Switch #: SWTI000213

Switch type: Binary

Switch subtype: Allostery

Description:
Ligand binding to the T cell receptor complex TCR-CD3 results in a conformational change that exposes an SH3-binding motif in T-cell surface glycoprotein CD3 epsilon chain (CD3E), resulting in recruitment of Cytoplasmic protein NCK2 (NCK2), involved in T cell activation.

Participants:
(1) T-cell surface glycoprotein CD3 epsilon chain (CD3E)
(2) Cytoplasmic protein NCK2 (NCK2)

(1) Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation.
Gil et al. Cell (2002)

Other switches involving participants
T-cell surface glycoprotein CD3 epsilon chain (CD3E) - 2 more (view)
Cytoplasmic protein NCK2 (NCK2) - 6 more (view)

Other switches involving interfaces
SH3 domain - 7 more (view)
LIG_SH3_5 - 1 more (view)