switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:P23458 (5 hits) x

x Coloured by: Modifier evidence source
Curated inferred

x Index

Epidermal growth factor receptor	Proto-oncogene tyrosine-protein kinase Src	Receptor tyrosine-protein kinase erbB-2
Tyrosine-protein kinase ABL1

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Protein

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Information

Evidence

Epidermal growth factor receptor - EGFR - Homo sapiens
LIG_SH2_IE	EGFR_HUMAN	1008	1024	Binary	Physicochemical compatibility	Phosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Tyrosine-protein kinase JAK1 (JAK1) protein.	details	Inferred
Proto-oncogene tyrosine-protein kinase Src - SRC - Homo sapiens
LIG_SH2_IE	EGFR_HUMAN	1008	1024	Binary	Physicochemical compatibility	Phosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Tyrosine-protein kinase JAK1 (JAK1) protein.	details	Inferred
LIG_SH2_IE	EGFR_HUMAN	1008	1024	Binary	Physicochemical compatibility	Phosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Tyrosine-protein kinase JAK1 (JAK1) protein.	details	Inferred
Receptor tyrosine-protein kinase erbB-2 - ERBB2 - Homo sapiens
LIG_SH2_IE	ERBB2_HUMAN	1015	1031	Binary	Physicochemical compatibility	Phosphorylation of Y1023 in the SH2-binding motif of Receptor tyrosine-protein kinase erbB-2 (ERBB2) induces binding to the Tyrosine-protein kinase JAK1 (JAK1) protein.	details	Inferred
Tyrosine-protein kinase ABL1 - ABL1 - Homo sapiens
LIG_SH2_IE	EGFR_HUMAN	1008	1024	Binary	Physicochemical compatibility	Phosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Tyrosine-protein kinase JAK1 (JAK1) protein.	details	Inferred