Switch #: SWTI000325

Switch type: Specificity

Switch subtype: Domain hiding

Description:
PIP3 (1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate), a product of PI3-kinase, binds to the SH2 domains of PI3K (Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)) and thereby blocks its interaction with tyrosine-phosphorylated SH2 motif containing proteins.

Participants:
(1) 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
(2) Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)
(3) Insulin receptor (INSR)

(1) Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins.
Rameh et al. Cell (1995)

Other switches involving participants
Insulin receptor (INSR) - 1 more (view)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) - 6 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
LIG_SH2_STAT5 - 7 more (view)