Switch #: SWTI000196

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of S241 and S290 adjacent to the NLS of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) by Glycogen synthase kinase-3 beta (GSK3B) and Glycogen synthase kinase-3 beta (GSK3B) inhibits nuclear import of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) by disrupting its interaction with Importin subunit alpha-2 (KPNA2). Calcium-dependent dephosphorylation by calcineurin promotes nuclear import.

Participants:
(1) Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)
(2) Importin subunit alpha-2 (KPNA2)

(1) Protein kinase A negatively modulates the nuclear accumulation of NF-ATc1 by priming for subsequent phosphorylation by glycogen synthase kinase-3.
Sheridan et al. J. Biol. Chem. (2002)

Other switches involving participants
Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) - 4 more (view)

Other switches involving interfaces
TRG_NLS_MonoExtN_4 - 10 more (view)
Armadillo/beta-catenin-like repeat - 16 more (view)