Switch #: SWTI000705

Switch type: Specificity

Switch subtype: Altered binding specificity

Description:
Acetylation of K33 in the SUMO2 inhibits binding to the Death domain-associated protein 6 (DAXX) protein see switch details. SUMO-modified forms of Protein PML (PML) are essential for the recruitment of Small ubiquitin-related modifier 2 (SUMO2) to PML nuclear bodies. The acetylated versions of SUMO1/2 failed to trigger recruitment of Small ubiquitin-related modifier 2 (SUMO2) into the nuclear bodies. An additional interaction is also possible upon acetylation with the Bromodomain of Histone acetyltransferase p300 (EP300) shown to bind the acetylated version of SUMO2. This does not occur with acetylated SUMO1. Acetylation is countered by Histone deacetylase family, HD type 1 subfamily.

Participants:
(1) Death domain-associated protein 6 (DAXX)
(2) Small ubiquitin-related modifier 2 (SUMO2)
(3) Histone acetyltransferase p300 (EP300)

(1) An Acetylation Switch Regulates SUMO-Dependent Protein Interaction Networks.
Ullmann et al. Mol. Cell (2012)

Other switches involving participants
Death domain-associated protein 6 (DAXX) - 5 more (view)
Small ubiquitin-related modifier 2 (SUMO2) - 3 more (view)

Other switches involving interfaces
LIG_SUMO_SBM_1 - 10 more (view)
Ubiquitin-2 like Rad60 SUMO-like - 10 more (view)