Switch #: SWTI000704

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y447 in the SH2-binding motif of GRB2-associated-binding protein 1 (GAB1) induces binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1).

Participants:
(1) GRB2-associated-binding protein 1 (GAB1)
(2) Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

(1) Identification of major tyrosine phosphorylation sites in the human insulin receptor substrate Gab-1 by insulin receptor kinase in vitro.
Lehr et al. Biochemistry (2000)

Other switches involving participants
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) - 6 more (view)
GRB2-associated-binding protein 1 (GAB1) - 1 more (view)

Other switches involving interfaces
LIG_SH2_STAT5 - 7 more (view)
SH2 domain - 140 more (view)