Switches.ELM

Switch #:

SWTI000199

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y309 in the PDZ-binding motif of Syndecan-1 (SDC1) prevents binding to the PDZ domain of Syntenin-1 (SDCBP), an interaction involved in the formation of cellular protrusions.

Participants:
(1) Syndecan-1 (SDC1)
(2) Syntenin-1 (SDCBP)

Interactions

Interaction #1 SDC1 - SDCBP

Interfaces
(1) LIG_PDZ_Class_2 motif (₃₀₅QEEFYA₃₁₀) in Syndecan-1 (SDC1)
(2) PDZ domain (Also known as DHR or GLGF)_(198-270) in Syntenin-1 (SDCBP)

Interaction Regulation
PTM-dependent Abrogation (Phosphorylation of Y₃₀₉ on Syndecan-1 (SDC1)) of the Syndecan-1 (SDC1) LIG_PDZ_Class_2 motif - Syntenin-1 (SDCBP) PDZ domain (Also known as DHR or GLGF) interaction

Context

Switch localisation
ELM curated: cytosol, internal side of plasma membrane

Inferred: focal adhesion

References

(1) Tyrosine dephosphorylation of the syndecan-1 PDZ binding domain regulates syntenin-1 recruitment.
Sulka et al. J. Biol. Chem. (2009)