Interaction #1 POLD3 - PCNA
(1) LIG_PCNA_PIPBox_1 motif (456QVSITGFFQR465) in DNA polymerase delta subunit 3 (POLD3)
(2) Proliferating cell nuclear antigen, C-terminal domain (127-254) in Proliferating cell nuclear antigen (PCNA)
PTM-dependent Inhibition (Phosphorylation of S458 on DNA polymerase delta subunit 3 (POLD3)) of the DNA polymerase delta subunit 3 (POLD3) LIG_PCNA_PIPBox_1 motif - Proliferating cell nuclear antigen (PCNA) Proliferating cell nuclear antigen, C-terminal domain interaction
Regulatory Enzymes for switch
Modifying enzymes for residue: S458: cAMP subfamily
Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S458 : cAMP-dependent protein kinase catalytic subunit alpha (PRKACA).
ELM curated: nucleus
Switch cell cycle phase
Curated: mitotic S phase
Curated: Synthesis of DNA, DNA replication, Base excision repair, Nucleotide excision repair, Mismatch repair
(1) Phosphorylation of the p68 subunit of Pol δ acts as a molecular switch to regulate its interaction with PCNA.
Other switches involving participants