Interaction #1 GAB1 - PIK3R1
(1) LIG_SH2_STAT5 motif (447YVPM450) in GRB2-associated-binding protein 1 (GAB1)
(2) SH2 domain (333-408) and (624-698) in Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)
PTM-dependent Induction (Phosphorylation of Y447 on GRB2-associated-binding protein 1 (GAB1)) of the GRB2-associated-binding protein 1 (GAB1) LIG_SH2_STAT5 motif - Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) SH2 domain interaction
Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y447 : Hepatocyte growth factor receptor (MET), Epidermal growth factor receptor (EGFR), Insulin receptor (INSR).
ELM curated: cytosol
Curated: ErbB signaling pathway
(1) Identification of major tyrosine phosphorylation sites in the human insulin receptor substrate Gab-1 by insulin receptor kinase in vitro.
Other switches involving participants