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Switch #:
SWTI000197
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S21 adjacent to the SH3-binding motif of Serine/threonine-protein kinase PAK 1 (PAK1) by RAC subfamily inhibits binding to Cytoplasmic protein NCK1 (NCK1), which regulates its localization to focal contacts.

Participants:
(1) Serine/threonine-protein kinase PAK 1 (PAK1)
(2) Cytoplasmic protein NCK1 (NCK1)

Interactions
Interaction #1 PAK1 - NCK1

Interfaces
(1) LIG_SH3_2 motif (13PAPPMR18) in Serine/threonine-protein kinase PAK 1 (PAK1)
(2) SH3 domain (112-157) in Cytoplasmic protein NCK1 (NCK1)

Interaction Regulation
PTM-dependent Abrogation (Phosphorylation of S21 on Serine/threonine-protein kinase PAK 1 (PAK1)) of the Serine/threonine-protein kinase PAK 1 (PAK1) LIG_SH3_2 motif - Cytoplasmic protein NCK1 (NCK1) SH3 domain interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S21: RAC subfamily

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S21 : cGMP-dependent protein kinase 1 (PRKG1).

Context
Switch localisation
ELM curated: cytosol, focal adhesion, plasma membrane
Inferred: cytosol, plasma membrane


Switch pathways
Inferred: Axon guidance, T cell receptor signaling pathway, ErbB signaling pathway
References

(1) Akt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migration.
Zhou et al. Mol. Cell. Biol. (2003)

See also

Other switches involving participants
Cytoplasmic protein NCK1 (NCK1) - 3 more (view)

Other switches involving interfaces
LIG_SH3_2 - 5 more (view)
SH3 domain - 7 more (view)


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