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The switches.ELM resource, hosted by the ELM consortium at the European Molecular Biology Laboratory (EMBL), consists of a database that curates experimentally validated motif-based molecular switches and a prediction tool to identify possible switching mechanisms that might regulate a user-submitted motif of interest. This tool helps to extend knowledge and direct research on how motifs mediate cooperative decision-making in a context-dependent manner and direct reliable and robust cell regulation.

Switch of the month

A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Aragon et al., Genes Dev, 2011

Links: PubMed Genes Dev switches.ELM

Submit a paper for curation



View predicted switches in the ELM database.

View switches currently awaiting curation.
Please cite

The switches.ELM resource: a compendium of conditional regulatory interaction interfaces.
Van Roey K, Dinkel H, Weatheritt RJ, Gibson TJ, Davey NE.
(Published version | Open access submitted version)
Search database


Examples: Phosphorylation | Mouse | DOC_CYCLIN_1
Analyse proteins for novel switches


Examples: P04637 | TP53 | Tumor suppressor p53
Please send any suggestions/comments to: switches@elm.eu.org