Switches.ELM

Switch #:

SWTI000438

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y145 in the SH2-binding motif of Lymphocyte cytosolic protein 2 (Lcp2) induces binding to the Tyrosine-protein kinase ITK/TSK (Itk) protein.

Participants:
(1) Lymphocyte cytosolic protein 2 (Lcp2)
(2) Tyrosine-protein kinase ITK/TSK (Itk)

Interactions

Interaction #1 Lcp2 - Itk

Interfaces
(1) ELM:LIG_SH2_IA motif (₁₄₃ADYEPP₁₄₈) in Lymphocyte cytosolic protein 2 (Lcp2)
(2) SH2 domain_(245-328) in Tyrosine-protein kinase ITK/TSK (Itk)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y₁₄₅ on Lymphocyte cytosolic protein 2 (Lcp2)) of the Lymphocyte cytosolic protein 2 (Lcp2) LIG_SH2_IA motif - Tyrosine-protein kinase ITK/TSK (Itk) SH2 domain interaction

Additional Information
Structural information: 2EU0

Context

Switch localisation

Switch pathways

References

(1) Molecular details of Itk activation by prolyl isomerization and phospholigand binding: the NMR structure of the Itk SH2 domain bound to a phosphopeptide.
Pletneva et al. J. Mol. Biol. (2006)