Switches.ELM

Switch #:

SWTI000195

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S896 adjacent to the ER retention motif of Glutamate [NMDA] receptor subunit zeta-1 (GRIN1) by PKC subfamily (and possibly S897 by PKA) inactivates the motif and promotes delivery of the receptor to the plasma membrane. Optimal trafficking upon dual phosphorylation of S896 and S897 allows regulation of receptor trafficking by coordinated PKA and PKC signaling.

Participants:
(1) Glutamate [NMDA] receptor subunit zeta-1 (GRIN1)
(2) Coatomer subunit beta (COPB1)

Interactions

Interaction #1 GRIN1 - COPB1

Interfaces
(1) TRG_ER_diArg_1 motif (₈₉₃RRR₈₉₅) in Glutamate [NMDA] receptor subunit zeta-1 (GRIN1)
(2) Adaptin N terminal region_(18-539) in Coatomer subunit beta (COPB1)

Interaction Regulation
PTM-dependent Abrogation (Phosphorylation of S₈₉₆ on Glutamate [NMDA] receptor subunit zeta-1 (GRIN1)) of the Glutamate [NMDA] receptor subunit zeta-1 (GRIN1) TRG_ER_diArg_1 motif - Coatomer subunit beta (COPB1) Adaptin N terminal region interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S₈₉₆: PKC subfamily

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S₈₉₆ : PKC_group.

Context

Switch localisation
ELM curated: rough endoplasmic reticulum, endoplasmic reticulum cisterna, cytosol, endoplasmic reticulum membrane, endoplasmic reticulum membrane, integral protein, ER-Golgi transport vesicle membrane, Golgi-ER transport vesicle membrane

References

(1) An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing.
Scott et al. J. Neurosci. (2001)

(2) Coordinated PKA and PKC phosphorylation suppresses RXR-mediated ER retention and regulates the surface delivery of NMDA receptors.
Scott et al. Neuropharmacology (2003)