Switches.ELM

Switch #:

SWTI000187

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Under normoxic conditions interaction of Hypoxia-inducible factor 1-alpha (HIF1A) with transcriptional coactivators such as CREB-binding protein (Crebbp) is inhibited by hydroxylation of N803.

Participants:
(1) Hypoxia-inducible factor 1-alpha (HIF1A)
(2) CREB-binding protein (Crebbp)

Interactions

Interaction #1 HIF1A - Crebbp

Interfaces
(1) ELM:LIG_TAZ1 motif (₇₉₂LPQL₇₉₅) in Hypoxia-inducible factor 1-alpha (HIF1A)
(2) TAZ zinc finger_(351-431) in CREB-binding protein (Crebbp)

Interaction Regulation
PTM-dependent Abrogation (Hydroxylation of N₈₀₃ on Hypoxia-inducible factor 1-alpha (HIF1A)) of the Hypoxia-inducible factor 1-alpha (HIF1A) LIG_TAZ1 motif - CREB-binding protein (Crebbp) TAZ zinc finger interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: N₈₀₃: Hypoxia-inducible factor 1-alpha inhibitor (HIF1AN)

Additional Information
Structural information: 1L8C

Context

Switch localisation
Curated: nucleus

References

(1) Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response.
Dames et al. Proc. Natl. Acad. Sci. U.S.A. (2002)