Switch #: SWTI000218

Switch type: Binary

Switch subtype: Allostery

Description:
Binding of Ezrin (EZR) via its FERM domain to the EB domain of Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) results in allosteric coupling to the second PDZ domain of Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1), which results in relief of the intramolecular interaction with the PDZ binding ligand, thereby increasing the affinity of the PDZ domain for other ligands, including Catenin beta-1 (CTNNB1).

Participants:
(1) Catenin beta-1 (CTNNB1)
(2) Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1)

(1) A conformational switch in the scaffolding protein NHERF1 controls autoinhibition and complex formation.
Bhattacharya et al. J. Biol. Chem. (2010)

Other switches involving participants
Catenin beta-1 (CTNNB1) - 3 more (view)
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) - 5 more (view)

Other switches involving interfaces
PDZ domain (Also known as DHR or GLGF) - 45 more (view)
LIG_PDZ_Class_1 - 41 more (view)