Switches.ELM

Switch #:

SWTI000115

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of T1075 in the 14-3-3-binding motif of Serine/threonine-protein kinase RIM15 (RIM15) induces binding to the Protein BMH2 (BMH2) protein. This interaction sequesters Serine/threonine-protein kinase RIM15 (RIM15) in the cytoplasm, thereby inhibiting its function.

Participants:
(1) Serine/threonine-protein kinase RIM15 (RIM15)
(2) Protein BMH2 (BMH2)

Interactions

Interaction #1 RIM15 - BMH2

Interfaces
(1) LIG_14-3-3_3 motif (₁₀₇₂RSSTPP₁₀₇₇) in Serine/threonine-protein kinase RIM15 (RIM15)
(2) 14-3-3 protein_(5-241) in Protein BMH2 (BMH2)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of T₁₀₇₅ on Serine/threonine-protein kinase RIM15 (RIM15)) of the Serine/threonine-protein kinase RIM15 (RIM15) LIG_14-3-3_3 motif - Protein BMH2 (BMH2) 14-3-3 protein interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: T₁₀₇₅: Cyclin-dependent protein kinase PHO85 (PHO85)

Context

References

(1) Regulation of G0 entry by the Pho80-Pho85 cyclin-CDK complex.
Wanke et al. EMBO J. (2005)