Switch #: SWTI000436

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y402 in the SH2-binding motif of Protein-tyrosine kinase 2-beta (PTK2B) induces binding to the Megakaryocyte-associated tyrosine-protein kinase (MATK) protein.

Participants:
(1) Protein-tyrosine kinase 2-beta (PTK2B)
(2) Megakaryocyte-associated tyrosine-protein kinase (MATK)

(1) Csk homologous kinase associates with RAFTK/Pyk2 in breast cancer cells and negatively regulates its activation and breast cancer cell migration.
McShan et al. Int. J. Oncol. (2002)

Other switches involving participants
Megakaryocyte-associated tyrosine-protein kinase (MATK) - 1 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IB - 13 more (view)