Switch #: SWTI000222

Switch type: Binary

Switch subtype: Allostery

Description:
Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (AP2M1) subunit for recruitment of Transferrin receptor protein 1 (TFRC) via an endocytosis motif.

Participants:
(1) Transferrin receptor protein 1 (TFRC)
(2) AP-2 complex subunit mu (AP2M1)

(1) A point mutation in the cytoplasmic domain of the transferrin receptor inhibits endocytosis.
Alvarez et al. Biochem. J. (1990)

(2) Role of the human transferrin receptor cytoplasmic domain in endocytosis: localization of a specific signal sequence for internalization.
Jing et al. J. Cell Biol. (1990)

(3) YTRF is the conserved internalization signal of the transferrin receptor, and a second YTRF signal at position 31-34 enhances endocytosis.
Collawn et al. J. Biol. Chem. (1993)

Other switches involving participants
AP-2 complex subunit mu (AP2M1) - 15 more (view)

Other switches involving interfaces
TRG_ENDOCYTIC_2 - 21 more (view)
Adaptor complexes medium subunit family - 21 more (view)