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Switch #:
SWTI000043
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S77 in the Pin1-binding motif of Retinoic acid receptor alpha (RARA) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Retinoic acid receptor alpha (RARA)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interactions
Interaction #1 RARA - PIN1

Interfaces
(1) DOC_WW_Pin1_4 motif (74SPPSPP79) in Retinoic acid receptor alpha (RARA)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S77 on Retinoic acid receptor alpha (RARA)) of the Retinoic acid receptor alpha (RARA) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) WW domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S77 : Cyclin-dependent kinase 7 (CDK7).

Context
Switch localisation
ELM curated: nucleus, cytosol
Inferred: cytoplasm, nucleoplasm
References

(1) The peptidyl-prolyl isomerase Pin1 regulates phospho-Ser77 retinoic acid receptor alpha stability.
Brondani et al. Biochem. Biophys. Res. Commun. (2005)

See also

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) - 55 more (view)
Retinoic acid receptor alpha (RARA) - 2 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)


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