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Switch #:
SWTI000439
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y813 in the SH2-binding motif of Tyrosine-protein kinase JAK2 (Jak2) induces binding to the Signal transducer and activator of transcription 5B (Stat5b) protein.

Participants:
(1) Tyrosine-protein kinase JAK2 (Jak2)
(2) Signal transducer and activator of transcription 5B (Stat5b)

Interactions
Interaction #1 Jak2 - Stat5b

Interfaces
(1) ELM:LIG_SH2_III motif (804DLNSLFTPDYELLTEND820) in Tyrosine-protein kinase JAK2 (Jak2)
(2) SH2 domain (593-670) in Signal transducer and activator of transcription 5B (Stat5b)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y813 on Tyrosine-protein kinase JAK2 (Jak2)) of the Tyrosine-protein kinase JAK2 (Jak2) LIG_SH2_III motif - Signal transducer and activator of transcription 5B (Stat5b) SH2 domain interaction


Context
Switch localisation
References

(1) Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta.
Kurzer et al. Mol. Cell. Biol. (2004)

See also

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_III - 15 more (view)




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