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Switch #:
SWTI000435
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y281 in the SH2-binding motif of Signaling lymphocytic activation molecule (SLAMF1) induces binding to the SH2 domain-containing protein 1B (Sh2d1b) protein.

Participants:
(1) Signaling lymphocytic activation molecule (SLAMF1)
(2) SH2 domain-containing protein 1B (Sh2d1b)

Interactions
Interaction #1 SLAMF1 - Sh2d1b

Interfaces
(1) ELM:LIG_SH2_IB motif (273VEKKSLTIYAQVQK286) in Signaling lymphocytic activation molecule (SLAMF1)
(2) SH2 domain (5-86) in SH2 domain-containing protein 1B (Sh2d1b)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y281 on Signaling lymphocytic activation molecule (SLAMF1)) of the Signaling lymphocytic activation molecule (SLAMF1) LIG_SH2_IB motif - SH2 domain-containing protein 1B (Sh2d1b) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y281 : Tyrosine-protein kinase Fyn (FYN).

Additional Information
Structural information: 1I3Z
References

(1) Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.
Morra et al. EMBO J. (2001)

See also

Other switches involving participants
Signaling lymphocytic activation molecule (SLAMF1) - 3 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IB - 13 more (view)




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