Switch #: SWTI000674

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of S1104 in the PDZ-binding motif of Platelet-derived growth factor receptor beta (PDGFRB) by Beta-adrenergic receptor kinase 1 (ADRBK1) inhibits binding to Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1). Binding of Platelet-derived growth factor receptor beta (PDGFRB) to Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) potentiates dimerisation and signalling of the receptor, while phosphorylation at S1104 desensitises the receptor.

Participants:
(1) Platelet-derived growth factor receptor beta (PDGFRB)
(2) Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1)

(1) Phosphorylation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-2 reduces receptor signaling and interaction with the Na(+)/H(+) exchanger regulatory factor.
Hildreth et al. J. Biol. Chem. (2004)

Other switches involving participants
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) - 5 more (view)
Platelet-derived growth factor receptor beta (PDGFRB) - 2 more (view)

Other switches involving interfaces
PDZ domain (Also known as DHR or GLGF) - 45 more (view)
LIG_PDZ_Class_1 - 41 more (view)