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Switch #:
SWTI000437
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y727 in the SH2-binding motif of BDNF/NT-3 growth factors receptor (NTRK2) induces binding to the Cytoplasmic protein NCK2 (NCK2) protein.

Participants:
(1) BDNF/NT-3 growth factors receptor (NTRK2)
(2) Cytoplasmic protein NCK2 (NCK2)

Interactions
Interaction #1 NTRK2 - NCK2

Interfaces
(1) ELM:LIG_SH2_IA motif (714MLPIRWMPPESIMYRKF730) in BDNF/NT-3 growth factors receptor (NTRK2)
(2) SH2 domain (285-323) in Cytoplasmic protein NCK2 (NCK2)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y727 on BDNF/NT-3 growth factors receptor (NTRK2)) of the BDNF/NT-3 growth factors receptor (NTRK2) LIG_SH2_IA motif - Cytoplasmic protein NCK2 (NCK2) SH2 domain interaction

Context
Switch localisation
Inferred: cytosol
References

(1) Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor.
Suzuki et al. Biochem. Biophys. Res. Commun. (2002)

See also

Other switches involving participants
Cytoplasmic protein NCK2 (NCK2) - 6 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IA - 16 more (view)


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