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(1) Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP.
Tempé et al. Mol. Cell. Biol. (2006)

(2) Identification of a suppressive mechanism for Hedgehog signaling through a novel interaction of Gli with 14-3-3.
Asaoka et al. J. Biol. Chem. (2010)

(3) A CDK-catalysed regulatory phosphorylation for formation of the DNA replication complex Sld2-Dpb11.
Tak et al. EMBO J. (2006)

(4) Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression.
Li et al. Mol. Cell (2004)

(5) Phosphorylation of p53 by TAF1 Inactivates p53-Dependent Transcription in the DNA Damage Response.
Wu et al. Mol. Cell (2013)

(6) Fbw7 dimerization determines the specificity and robustness of substrate degradation.
Welcker et al. Genes Dev. (2013)

(7) Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis.
Liu et al. Nat. Cell Biol. (2013)

(8) Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair.
D'Angiolella et al. Cell (2012)

(9) Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6.
Jiang et al. Proc. Natl. Acad. Sci. U.S.A. (1999)

(10) Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
Petersen et al. EMBO J. (1999)

(11) The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73.
Levy et al. Cell Death Differ. (2007)
Annotated: SWTI000678

(12) JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis.
Lei et al. Proc. Natl. Acad. Sci. U.S.A. (2003)
Annotated: SWTI000462

(13) Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells.
Dubielecka et al. FEBS Lett. (2010)

(14) Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition.
Kim et al. Proc. Natl. Acad. Sci. U.S.A. (2010)

(15) Nerve growth factor-induced phosphorylation of amphiphysin-1 by casein kinase 2 regulates clathrin-amphiphysin interactions.
Döring et al. J. Neurochem. (2006)
Annotated: SWTI000676

(16) Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases.
Reynolds et al. J. Biol. Chem. (2008)
Annotated: SWTI000198

(17) Phosphorylation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-2 reduces receptor signaling and interaction with the Na(+)/H(+) exchanger regulatory factor.
Hildreth et al. J. Biol. Chem. (2004)
Annotated: SWTI000674

(18) Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation.
McAvoy et al. Biochemistry (1999)
Annotated: SWTI000673

(19) Phosphorylation of the p68 subunit of Pol δ acts as a molecular switch to regulate its interaction with PCNA.
Rahmeh et al. Biochemistry (2012)
Annotated: SWTI000679

(20) Homologous regions of Fen1 and p21Cip1 compete for binding to the same site on PCNA: a potential mechanism to co-ordinate DNA replication and repair.
Warbrick et al. Oncogene (1997)

(21) Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-delta p66 subunit and flap endonuclease-1.
Bruning et al. Structure (2004)

(22) Purification and characterization of a brain-specific protein kinase C substrate, neurogranin (p17). Identification of a consensus amino acid sequence between neurogranin and neuromodulin (GAP43) that corresponds to the protein kinase C phosphorylation site and the calmodulin-binding domain.
Baudier et al. J. Biol. Chem. (1991)

(23) The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie.
Badouel et al. Dev. Cell (2009)

(24) Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization.
García-Alvarez et al. Proc. Natl. Acad. Sci. U.S.A. (2007)

(25) An acylation cycle regulates localization and activity of palmitoylated Ras isoforms.
Rocks et al. Science (2005)

(26) Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21 (formin-binding protein 21).
Huang et al. J. Biol. Chem. (2009)

(27) Multivalent binding of formin-binding protein 21 (FBP21)-tandem-WW domains fosters protein recognition in the pre-spliceosome.
Klippel et al. J. Biol. Chem. (2011)

(28) Solution structure and ligand recognition of the WW domain pair of the yeast splicing factor Prp40.
Wiesner et al. J. Mol. Biol. (2002)

(29) The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation.
Viñas-Castells et al. J. Biol. Chem. (2010)
Annotated: SWTI000297

(30) DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system.
Clarke et al. Biochem. J. (2005)

(31) Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1.
Kumagai et al. Nat. Cell Biol. (2003)

(32) L1 endocytosis is controlled by a phosphorylation-dephosphorylation cycle stimulated by outside-in signaling by L1.
Schaefer et al. J. Cell Biol. (2002)
Annotated: SWTI000680

(33) A neuronal form of the cell adhesion molecule L1 contains a tyrosine-based signal required for sorting to the axonal growth cone.
Kamiguchi et al. J. Neurosci. (1998)
Annotated: SWTI000488

(34) Dephosphorylation and internalization of cell adhesion molecule L1 induced by theta burst stimulation in rat hippocampus.
Itoh et al. Mol. Cell. Neurosci. (2005)

(35) The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-alpha-induced priming of the NADPH oxidase in human neutrophils.
Boussetta et al. Blood (2010)
Annotated: SWTI000044

(36) Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc.
Tarr et al. J. Biol. Chem. (2002)

(37) Phosphorylation of the skeletal muscle glycogen-targetting subunit of protein phosphatase 1 in response to adrenaline in vivo.
Walker et al. FEBS Lett. (2000)

(38) c-Jun N-terminal kinase (JNK) positively regulates NFATc2 transactivation through phosphorylation within the N-terminal regulatory domain.
Ortega-Pérez et al. J. Biol. Chem. (2005)

(39) Two 14-3-3 binding motifs are required for stable association of Forkhead transcription factor FOXO4 with 14-3-3 proteins and inhibition of DNA binding.
Obsil et al. Biochemistry (2003)
Annotated: SWTI000690

(40) Exit of major histocompatibility complex class II-invariant chain p35 complexes from the endoplasmic reticulum is modulated by phosphorylation.
Kuwana et al. Proc. Natl. Acad. Sci. U.S.A. (1998)

(41) Phosphorylation at Ser473 regulates heterochromatin protein 1 binding and corepressor function of TIF1beta/KAP1.
Chang et al. BMC Mol. Biol. (2008)
Annotated: SWTI000185

(42) Defining pathways of spindle checkpoint silencing: functional redundancy between Cdc20 ubiquitination and p31(comet).
Jia et al. Mol. Biol. Cell (2011)

(43) ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation.
Meulmeester et al. Cell Cycle (2005)

(44) Sororin mediates sister chromatid cohesion by antagonizing Wapl.
Nishiyama et al. Cell (2010)

(45) Sequence-Specific Recognition of a PxLPxI/L Motif by an Ankyrin Repeat Tumbler Lock.
Xu et al. Sci Signal (2012)

(46) Multisite Phosphorylation Disrupts Arginine-Glutamate Salt Bridge Networks Required for Binding of Cytoplasmic Linker-associated Protein 2 (CLASP2) to End-binding Protein 1 (EB1).
Kumar et al. J. Biol. Chem. (2012)

(47) Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment.
Wang et al. Proc. Natl. Acad. Sci. U.S.A. (2012)

(48) Janus kinase 2 is associated with a box 1-like motif and phosphorylates a critical tyrosine residue in the cytoplasmic region of cytotoxic T lymphocyte associated molecule-4.
Chikuma et al. J. Cell. Biochem. (2000)

(49) Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP.
Cory et al. Mol. Cell (2003)

(50) The tyrosine kinase c-Abl protects c-Jun from ubiquitination-mediated degradation in T cells.
Gao et al. J. Biol. Chem. (2006)
Annotated: SWTI000684

(51) A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation.
Shalizi et al. Science (2006)

(52) SUMO-specific protease 1 is critical for early lymphoid development through regulation of STAT5 activation.
Van Nguyen et al. Mol. Cell (2012)

(53) A Redox-Regulated SUMO/Acetylation Switch of HIPK2 Controls the Survival Threshold to Oxidative Stress.
de la Vega et al. Mol. Cell (2012)

(54) Tandem Protein Interaction Modules Organize the Ubiquitin-Dependent Response to DNA Double-Strand Breaks.
Panier et al. (2012)

(55) Regulation of G0 entry by the Pho80-Pho85 cyclin-CDK complex.
Wanke et al. EMBO J. (2005)
Annotated: SWTI000115

(56) CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis.
Mailand et al. Cell (2005)

(57) The processivity of multiubiquitination by the APC determines the order of substrate degradation.
Rape et al. Cell (2006)

(58) Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.
Huang et al. Mol. Cell (2011)

(59) PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation.
Wu et al. Nat. Cell Biol. (2009)

(60) Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase.
Liu et al. J. Cell Biol. (2010)

(61) Dual roles of the SUMO-interacting motif in the regulation of Srs2 sumoylation.
Kolesar et al. (2012)

(62) Elg1, an alternative subunit of the RFC clamp loader, preferentially interacts with SUMOylated PCNA.
Parnas et al. EMBO J. (2010)

(63) Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2.
Armstrong et al. Nature (2012)

(64) An Acetylation Switch Regulates SUMO-Dependent Protein Interaction Networks.
Ullmann et al. Mol. Cell (2012)
Annotated: SWTI000706

(65) Negative regulation of the stability and tumor suppressor function of fbw7 by the pin1 prolyl isomerase.
Min et al. Mol. Cell (2012)
Annotated: SWTI000661

(66) PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.
Cui et al. Nat. Struct. Mol. Biol. (2012)

(67) Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding.
Chen et al. Mol. Cell. Biol. (2003)

(68) Complex phosphorylation dynamics control the composition of the Syk interactome in B cells.
Bohnenberger et al. Eur. J. Immunol. (2011)

(69) Post-translational modification of Bid has differential effects on its susceptibility to cleavage by caspase 8 or caspase 3.
Degli Esposti et al. J. Biol. Chem. (2003)

(70) Functional interplay between caspase cleavage and phosphorylation sculpts the apoptotic proteome.
Dix et al. Cell (2012)

(71) Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase.
Zhang et al. Proc. Natl. Acad. Sci. U.S.A. (2009)

(72) O-GlcNAc transferase catalyzes site-specific proteolysis of HCF-1.
Capotosti et al. Cell (2011)

(73) A short Gfi-1B isoform controls erythroid differentiation by recruiting the LSD1-CoREST complex through the dimethylation of its SNAG domain.
Laurent et al. J. Cell. Sci. (2012)

(74) L-Ilf3 and L-NF90 traffic to the nucleolus granular component: alternatively-spliced exon 3 encodes a nucleolar localization motif.
Viranaicken et al. PLoS ONE (2011)

(75) The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase.
Liu et al. J. Biol. Chem. (2010)

(76) A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP).
Zhao et al. Genes Dev. (2010)
Annotated: SWTI000691

(77) Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore-microtubule attachments.
Maia et al. J. Cell Biol. (2012)

(78) Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β Pathways.
Aragón et al. Structure (2012)

(79) Internalization of proprotein convertase PC7 from plasma membrane is mediated by a novel motif.
Declercq et al. J. Biol. Chem. (2012)

(80) Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p.
Cheeseman et al. Cell (2002)

(81) Tissue-specific splicing of a ubiquitously expressed transcription factor is essential for muscle differentiation.
Sebastian et al. Genes Dev. (2013)

(82) Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7.
Randell et al. Mol. Cell (2010)

(83) Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo.
Cole et al. J. Biol. Chem. (2006)

(84) MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components.
Yamagishi et al. Nat. Cell Biol. (2012)

(85) Phosphoregulation of Spc105 by Mps1 and PP1 regulates Bub1 localization to kinetochores.
London et al. Curr. Biol. (2012)

(86) Phosphodependent recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 kinase maintains the spindle checkpoint.
Shepperd et al. Curr. Biol. (2012)

(87) Structural basis for the interaction between focal adhesion kinase and CD4.
Garron et al. J. Mol. Biol. (2008)

(88) Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Poy et al. Mol. Cell (1999)
Annotated: SWTI000434

(89) Crystal structure of peroxisomal targeting signal-2 bound to its receptor complex Pex7p-Pex21p.
Pan et al. Nat. Struct. Mol. Biol. (2013)

(90) Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.
Downing et al. Genome Res. (2011)

(91) Structural and functional evidence that Rad4 competes with Rad2 for binding to the Tfb1 subunit of TFIIH in NER.
Lafrance-Vanasse et al. Nucleic Acids Res. (2013)

(92) Nine-amino-acid transactivation domain: establishment and prediction utilities.
Piskacek et al. Genomics (2007)

(93) Atg29 phosphorylation regulates coordination of the Atg17-Atg31-Atg29 complex with the Atg11 scaffold during autophagy initiation.
Mao et al. Proc. Natl. Acad. Sci. U.S.A. (2013)

(94) Allosteric mechanism of water-channel gating by Ca(2+)-calmodulin.
Reichow et al. Nat. Struct. Mol. Biol. (2013)

(95) Structural basis for the inhibition of Polo-like kinase 1.
Xu et al. Nat. Struct. Mol. Biol. (2013)

(96) Anaphase promoting complex-dependent degradation of transcriptional repressors Nrm1 and Yhp1 in Saccharomyces cerevisiae.
Ostapenko et al. Mol. Biol. Cell (2011)

(97) KLHL2 interacts with and ubiquitinates WNK kinases.
Takahashi et al. Biochem. Biophys. Res. Commun. (2013)

(98) Crystal structure of the tyrosine phosphatase SHP-2.
Hof et al. Cell (1998)

(99) Sequential primed kinases create a damage-responsive phosphodegron on Eco1.
Lyons et al. Nat. Struct. Mol. Biol. (2013)

(100) Positive feedback sharpens the anaphase switch.
Holt et al. Nature (2008)

(101) Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1.
Enquist-Newman et al. Mol. Cell (2008)

(102) Regulation of Nox1 activity via protein kinase A-mediated phosphorylation of NoxA1 and 14-3-3 binding.
Kim et al. J. Biol. Chem. (2007)

(103) Protein kinase A negatively modulates the nuclear accumulation of NF-ATc1 by priming for subsequent phosphorylation by glycogen synthase kinase-3.
Sheridan et al. J. Biol. Chem. (2002)
Annotated: SWTI000196

(104) APC/C(Cdh1)-dependent degradation of Cdc20 requires a phosphorylation on CRY-box by Polo-like kinase-1 during somatic cell cycle.
Hyun et al. Biochem. Biophys. Res. Commun. (2013)

(105) Functionally distinct isoforms of Cik1 are differentially regulated by APC/C-mediated proteolysis.
Benanti et al. Mol. Cell (2009)

(106) Molecular basis for defect in Alix-binding by alternatively spliced isoform of ALG-2 (ALG-2DeltaGF122) and structural roles of F122 in target recognition.
Inuzuka et al. BMC Struct. Biol. (2010)

(107) Balanced interactions of calcineurin with AKAP79 regulate Ca2+-calcineurin-NFAT signaling.
Li et al. Nat. Struct. Mol. Biol. (2012)

(108) AKAP signalling complexes: focal points in space and time.
Wong et al. Nat. Rev. Mol. Cell Biol. (2004)

(109) Molecular mechanism of convergent regulation of brain Na(+) channels by protein kinase C and protein kinase A anchored to AKAP-15.
Cantrell et al. Mol. Cell. Neurosci. (2002)

(110) Structural features of Argonaute-GW182 protein interactions.
Pfaff et al. Proc. Natl. Acad. Sci. U.S.A. (2013)

(111) A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization.
Jeyasekharan et al. Nat. Struct. Mol. Biol. (2013)

(112) Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases.
Kanemori et al. Proc. Natl. Acad. Sci. U.S.A. (2005)

(113) Dephosphorylation of Cdc20 is required for its C-box-dependent activation of the APC/C.
Labit et al. EMBO J. (2012)

(114) Regulation of Autophosphorylation Controls PLK4 Self-Destruction and Centriole Number.
Cunha-Ferreira et al. Curr. Biol. (2013)

(115) Polo-like Kinase 4 Autodestructs by Generating Its Slimb-Binding Phosphodegron.
Klebba et al. Curr. Biol. (2013)

(116) Direct binding between BubR1 and B56-PP2A phosphatase complexes regulate mitotic progression.
Kruse et al. J. Cell. Sci. (2013)

(117) Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation.
Gil et al. Cell (2002)
Annotated: SWTI000213

(118) A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activators.
Szlyk et al. Nat. Struct. Mol. Biol. (2013)

(119) Small ubiquitin-like Modifier (SUMO) modification inhibits GLI2 protein transcriptional activity in vitro and in vivo.
Han et al. J. Biol. Chem. (2012)

(120) Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins.
Quinlan et al. Mol. Cell. Biol. (2006)

(121) Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex.
Hiraga et al. Genes Dev. (2014)

(122) The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus.
Kaffman et al. Nature (1998)

(123) Nuclear export of Ho endonuclease of yeast via Msn5.
Bakhrat et al. Curr. Genet. (2008)

(124) Calcineurin-dependent regulation of Crz1p nuclear export requires Msn5p and a conserved calcineurin docking site.
Boustany et al. Genes Dev. (2002)

(125) Regulatory evolution in proteins by turnover and lineage-specific changes of cyclin-dependent kinase consensus sites.
Moses et al. Proc. Natl. Acad. Sci. U.S.A. (2007)

(126) SUMO Chain-Induced Dimerization Activates RNF4.
Rojas-Fernandez et al. Mol. Cell (2014)

(127) Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression.
Lukong et al. J. Biol. Chem. (2005)

(128) Spatial regulation of the start repressor Whi5.
Taberner et al. Cell Cycle (2009)

(129) The yeast ess1 prolyl isomerase controls swi6 and whi5 nuclear localization.
Atencio et al. G3 (Bethesda) (2014)

(130) Regulation of nuclear import by phosphorylation adjacent to nuclear localization signals.
Harreman et al. J. Biol. Chem. (2004)
Annotated: SWTI000183

(131) The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5.
Moll et al. Cell (1991)

(132) Clb6/Cdc28 and Cdc14 regulate phosphorylation status and cellular localization of Swi6.
Geymonat et al. Mol. Cell. Biol. (2004)

(133) Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase.
Woodbury et al. Nat. Cell Biol. (2007)

(134) The Calcineurin Signaling Network Evolves via Conserved Kinase-Phosphatase Modules that Transcend Substrate Identity.
Goldman et al. Mol. Cell (2014)

(135) Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases.
Yang et al. Mol. Cell. Biol. (2002)

(136) Phosphorylation of calsenilin at Ser63 regulates its cleavage by caspase-3.
Choi et al. Mol. Cell. Neurosci. (2003)

(137) Tandem phosphorylation within an intrinsically disordered region regulates ACTN4 function.
Travers et al. Sci Signal (2015)

(138) Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase.
Rodier et al. EMBO J. (2008)

(139) Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response.
Nantajit et al. PLoS ONE (2010)

(140) Viral and cellular proteins containing FGDF motifs bind G3BP to block stress granule formation.
Panas et al. PLoS Pathog. (2015)

(141) Structural analysis of the regulation of the DYNLL/LC8 binding to Nek9 by phosphorylation.
Gallego et al. J. Biol. Chem. (2013)

(142) [Protection of the personnel in special radiological rooms].
Busuoli et al. Minerva Fisiconucl ()

(143) Beta-catenin mutations in hepatocellular carcinoma correlate with a low rate of loss of heterozygosity.
Legoix et al. Oncogene (1999)


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