Switch #: SWTI000221

Switch type: Binary

Switch subtype: Allostery

Description:
Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (AP2M1) subunit for recruitment of Epidermal growth factor receptor (EGFR) via an endocytosis motif.

Participants:
(1) Epidermal growth factor receptor (EGFR)
(2) AP-2 complex subunit mu (AP2M1)

(1) Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis.
Nesterov et al. EMBO J. (1999)

Other switches involving participants
AP-2 complex subunit mu (AP2M1) - 15 more (view)
Epidermal growth factor receptor (EGFR) - 14 more (view)

Other switches involving interfaces
TRG_ENDOCYTIC_2 - 21 more (view)
Adaptor complexes medium subunit family - 21 more (view)