Switches.ELM

Switch #:

SWTI000185

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S473 close to the Chromo shadow domain-binding motif of Transcription intermediary factor 1-beta (Trim28) by Protein kinase C delta type (Prkcd) negatively regulates its interaction with Chromobox protein homolog 1 (Cbx1), which is crucial for heterochromatin formation and maintenance. This results in relief of transcription repression and promotion of cell cycle progression.

Participants:
(1) Transcription intermediary factor 1-beta (Trim28)
(2) Chromobox protein homolog 1 (Cbx1)

Interactions

Interaction #1 Trim28 - Cbx1

Interfaces
(1) LIG_HP1_1 motif (₄₈₆PRVSL₄₉₀) in Transcription intermediary factor 1-beta (Trim28)
(2) Chromo shadow domain_(115-172) in Chromobox protein homolog 1 (Cbx1)

Interaction Regulation
PTM-dependent Abrogation (Phosphorylation of S₄₇₃ on Transcription intermediary factor 1-beta (Trim28)) of the Transcription intermediary factor 1-beta (Trim28) LIG_HP1_1 motif - Chromobox protein homolog 1 (Cbx1) Chromo shadow domain interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S₄₇₃: Protein kinase C delta type (Prkcd)

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S₄₇₃ : Protein kinase C delta type (PRKCD).

Context

References

(1) Phosphorylation at Ser473 regulates heterochromatin protein 1 binding and corepressor function of TIF1beta/KAP1.
Chang et al. BMC Mol. Biol. (2008)

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