Switch #: SWTI000706

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Acetylation of K37 in the SUMO1 inhibits binding to the Small ubiquitin-related modifier 1 (SUMO1) protein see switch details. SUMO-modified forms of Protein PML (PML) are essential for the recruitment of DAXX to PML nuclear bodies. The acetylated versions of SUMO1/2 failed to trigger recruitment of DAXX into the nuclear bodies. Acetylation is countered by Histone deacetylase family, HD type 1 subfamily.

Participants:
(1) Death domain-associated protein 6 (DAXX)
(2) Small ubiquitin-related modifier 1 (SUMO1)

(1) An Acetylation Switch Regulates SUMO-Dependent Protein Interaction Networks.
Ullmann et al. Mol. Cell (2012)

Other switches involving participants
Death domain-associated protein 6 (DAXX) - 5 more (view)
Small ubiquitin-related modifier 1 (SUMO1) - 6 more (view)

Other switches involving interfaces
LIG_SUMO_SBM_1 - 10 more (view)
Ubiquitin-2 like Rad60 SUMO-like - 10 more (view)