Switch #: SWTI000434

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y281 in the SH2-binding motif of Signaling lymphocytic activation molecule (SLAMF1) induces binding to the SH2 domain-containing protein 1A (SH2D1A) protein.

Participants:
(1) Signaling lymphocytic activation molecule (SLAMF1)
(2) SH2 domain-containing protein 1A (SH2D1A)

(1) Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Poy et al. Mol. Cell (1999)

Other switches involving participants
Signaling lymphocytic activation molecule (SLAMF1) - 3 more (view)
SH2 domain-containing protein 1A (SH2D1A) - 2 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IB - 13 more (view)