switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:P64897 (2 hits) x

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Curated inferred

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Evidence

Probable serine/threonine-protein kinase pknG - PKNG - Mycobacterium tuberculosis
LIG_FHA_1	Y1827_MYCTU	19	25	Binary	Physicochemical compatibility	Phosphorylation of T21 in the FHA-binding motif of Uncharacterized protein Rv1827/MT1875 (Rv1827) by Probable serine/threonine-protein kinase pknG (pknG) results in auto-inhibition due to an intramolecular interaction with the FHA domain. As a result, phosphorylation-independent interactions of the FHA domain with metabolic enzymes, which regulate the catalytic activity of these enzymes, are blocked (See also switch details).	details	Curated
Serine/threonine-protein kinase pknB - PKNB - Mycobacterium tuberculosis
LIG_FHA_1	Y1827_MYCTU	20	26	Binary	Physicochemical compatibility	Phosphorylation of T22 in the FHA-binding motif of Uncharacterized protein Rv1827/MT1875 (Rv1827) by Serine/threonine-protein kinase pknB (pknB) results in auto-inhibition due to an intramolecular interaction with the FHA domain. As a result, phosphorylation-independent interactions of the FHA domain with metabolic enzymes, which regulate the catalytic activity of these enzymes, are blocked (See also switch details).	details	Curated