Switches.ELM

Switch #:

SWTI000324

Switch type:
Specificity

Switch subtype:
Domain hiding

Description:
An intramolecular interaction of an SH3 binding motif, encoded by exon 12A, in Isoform II2 of Myc box-dependent-interacting protein 1 (BIN1) with the SH3 domain of Bin1 prevents interaction of the Bin1 SH3 domain with the SH3 binding motif of Myc proto-oncogene protein (MYC).

Participants:
(1) Isoform II2 of Myc box-dependent-interacting protein 1 (BIN1)
(2) Myc proto-oncogene protein (MYC)

Interactions

Interaction #1 BIN1 - BIN1(intramolecular)
intramolecular
Is mutually exclusive with Interaction #2 MYC - BIN1

Interfaces
(1) LIG_SH3_3 motif (₃₀₅RKGPPVP₃₁₁) in Isoform II2 of Myc box-dependent-interacting protein 1 (BIN1)
(2) Variant SH3 domain_(413-479) in Isoform II2 of Myc box-dependent-interacting protein 1 (BIN1)
Additional Information
Structural information: 1MV3

Interaction #2 MYC - BIN1

Is mutually exclusive with Interaction #1 BIN1 - BIN1

Interfaces
(3) LIG_SH3_2 motif (₆₀PLSPSR₆₅) in Myc proto-oncogene protein (MYC)
(4) Variant SH3 domain_(413-479) in Isoform II2 of Myc box-dependent-interacting protein 1 (BIN1)

Interaction Regulation
Effector binding Abrogation (Isoform II2 of Myc box-dependent-interacting protein 1 (BIN1)) of the Myc proto-oncogene protein (MYC) LIG_SH3_2 motif - Isoform II2 of Myc box-dependent-interacting protein 1 (BIN1) Variant SH3 domain interaction

Additional Information
Structural information: 1MV0

Context

References

(1) A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants.
Pineda-Lucena et al. J. Mol. Biol. (2005)