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Switch #:
SWTI000194
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S385 adjacent to the cleavage motif of Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) by CK2 subfamily prevents cleavage by Caspase-3 (CASP3).

Participants:
(1) Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)
(2) Caspase-3 (CASP3)

Interactions
Context
References

(1) Phosphorylation-regulated cleavage of the tumor suppressor PTEN by caspase-3: implications for the control of protein stability and PTEN-protein interactions.
Torres et al. J. Biol. Chem. (2003)

See also

Other switches involving participants
Caspase-3 (CASP3) - 2 more (view)

Other switches involving interfaces
Caspase domain - 3 more (view)
CLV_C14_Caspase3-7 - 1 more (view)




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