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Switch #:
SWTI000044
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S345 in the Pin1-binding motif of Neutrophil cytosol factor 1 (NCF1) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Neutrophil cytosol factor 1 (NCF1)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interactions
Interaction #1 NCF1 - PIN1

Interfaces
(1) DOC_WW_Pin1_4 motif (342GPQSPG347) in Neutrophil cytosol factor 1 (NCF1)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S345 on Neutrophil cytosol factor 1 (NCF1)) of the Neutrophil cytosol factor 1 (NCF1) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) WW domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S345 : Mitogen-activated protein kinase 1 (MAPK1), Interleukin-1 receptor-associated kinase 4 (IRAK4), Mitogen-activated protein kinase 3 (MAPK3), Mitogen-activated protein kinase 14 (MAPK14).

Context
Switch localisation
ELM curated: nucleus, cytosol
References

(1) The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-alpha-induced priming of the NADPH oxidase in human neutrophils.
Boussetta et al. Blood (2010)

See also

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) - 55 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)


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