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Switch #:
SWTI000193
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S176 adjacent to the cleavage motif of Caspase-3 (CASP3) by CK2 subfamily prevents cleavage by Caspase-8 (CASP8) and thus activation of Caspase-3 (CASP3).

Participants:
(1) Caspase-3 (CASP3)
(2) Caspase-8 (CASP8)

Interactions
Interaction #1 CASP3 - CASP8

Interfaces
(1) ELM:CLV_C14_caspase-8-10 motif (172IETD175) in Caspase-3 (CASP3)
(2) Caspase domain (234-476) in Caspase-8 (CASP8)

Interaction Regulation
PTM-dependent Abrogation (Phosphorylation of S176 on Caspase-3 (CASP3)) of the Caspase-3 (CASP3) CLV_C14_caspase-8-10 motif - Caspase-8 (CASP8) Caspase domain interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S176: CK2 subfamily

Context
Switch localisation
Curated: cytosol
Inferred: cytosol


Switch pathways
Curated: Apoptosis, Apoptotic execution phase
Inferred: p53 signaling pathway
References

(1) A peptide-based target screen implicates the protein kinase CK2 in the global regulation of caspase signaling.
Duncan et al. Sci Signal (2011)

See also

Other switches involving participants
Caspase-3 (CASP3) - 2 more (view)

Other switches involving interfaces
Caspase domain - 3 more (view)


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