Switch #: SWTI000186

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of S198 in the NES of M-phase inducer phosphatase 3 (CDC25C) by Serine/threonine-protein kinase PLK1 (PLK1) inhibits binding to Exportin-1 (XPO1), thus promoting nuclear localization of M-phase inducer phosphatase 3 (CDC25C).

Participants:
(1) M-phase inducer phosphatase 3 (CDC25C)
(2) Exportin-1 (XPO1)

(1) Plk1 promotes nuclear translocation of human Cdc25C during prophase.
Toyoshima-Morimoto et al. EMBO Rep. (2002)

Other switches involving participants
M-phase inducer phosphatase 3 (CDC25C) - 2 more (view)
Exportin-1 (XPO1) - 7 more (view)

Other switches involving interfaces
TRG_NES_CRM1_1 - 3 more (view)
Exportin 1-like protein - 9 more (view)