Switch #: SWTI000439

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y813 in the SH2-binding motif of Tyrosine-protein kinase JAK2 (Jak2) induces binding to the Signal transducer and activator of transcription 5B (Stat5b) protein.

Participants:
(1) Tyrosine-protein kinase JAK2 (Jak2)
(2) Signal transducer and activator of transcription 5B (Stat5b)

(1) Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta.
Kurzer et al. Mol. Cell. Biol. (2004)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_III - 15 more (view)