Switches.ELM

Switch #:

SWTI000219

Switch type:
Binary

Switch subtype:
Allostery

Description:
Binding of calcium(2+) to Recoverin (RCVRN) results in a conformational change in Recoverin that makes the myristoyl moiety available for binding to the membrane.

Participants:
(1) Recoverin (RCVRN)
(2) membrane

Interactions

Interaction #1 RCVRN - membrane

Interfaces
(1) MOD_NMyristoyl motif (₁MGNSKSG₇) in Recoverin (RCVRN)
(2) membrane

Interaction Regulation
Effector binding Induction (calcium(2+)) of the Recoverin (RCVRN) MOD_NMyristoyl motif - membrane interaction

Additional Information
Structural information: 1IKU, 1JSA

Context

Switch localisation
Curated: membrane
ELM curated: anchored to plasma membrane, cytosol

References

(1) Conformational dynamics of recoverin's Ca2+-myristoyl switch probed by 15N NMR relaxation dispersion and chemical shift analysis.
Xu et al. Proteins (2011)

(2) Sequestration of the membrane-targeting myristoyl group of recoverin in the calcium-free state.
Tanaka et al. Nature (1995)

(3) Molecular mechanics of calcium-myristoyl switches.
Ames et al. Nature (1997)