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Switch #:
SWTI000183
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S160 adjacent to the NLS of Regulatory protein SWI6 (SWI6) decreases nuclear import of this protein by decreasing the affinity for Importin subunit alpha (SRP1).

Participants:
(1) Regulatory protein SWI6 (SWI6)
(2) Importin subunit alpha (SRP1)

Interactions
Interaction #1 SWI6 - SRP1

Interfaces
(1) TRG_NLS_MonoExtN_4 motif (161PLKKLKI167) in Regulatory protein SWI6 (SWI6)
(2) Armadillo/beta-catenin-like repeat (119-457) in Importin subunit alpha (SRP1)

Interaction Regulation
PTM-dependent Abrogation (Phosphorylation of S160 on Regulatory protein SWI6 (SWI6)) of the Regulatory protein SWI6 (SWI6) TRG_NLS_MonoExtN_4 motif - Importin subunit alpha (SRP1) Armadillo/beta-catenin-like repeat interaction

Additional Information
Affinity : S160: 0.045 µM, S160E: 0.163 µM
Context
Switch localisation
Curated: cytosol
ELM curated: Nuclear pore, nucleus, NLS-dependent protein nuclear import complex
Inferred: cytoplasm
References

(1) Regulation of nuclear import by phosphorylation adjacent to nuclear localization signals.
Harreman et al. J. Biol. Chem. (2004)

See also

Other switches involving participants
Importin subunit alpha (SRP1) - 1 more (view)

Other switches involving interfaces
Armadillo/beta-catenin-like repeat - 16 more (view)
TRG_NLS_MonoExtN_4 - 10 more (view)


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