About Help Definitions Submit Search Analyse Browse Home


Switch #:
SWTI000187
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Under normoxic conditions interaction of Hypoxia-inducible factor 1-alpha (HIF1A) with transcriptional coactivators such as CREB-binding protein (Crebbp) is inhibited by hydroxylation of N803.

Participants:
(1) Hypoxia-inducible factor 1-alpha (HIF1A)
(2) CREB-binding protein (Crebbp)

Interactions
Interaction #1 HIF1A - Crebbp

Interfaces
(1) ELM:LIG_TAZ1 motif (792LPQL795) in Hypoxia-inducible factor 1-alpha (HIF1A)
(2) TAZ zinc finger (351-431) in CREB-binding protein (Crebbp)

Interaction Regulation
PTM-dependent Abrogation (Hydroxylation of N803 on Hypoxia-inducible factor 1-alpha (HIF1A)) of the Hypoxia-inducible factor 1-alpha (HIF1A) LIG_TAZ1 motif - CREB-binding protein (Crebbp) TAZ zinc finger interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: N803: Hypoxia-inducible factor 1-alpha inhibitor (HIF1AN)

Additional Information
Structural information: 1L8C
Context
References

(1) Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response.
Dames et al. Proc. Natl. Acad. Sci. U.S.A. (2002)

See also

Other switches involving participants
Hypoxia-inducible factor 1-alpha (HIF1A) - 2 more (view)

Other switches involving interfaces
TAZ zinc finger - 1 more (view)




Loading visualisation

           
Please send any suggestions/comments to: switches@elm.eu.org