Introduction

The switches.ELM resource, hosted by the ELM consortium at the European Molecular Biology Laboratory (EMBL), consists of a database that curates experimentally validated motif-based molecular switches and a prediction tool to identify possible switching mechanisms that might regulate a user-submitted motif of interest. This tool helps to extend knowledge and direct research on how motifs mediate cooperative decision-making in a context-dependent manner and direct reliable and robust cell regulation.

Switch of the month

A Smad action turnover switch operated by WW domain readers of a phosphoserine code. Aragon et al., Genes Dev, 2011 Links: PubMed Genes Dev switches.ELM