About Help Definitions Submit Search Analyse Browse Home


Switch #:
SWTI000440
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y362 in the SH2-binding motif of Breast cancer anti-estrogen resistance protein 1 (BCAR1) induces binding to the Adapter molecule crk (CRK) protein.

Participants:
(1) Breast cancer anti-estrogen resistance protein 1 (BCAR1)
(2) Adapter molecule crk (CRK)

Interactions
Interaction #1 BCAR1 - CRK

Interfaces
(1) ELM:LIG_SH2_IB motif (358AEDVYDVPPPA368) in Breast cancer anti-estrogen resistance protein 1 (BCAR1)
(2) SH2 domain (13-104) in Adapter molecule crk (CRK)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y362 on Breast cancer anti-estrogen resistance protein 1 (BCAR1)) of the Breast cancer anti-estrogen resistance protein 1 (BCAR1) LIG_SH2_IB motif - Adapter molecule crk (CRK) SH2 domain interaction

Additional Information
Affinity : 0.35 µM
Context
Switch localisation
Inferred: cytosol


Switch pathways
Inferred: Chemokine signaling pathway, Regulation of actin cytoskeleton, Focal adhesion
References

(1) SH2 domains recognize contextual peptide sequence information to determine selectivity.
Liu et al. Mol. Cell Proteomics (2010)

See also

Other switches involving participants
Adapter molecule crk (CRK) - 7 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IB - 13 more (view)


Loading visualisation

           
Please send any suggestions/comments to: switches@elm.eu.org