Switch #: SWTI000661

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of T205 in the Pin1-binding motif of F-box/WD repeat-containing protein 7 (FBXW7) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein. Pin1 interacts with Fbw7 in a phoshorylation-dependent manner and promotes Fbw7 self-ubiquitination and protein degradation by disrupting Fbw7 dimerization. Paper also shows the over-expression of Pin1 suppresses the ability of Fbw7 to inhibit cell transformation and proliferation, suggesting a link between Pin1 overexpression and cancer.

Participants:
(1) F-box/WD repeat-containing protein 7 (FBXW7)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

(1) Negative regulation of the stability and tumor suppressor function of fbw7 by the pin1 prolyl isomerase.
Min et al. Mol. Cell (2012)

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) - 55 more (view)
F-box/WD repeat-containing protein 7 (FBXW7) - 8 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)