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Switch #:
SWTI000198
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S210 adjacent to the SH3-binding motif of Isoform Tau-F of Microtubule-associated protein tau (MAPT) inhibits binding to Tyrosine-protein kinase Fyn (Fyn).

Participants:
(1) Isoform Tau-F of Microtubule-associated protein tau (MAPT)
(2) Tyrosine-protein kinase Fyn (Fyn)

Interactions
Context
References

(1) Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases.
Reynolds et al. J. Biol. Chem. (2008)

See also

Other switches involving interfaces
SH3 domain - 7 more (view)
LIG_SH3_3 - 5 more (view)




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