Switch #: SWTI000217

Switch type: Binary

Switch subtype: Allostery

Description:
Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (AP2S1) subunit for recruitment of T-cell surface glycoprotein CD4 (CD4) via an endocytosis motif.

Participants:
(1) T-cell surface glycoprotein CD4 (CD4)
(2) AP-2 complex subunit sigma (AP2S1)

(1) A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex.
Jackson et al. Cell (2010)

Other switches involving participants
AP-2 complex subunit sigma (AP2S1) - 11 more (view)

Other switches involving interfaces
TRG_LysEnd_APsAcLL_1 - 14 more (view)
Clathrin adaptor complex small chain - 15 more (view)