Switch #: SWTI000680

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y1176 in the endocytotic motif of Neural cell adhesion molecule L1 (L1CAM) by Proto-oncogene tyrosine-protein kinase Src (SRC) abolishes binding to the AP-2 complex subunit mu (AP2M1) and thereby inhibits internalisation of Neural cell adhesion molecule L1 (L1CAM).

Participants:
(1) Neural cell adhesion molecule L1 (L1CAM)
(2) AP-2 complex subunit mu (AP2M1)

(1) L1 endocytosis is controlled by a phosphorylation-dephosphorylation cycle stimulated by outside-in signaling by L1.
Schaefer et al. J. Cell Biol. (2002)

Other switches involving participants
AP-2 complex subunit mu (AP2M1) - 15 more (view)
Neural cell adhesion molecule L1 (L1CAM) - 3 more (view)

Other switches involving interfaces
TRG_ENDOCYTIC_2 - 21 more (view)
Adaptor complexes medium subunit family - 21 more (view)