Interaction #1 NCF1 - PIN1
(1) DOC_WW_Pin1_4 motif (342GPQSPG347) in Neutrophil cytosol factor 1 (NCF1)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)
PTM-dependent Induction (Phosphorylation of S345 on Neutrophil cytosol factor 1 (NCF1)) of the Neutrophil cytosol factor 1 (NCF1) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) WW domain interaction
Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S345 : Mitogen-activated protein kinase 1 (MAPK1), Interleukin-1 receptor-associated kinase 4 (IRAK4), Mitogen-activated protein kinase 3 (MAPK3), Mitogen-activated protein kinase 14 (MAPK14).
ELM curated: nucleus, cytosol
(1) The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-alpha-induced priming of the NADPH oxidase in human neutrophils.
Other switches involving participants