Interaction #1 CD4 - AP2S1
(1) TRG_LysEnd_APsAcLL_1 motif (434QIKRLL439) in T-cell surface glycoprotein CD4 (CD4)
(2) Clathrin adaptor complex small chain (1-142) in AP-2 complex subunit sigma (AP2S1)
Effector binding Induction (1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate) of the T-cell surface glycoprotein CD4 (CD4) TRG_LysEnd_APsAcLL_1 motif - AP-2 complex subunit sigma (AP2S1) Clathrin adaptor complex small chain interaction
(1) A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex.
Other switches involving participants