Switches.ELM

Switch #:

SWTI000216

Switch type:
Binary

Switch subtype:
Allostery

Description:
Binding of Beta-arrestin-1 (ARRB1) to ligand-induced, phosphorylated GPCRs results in a conformational change that makes the AP2-beta interaction motif in Beta-arrestin-1 (ARRB1) accessible for binding to AP-2 complex subunit beta (AP2B1), which mediates internalization of the GPCR.

Participants:
(1) Beta-arrestin-1 (ARRB1)
(2) AP-2 complex subunit beta (AP2B1)

Interactions

Interaction #1 ARRB1 - AP2B1

Interfaces
(1) TRG_AP2beta_CARGO_1 motif (₃₈₅DIVFEDFARQR₃₉₅) in Beta-arrestin-1 (ARRB1)
(2) Beta2-adaptin appendage, C-terminal sub-domain_(826-936) in AP-2 complex subunit beta (AP2B1)

Interaction Regulation
Effector binding Induction of the Beta-arrestin-1 (ARRB1) TRG_AP2beta_CARGO_1 motif - AP-2 complex subunit beta (AP2B1) Beta2-adaptin appendage, C-terminal sub-domain interaction

Additional Information
Structural information: 1G4M

Context

Switch pathways

References

(1) Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly.
Edeling et al. Dev. Cell (2006)