Description: Participants: Interactions ![]() 1Interaction #1 YWHAZ - YWHAZ Interfaces (1) 14-3-3 protein in 14-3-3 protein zeta/delta (YWHAZ) (2) 14-3-3 protein (3-236) in 14-3-3 protein zeta/delta (YWHAZ) 2Interaction #2 FOXO4 - Interaction #1 YWHAZ - YWHAZ Requires Interaction #1 YWHAZ - YWHAZ Interfaces (3) LIG_14-3-3_1 motif (29RSCTWP34) in Forkhead box protein O4 (FOXO4) (4) Interaction #1 YWHAZ - YWHAZ Interaction Regulation PTM-dependent Induction (Phosphorylation of T32 on Forkhead box protein O4 (FOXO4)) of the Forkhead box protein O4 (FOXO4) LIG_14-3-3_1 motif - 14-3-3 protein interaction Regulatory Enzymes for switch Modifying enzymes for residue: T32: RAC-alpha serine/threonine-protein kinase (AKT1) 2Interaction #3 FOXO4 - Interaction #1 YWHAZ - YWHAZ Requires Interaction #1 YWHAZ - YWHAZ Interfaces (5) LIG_14-3-3_2 motif (193RRAASMD199) in Forkhead box protein O4 (FOXO4) (6) Interaction #1 YWHAZ - YWHAZ Interaction Regulation PTM-dependent Induction (Phosphorylation of S197 on Forkhead box protein O4 (FOXO4)) of the Forkhead box protein O4 (FOXO4) LIG_14-3-3_2 motif - 14-3-3 protein interaction Regulatory Enzymes for switch Modifying enzymes for residue: S197: RAC-alpha serine/threonine-protein kinase (AKT1) Inferred Regulatory Enzymes for switch Putative modifying enzymes for residue: S197 : PKB_group, RAC-alpha serine/threonine-protein kinase (AKT1). Context References (1) Two 14-3-3 binding motifs are required for stable association of Forkhead transcription factor FOXO4 with 14-3-3 proteins and inhibition of DNA binding. See also Other switches involving participants |
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