q93009, P04637 USP7, TP53 Environmental Information Processing; Signal Transduction, Human Diseases; Neurodegenerative Diseases, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers hsa:7874, hsa:7157 P:virus-host interaction GO:0019048 C:PML body, C:cytosol, C:nucleus GO:0016605, GO:0005829, GO:0005634 C:nucleus GO:0005634 nucleus GO:0005634 SWTI000521 Q9UK53, P12004 ING1, PCNA Genetic Information Processing; Replication and Repair, Human Diseases; Infectious Diseases hsa:3621, hsa:5111 SWTI000522 P78381, P53621 SLC35A2, COPA hsa:7355, hsa:1314 rough endoplasmic reticulum, endoplasmic reticulum, COPI coated vesicle membrane, endoplasmic reticulum cisterna, cytosol, endoplasmic reticulum membrane, endoplasmic reticulum membrane, integral protein, ER-Golgi transport vesicle membrane, Golgi-ER transport vesicle membrane GO:0005791, GO:0005783, GO:0030663, GO:0016022, GO:0005829, GO:0005789, GO:0030176, GO:0012507, GO:0012508 SWTI000523 O94826, P13051 TOMM70A, UNG hsa:9868, hsa:7374 SWTI000524 P20020, P62158 ATP2B1, CALM1 Hemostasis Salivary secretion, Calcium signaling pathway path:hsa04970, path:hsa04020 Environmental Information Processing; Signal Transduction, Human Diseases; Substance Dependence, Organismal Systems; Endocrine System, Human Diseases; Infectious Diseases, Organismal Systems; Digestive System, Organismal Systems; Nervous System, Organismal Systems; Sensory System hsa:490, hsa:801 SWTI000525 Q96PU5, P84022 NEDD4L, SMAD3 Signaling by TGF-beta Receptor Complex, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Signal Transduction, TGF-beta receptor signaling activates SMADs, Generic Transcription Pathway, Downregulation of TGF-beta receptor signaling, Gene Expression, Downregulation of SMAD2/3:SMAD4 transcriptional activity Endocytosis path:hsa04144 Environmental Information Processing; Signal Transduction, Cellular Processes; Transport and Catabolism, Human Diseases; Infectious Diseases, Human Diseases; Cancers hsa:23327, hsa:4088 P:negative regulation of transcription from RNA polymerase II promoter, P:transcription initiation from RNA polymerase II promoter, P:negative regulation of transforming growth factor beta receptor signaling pathway, P:transforming growth factor beta receptor signaling pathway GO:0000122, GO:0006367, GO:0030512, GO:0007179 C:cytosol, C:nucleoplasm GO:0005829, GO:0005654 C:cytosol GO:0005829 cytosol, integral membrane protein, integral plasma membrane protein GO:0005829, GO:0016021, GO:0005887 UNIPROTFAM:CDC2/CDKX subfamily, UNIPROT:P49841, UNIPROTFAM:CDC2/CDKX subfamily P49841, UNIPROTFAM:CDC2/CDKX subfamily MAPK1, MAPK1, MAPK1, MAPK1, MAPK1, MAPK1 P28482, P28482, P28482, P28482, P28482, P28482 204, 204, 204, 208, 208, 208 ERK2, CDK4, MELK, ERK2, CDK4, CDK9, CDK8 P28482, P11802, Q61846, P28482, P11802, P50750, P49336 204, 204, 204, 208, 208, 208, 208 SWTI000526 Q96PU5, P84022 NEDD4L, SMAD3 Signaling by TGF-beta Receptor Complex, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Signal Transduction, TGF-beta receptor signaling activates SMADs, Generic Transcription Pathway, Downregulation of TGF-beta receptor signaling, Gene Expression, Downregulation of SMAD2/3:SMAD4 transcriptional activity Endocytosis path:hsa04144 Environmental Information Processing; Signal Transduction, Cellular Processes; Transport and Catabolism, Human Diseases; Infectious Diseases, Human Diseases; Cancers hsa:23327, hsa:4088 P:negative regulation of transcription from RNA polymerase II promoter, P:transcription initiation from RNA polymerase II promoter, P:negative regulation of transforming growth factor beta receptor signaling pathway, P:transforming growth factor beta receptor signaling pathway GO:0000122, GO:0006367, GO:0030512, GO:0007179 C:cytosol, C:nucleoplasm GO:0005829, GO:0005654 UNIPROT:P49841, UNIPROTFAM:CDC2/CDKX subfamily P49841, UNIPROTFAM:CDC2/CDKX subfamily MAPK1, MAPK1, MAPK1, MAPK1, MAPK1, MAPK1 P28482, P28482, P28482, P28482, P28482, P28482 204, 204, 204, 208, 208, 208 ERK2, CDK4, MELK, ERK2, CDK4, CDK9, CDK8 P28482, P11802, Q61846, P28482, P11802, P50750, P49336 204, 204, 204, 208, 208, 208, 208 SWTI000527 P55211, P98170 CASP9, XIAP Intrinsic Pathway for Apoptosis, SMAC binds to IAPs, Apoptosis, Apoptotic factor-mediated response, SMAC-mediated apoptotic response, SMAC-mediated dissociation of IAP:caspase complexes Apoptosis path:hsa04210 Environmental Information Processing; Signal Transduction, Human Diseases; Neurodegenerative Diseases, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers hsa:842, hsa:331 P:induction of apoptosis by intracellular signals, P:response to DNA damage stimulus GO:0008629, GO:0006974 C:nucleus GO:0005634 Cytoplasm, cytosol, mitochondrion GO:0005737, GO:0005829, GO:0005739 SWTI000528 P55211, Q13490 CASP9, BIRC2 Immune System, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Apoptosis, Innate Immune System, NOD1/2 Signaling Pathway Apoptosis path:hsa04210 Environmental Information Processing; Signal Transduction, Human Diseases; Neurodegenerative Diseases, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers hsa:842, hsa:329 C:nucleus GO:0005634 Cytoplasm, cytosol, mitochondrion GO:0005737, GO:0005829, GO:0005739 SWTI000529 P55210, Q13490 CASP7, BIRC2 Apoptotic cleavage of cellular proteins, Apoptotic execution phase, Apoptosis Apoptosis path:hsa04210 Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers hsa:840, hsa:329 P:cellular component disassembly involved in apoptotic process GO:0006921 C:cytosol GO:0005829 C:cytosol GO:0005829 Cytoplasm, cytosol, mitochondrion GO:0005737, GO:0005829, GO:0005739 SWTI000530 Q24306, O02002 th, Dcp-1 dme:Dmel_CG12284, dme:Dmel_CG5370 cytosol, mitochondrion GO:0005829, GO:0005739 SWTI000531 O01382, Q24306 Ice, th dme:Dmel_CG7788, dme:Dmel_CG12284 cytosol, mitochondrion GO:0005829, GO:0005739 SWTI000532 P48542, Q3UHD6 Kcnj6, Snx27 Organismal Systems; Nervous System mmu:16522, mmu:76742 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000533 P52294, P15791 KPNA1, Camk2d Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Nervous System, Organismal Systems; Endocrine System hsa:3836, rno:24246 Nuclear pore, nucleus, NLS-dependent protein nuclear import complex GO:0005643, GO:0005634, GO:0042564 SWTI000534 Q8C437, P84091 Pex5l, Ap2m1 mmu:58869, mmu:11773 cytosol, clathrin-coated endocytic vesicle, plasma membrane GO:0005829, GO:0045334, GO:0005886 SWTI000535 Q8C437, P62743 Pex5l, Ap2s1 mmu:58869, mmu:232910 Endocytic vesicle, cytosol GO:0030139, GO:0005829 SWTI000536 P63279, Q9ULV5 UBE2I, HSF4 hsa:7329, hsa:3299 nucleus, PML body GO:0005634, GO:0016605 SWTI000537 P63279, Q9ULV5 UBE2I, HSF4 hsa:7329, hsa:3299 nucleus, PML body GO:0005634, GO:0016605 SWTI000538 O15350, Q13526 TP73, PIN1 hsa:7161, hsa:5300 nucleus, cytosol GO:0005634, GO:0005829 SWTI000539 O15350, Q13526 TP73, PIN1 hsa:7161, hsa:5300 nucleus, cytosol GO:0005634, GO:0005829 SWTI000540 O15350, Q13526 TP73, PIN1 hsa:7161, hsa:5300 nucleus, cytosol GO:0005634, GO:0005829 SWTI000541 Q96FJ2, Q9Y4I1 DYNLL2, MYO5A hsa:140735, hsa:4644 P:transport GO:0006810 C:myosin complex GO:0016459 SWTI000542 Q13127, Q9Y297 REST, BTRC Environmental Information Processing; Signal Transduction hsa:5978, hsa:8945 P:positive regulation of transcription, DNA-dependent GO:0045893 C:cytosol GO:0005829 SWTI000543 P52294, Q969H0 KPNA1, FBXW7 Immune System hsa:3836, hsa:55294 P:virus-host interaction GO:0019048 C:nucleoplasm GO:0005654 Nuclear pore, nucleus, NLS-dependent protein nuclear import complex GO:0005643, GO:0005634, GO:0042564 SWTI000544 Q969H0, O14980 FBXW7, XPO1 Signal Transduction Genetic Information Processing; Translation, Human Diseases; Infectious Diseases hsa:55294, hsa:7514 P:virus-host interaction GO:0019048 C:nucleolus, C:nucleoplasm GO:0005730, GO:0005654 SWTI000545 P53680, Q8WY21 AP2S1, SORCS1 hsa:1175, hsa:114815 SWTI000546 Q8WY21, Q96CW1 SORCS1, AP2M1 hsa:114815, hsa:1173 cytosol, clathrin-coated endocytic vesicle, plasma membrane GO:0005829, GO:0045334, GO:0005886 SWTI000547 O60880, Q9NQ25 SH2D1A, SLAMF7 hsa:4068, hsa:57823 cytosol GO:0005829 SWTI000548 P60953, P49354 CDC42, FNTA Developmental Biology, Axon guidance, Inactivation of Cdc42 and Rac, Signaling by Robo receptor Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Communication, Human Diseases; Cancers, Organismal Systems; Immune System hsa:998, hsa:2339 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol GO:0005829 SWTI000549 P60953, Q9Y397 CDC42, ZDHHC9 Developmental Biology, Axon guidance, Inactivation of Cdc42 and Rac, Signaling by Robo receptor Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Cellular Processes; Cell Communication, Organismal Systems; Immune System hsa:998, hsa:51114 C:Golgi membrane GO:0000139 SWTI000550 P31809, P70677 Ceacam1, Casp3 Human Diseases; Neurodegenerative Diseases, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers mmu:26365, mmu:12367 SWTI000551 O55207, Q9WVJ4 Synj2, Synj2bp rno:84018, rno:64531 P:intracellular distribution of mitochondria GO:0048312 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000552 Q9ES52, P26450 Inpp5d, Pik3r1 B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Phosphatidylinositol signaling system path:mmu04662, path:mmu04664, path:mmu04666, path:mmu04070 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System mmu:16331, mmu:18708 P:positive regulation of apoptotic process, P:negative regulation of osteoclast differentiation GO:0043065, GO:0045671 C:plasma membrane GO:0005886 SWTI000553 P13285, Q8C863 LMP2, Itch mmu:16396 cytosol, integral membrane protein, integral plasma membrane protein GO:0005829, GO:0016021, GO:0005887 SWTI000554 P13285, Q8C863 LMP2, Itch mmu:16396 cytosol, integral membrane protein, integral plasma membrane protein GO:0005829, GO:0016021, GO:0005887 SWTI000555 Q60575, Q9Z0G0 Kif1b, Gipc1 mmu:16561, mmu:67903 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000556 Q80TQ2, P39429 Cyld, Traf2 Osteoclast differentiation, RIG-I-like receptor signaling pathway path:mmu04380, path:mmu04622 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Development, Human Diseases; Cancers, Organismal Systems; Immune System mmu:74256, mmu:22030 P:positive regulation of extrinsic apoptotic signaling pathway GO:2001238 F:zinc ion binding GO:0008270 SWTI000557 P29351, Q91Y57 Ptpn6, Siglec12 Organismal Systems; Immune System mmu:15170, mmu:83382 cytosol GO:0005829 SWTI000558 P35235, Q91Y57 Ptpn11, Siglec12 Human Diseases; Cancers, Organismal Systems; Immune System mmu:19247, mmu:83382 cytosol GO:0005829 SWTI000559 Q86YW5, Q06124 TREML1, PTPN11 Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Immune System hsa:340205, hsa:5781 cytosol GO:0005829 SWTI000560 P22756, Q9EP80 Grik1, Pick1 rno:29559, rno:84591 C:presynaptic membrane GO:0042734 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000561 P22756, P97879 Grik1, Grip1 rno:29559, rno:84016 P:nervous system development GO:0007399 C:postsynaptic membrane, C:neuronal cell body, C:cell junction GO:0045211, GO:0043025, GO:0030054 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000562 P22756, P53618 Grik1, COPB1 rno:29559, hsa:1315 SWTI000563 Q5BJF6, P06493 ODF2, CDK1 Recruitment of mitotic centrosome proteins and complexes, Loss of proteins required for interphase microtubule organizationfrom the centrosome, G2/M Transition, Cell Cycle, Centrosome maturation, Mitotic G2-G2/M phases, Cell Cycle, Mitotic, Loss of Nlp from mitotic centrosomes Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death hsa:4957, hsa:983 P:G2/M transition of mitotic cell cycle GO:0000086 C:cytosol GO:0005829 C:cytosol GO:0005829 nucleus, cytosol, cycloplasmic cyclin-dependent protein kinase holoenzyme complex GO:0005634, GO:0005829, GO:0000308 SWTI000564 P24390, P15246 KDELR1, PCMT1 hsa:10945, bta:613854 endoplasmic reticulum cisterna, Golgi lumen, rough endoplasmic reticulum, endoplasmic reticulum, endoplasmic reticulum lumen GO:0016022, GO:0005796, GO:0005791, GO:0005783, GO:0005788 SWTI000565 P24390, Q32P28 KDELR1, LEPRE1 hsa:10945, hsa:64175 endoplasmic reticulum cisterna, Golgi lumen, rough endoplasmic reticulum, endoplasmic reticulum, endoplasmic reticulum lumen GO:0016022, GO:0005796, GO:0005791, GO:0005783, GO:0005788 SWTI000566 Q13485, O14980 SMAD4, XPO1 Signal Transduction, TGF-beta receptor signaling activates SMADs, Gene Expression, Signaling by TGF-beta Receptor Complex Genetic Information Processing; Translation, Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers hsa:4089, hsa:7514 P:negative regulation of transcription from RNA polymerase II promoter, P:transforming growth factor beta receptor signaling pathway GO:0000122, GO:0007179 C:cytosol GO:0005829 SWTI000567 P15565, O94826 TRM1, TOMM70A sce:YDR120C, hsa:9868 SWTI000568 Q80UN9, O94826 Trit1, TOMM70A mmu:66966, hsa:9868 SWTI000569 Q15046, O94826 KARS, TOMM70A hsa:3735, hsa:9868 SWTI000570 Q9NS18, O94826 GLRX2, TOMM70A hsa:51022, hsa:9868 SWTI000571 O15527, P52294 OGG1, KPNA1 hsa:4968, hsa:3836 Nuclear pore, nucleus, NLS-dependent protein nuclear import complex GO:0005643, GO:0005634, GO:0042564 SWTI000572 O94826, P33316 TOMM70A, DUT hsa:9868, hsa:1854 SWTI000573 O94973, P98082 AP2A2, DAB2 Endocytosis path:hsa04144 Cellular Processes; Transport and Catabolism hsa:161, hsa:1601 cytosol, clathrin-coated endocytic vesicle GO:0005829, GO:0045334 SWTI000574 O94973, P98082 AP2A2, DAB2 Endocytosis path:hsa04144 Cellular Processes; Transport and Catabolism hsa:161, hsa:1601 cytosol, clathrin-coated endocytic vesicle GO:0005829, GO:0045334 SWTI000575 P52294, P29590 KPNA1, PML Interferon Signaling, Immune System, Cytokine Signaling in Immune system Human Diseases; Cancers, Human Diseases; Infectious Diseases hsa:3836, hsa:5371 P:virus-host interaction GO:0019048 C:cytosol GO:0005829 SWTI000576 P63279, P29590 UBE2I, PML Ubiquitin mediated proteolysis path:hsa04120 Human Diseases; Infectious Diseases, Human Diseases; Cancers, Genetic Information Processing; Folding, Sorting and Degradation hsa:7329, hsa:5371 P:virus-host interaction GO:0019048 C:cytoplasm, C:PML body GO:0005737, GO:0016605 C:PML body GO:0016605 nucleus, PML body GO:0005634, GO:0016605 SWTI000577 P29590, O14980 PML, XPO1 Genetic Information Processing; Translation, Human Diseases; Cancers, Human Diseases; Infectious Diseases hsa:5371, hsa:7514 P:transforming growth factor beta receptor signaling pathway, P:virus-host interaction GO:0007179, GO:0019048 C:nucleolus, C:cytosol GO:0005730, GO:0005829 C:cytosol GO:0005829 nucleus, cytosol GO:0005634, GO:0005829 SWTI000578 P05710, P53680 Prlr, AP2S1 Immune System, Signal Transduction Environmental Information Processing; Signal Transduction, Environmental Information Processing; Signaling Molecules and Interaction rno:24684, hsa:1175 Endocytic vesicle, cytosol GO:0030139, GO:0005829 SWTI000579 Q9UHK6, P50542 AMACR, PEX5 Peroxisome path:hsa04146 Cellular Processes; Transport and Catabolism hsa:23600, hsa:5830 C:peroxisomal matrix, C:mitochondrion GO:0005782, GO:0005739 C:peroxisomal matrix GO:0005782 peroxisomal matrix, peroxisome GO:0005782, GO:0005777 SWTI000580 P38398, P52294 BRCA1, KPNA1 hsa:672, hsa:3836 C:nucleoplasm GO:0005654 Nuclear pore, nucleus, NLS-dependent protein nuclear import complex GO:0005643, GO:0005634, GO:0042564 SWTI000581 P40337, Q9Y2N7 VHL, HIF3A Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha, Cellular response to hypoxia, Regulation of Hypoxia-inducible Factor (HIF) by Oxygen, Cellular responses to stress, Nuclear Export of Ubiquitinated HIF-alpha:VHL:EloB/C:CUL2:RBX1 Complex, Destruction of Ubiquitinated HIF-alpha by the Proteasome Human Diseases; Cancers hsa:7428, hsa:64344 C:cytosol, C:nucleoplasm GO:0005829, GO:0005654 C:cytosol GO:0005829 nucleus, cytosol GO:0005634, GO:0005829 SWTI000582 P42229 STAT5A Human Diseases; Cancers, Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases hsa:6776 cytosol GO:0005829 SWTI000583 P54256, P63102 Hap1, Ywhaz Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death rno:29430, rno:25578 C:perinuclear region of cytoplasm GO:0048471 SWTI000584 Q702N8, Q8N8S7 XIRP1, ENAH hsa:165904, hsa:55740 cytosol, plasma membrane GO:0005829, GO:0005886 SWTI000585 Q702N8, P50552 XIRP1, VASP Organismal Systems; Immune System hsa:165904, hsa:7408 cytosol, plasma membrane GO:0005829, GO:0005886 SWTI000586 Q92796, Q9Y2T3 DLG3, GDA hsa:1741, hsa:9615 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000587 Q9GZV5, P62258 WWTR1, YWHAE Signal Transduction, Signaling by Hippo Cellular Processes; Cell Growth and Death hsa:25937, hsa:7531 P:hippo signaling cascade GO:0035329 C:cytosol GO:0005829 C:cytosol GO:0005829 nucleus, cytosol, internal side of plasma membrane GO:0005634, GO:0005829, GO:0009898 SWTI000588 Q05586, P78352 GRIN1, DLG4 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, Activation of NMDA receptor upon glutamate binding and postsynaptic events, Neuronal System, Post NMDA receptor activation events, CREB phosphorylation through the activation of CaMKII, CREB phosphorylation through the activation of Ras, Ras activation uopn Ca2+ infux through NMDA receptor, Unblocking of NMDA receptor, glutamate binding and activation, Transmission across Chemical Synapses Glutamatergic synapse path:hsa04724 Human Diseases; Substance Dependence, Human Diseases; Neurodegenerative Diseases, Organismal Systems; Nervous System hsa:2902, hsa:1742 P:positive regulation of excitatory postsynaptic membrane potential, P:positive regulation of transcription from RNA polymerase II promoter GO:2000463, GO:0045944 C:excitatory synapse, C:postsynaptic membrane, C:postsynaptic density, C:cell junction GO:0060076, GO:0045211, GO:0014069, GO:0030054 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000589 Q05586, P78352, P53618 GRIN1, DLG4, COPB1 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, CREB phosphorylation through the activation of Ras, Unblocking of NMDA receptor, glutamate binding and activation, Post NMDA receptor activation events, Ras activation uopn Ca2+ infux through NMDA receptor, Transmission across Chemical Synapses, Activation of NMDA receptor upon glutamate binding and postsynaptic events, Neuronal System, CREB phosphorylation through the activation of CaMKII Glutamatergic synapse path:hsa04724 Human Diseases; Substance Dependence, Human Diseases; Neurodegenerative Diseases, Organismal Systems; Nervous System hsa:2902, hsa:1742, hsa:1315 P:positive regulation of excitatory postsynaptic membrane potential, P:positive regulation of transcription from RNA polymerase II promoter GO:2000463, GO:0045944 C:excitatory synapse, C:postsynaptic membrane, C:postsynaptic density, C:plasma membrane, C:cell junction GO:0060076, GO:0045211, GO:0014069, GO:0005886, GO:0030054 cytosol, internal side of plasma membrane, rough endoplasmic reticulum, endoplasmic reticulum cisterna, cytosol, endoplasmic reticulum membrane, endoplasmic reticulum membrane, integral protein, ER-Golgi transport vesicle membrane, Golgi-ER transport vesicle membrane GO:0005829, GO:0009898, GO:0005791, GO:0016022, GO:0005829, GO:0005789, GO:0030176, GO:0012507, GO:0012508 SWTI000590 O55207, Q9WVJ4 Synj2, Synj2bp rno:84018, rno:64531 P:intracellular distribution of mitochondria GO:0048312 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000591 O55207, O35964 Synj2, Sh3gl1 rno:84018, rno:81922 cytosol, focal adhesion, plasma membrane GO:0005829, GO:0005925, GO:0005886 SWTI000592 O14745, P51790 SLC9A3R1, CLCN3 hsa:9368, hsa:1182 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000593 P19491, Q9EP80 Gria2, Pick1 Organismal Systems; Nervous System, Human Diseases; Substance Dependence rno:29627, rno:84591 C:presynaptic membrane, C:postsynaptic density GO:0042734, GO:0014069 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000594 Q66T02, Q9Z0G0 Plekhg5, Gipc1 mmu:269608, mmu:67903 P:endothelial cell migration GO:0043542 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000595 P62161, P38377 Calm1, SEC61A1 Environmental Information Processing; Signal Transduction, Human Diseases; Substance Dependence, Human Diseases; Infectious Diseases, Genetic Information Processing; Folding, Sorting and Degradation, Organismal Systems; Digestive System, Organismal Systems; Nervous System, Organismal Systems; Sensory System, Organismal Systems; Endocrine System rno:24242, cfa:404006 cytosol, intracellular GO:0005829, GO:0005622 SWTI000597 P31016, P97924 Dlg4, Kalrn rno:29495, rno:84009 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000598 Q8TEW0, Q9NQ66 PARD3, PLCB1 Signal Transduction Chemokine signaling pathway path:hsa04062 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Neurodegenerative Diseases, Organismal Systems; Digestive System, Cellular Processes; Cell Communication, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:56288, hsa:23236 C:cytosol GO:0005829 F:phosphatidylinositol-4,5-bisphosphate binding GO:0005546 C:cytosol GO:0005829 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000599 P70441, Q9Z1B3 Slc9a3r1, Plcb1 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Neurodegenerative Diseases, Organismal Systems; Digestive System, Organismal Systems; Nervous System, Organismal Systems; Endocrine System mmu:26941, mmu:18795 C:cytoplasm GO:0005737 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000600 Q9NQ66, Q9BYB0 PLCB1, SHANK3 Glutamatergic synapse path:hsa04724 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Neurodegenerative Diseases, Organismal Systems; Digestive System, Organismal Systems; Nervous System, Organismal Systems; Endocrine System hsa:23236, hsa:85358 P:memory GO:0007613 cytosol, focal adhesion, plasma membrane GO:0005829, GO:0005925, GO:0005886 SWTI000601 P84091, O70161 Ap2m1, Pip5k1c Endocytosis path:mmu04144 Cellular Processes; Transport and Catabolism mmu:11773, mmu:18717 cytosol, clathrin-coated endocytic vesicle, plasma membrane GO:0005829, GO:0045334, GO:0005886 SWTI000602 P26039, O70161 Tln1, Pip5k1c Focal adhesion path:mmu04510 Cellular Processes; Cell Communication mmu:21894, mmu:18717 P:cell adhesion GO:0007155 C:focal adhesion, C:ruffle membrane GO:0005925, GO:0032587 SWTI000603 P26039, O70161 Tln1, Pip5k1c Focal adhesion path:mmu04510 Cellular Processes; Cell Communication mmu:21894, mmu:18717 P:cell adhesion GO:0007155 C:focal adhesion, C:ruffle membrane GO:0005925, GO:0032587 UNIPROT:P49615 P49615 SWTI000604 P26039, O70161 Tln1, Pip5k1c Focal adhesion path:mmu04510 Cellular Processes; Cell Communication mmu:21894, mmu:18717 P:cell adhesion GO:0007155 C:focal adhesion, C:ruffle membrane GO:0005925, GO:0032587 SRC P12931 644 Src P12931 644 SWTI000605 Q9DBG3, O70161 Ap2b1, Pip5k1c Endocytosis path:mmu04144 Cellular Processes; Transport and Catabolism mmu:71770, mmu:18717 SWTI000606 Q9DBG3, O70161 Ap2b1, Pip5k1c Endocytosis path:mmu04144 Cellular Processes; Transport and Catabolism mmu:71770, mmu:18717 UNIPROT:P49615 P49615 SWTI000607 P52294, Q00987 KPNA1, MDM2 Immune System, Disease Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers hsa:3836, hsa:4193 P:virus-host interaction GO:0019048 C:cytosol, C:nucleoplasm GO:0005829, GO:0005654 Nuclear pore, nucleus, NLS-dependent protein nuclear import complex GO:0005643, GO:0005634, GO:0042564 SWTI000608 O14980, Q00987 XPO1, MDM2 Cell Cycle, Signal Transduction, Disease Genetic Information Processing; Translation, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers hsa:7514, hsa:4193 P:protein localization to nucleus, P:virus-host interaction, P:negative regulation of transcription from RNA polymerase II promoter GO:0034504, GO:0019048, GO:0000122 C:nucleolus, C:cytosol, C:nucleoplasm GO:0005730, GO:0005829, GO:0005654 SWTI000609 O60716, O14980 CTNND1, XPO1 Genetic Information Processing; Translation, Human Diseases; Infectious Diseases hsa:1500, hsa:7514 C:cytosol GO:0005829 C:cytosol GO:0005829 nucleus, cytosol GO:0005634, GO:0005829 SWTI000610 O14980, Q14494 XPO1, NFE2L1 Genetic Information Processing; Translation, Human Diseases; Infectious Diseases hsa:7514, hsa:4779 SWTI000611 Q9UQB8, Q92796 BAIAP2, DLG3 hsa:10458, hsa:1741 C:plasma membrane GO:0005886 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000612 P27732, P62161 Cacna1d, Calm1 Vascular smooth muscle contraction, Calcium signaling pathway, Dopaminergic synapse, GnRH signaling pathway, Circadian entrainment path:rno04270, path:rno04020, path:rno04728, path:rno04912, path:rno04713 Environmental Information Processing; Signal Transduction, Human Diseases; Substance Dependence, Organismal Systems; Environmental Adaptation, Organismal Systems; Circulatory System, Human Diseases; Infectious Diseases, Human Diseases; Neurodegenerative Diseases, Organismal Systems; Digestive System, Organismal Systems; Nervous System, Organismal Systems; Sensory System, Human Diseases; Cardiovascular Diseases, Organismal Systems; Endocrine System rno:29716, rno:24242 cytosol, intracellular GO:0005829, GO:0005622 SWTI000613 O75925, P63165 PIAS1, SUMO1 Regulation of IFNG signaling, Interferon gamma signaling, Cytokine Signaling in Immune system, Interferon Signaling, Immune System hsa:8554, hsa:7341 P:interferon-gamma-mediated signaling pathway, P:regulation of interferon-gamma-mediated signaling pathway, P:protein sumoylation GO:0060333, GO:0060334, GO:0016925 C:nuclear speck, C:nucleoplasm GO:0016607, GO:0005654 F:SUMO ligase activity GO:0019789 UNIPROTFAM:CK2 subfamily, UNIPROTFAM:CK2 subfamily, UNIPROTFAM:CK2 subfamily UNIPROTFAM:CK2 subfamily CK2-A1, CK2-A1, CK2-A1 P68400, P68400, P68400 466, 467, 468 SWTI000614 Q96CW1, O60331 AP2M1, PIP5K1C Axon guidance, Developmental Biology Endocytosis path:hsa04144 Cellular Processes; Transport and Catabolism hsa:1173, hsa:23396 P:axon guidance GO:0007411 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol, clathrin-coated endocytic vesicle, plasma membrane GO:0005829, GO:0045334, GO:0005886 UNIPROT:P49615 P49615 SWTI000615 O43639, P97318 NCK2, Dab1 hsa:8440, mmu:13131 UNIPROT:P05480 P05480 SRC P12931 220 Src, Src, Abl P12931, P05480, P00519 220, 220, 220 SWTI000616 O43639, P97318 NCK2, Dab1 hsa:8440, mmu:13131 SRC, SRC P12931, P12931 232, 232 Src, Abl P12931, P00519 232, 232 SWTI000617 Q64010, P97318 Crk, Dab1 Environmental Information Processing; Signal Transduction, Human Diseases; Cancers, Organismal Systems; Immune System mmu:12928, mmu:13131 UNIPROT:P05480 P05480 SRC P12931 220 Src, Src, Abl P12931, P05480, P00519 220, 220, 220 SWTI000618 Q64010, P97318 Crk, Dab1 Environmental Information Processing; Signal Transduction, Human Diseases; Cancers, Organismal Systems; Immune System mmu:12928, mmu:13131 SRC, SRC P12931, P12931 232, 232 Src, Abl P12931, P00519 232, 232 SWTI000619 P05480, P97318 Src, Dab1 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Communication mmu:20779, mmu:13131 cytosol GO:0005829 SWTI000620 P05480, P97318 Src, Dab1 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Communication mmu:20779, mmu:13131 cytosol GO:0005829 Src P05480 SRC P12931 198 Src P12931 198 SWTI000621 O43639, P97318 NCK2, Dab1 hsa:8440, mmu:13131 SRC, SRC P12931, P12931 232, 232 Src, Abl P12931, P00519 232, 232 SWTI000622 Q64010, P97318 Crk, Dab1 Environmental Information Processing; Signal Transduction, Human Diseases; Cancers, Organismal Systems; Immune System mmu:12928, mmu:13131 SRC, SRC P12931, P12931 232, 232 Src, Abl P12931, P00519 232, 232 SWTI000623 P05480, P97318 Src, Dab1 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Communication mmu:20779, mmu:13131 cytosol GO:0005829 SWTI000624 P05480, P97318 Src, Dab1 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Communication mmu:20779, mmu:13131 cytosol GO:0005829 Src P05480 SRC P12931 198 Src P12931 198 SWTI000625 P16471, Q9UKB1 PRLR, FBXW11 Immune System Environmental Information Processing; Signal Transduction, Environmental Information Processing; Signaling Molecules and Interaction hsa:5618, hsa:23291 nucleoplasm, nucleus, Chromosome, cytosol GO:0005654, GO:0005634, GO:0005694, GO:0005829 SWTI000626 P16471, P42229 PRLR, STAT5A Signaling by ERBB4, Nuclear signaling by ERBB4, Immune System, Growth hormone receptor signaling, Signal Transduction, Prolactin receptor signaling, Cytokine Signaling in Immune system Jak-STAT signaling pathway path:hsa04630 Human Diseases; Cancers, Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Environmental Information Processing; Signaling Molecules and Interaction hsa:5618, hsa:6776 P:lactation, P:regulation of cell adhesion, P:regulation of epithelial cell differentiation, P:JAK-STAT cascade involved in growth hormone signaling pathway GO:0007595, GO:0030155, GO:0030856, GO:0060397 cytosol GO:0005829 SWTI000627 Q24546, KAPC_DROME Syn, Pka-C1 Environmental Information Processing; Signal Transduction dme:Dmel_CG3985, dme:Dmel_CG4379 P:behavioral response to ethanol, P:olfactory learning GO:0048149, GO:0008355 F:ATP binding GO:0005524 cAMP-dependent protein kinase complex, cytosol, nucleus GO:0005952, GO:0005829, GO:0005634 UNIPROT:P12370 P12370 SWTI000628 P23634, Q12959 ATP2B4, DLG1 Organismal Systems; Digestive System hsa:493, hsa:1739 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000629 P23634, Q92796 ATP2B4, DLG3 Organismal Systems; Digestive System hsa:493, hsa:1741 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000630 P31016, P97924 Dlg4, Kalrn rno:29495, rno:84009 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000631 P31016, P97924 Dlg4, Kalrn rno:29495, rno:84009 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000632 P64897 garA mtc:MT1875 nucleus GO:0005634 UNIPROT:P0A5S4 P0A5S4 SWTI000633 P62161, P38377 Calm1, SEC61A1 Environmental Information Processing; Signal Transduction, Human Diseases; Substance Dependence, Human Diseases; Infectious Diseases, Genetic Information Processing; Folding, Sorting and Degradation, Organismal Systems; Digestive System, Organismal Systems; Nervous System, Organismal Systems; Sensory System, Organismal Systems; Endocrine System rno:24242, cfa:404006 cytosol, intracellular GO:0005829, GO:0005622 SWTI000634 Q05586, P78352 GRIN1, DLG4 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, Activation of NMDA receptor upon glutamate binding and postsynaptic events, Neuronal System, Post NMDA receptor activation events, CREB phosphorylation through the activation of CaMKII, CREB phosphorylation through the activation of Ras, Ras activation uopn Ca2+ infux through NMDA receptor, Unblocking of NMDA receptor, glutamate binding and activation, Transmission across Chemical Synapses Glutamatergic synapse path:hsa04724 Human Diseases; Substance Dependence, Human Diseases; Neurodegenerative Diseases, Organismal Systems; Nervous System hsa:2902, hsa:1742 P:positive regulation of excitatory postsynaptic membrane potential, P:positive regulation of transcription from RNA polymerase II promoter GO:2000463, GO:0045944 C:excitatory synapse, C:postsynaptic membrane, C:postsynaptic density, C:cell junction GO:0060076, GO:0045211, GO:0014069, GO:0030054 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000635 Q05586, P78352, P53618 GRIN1, DLG4, COPB1 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, CREB phosphorylation through the activation of Ras, Unblocking of NMDA receptor, glutamate binding and activation, Post NMDA receptor activation events, Ras activation uopn Ca2+ infux through NMDA receptor, Transmission across Chemical Synapses, Activation of NMDA receptor upon glutamate binding and postsynaptic events, Neuronal System, CREB phosphorylation through the activation of CaMKII Glutamatergic synapse path:hsa04724 Human Diseases; Substance Dependence, Human Diseases; Neurodegenerative Diseases, Organismal Systems; Nervous System hsa:2902, hsa:1742, hsa:1315 P:positive regulation of excitatory postsynaptic membrane potential, P:positive regulation of transcription from RNA polymerase II promoter GO:2000463, GO:0045944 C:excitatory synapse, C:postsynaptic membrane, C:postsynaptic density, C:plasma membrane, C:cell junction GO:0060076, GO:0045211, GO:0014069, GO:0005886, GO:0030054 cytosol, internal side of plasma membrane, rough endoplasmic reticulum, endoplasmic reticulum cisterna, cytosol, endoplasmic reticulum membrane, endoplasmic reticulum membrane, integral protein, ER-Golgi transport vesicle membrane, Golgi-ER transport vesicle membrane GO:0005829, GO:0009898, GO:0005791, GO:0016022, GO:0005829, GO:0005789, GO:0030176, GO:0012507, GO:0012508 SWTI000636 Q05586, P78352 GRIN1, DLG4 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, Activation of NMDA receptor upon glutamate binding and postsynaptic events, Neuronal System, Post NMDA receptor activation events, CREB phosphorylation through the activation of CaMKII, CREB phosphorylation through the activation of Ras, Ras activation uopn Ca2+ infux through NMDA receptor, Unblocking of NMDA receptor, glutamate binding and activation, Transmission across Chemical Synapses Glutamatergic synapse path:hsa04724 Human Diseases; Substance Dependence, Human Diseases; Neurodegenerative Diseases, Organismal Systems; Nervous System hsa:2902, hsa:1742 P:positive regulation of excitatory postsynaptic membrane potential, P:positive regulation of transcription from RNA polymerase II promoter GO:2000463, GO:0045944 C:excitatory synapse, C:postsynaptic membrane, C:postsynaptic density, C:cell junction GO:0060076, GO:0045211, GO:0014069, GO:0030054 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000637 Q05586, P78352, P53618 GRIN1, DLG4, COPB1 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, CREB phosphorylation through the activation of Ras, Unblocking of NMDA receptor, glutamate binding and activation, Post NMDA receptor activation events, Ras activation uopn Ca2+ infux through NMDA receptor, Transmission across Chemical Synapses, Activation of NMDA receptor upon glutamate binding and postsynaptic events, Neuronal System, CREB phosphorylation through the activation of CaMKII Glutamatergic synapse path:hsa04724 Human Diseases; Substance Dependence, Human Diseases; Neurodegenerative Diseases, Organismal Systems; Nervous System hsa:2902, hsa:1742, hsa:1315 P:positive regulation of excitatory postsynaptic membrane potential, P:positive regulation of transcription from RNA polymerase II promoter GO:2000463, GO:0045944 C:excitatory synapse, C:postsynaptic membrane, C:postsynaptic density, C:plasma membrane, C:cell junction GO:0060076, GO:0045211, GO:0014069, GO:0005886, GO:0030054 cytosol, internal side of plasma membrane, rough endoplasmic reticulum, endoplasmic reticulum cisterna, cytosol, endoplasmic reticulum membrane, endoplasmic reticulum membrane, integral protein, ER-Golgi transport vesicle membrane, Golgi-ER transport vesicle membrane GO:0005829, GO:0009898, GO:0005791, GO:0016022, GO:0005829, GO:0005789, GO:0030176, GO:0012507, GO:0012508 SWTI000638 Q92796, Q9Y2T3 DLG3, GDA hsa:1741, hsa:9615 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000639 P29351, Q91Y57 Ptpn6, Siglec12 Organismal Systems; Immune System mmu:15170, mmu:83382 cytosol GO:0005829 SWTI000640 P35235, Q91Y57 Ptpn11, Siglec12 Human Diseases; Cancers, Organismal Systems; Immune System mmu:19247, mmu:83382 cytosol GO:0005829 SWTI000641 Q86YW5, Q06124 TREML1, PTPN11 Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Immune System hsa:340205, hsa:5781 cytosol GO:0005829 SWTI000642 Q9ES52, P26450 Inpp5d, Pik3r1 B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Phosphatidylinositol signaling system path:mmu04662, path:mmu04664, path:mmu04666, path:mmu04070 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System mmu:16331, mmu:18708 P:positive regulation of apoptotic process, P:negative regulation of osteoclast differentiation GO:0043065, GO:0045671 C:plasma membrane GO:0005886 SWTI000643 P13285, Q8C863 LMP2, Itch mmu:16396 cytosol, integral membrane protein, integral plasma membrane protein GO:0005829, GO:0016021, GO:0005887 SWTI000644 P55210, Q13490 CASP7, BIRC2 Apoptotic cleavage of cellular proteins, Apoptotic execution phase, Apoptosis Apoptosis path:hsa04210 Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers hsa:840, hsa:329 P:cellular component disassembly involved in apoptotic process GO:0006921 C:cytosol GO:0005829 C:cytosol GO:0005829 Cytoplasm, cytosol, mitochondrion GO:0005737, GO:0005829, GO:0005739 SWTI000645 P55210, Q13490 CASP7, BIRC2 Apoptotic cleavage of cellular proteins, Apoptotic execution phase, Apoptosis Apoptosis path:hsa04210 Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers hsa:840, hsa:329 P:cellular component disassembly involved in apoptotic process GO:0006921 C:cytosol GO:0005829 C:cytosol GO:0005829 Cytoplasm, cytosol, mitochondrion GO:0005737, GO:0005829, GO:0005739 SWTI000646 P20020, P62158 ATP2B1, CALM1 Hemostasis Salivary secretion, Calcium signaling pathway path:hsa04970, path:hsa04020 Environmental Information Processing; Signal Transduction, Human Diseases; Substance Dependence, Organismal Systems; Endocrine System, Human Diseases; Infectious Diseases, Organismal Systems; Digestive System, Organismal Systems; Nervous System, Organismal Systems; Sensory System hsa:490, hsa:801 SWTI000647 P98170, Q9NR28 XIAP, DIABLO Intrinsic Pathway for Apoptosis, Apoptosis, SMAC-mediated apoptotic response, SMAC binds to IAPs, Apoptotic factor-mediated response, SMAC-mediated dissociation of IAP:caspase complexes Human Diseases; Infectious Diseases, Human Diseases; Cancers hsa:331, hsa:56616 P:induction of apoptosis by intracellular signals GO:0008629 C:cytosol GO:0005829 SWTI000648 P42566, O43426 EPS15, SYNJ1 hsa:2060, hsa:8867 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol, plasma membrane GO:0005829, GO:0005886 SWTI000649 P42566, O43426 EPS15, SYNJ1 hsa:2060, hsa:8867 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol, plasma membrane GO:0005829, GO:0005886 SWTI000650 P42566, O43426 EPS15, SYNJ1 hsa:2060, hsa:8867 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol, plasma membrane GO:0005829, GO:0005886 SWTI000651 P42566, O43426 EPS15, SYNJ1 hsa:2060, hsa:8867 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol, plasma membrane GO:0005829, GO:0005886 SWTI000652 P42566, O43426 EPS15, SYNJ1 hsa:2060, hsa:8867 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol, plasma membrane GO:0005829, GO:0005886 SWTI000653 P42566, O43426 EPS15, SYNJ1 hsa:2060, hsa:8867 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol, plasma membrane GO:0005829, GO:0005886 SWTI000654 P49023, P20936 PXN, RASA1 Signal Transduction Environmental Information Processing; Signal Transduction, Organismal Systems; Immune System hsa:5829, hsa:5921 SWTI000655 P70441, P97288 Slc9a3r1, Htr4 mmu:26941, mmu:15562 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 SWTI000656 P27986, Q15303 PIK3R1, ERBB4 Signaling by ERBB4, Signaling by ERBB2, Downstream signal transduction, NGF signalling via TRKA from the plasma membrane, PI-3K cascade, Signaling by PDGF, PI3K events in ERBB4 signaling, Immune System, Downstream signaling of activated FGFR, Downstream Signaling Events Of B Cell Receptor (BCR), GAB1 signalosome, DAP12 signaling, Signalling by NGF, Signal Transduction, Signaling by EGFR, Signaling by FGFR in disease, Constitutive PI3K/AKT Signaling in Cancer, PIP3 activates AKT signaling, Disease, Signaling by SCF-KIT, Signaling by the B Cell Receptor (BCR), PI3K/AKT Signaling in Cancer, Signaling by EGFR in Cancer, PI3K events in ERBB2 signaling, PI3K/AKT activation, Adaptive Immune System, Innate Immune System, DAP12 interactions, Signaling by FGFR ErbB signaling pathway path:hsa04012 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:5295, hsa:2066 P:positive regulation of glucose import GO:0046326 SWTI000657 Q15303, Q96J02 ERBB4, ITCH Signaling by ERBB4, Immune System, Downregulation of ERBB4 signaling, Signal Transduction, Innate Immune System, Adaptive Immune System Endocytosis path:hsa04144 Environmental Information Processing; Signal Transduction, Cellular Processes; Transport and Catabolism hsa:2066, hsa:83737 P:negative regulation of apoptotic process, P:apoptotic process GO:0043066, GO:0006915 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol, integral membrane protein, integral plasma membrane protein GO:0005829, GO:0016021, GO:0005887 SWTI000658 Q4VCS5, P46937 AMOT, YAP1 Signal Transduction, Signaling by Hippo hsa:154796, hsa:10413 P:vasculogenesis, P:hippo signaling cascade GO:0001570, GO:0035329 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol, integral membrane protein, integral plasma membrane protein GO:0005829, GO:0016021, GO:0005887 SWTI000659 O43613, Q06124 HCRTR1, PTPN11 Signal Transduction Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Immune System hsa:3061, hsa:5781 cytosol, cytosol GO:0005829, GO:0005829 Src P12931 358 SWTI000660 P62993, Q14118, P11532 GRB2, DAG1, DMD Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Development, Cellular Processes; Cell Communication, Human Diseases; Cancers, Human Diseases; Cardiovascular Diseases, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:2885, hsa:1605, hsa:1756 P:virus-host interaction GO:0019048 C:cytoskeleton, C:sarcolemma, C:cytosol, C:dystrophin-associated glycoprotein complex, C:costamere GO:0005856, GO:0042383, GO:0005829, GO:0016010, GO:0043034 F:structural constituent of muscle GO:0008307 C:cytosol GO:0005829 cytosol, integral membrane protein, integral plasma membrane protein, cytosol, focal adhesion, plasma membrane GO:0005829, GO:0016021, GO:0005887, GO:0005829, GO:0005925, GO:0005886 SWTI000661 Q13526, Q969H0 PIN1, FBXW7 Immune System hsa:5300, hsa:55294 C:nucleoplasm GO:0005654 nucleus, cytosol GO:0005634, GO:0005829 SWTI000662 O75925, P61956 PIAS1, SUMO2 hsa:8554, hsa:6613 P:protein sumoylation GO:0016925 SWTI000663 O75925, P63165 PIAS1, SUMO1 Regulation of IFNG signaling, Interferon gamma signaling, Cytokine Signaling in Immune system, Interferon Signaling, Immune System hsa:8554, hsa:7341 P:interferon-gamma-mediated signaling pathway, P:regulation of interferon-gamma-mediated signaling pathway, P:protein sumoylation GO:0060333, GO:0060334, GO:0016925 C:nuclear speck, C:nucleoplasm GO:0016607, GO:0005654 F:SUMO ligase activity GO:0019789 SWTI000664 O75928, P61956 PIAS2, SUMO2 Human Diseases; Cancers hsa:9063, hsa:6613 P:protein sumoylation GO:0016925 C:nucleus GO:0005634 SWTI000665 O75928, P63165 PIAS2, SUMO1 Human Diseases; Cancers hsa:9063, hsa:7341 P:protein sumoylation GO:0016925 C:nuclear speck GO:0016607 F:SUMO ligase activity GO:0019789 SWTI000666 P63279, P29590, P61956, Q9UER7 UBE2I, PML, SUMO2, DAXX Ubiquitin mediated proteolysis, RNA transport path:hsa04120, path:hsa03013 Genetic Information Processing; Translation, Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Genetic Information Processing; Folding, Sorting and Degradation, Human Diseases; Cancers hsa:7329, hsa:5371, hsa:6613, hsa:1616 P:virus-host interaction, P:negative regulation of transcription, DNA-dependent, P:protein sumoylation, P:transcription, DNA-dependent GO:0019048, GO:0045892, GO:0016925, GO:0006351 C:cytoplasm, C:PML body, C:nucleolus, C:cytosol, C:nucleus GO:0005737, GO:0016605, GO:0005730, GO:0005829, GO:0005634 C:nucleus, C:PML body GO:0005634, GO:0016605 nucleus, PML body GO:0005634, GO:0016605 SWTI000667 P63279, P29590, P63165, Q9UER7 UBE2I, PML, SUMO1, DAXX Interferon gamma signaling, Interferon Signaling, Cytokine Signaling in Immune system, Immune System Ubiquitin mediated proteolysis, RNA transport path:hsa04120, path:hsa03013 Genetic Information Processing; Translation, Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Genetic Information Processing; Folding, Sorting and Degradation, Human Diseases; Cancers hsa:7329, hsa:5371, hsa:7341, hsa:1616 P:virus-host interaction, P:negative regulation of transcription, DNA-dependent, P:protein sumoylation, P:interferon-gamma-mediated signaling pathway, P:transcription, DNA-dependent GO:0019048, GO:0045892, GO:0016925, GO:0060333, GO:0006351 C:cytoplasm, C:PML body, C:nucleolus, C:nuclear membrane, C:cytosol, C:dendrite, C:synapse GO:0005737, GO:0016605, GO:0005730, GO:0031965, GO:0005829, GO:0030425, GO:0045202 F:SUMO ligase activity GO:0019789 C:PML body GO:0016605 nucleus, PML body GO:0005634, GO:0016605 SWTI000668 Q92731, P49841, P63279 ESR2, GSK3B, UBE2I Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Nervous System, Human Diseases; Cancers, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:2100, hsa:2932, hsa:7329 P:negative regulation of transcription from RNA polymerase II promoter, P:positive regulation of sequence-specific DNA binding transcription factor activity GO:0000122, GO:0051091 F:ATP binding GO:0005524 cytosol, nucleus GO:0005829, GO:0005634 SWTI000669 Q92731, P63279 ESR2, UBE2I hsa:2100, hsa:7329 P:negative regulation of transcription from RNA polymerase II promoter, P:positive regulation of sequence-specific DNA binding transcription factor activity GO:0000122, GO:0051091 SWTI000670 O15131, Q13309 KPNA5, SKP2 Immune System Human Diseases; Cancers, Human Diseases; Infectious Diseases hsa:3841, hsa:6502 C:nucleoplasm, C:cytosol GO:0005654, GO:0005829 Nuclear pore, nucleus, NLS-dependent protein nuclear import complex GO:0005643, GO:0005634, GO:0042564 UNIPROT:Q09472 Q09472 SWTI000671 O60684, Q13309 KPNA6, SKP2 Human Diseases; Cancers, Human Diseases; Infectious Diseases hsa:23633, hsa:6502 Nuclear pore, nucleus, NLS-dependent protein nuclear import complex GO:0005643, GO:0005634, GO:0042564 UNIPROT:Q09472 Q09472 SWTI000672 Q9H0B6, Q8IWE5 KLC2, PLEKHM2 Human Diseases; Infectious Diseases hsa:64837, hsa:23207 SWTI000673 P62138, O35867 Ppp1ca, Ppp1r9a Human Diseases; Substance Dependence, Organismal Systems; Nervous System rno:24668, rno:84685 C:dendritic spine GO:0043197 nucleus, cytosol, protein phosphatase type 1 complex GO:0005634, GO:0005829, GO:0000164 UNIPROTFAM:cAMP subfamily UNIPROTFAM:cAMP subfamily PKACa P27791 461 SWTI000674 O14745, P09619 SLC9A3R1, PDGFRB Environmental Information Processing; Signal Transduction, Human Diseases; Cancers, Cellular Processes; Cell Communication hsa:9368, hsa:5159 C:apical plasma membrane GO:0016324 cytosol, internal side of plasma membrane GO:0005829, GO:0009898 UNIPROT:P25098 P25098 GRK-2 P25098 1104 GRK2 P21146 1104 SWTI000675 Q00610, P49418 CLTC, AMPH Cellular Processes; Transport and Catabolism hsa:1213, hsa:273 cytoskeleton, Golgi apparatus, cytosol, Golgi trans-face, clathrin-coated endocytic vesicle GO:0005856, GO:0005794, GO:0005829, GO:0005802, GO:0045334 UNIPROTFAM:CK2 subfamily UNIPROTFAM:CK2 subfamily CK2-A1 P68400 350 SWTI000676 Q00610, P49418 CLTC, AMPH Cellular Processes; Transport and Catabolism hsa:1213, hsa:273 cytoskeleton, cytosol, clathrin-coated endocytic vesicle GO:0005856, GO:0005829, GO:0045334 UNIPROTFAM:CK2 subfamily UNIPROTFAM:CK2 subfamily CK2-A1 P68400 387 SWTI000677 Q00610, P49418 CLTC, AMPH Cellular Processes; Transport and Catabolism hsa:1213, hsa:273 cytoskeleton, Golgi apparatus, cytosol, Golgi trans-face, clathrin-coated endocytic vesicle, cytoskeleton, cytosol, clathrin-coated endocytic vesicle GO:0005856, GO:0005794, GO:0005829, GO:0005802, GO:0045334, GO:0005856, GO:0005829, GO:0045334 SWTI000678 O15350, P46937, Q96J02 TP73, YAP1, ITCH Signaling by ERBB4, Signal Transduction hsa:7161, hsa:10413, hsa:83737 P:negative regulation of apoptotic process, P:inflammatory response, P:positive regulation of transcription from RNA polymerase II promoter GO:0043066, GO:0006954, GO:0045944 C:cytosol, C:transcription factor complex GO:0005829, GO:0005667 F:chromatin binding, F:transcription regulatory region DNA binding GO:0003682, GO:0044212 C:cytosol GO:0005829 cytosol, integral membrane protein, integral plasma membrane protein, cytosol, integral membrane protein, integral plasma membrane protein GO:0005829, GO:0016021, GO:0005887, GO:0005829, GO:0016021, GO:0005887 SWTI000679 P12004, Q15054 PCNA, POLD3 Global Genomic NER (GG-NER), Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Gap-filling DNA repair synthesis and ligation in TC-NER, Transcription-coupled NER (TC-NER), Resolution of Abasic Sites (AP sites), Processive synthesis on the C-strand of the telomere, Lagging Strand Synthesis, Removal of the Flap Intermediate from the C-strand, Cell Cycle, Extension of Telomeres, Nucleotide Excision Repair, DNA Repair, Removal of the Flap Intermediate, Processive synthesis on the lagging strand, Leading Strand Synthesis, Processive synthesis on the leading strand, Repair synthesis for gap-filling by DNA polymerase in TC-NER, Repair synthesis of patch ~27-30 bases long by DNA polymerase, Gap-filling DNA repair synthesis and ligation in GG-NER, Removal of DNA patch containing abasic residue, Cell Cycle, Mitotic, Telomere Maintenance, DNA strand elongation, Chromosome Maintenance, Base Excision Repair, S Phase, DNA Replication, Telomere C-strand (Lagging Strand) Synthesis, Polymerase switching on the C-strand of the telomere, Polymerase switching, Synthesis of DNA Mismatch repair, DNA replication, Nucleotide excision repair, Base excision repair path:hsa03430, path:hsa03030, path:hsa03420, path:hsa03410 Metabolism; Nucleotide Metabolism, Genetic Information Processing; Replication and Repair, Human Diseases; Infectious Diseases hsa:5111, hsa:10714 P:telomere maintenance via recombination, P:base-excision repair, P:transcription-coupled nucleotide-excision repair, P:S phase of mitotic cell cycle, P:telomere maintenance via semi-conservative replication, P:mismatch repair, P:nucleotide-excision repair, DNA gap filling, P:DNA strand elongation involved in DNA replication GO:0000722, GO:0006284, GO:0006283, GO:0000084, GO:0032201, GO:0006298, GO:0006297, GO:0006271 C:nucleoplasm GO:0005654 nucleus GO:0005634 UNIPROTFAM:cAMP subfamily UNIPROTFAM:cAMP subfamily PKACa P17612 458 SWTI000680 Q96CW1, P32004 AP2M1, L1CAM Axon guidance, Signal transduction by L1, L1CAM interactions, Developmental Biology, Recycling pathway of L1 hsa:1173, hsa:3897 P:axon guidance GO:0007411 C:plasma membrane GO:0005886 C:plasma membrane GO:0005886 cytosol, clathrin-coated endocytic vesicle, plasma membrane GO:0005829, GO:0045334, GO:0005886 UNIPROT:P12931 P12931 Src P12931 1176 SWTI000681 Q93009, O15151 USP7, MDM4 Human Diseases; Infectious Diseases hsa:7874, hsa:4194 C:nucleus GO:0005634 C:nucleus GO:0005634 nucleus GO:0005634 UNIPROT:Q13315 Q13315 ATM NP_000042 403 SWTI000682 P63104, O15151 YWHAZ, MDM4 Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death hsa:7534, hsa:4194 nucleus, cytosol, internal side of plasma membrane, nucleus, cytosol, internal side of plasma membrane GO:0005634, GO:0005829, GO:0009898, GO:0005634, GO:0005829, GO:0009898 UNIPROT:O96017, UNIPROT:O96017 O96017 Chk1, Chk2 O14757, O96017 342, 342 SWTI000683 P25322, Q9WTQ5 Ccnd1, Akap12 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers mmu:12443, mmu:83397 nucleus, cytosol GO:0005634, GO:0005829 UNIPROTFAM:PKC subfamily UNIPROTFAM:PKC subfamily SWTI000684 Q8C863, P05627 Itch, Jun Environmental Information Processing; Signal Transduction, Human Diseases; Substance Dependence, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Immune System mmu:16396, mmu:16476 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol, integral membrane protein, integral plasma membrane protein GO:0005829, GO:0016021, GO:0005887 UNIPROT:P00520 P00520 SWTI000685 O60566, P14635, Q12834 BUB1B, CCNB1, CDC20 Degradation of multiubiquitinated Nek2A, M Phase, Cell Cycle, Mitotic Spindle Checkpoint, Degradation multiubiquitinated Cyclin A, Mitotic Prometaphase, Degradation of multiubiquitinated Cyclin B, APC/C:Cdc20 mediated degradation of Cyclin B, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Regulation of APC/C activators between G1/S and early anaphase, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Regulation of mitotic cell cycle, Cell Cycle, Mitotic, Cell Cycle Checkpoints, Phosphorylation of Emi1, APC-Cdc20 mediated degradation of Nek2A, APC/C:Cdc20 mediated degradation of mitotic proteins, DNA Replication, Inactivation of APC/C via direct inhibition of the APC/C complex, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, APC/C-mediated degradation of cell cycle proteins, Mitotic M-M/G1 phases Cell cycle, Oocyte meiosis path:hsa04110, path:hsa04114 Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death hsa:701, hsa:891, hsa:991 P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, P:cell division, P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, P:mitotic prometaphase, P:mitotic cell cycle spindle assembly checkpoint GO:0051437, GO:0051436, GO:0051301, GO:0031145, GO:0000236, GO:0007094 C:centrosome, C:cytosol, C:nucleoplasm, C:perinuclear region of cytoplasm, C:spindle pole GO:0005813, GO:0005829, GO:0005654, GO:0048471, GO:0000922 C:cytosol GO:0005829 cytosol, nucleus, nucleus, cytosol GO:0005829, GO:0005634, GO:0005634, GO:0005829 SWTI000686 O60566, O95997, Q12834 BUB1B, PTTG1, CDC20 Degradation of multiubiquitinated Nek2A, M Phase, Cell Cycle, Mitotic Spindle Checkpoint, Degradation multiubiquitinated Cyclin A, Mitotic Prometaphase, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Regulation of APC/C activators between G1/S and early anaphase, Degradation of multiubiquitinated Securin, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Regulation of mitotic cell cycle, Degradation of multiubiquitinated cell cycle proteins, Cell Cycle, Mitotic, Cell Cycle Checkpoints, APC/C:Cdc20 mediated degradation of Securin, APC-Cdc20 mediated degradation of Nek2A, APC/C:Cdc20 mediated degradation of mitotic proteins, DNA Replication, Inactivation of APC/C via direct inhibition of the APC/C complex, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, APC/C-mediated degradation of cell cycle proteins, Mitotic M-M/G1 phases Cell cycle, Oocyte meiosis path:hsa04110, path:hsa04114 Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death hsa:701, hsa:9232, hsa:991 P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, P:cell division, P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, P:mitotic prometaphase, P:mitotic cell cycle spindle assembly checkpoint GO:0051436, GO:0051301, GO:0031145, GO:0000236, GO:0007094 C:cytosol, C:perinuclear region of cytoplasm GO:0005829, GO:0048471 C:cytosol GO:0005829 cytosol, nucleus, nucleus, cytosol GO:0005829, GO:0005634, GO:0005634, GO:0005829 SWTI000687 Q08981, P24869, P53197 ACM1, CLB2, CDH1 Cell cycle path:sce04111 Cellular Processes; Cell Growth and Death sce:YPL267W, sce:YPR119W, sce:YGL003C P:mitosis, P:cell division GO:0007067, GO:0051301 C:cytoplasm, C:nucleus GO:0005737, GO:0005634 C:nucleus GO:0005634 cytosol, nucleus, nucleus, cytosol GO:0005829, GO:0005634, GO:0005634, GO:0005829 SWTI000688 Q08981, P27895, P53197 ACM1, CIN8, CDH1 sce:YPL267W, sce:YEL061C, sce:YGL003C P:mitosis, P:cell division GO:0007067, GO:0051301 C:cytoplasm GO:0005737 cytosol, nucleus, nucleus, cytosol GO:0005829, GO:0005634, GO:0005634, GO:0005829 SWTI000689 Q08981, P34244, P53197 ACM1, HSL1, CDH1 Cell cycle path:sce04111 Cellular Processes; Cell Growth and Death sce:YPL267W, sce:YKL101W, sce:YGL003C P:mitosis, P:cell division GO:0007067, GO:0051301 C:cytoplasm GO:0005737 cytosol, nucleus, nucleus, cytosol GO:0005829, GO:0005634, GO:0005634, GO:0005829 SWTI000690 P63104, P98177 YWHAZ, FOXO4 Immune System, Adaptive Immune System Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death hsa:7534, hsa:4303 C:cytosol GO:0005829 C:cytosol GO:0005829 nucleus, cytosol, internal side of plasma membrane, cytosol, internal side of plasma membrane, nucleus, mitochondrion GO:0005634, GO:0005829, GO:0009898, GO:0005829, GO:0009898, GO:0005634, GO:0005739 UNIPROT:P31749, UNIPROT:P31749 P31749 PKB_group 197 Akt1 P31749 197 SWTI000691 O95835, Q9Y297, P49674, P46937 LATS1, BTRC, CSNK1E, YAP1 Signaling by ERBB4, Nuclear signaling by ERBB4, Cell Cycle, Circadian Clock, Signal Transduction, Signaling by Hippo, Cell Cycle, Mitotic Circadian rhythm, Wnt signaling pathway, Hedgehog signaling pathway path:hsa04710, path:hsa04310, path:hsa04340 Environmental Information Processing; Signal Transduction, Organismal Systems; Environmental Adaptation hsa:9113, hsa:8945, hsa:1454, hsa:10413 P:positive regulation of canonical Wnt receptor signaling pathway, P:signal transduction, P:G2/M transition of mitotic cell cycle, P:hippo signaling cascade GO:0090263, GO:0007165, GO:0000086, GO:0035329 C:cytosol, C:nucleus GO:0005829, GO:0005634 F:protein serine/threonine kinase activity, F:ATP binding GO:0004674, GO:0005524 C:nucleus, C:cytosol GO:0005634, GO:0005829 nucleus, cytosol, nucleus, cytosol GO:0005634, GO:0005829, GO:0005634, GO:0005829 SWTI000692 P46527, P61981, P52294 CDKN1B, YWHAG, KPNA1 Cell Cycle, Immune System, Disease, Cell Cycle, Mitotic Cell cycle, PI3K-Akt signaling pathway path:hsa04110, path:hsa04151 Human Diseases; Cancers, Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death hsa:1027, hsa:7532, hsa:3836 C:nucleoplasm, C:cytosol GO:0005654, GO:0005829 UNIPROT:P31749 P31749 PKB_group, PKB_group, PKB_group , , 157, 157, 157 SGK1, Pim1, Akt1 O00141, P11309, P31749 157, 157, 157 SWTI000693 P46527, P61981, P27348 CDKN1B, YWHAG, YWHAQ Cell Cycle, Membrane Trafficking, Translocation of GLUT4 to the Plasma Membrane, Cell Cycle, Mitotic Cell cycle, Oocyte meiosis, PI3K-Akt signaling pathway path:hsa04110, path:hsa04114, path:hsa04151 Human Diseases; Cancers, Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death hsa:1027, hsa:7532, hsa:10971 P:protein targeting, P:negative regulation of transcription, DNA-dependent GO:0006605, GO:0045892 C:cytosol GO:0005829 UNIPROT:P31749, UNIPROT:P31749, UNIPROT:Q15418, UNIPROT:P51812 Q15418, P31749, P51812 RSK_group, RSK-2 , Q15349 198, 198 AMPKA1, p90RSK, SGK1, RSK2, Pim1, Akt1 Q13131, Q63531, O00141, P18654, P11309, P31749 198, 198, 198, 198, 198, 198 SWTI000694 P12004, P38936 PCNA, CDKN1A Mitotic G1-G1/S phases, Cell Cycle, G1/S Transition, Cell Cycle, Mitotic, S Phase, DNA Replication, Synthesis of DNA Cell cycle path:hsa04110 Environmental Information Processing; Signal Transduction, Human Diseases; Cancers, Genetic Information Processing; Replication and Repair, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death hsa:5111, hsa:1026 P:S phase of mitotic cell cycle GO:0000084 C:PCNA-p21 complex, C:nucleoplasm GO:0070557, GO:0005654 nucleus GO:0005634 UNIPROT:P31749 P31749 PKB_group, PKC_alpha, PIM-1, PKB_group, PKB_group , P17252, P11309, , 145, 145, 145, 145, 145 Pim2, Pim1, DAPK3, Akt1 Q9P1W9, P11309, O43293, P31749 145, 145, 145, 145 SWTI000695 P12004, P38936 PCNA, CDKN1A Mitotic G1-G1/S phases, Cell Cycle, G1/S Transition, Cell Cycle, Mitotic, S Phase, DNA Replication, Synthesis of DNA Cell cycle path:hsa04110 Environmental Information Processing; Signal Transduction, Human Diseases; Cancers, Genetic Information Processing; Replication and Repair, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death hsa:5111, hsa:1026 P:S phase of mitotic cell cycle GO:0000084 C:PCNA-p21 complex, C:nucleoplasm GO:0070557, GO:0005654 nucleus GO:0005634 UNIPROTFAM:PKC subfamily UNIPROTFAM:PKC subfamily PKB_group, PKC_alpha, PIM-1 , P17252, P11309 146, 146, 146 Pim2, PKCA, Pim1, Akt1 Q9P1W9, P17252, P11309, P31749 146, 146, 146, 146 SWTI000696 Q13541, P06730 EIF4EBP1, EIF4E PKB-mediated events, Cap-dependent Translation Initiation, mTOR signalling, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Signal Transduction, Insulin receptor signalling cascade, Metabolism of proteins, Translation, Gene Expression, IRS-mediated signalling, Release of eIF4E, Eukaryotic Translation Initiation, mTORC1-mediated signalling, Signaling by Insulin receptor, PI3K Cascade, IRS-related events HIF-1 signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, RNA transport, Insulin signaling pathway path:hsa04066, path:hsa04150, path:hsa04151, path:hsa03013, path:hsa04910 Genetic Information Processing; Translation, Environmental Information Processing; Signal Transduction, Organismal Systems; Endocrine System hsa:1978, hsa:1977 P:positive regulation of mitotic cell cycle, P:insulin receptor signaling pathway, P:G1/S transition of mitotic cell cycle GO:0045931, GO:0008286, GO:0000082 C:cytosol GO:0005829 C:cytosol GO:0005829 cytosol GO:0005829 UNIPROT:P42345 P42345 mTOR P42345 65 ERK1, ERK2, mTOR, mTOR, DYRK2 P27361, P28482, Q9JLN9, P42345, Q92630 65, 65, 65, 65, 65 SWTI000697 Q61337, P68254 Bad, Ywhaq PI3K-Akt signaling pathway path:mmu04151 Environmental Information Processing; Signal Transduction, Human Diseases; Neurodegenerative Diseases, Human Diseases; Infectious Diseases, Cellular Processes; Cell Growth and Death, Human Diseases; Cancers mmu:12015, mmu:22630 UNIPROT:P31750 P31750 PKB_group, PKB_group , 136, 136 Pim2, Akt1, PKACa, Pim3, Pim1, Pim3, PKACa, p90RSK, PAK1, Pim1, Akt1, PKACa Q9P1W9, P31750, P17612, P58750, P06803, Q86V86, P00517, Q15418, Q13153, P11309, P31749, P05132 136, 136, 136, 136, 136, 136, 136, 136, 136, 136, 136, 136 SWTI000698 P00533, P19174 EGFR, PLCG1 Signaling by ERBB2, PLCG1 events in ERBB2 signaling, Downstream signal transduction, Axon guidance, NGF signalling via TRKA from the plasma membrane, Immune System, Downstream signaling of activated FGFR, DAP12 signaling, Signalling by NGF, Signaling by FGFR in disease, Signal Transduction, Signaling by constitutively active EGFR, Signaling by PDGF, Signaling by EGFR, Innate Immune System, Developmental Biology, Disease, Signaling by the B Cell Receptor (BCR), EGFR interacts with phospholipase C-gamma, Adaptive Immune System, DAP12 interactions, Signaling by EGFR in Cancer, Signaling by FGFR Calcium signaling pathway, HIF-1 signaling pathway, ErbB signaling pathway path:hsa04020, path:hsa04066, path:hsa04012 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Communication, Human Diseases; Cancers, Organismal Systems; Immune System hsa:1956, hsa:5335 P:axon guidance, P:activation of phospholipase C activity GO:0007411, GO:0007202 cytosol GO:0005829 SRC P12931 1016 Src, Abl, EGFR P12931, P00519, P00533 1016, 1016, 1016 SWTI000699 P00533, P46108 EGFR, CRK Downstream signal transduction, NGF signalling via TRKA from the plasma membrane, Immune System, Signalling by NGF, Signal Transduction, Signaling by PDGF Regulation of actin cytoskeleton, ErbB signaling pathway, MAPK signaling pathway, Focal adhesion path:hsa04810, path:hsa04012, path:hsa04010, path:hsa04510 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Cellular Processes; Cell Communication, Cellular Processes; Cell Motility, Human Diseases; Cancers, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:1956, hsa:1398 C:endosome, C:nucleus GO:0005768, GO:0005634 cytosol GO:0005829 SRC, SRC, SRC P12931, P12931, P12931 1125, 1125, 1125 Src P12931 1125 SWTI000700 P00533, P16333 EGFR, NCK1 Downstream signal transduction, Axon guidance, Immune System, Signal Transduction, Signaling by PDGF, Developmental Biology, Signaling by the B Cell Receptor (BCR), Adaptive Immune System ErbB signaling pathway path:hsa04012 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Development, Cellular Processes; Cell Communication, Human Diseases; Cancers hsa:1956, hsa:4690 P:axon guidance GO:0007411 C:nucleus GO:0005634 cytosol GO:0005829 SRC P12931 1016 Src, Abl, EGFR P12931, P00519, P00533 1016, 1016, 1016 SWTI000701 P62993, P21860 GRB2, ERBB3 Signaling by ERBB4, Signaling by ERBB2, DAP12 signaling, PI3K events in ERBB2 signaling, Signaling by PDGF, Constitutive PI3K/AKT Signaling in Cancer, PI3K/AKT Signaling in Cancer, NGF signalling via TRKA from the plasma membrane, Downstream Signaling Events Of B Cell Receptor (BCR), Signal Transduction, Signaling by FGFR, DAP12 interactions, Signaling by EGFR in Cancer, PI-3K cascade, PI3K events in ERBB4 signaling, Downstream signaling of activated FGFR, Signaling by SCF-KIT, SHC1 events in ERBB2 signaling, Signaling by EGFR, Signaling by FGFR in disease, Signaling by the B Cell Receptor (BCR), PI3K/AKT activation, Innate Immune System, Downstream signal transduction, Immune System, GAB1 signalosome, Signalling by NGF, PIP3 activates AKT signaling, Disease, Adaptive Immune System ErbB signaling pathway path:hsa04012 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Development, Cellular Processes; Cell Communication, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:2885, hsa:2065 cytosol GO:0005829 SWTI000702 Q05397, P05480 PTK2, Src Developmental Biology, Signal Transduction, Axon guidance, Netrin mediated repulsion signals, NCAM signaling for neurite out-growth, Netrin-1 signaling Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Cellular Processes; Cell Communication, Cellular Processes; Cell Motility, Organismal Systems; Immune System hsa:5747, mmu:20779 P:peptidyl-tyrosine phosphorylation GO:0018108 C:cytoskeleton, C:cytosol, C:nucleus GO:0005856, GO:0005829, GO:0005634 F:non-membrane spanning protein tyrosine kinase activity, F:ATP binding GO:0004715, GO:0005524 C:cytosol GO:0005829 cytosol GO:0005829 FAK Q05397 397 Src, Fgr, Met, FAK P12931, P09769, P08581, Q05397 397, 397, 397, 397 SWTI000703 Q13480, P27986 GAB1, PIK3R1 Signaling by ERBB4, Signaling by ERBB2, Downstream signal transduction, NGF signalling via TRKA from the plasma membrane, PI-3K cascade, Signaling by PDGF, PI3K events in ERBB4 signaling, Immune System, Downstream signaling of activated FGFR, Downstream Signaling Events Of B Cell Receptor (BCR), Insulin receptor signalling cascade, GAB1 signalosome, DAP12 signaling, Signalling by NGF, Signal Transduction, Signaling by constitutively active EGFR, Signaling by Insulin receptor, Signaling by EGFR, Signaling by FGFR in disease, IRS-mediated signalling, PI3K Cascade, Constitutive PI3K/AKT Signaling in Cancer, PIP3 activates AKT signaling, Disease, Signaling by SCF-KIT, Signaling by the B Cell Receptor (BCR), PI3K/AKT Signaling in Cancer, Signaling by EGFR in Cancer, PI3K events in ERBB2 signaling, PI3K/AKT activation, Adaptive Immune System, Innate Immune System, DAP12 interactions, Signaling by FGFR, IRS-related events, Signaling by FGFR mutants Neurotrophin signaling pathway, ErbB signaling pathway path:hsa04722, path:hsa04012 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:2549, hsa:5295 P:fibroblast growth factor receptor signaling pathway, P:insulin receptor signaling pathway, P:epidermal growth factor receptor signaling pathway GO:0008543, GO:0008286, GO:0007173 cytosol GO:0005829 INSR, EGFR, Met P06213, P00533, P08581 472, 472, 472 InsR, EGFR P06213, P00533 472, 472 SWTI000704 Q13480, P27986 GAB1, PIK3R1 Signaling by ERBB4, Signaling by ERBB2, Downstream signal transduction, NGF signalling via TRKA from the plasma membrane, PI-3K cascade, Signaling by PDGF, PI3K events in ERBB4 signaling, Immune System, Downstream signaling of activated FGFR, Downstream Signaling Events Of B Cell Receptor (BCR), Insulin receptor signalling cascade, GAB1 signalosome, DAP12 signaling, Signalling by NGF, Signal Transduction, Signaling by constitutively active EGFR, Signaling by Insulin receptor, Signaling by EGFR, Signaling by FGFR in disease, IRS-mediated signalling, PI3K Cascade, Constitutive PI3K/AKT Signaling in Cancer, PIP3 activates AKT signaling, Disease, Signaling by SCF-KIT, Signaling by the B Cell Receptor (BCR), PI3K/AKT Signaling in Cancer, Signaling by EGFR in Cancer, PI3K events in ERBB2 signaling, PI3K/AKT activation, Adaptive Immune System, Innate Immune System, DAP12 interactions, Signaling by FGFR, IRS-related events, Signaling by FGFR mutants Neurotrophin signaling pathway, ErbB signaling pathway path:hsa04722, path:hsa04012 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Human Diseases; Cancers, Organismal Systems; Nervous System, Organismal Systems; Immune System, Organismal Systems; Endocrine System hsa:2549, hsa:5295 P:fibroblast growth factor receptor signaling pathway, P:insulin receptor signaling pathway, P:epidermal growth factor receptor signaling pathway GO:0008543, GO:0008286, GO:0007173 cytosol GO:0005829 INSR, EGFR, Met P06213, P00533, P08581 447, 447, 447 InsR, EGFR P06213, P00533 447, 447 SWTI000705 Q09472, P61956, Q9UER7 EP300, SUMO2, DAXX Environmental Information Processing; Signal Transduction, Human Diseases; Neurodegenerative Diseases, Human Diseases; Infectious Diseases, Human Diseases; Cancers hsa:2033, hsa:6613, hsa:1616 P:virus-host interaction, P:apoptotic process, P:transcription, DNA-dependent GO:0019048, GO:0006915, GO:0006351 SWTI000706 P63165, Q9UER7 SUMO1, DAXX hsa:7341, hsa:1616 P:negative regulation of transcription, DNA-dependent GO:0045892 SWTI000707 P29590, P63165 PML, SUMO1 Interferon gamma signaling, Interferon Signaling, Cytokine Signaling in Immune system, Immune System Human Diseases; Cancers, Human Diseases; Infectious Diseases hsa:5371, hsa:7341 P:interferon-gamma-mediated signaling pathway, P:negative regulation of transcription, DNA-dependent GO:0060333, GO:0045892 C:cytoplasm, C:nuclear membrane GO:0005737, GO:0031965 SWTI000708 P63279, O95644 UBE2I, NFATC1 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Development, Organismal Systems; Immune System hsa:7329, hsa:4772 nucleus, PML body GO:0005634, GO:0016605 SWTI000709 P63279, O95644 UBE2I, NFATC1 Environmental Information Processing; Signal Transduction, Human Diseases; Infectious Diseases, Organismal Systems; Development, Organismal Systems; Immune System hsa:7329, hsa:4772 nucleus, PML body GO:0005634, GO:0016605 SWTI000710 P30822, P21192 CRM1, ACE2 Genetic Information Processing; Translation sce:YGR218W, sce:YLR131C C:nucleus GO:0005634 UNIPROT:P53894 P53894 SWTI000711 P30822, P21192 CRM1, ACE2 Genetic Information Processing; Translation sce:YGR218W, sce:YLR131C C:nucleus GO:0005634 UNIPROT:P53894 P53894