Switches.ELM

Switch #:

SWTI000188

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of T121 adjacent to the NLS of Parathyroid hormone-related protein (PTHLH) by Cyclin-dependent kinase 2 (CDK2) disrupts the interaction with Importin subunit beta-1 (KPNB1) and down-regulates nuclear import.

Participants:
(1) Parathyroid hormone-related protein (PTHLH)
(2) Importin subunit beta-1 (KPNB1)

Interactions

Interaction #1 PTHLH - KPNB1

Interfaces
(1) TRG_NLS_Bipartite_1 motif (₁₂₄KKKKGKPGKRKEQEKKKRRTR₁₄₄) in Parathyroid hormone-related protein (PTHLH)
(2) Armadillo/beta-catenin-like repeat_(399-437) in Importin subunit beta-1 (KPNB1)

Interaction Regulation
PTM-dependent Abrogation (Phosphorylation of T₁₂₁ on Parathyroid hormone-related protein (PTHLH)) of the Parathyroid hormone-related protein (PTHLH) TRG_NLS_Bipartite_1 motif - Importin subunit beta-1 (KPNB1) Armadillo/beta-catenin-like repeat interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: T₁₂₁: Cyclin-dependent kinase 2 (CDK2)

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: T₁₂₁ : Cyclin-dependent kinase 2 (CDK2).

Context

References

(1) Phosphorylation meets nuclear import: a review.
Nardozzi et al. Cell Commun. Signal (2010)