Switch #: SWTI000215

Switch type: Binary

Switch subtype: Allostery

Description:
Binding of Mad1-bound Closed (C-) Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) to Open (O-) Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) switches conformation of the latter to the C conformation, making the binding site for Cell division cycle protein 20 homolog (CDC20) available. This sequesters Cell division cycle protein 20 homolog (CDC20) to the spindle assembly checkpoint and prevents onset of anaphase.

Participants:
(1) Cell division cycle protein 20 homolog (CDC20)
(2) Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)

(1) Determinants of conformational dimerization of Mad2 and its inhibition by p31comet.
Mapelli et al. EMBO J. (2006)

Other switches involving participants
Cell division cycle protein 20 homolog (CDC20) - 3 more (view)