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Switch #:
SWTI000676
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of T387 adjacent to the clathrin-binding motif of Amphiphysin (AMPH) by CK2 subfamily inhibits binding to the Clathrin heavy chain 1 (CLTC). A second clathrin-binding motif in Amphiphysin (AMPH) is regulated in a similar manner (see switch details). Both these motifs cooperate in avidity-based binding to Clathrin heavy chain 1 (CLTC) (see switch details).

Participants:
(1) Amphiphysin (AMPH)
(2) Clathrin heavy chain 1 (CLTC)

Interactions
Interaction #1 AMPH - CLTC

Interfaces
(1) LIG_Clathr_ClatBox_2 motif (380LPWDLW385) in Amphiphysin (AMPH)
(2) Clathrin propeller repeat (19-56) and (148-187) and (198-234) in Clathrin heavy chain 1 (CLTC)

Interaction Regulation
PTM-dependent Inhibition (Phosphorylation of T387 on Amphiphysin (AMPH)) of the Amphiphysin (AMPH) LIG_Clathr_ClatBox_2 motif - Clathrin heavy chain 1 (CLTC) Clathrin propeller repeat interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: T387: CK2 subfamily


Context
References

(1) Nerve growth factor-induced phosphorylation of amphiphysin-1 by casein kinase 2 regulates clathrin-amphiphysin interactions.
Döring et al. J. Neurochem. (2006)

See also

Other switches involving participants
Clathrin heavy chain 1 (CLTC) - 4 more (view)
Amphiphysin (AMPH) - 2 more (view)

Other switches involving interfaces
Clathrin propeller repeat - 4 more (view)
LIG_Clathr_ClatBox_2 - 2 more (view)




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