Switch #: SWTI000220

Switch type: Binary

Switch subtype: Allostery

Description:
Phosphorylation of cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) at S11 shifts the conformational equilibrium to the myristoyl-out conformation, making the myristoyl moiety available for interaction with the membrane.

Participants:
(1) cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)
(2) membrane

(1) A myristoyl/phosphoserine switch controls cAMP-dependent protein kinase association to membranes.
Gaffarogullari et al. J. Mol. Biol. (2011)

(2) Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations.
Zheng et al. Protein Sci. (1993)

Other switches involving participants
membrane - 1 more (view)
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) - 1 more (view)

Other switches involving interfaces
MOD_NMyristoyl - 2 more (view)