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| NP_000042 (?) | Serine-protein kinase ATM | Serine/threonine-protein kinase Chk1 |
| Serine/threonine-protein kinase Chk2 |
| Motif | Protein | Start | End | Switch Type | Switch Subtype | Switch description | Information | Evidence |
NP_000042 - ? - ? | ||||||||
| DOC_USP7_1 | MDM4_HUMAN | 398 | 402 | Binary | Physicochemical compatibility | Phosphorylation of S403 adjacent to the USP7-binding motif of Protein Mdm4 (MDM4) by Serine-protein kinase ATM (ATM) inhibits binding to the Ubiquitin carboxyl-terminal hydrolase 7 (USP7), thereby reducing deubiquitylation of Protein Mdm4 (MDM4). As a result, ubiquitylation by E3 ubiquitin-protein ligase Mdm2 (MDM2) is not countered and Protein Mdm4 (MDM4) is targeted for proteasomal degradation. | Inferred | |
Serine-protein kinase ATM - ATM - Homo sapiens | ||||||||
| DOC_USP7_1 | MDM4_HUMAN | 398 | 402 | Binary | Physicochemical compatibility | Phosphorylation of S403 adjacent to the USP7-binding motif of Protein Mdm4 (MDM4) by Serine-protein kinase ATM (ATM) inhibits binding to the Ubiquitin carboxyl-terminal hydrolase 7 (USP7), thereby reducing deubiquitylation of Protein Mdm4 (MDM4). As a result, ubiquitylation by E3 ubiquitin-protein ligase Mdm2 (MDM2) is not countered and Protein Mdm4 (MDM4) is targeted for proteasomal degradation. | Curated | |
Serine/threonine-protein kinase Chk1 - CHEK1 - Homo sapiens | ||||||||
| LIG_14-3-3_1 | MDM4_HUMAN | 364 | 369 | Avidity‑sensing | Optimal binding of 14-3-3 dimer to Hdmx in response to DNA damage requires phosphorylation of two 14-3-3-binding motifs by Chk2 kinase. Binding of 14-3-3 dimer is involved in inactivation of Hdmx, a negative regulator of p53, in response to DNA damage. | Inferred | ||
| LIG_14-3-3_3 | MDM4_HUMAN | 339 | 344 | Avidity‑sensing | Optimal binding of 14-3-3 dimer to Hdmx in response to DNA damage requires phosphorylation of two 14-3-3-binding motifs by Chk2 kinase. Binding of 14-3-3 dimer is involved in inactivation of Hdmx, a negative regulator of p53, in response to DNA damage. | Inferred | ||
Serine/threonine-protein kinase Chk2 - CHEK2 - Homo sapiens | ||||||||
| LIG_14-3-3_1 | MDM4_HUMAN | 364 | 369 | Avidity‑sensing | Optimal binding of 14-3-3 dimer to Hdmx in response to DNA damage requires phosphorylation of two 14-3-3-binding motifs by Chk2 kinase. Binding of 14-3-3 dimer is involved in inactivation of Hdmx, a negative regulator of p53, in response to DNA damage. | Curated | ||
| LIG_14-3-3_3 | MDM4_HUMAN | 339 | 344 | Avidity‑sensing | Optimal binding of 14-3-3 dimer to Hdmx in response to DNA damage requires phosphorylation of two 14-3-3-binding motifs by Chk2 kinase. Binding of 14-3-3 dimer is involved in inactivation of Hdmx, a negative regulator of p53, in response to DNA damage. | Curated | ||