Switch #: SWTI000214

Switch type: Binary

Switch subtype: Allostery

Description:
Binding of calcium(2+) to Programmed cell death protein 6 (PDCD6) opens a hydrophobic pocket on Programmed cell death protein 6 (PDCD6) that is required for binding of Programmed cell death 6-interacting protein (PDCD6IP).

Participants:
(1) Programmed cell death 6-interacting protein (PDCD6IP)
(2) Programmed cell death protein 6 (PDCD6)

(1) Structural basis for Ca2+ -dependent formation of ALG-2/Alix peptide complex: Ca2+/EF3-driven arginine switch mechanism.
Suzuki et al. Structure (2008)

Other switches involving interfaces
EF-hand domain pair - 5 more (view)